主要从事天然药物化学的研究与开发。主要是从中草药、药用植物、微生物等天然药物资源中寻找结构新颖、活性显著的天然产物，并以此为先导化合物，通过化学结构改造和优化等方法从中发现高效低毒的前药分子。
2021.7-至今 西安交通大学，药学院，副教授
2017.7-2021.6 西安交通大学，药学院，讲师
2012.9-2017.6 华中科技大学，同济药学院，博士
2008.9-2012.6 江苏大学，药学院，学士
主持国家自然科学基金面上项目、青年项目，陕西省重点研发计划、陕西省自然科学基金、中国博士后基金等国家级及省部级项目10余项。
1.国家自然科学基金面上项目, No. 32270412, 2023-01至2026-12, 54万元,主持
2.国家自然科学基金青年项目, No. 31800286, 2019-01至2021-12, 25万元,主持
3.陕西省重点研发计划（一般项目）, No. 2023-YBSF-187, 2023-01至2024-12, 6万元,主持
4.陕西省中医药管理局中医药传承创新暨“秦药”开发重点科学研究项目, No. 2021-02-ZZ-018, 2021-10至2023-10, 10万元,主持
5.中央高校基本科研业务费, No. xpt012022038, 2022-01至2022-12, 10万元,主持
6.中国博士后基金面上项目, No. 2021M702636, 2021-09至2023-08, 8万元,主持
7.陕西省自然科学基础研究计划项目, No. 2019JQ-194, 2019-01至2020-12, 3万元,主持
8.中国博士后基金面上项目, No. 2017M623200, 2017-07至2020-06, 5万元,主持
9.中央高校基本科研业务费, No. xjj2018169, 2018-01至2020-12, 15万元,主持
10.西安交通大学新讲师支持计划, No. xjj2017060, 2018.01-2021.12, 10万元,主持
以第一作者或者通讯作者在Bioorganic Chemistry, Journal of Natural Products, European Journal of Medicinal Chemistry, Phytochemistry等学术期刊上发表SCI研究论文20余篇。以第一申请人申请并授权专利3项。
1.Fuxin Zhang, Kailing Yang, Huanhuan Liu, Tao Yang, Ruixi Zhou, Xinxin Zhang,Guanqun Zhan*, Zengjun Guo**, Structurally diverse monoterpene indole alkaloids with vasorelaxant activities from the branches ofAlstonia scholaris, Phytochemistry, 2023, 209, 113610.https://doi.org/10.1016/j.phytochem.2023.113610
2.Fuxin Zhang, Tao Yang, Kailing Yang, Ruixi Zhou, Yu Zhang, Wenwen Chen, Zhetong Liu,Guanqun Zhan*, Zengjun Guo*, Cytotoxic alkaloids from the twigs and leaves ofCephalotaxus sinensis, Organic & Biomolecular Chemistry, 2023, 21, 169.https://doi.org/10.1039/d2ob01980a.
3.Guanqun Zhan, Biao Gao, Junfei Zhou, Tingting Liu, Guijuan Zheng, Zhong Jin*, Guangmin Yao*, Structurally diverse alkaloids with nine frameworks fromZephyranthes candidaand their acetylcholinesterase inhibitory and anti-inflammatory activities, Phytochemistry, 2023, 127, 113564.https://doi.org/10.1016/j.phytochem.2022.113564.
4.Fuxin Zhang, Huanhuan Liu, Kailing Yang, Tao Yang, Ruixi Zhou, Rongkun Miao,Guanqun Zhan*, Zengjun Guo*, New phenylpropanoids and monoterpene alkaloids with vasorelaxant activities from the branches ofAlstonia scholaris, Fitoterapia, 2022, 158, 10514.https://doi.org/10.1016/j.fitote.2022.105143
5.Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Gang Chang, Lei Zhang, Xinxin Zhanga,Hui Zhang, Zengjun Guo*, Monoterpene indole alkaloids with acetylcholinesterase inhibitory activityfrom the leaves ofRauvolfia vomitoria,Bioorganic Chemistry, 2020, 102, 104136.https://doi.org/10.1016/j.bioorg.2020.104136
6.Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Xincai Hao, Xi Zheng, Hui Zhang, Xinxin Zhang, Zengjun Guo*, Monoterpene indole alkaloids with diverse skeletons from the stems ofRauvolfia vomitoriaand their acetylcholinesterase inhibitory activities, Phytochemistry, 2020,177, 112450.https://doi.org/10.1016/j.phytochem.2020.112450
7.Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Yi Hao, Yu Zhang, Yingxu Zhang, Muhammad Khurm, Xinxin Zhang, Zengjun Guo*,Peraksine derivatives with potential anti-inflammatory activities from the stems ofRauvolfia vomitoria, Fitoterapia, 2020, 146, 104704.https://doi.org/10.1016/j.fitote.2020.104704
8.Guanqun Zhan, Rongkun Miao, Fuxin Zhang, Xingbin Wang, Xinxin Zhang, Zengjun Guo*,Cytotoxic Yohimbine-Type Alkaloids from the leaves ofRauvolfia vomitoria, Chemistry & Biodiversity, 2020, 17, e2000647.https://doi.org/10.1002/cbdv.202000647
9.Guanqun Zhan, Junfei Zhou, Junjun Liu, Jinfeng Huang, Hanqi Zhang, Rong Liu, Guangmin Yao*, Acetylcholinesterase inhibitory alkaloids from the whole plants ofZephyranthes carinata, Journal of Natural Products, 2017, 80(9), 2462-2471.https://doi.org/10.1021/acs.jnatprod.7b00301
10.Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa, Guangmin Yao*, Amaryllidaceae alkaloids with new framework types fromZephyranthes candidaas potent acetylcholinesterase inhibitors,European Journal of Medicinal Chemistry, 2017, 127, 771-780.http://dx.doi.org/10.1016/j.ejmech.2016.10.057
电子邮箱：gq,zhan@163.com; zhanguanqun@mail.xjtu.edu.en
联系电话：13572975056
个人主页：https://gr.xjtu.edu.cn/web/zhanguanqun
联系地址：1、陕西省西安市雁塔区雁塔西路76号（西安交通大学雁塔校区）
2、陕西省西安市中国西部科技创新港（西安交通大学创新港校区）
