教授·博士生导师·国家级青年人才·西安交通大学青年拔尖人才A类
单位：西安交通大学第一附属医院
邮箱：chaochen@xjtu.edu.cn
地址：西安交通大学创新港校区21号楼
教育及工作经历：
2023.03-至今，西安交通大学“青年拔尖人才计划”入选者，教授、博士生导师
2021.10-2023.03，香港科技大学·化学系，博士后（导师：唐本忠院士）
2019.10-2021.09，香港科技大学·化学及生物工程学系，博士后（导师：唐本忠院士）
2016.09-2019.06，南开大学·生物化学与分子生物学，博士（导师：丁丹教授）
2014.09-2016.06，南开大学·生物化学与分子生物学（导师：孔德令教授）
2010.09-2014.06，天津科技大学·生物制药工程专业，学士
研究领域（方向）
长期致力于精准肿瘤光学诊疗，主要方向包括：
1. 光学分子探针的开发与肿瘤等重大疾病精准诊断
2. 光敏/声敏分子的智能开发与肿瘤，肥胖等重大疾病治疗
3. 基于光学/声学促发的氧化应激生物学效益的可控干预与疾病治疗
科研项目
1. 新概念生物医用光学材料开发与应用·国家级青年人才项目·2025.01-2027.12·主持
2. 多功能AIE材料的制备及其用于调控T细胞分化的研究·NSFC 面上项目·2024.01-2027.12·主持
3. 近红外AIE金属有机笼与蛋白降解靶向嵌合体式复合作用下的免疫应答过程示踪及其调控机制研究·NSFC地区联合重点·2025.01-2028.12·参与
4. 三秦英才引进青年项目·陕西省人才项目·2024.01-2029.12·主持
5. 西安交通大学青年拔尖人才支持计划A类西安交通大学人才项目2023.03-2029.03·主持
科研成果
目前已发表SCI论文30余篇，总引用次数4000余次，H因子23 （Google Scholar）。其中，在J. Am. Chem. Soc., Adv. Mater., Angew. Chem. Int. Ed., Nat. Commun., Nat Protoc., CCS Chemistry, Adv. Sci., Adv. Funct. Mater., Chem. Sci.等JCR一区Top期刊发表第一作者/共同第一作者/通讯作者论文13篇, 其中IF>10的13篇, ESI高被引论文6篇，另已取得国家发明专利1项。
代表性论文
1. J. Liu, R. Zhang, Y. Bao, Y. Chen, W. Zheng, J. Yuan, Z. Zhang, P. Chen, Me. Ji, Y. Cheng,* P. Hou,* D. Dang, D. Ding, and C. Chen*. Highly Efficient and Universal Degradation of PD-L1 via Mitochondrial Oxidative Stress Evoked by Cationic AIE-Active Photosensitizers for Cancer Immunotherapy. Adv. Funct. Mater. 2025. 35, 2414495. (JCR 1区Top, IF: 13.1)
2. YJ. Chen, YX. Bao, YB. Wang, JZ. Liu, WF. Zheng, P. Chen, W. Wei, MJ. Ji, RY. Zhang, P. Hou, C. Chen*. Alkyl chain engineering of ionic AIE molecules for developing superior self-adjuvanted nanovaccines in cancer immunotherapy. Chem. Eng. J. 2025. 506. (JCR 1区, IF: 13.3)
3. C. Chen, X. Zhang, Z. Gao, G. Feng*, D. Ding* Preparation of AIEgen-based near-infrared afterglow luminescence nanoprobes for tumor imaging and image-guided tumor resection. Nat. Protoc. 2024. 19, 2408-2434. (JCR 1区Top, IF: 18.5)
4. C. Chen#, H. Gao#, H. Ou#, R. T.K. Kwok, Y. Tang, D. Zheng, D. Ding*. Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases. J. Am. Chem. Soc. 2022. 144, 3429–3441 (封面文章，JCR 1区Top, IF: 15.0)
5. C. Chen#, Z. Wang#, S. Jia#, Y. Zhang, S. Ji, Z. Zhao, R. T. K. Kwok, J. W. Y. Lam, D. Ding, Y. Shi*, B. Z. Tang*. Evoking Highly Immunogenic Ferroptosis Aided by Intramolecular Motion-Induced Photo-Hyperthermia for Cancer Therapy. Adv. Sci. 2022, 9, 2104885. (JCR 1区Top, IF: 15.1)
6. C. Chen#, R. Zhang#, J. Zhang#, Y. Zhang, H. Zhang, Z. Wang, X. Huang, S. Chen, R. T. K. Kwok, J. W. Y. Lam, D. Ding*, B. Z. Tang*. Taming Reactive Oxygen Species: Mitochondria-Targeting Aggregation-Induced Emission Luminogen for Neuron Protection via Photosensitization-Triggered Autophagy. CCS Chemistry 2021, 2791-2799.(JCR 1区Top, IF: 11.2)
7. C. Chen#, X. Ni#, H.-W. Tian, Q. Liu, D.-S. Guo, D. Ding*. Calixarene-Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image-Guided Cancer Surgery. Angew. Chem. Int. Ed. 2020, 132, 10094-10098. (JCR 1区Top, IF: 16.6)
8. C. Chen#, H. Ou#, R. Liu, D. Ding*. Regulating the Photophysical Property of Organic/Polymer Optical Agents for Promoted Cancer Phototheranostics. Adv. Mater. 2020, 32, 1806331. (JCR 1区Top, IF: 29.4)
9. S. Liu#, C. Chen#, Y. Li, H. Zhang, J. Liu, R. Wang, S. T. H. Wong, J. W. Y. Lam, D. Ding*, B. Z. Tang*. Constitutional Isomerization Enables Bright NIR-II AIEgen for Brain-Inflammation Imaging. Adv. Funct. Mater. 2020, 30, 1908125. (JCR 1区Top, IF: 19.0)
10. J. Chen#, J. Qi#, C. Chen#, J. Chen, L. Liu, R. Gao, T. Zhang, L. Song, D. Ding*, P. Zhang*, C. Liu*. Tocilizumab-Conjugated Polymer Nanoparticles for NIR-II Photoacoustic-Imaging-Guided Therapy of Rheumatoid Arthritis. Adv. Mater. 2020, 32, 2003399. (JCR 1区Top, IF: 29.4)
11. C. Chen#, X. Ni#, S. Jia, Y. Liang, X. Wu, D. Kong, D. Ding*. Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure, Adv. Mater. 2019, 31, 1904914. (封面文章, JCR 1区Top, IF: 29.4)
12. Z. Zhao#, C. Chen#, W. Wu#, F. Wang, L. Du, X. Zhang, Y. Xiong, X. He, Y. Cai, R. T. K. Kwok, J. W. Y. Lam, X. Gao, P. Sun, D. L. Phillips, D. Ding*, B. Z. Tang*. Highly Efficient Photothermal Nanoagent Achieved by Harvesting Energy via Excited-State Intramolecular Motion within Nanoparticles. Nat. Commun. 2019, 10, 768. (JCR 1区Top, IF: 16.6)
13. J. Qi#, C. Chen#, X. Zhang, X. Hu, S. Ji, R. T. K. Kwok, J. W. Y. Lam, D. Ding*, B. Z. Tang*. Light-Driven Transformable Optical Agent with Adaptive Functions for Boosting Cancer Surgery Outcomes. Nat. Commun. 2018, 9, 1848. (JCR 1区Top, IF: 16.6)
14. C. Chen#, Z. Song#, X. Zheng, Z. He, B. Liu*, X. Huang, D. Kong, D. Ding*, B. Z. Tang*. AIEgen-Based Theranostic System: Targeted Imaging of Cancer Cells and Adjuvant Amplification of Antitumor Efficacy of Paclitaxel. Chem. Sci. 2017, 8, 2191-2198. (JCR 1区Top, IF: 8.4)
15. J. Liu#, C. Chen#, S. Ji, Q. Liu*, D. Ding*, D. Zhao, B. Liu*. Long Wavelength Excitable Near-Infrared Fluorescent Nanoparticles with Aggregation-Induced Emission Characteristics for Image-Guided Tumor Resection. Chem. Sci. 2017, 8, 2782-2789. (JCR 1区Top, IF: 8.4)
联系方式
电子邮箱：chaochen@xjtu.edu.cn
联系电话：15022438784
个人主页：https://gr.xjtu.edu.cn/web/chaochen
联系地址： 西安交通大学创新港校区21号楼 Med-X研究院-肿瘤精准医疗研究所
