顾瑛

顾瑛

研究领域(方向)

激光在临床医学中的应用研究。

个人及工作简历

激光医学专家,中国科学院院士。1982年天津医科大学医疗系学士学位,1988年解放军医学院硕士学位,毕业后进入解放军总医院激光医学科工作,先后担任主治医师、副主任医师、副教授、主任医师、教授、博士研究生导师,1993年起担任解放军总医院激光医学科科主任,1999年入选国家“百千万人才工程”一二层,2000年解放军医学院博士学位,2015年当选中国科学院院士。

科研项目

负责和参加了国家自然科学基金、军队“八五”、“九五”、“十五”、“十一五”及国际、国内和军内合作科研课题50余项。

学术及科研成果、专利、论文

主要从事激光医学临床、科研和教学工作。发明了血管靶向光动力疗法(新型光动力疗法),完成了血管靶向光动力疗法的理论和机理、药物和设备、技术和方法、应用和规范的系统性创新研究,开创了血管靶向光动力治疗的新学术方向和应用领域。合作研发出国家化学1.1类新药——海姆泊芬。主持制定了我国首部激光医学临床技术操作规范和诊疗指南。曾获国际激光医学大会学术奖、国家发明奖、中国青年科技奖、中国科协“求是杰出青年奖”、军队科技进步奖等。获得“全国巾帼建功标兵”和“三八红旗手”荣誉称号,享受国家特殊津贴。

1. Zhao HY, Yin R, Wang Y, Lee YH, Luo T, Zhang JY, Qiu HX, Ambrose S, Wang LJ, Ren J, Yao J, Chen DF, Wang YC, Liang ZP, Zhen J, Wu SM, Ye ZL, Zeng J, Huang NY, Gu Y. Modulating mitochondrial morphology enhances antitumor effect of 5-ALA-mediated photodynamic therapy both in vitro and in vivo[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2017,176:81-91.

2. Qiu HX, Mao YP, Zeng J, Wang Y, Zhang JY, Huang NY, Liu QS, Yang YS, Linghu EQ, Gu Y. Vascular-targeted photodynamic therapy of gastric antral vascular ectasia (GAVE)[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2017,166:58-62.

3. Xu D, Yang SH, Wang Y, Gu Y, Xing D. Noninvasive and high-resolving photoacoustic dermoscopy of human skin[J]. Biomedical Optics Express, 2016,7(6):2095-2102.

4. Ge JC, Jia QY, Liu WM, Lan MH, Zhou BJ, Guo L, Zhou HY, Zhang HY, Wang Y, Gu Y, Meng XM, Wang PF. Carbon Dots with Intrinsic Theranostic Properties for Bioimaging, Red-Light-Triggered Photodynamic/Photothermal Simultaneous Therapy In Vitro and In Vivo[J]. Advanced Healthcare Materials, 2016,5(6):665-675.

5. Zhao HY, Yin R, Chen DF, Ren J, Wang YC, Zhanga JY, Deng H, Wang Y, Qiu HX, Huang NY, Zou QL, Zhao JQ, Gu Y. In vitro and in vivo antitumor activity of a novel hypocrellin B derivative for photodynamic therapy[J]. Photodiagnosis and Photodynamic Therapy, 2014,11(2):204-212.

6. Qiu HX, Mao YP, Gu Y, Zhu JG, Wang Y, Zeng J, Huang NY, Liu QS, Yang YS. The potential of photodynamic therapy to treat esophageal candidiasis coexisting with esophageal cancer[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2014,130:305-309.

7. Qiu HX, Zhou Y, Gu Y, Ang Q, Zhao S, Wang Y, Zeng J, Huang NY. Monitoring Microcirculation Changes in Port Wine Stains During Vascular Targeted Photodynamic Therapy by Laser Speckle Imaging[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2012,88(4):978-984.

8. Wang Y, Zuo ZH, Gu Y, Huang NY, Chen R, Li BH, Qiu HX, Zeng J, Zhu JG, Liang J. New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm[J]. JOURNAL OF BIOMEDICAL OPTICS, 2012,17(6).

9. Qiu HX, Gu Y, Wang Y, Huang NY. Twenty Years of Clinical Experience with a New Modality of Vascular-Targeted Photodynamic Therapy for Port Wine Stains[J]. DERMATOLOGIC SURGERY, 2011,37(11):1603-1610.

10. Wang Y, Gu Y, Zuo ZH, Huang NY. Choosing optimal wavelength for photodynamic therapy of port wine stains by mathematic simulation[J]. JOURNAL OF BIOMEDICAL OPTICS, 2011,16(9).

11. Fan SJ, Qiu HX, Huang HB, Gu Y, Zeng J. Effects of Photodynamic Therapy Using Hematoporphyrin Monomethyl Ether on Experimental Choroidal Neovascularization[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2010,86(4):972-980.

12. Wang Y, Gu Y, Liao XH, Chen R, Ding HY. Fluorescence monitoring of a photosensitizer and prediction of the therapeutic effect of photodynamic therapy for port wine stains[J]. EXPERIMENTAL BIOLOGY AND MEDICINE, 2010,235(2):175-180.

13. Zhang Y, Xie J, Zhang LY, Li C, Chen HX, Gu Y, Zhao JQ. A novel elsinochrome A derivative: a study of drug delivery and photodynamic activity[J]. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2009,8(12):1676-1682.

14. Huang NY, Cheng G, Li XS, Gu Y, Liu FG, Zhong QH, Wang Y, Zen J, Qiu HX, Chen HX. Influence of drug-light-interval on photodynamic therapy of port wine stains - Simulation and validation of mathematic models[J]. Photodiagnosis and Photodynamic Therapy, 2008,5(2):120-126.

联系方式

电子邮箱:

联系电话:029-82657541

个人主页:联系地址:精准外科与再生医学国家地方联合工程研究中心

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