研究领域（方向）：
细胞膜色谱技术
过敏性鼻炎的生物标志物分析
靶向肥大细胞的抗过敏中药活性分子筛选及其作用机制研究
个人及工作简历（个人受教育及工作经历）：
2020-11至今西安交通大学，药学院，副教授
2018-07至2020-10 西安交通大学，药学院，助理研究员
2017-07至2017-12 约翰·霍普金斯大学，医学院，实习生
2016-01至2016-06 约翰·霍普金斯大学，医学院，实习生
2012-09至2018-06 西安交通大学，药物分析学，医学博士
2008-09至2012-07 西安交通大学，制药工程，工学学士
主要科研项目
[1]国家自然科学基金委员会，青年科学基金项目，81903572，基于MRGPRX2的盐酸青藤碱代谢物类过敏成分筛选分析基础研究，2020-01至2022-12，21万元，结题，主持
[2]中国博士后科学基金会，博士后科学基金面上二等，2019M663755，细胞膜色谱用于筛选苍耳子中抗类过敏天然活性成分研究，2019-01至2020-12，8万元，结题，主持
[3]榆林市科技局，市级重要项目子课题，YF-ZDZX-01-ZKT03，榆林季节性过敏的治疗与防控研究，2024-01至2024-12，100万元，结题，主持
学术及科研成果、专利、论文
代表性学术论文：
[1]Chao Wang1, Na Wang2, Ling Gong, Hongfen Du, Shiqiong Luo, Xiaolan Ji, Yujuan Yuan, Yuanyuan Ding, Xukai Guan,Rui Liu#,Tao Zhang#. Plasma MRGPRX2 Correlates with Severity of Artemisia-Induced Allergic Rhinitis, Particularly in IgE-Negative Patients: A Cross-Sectional Study, Journal of Asthma and Allergy, 2025, 18:1761-1772.
[2]Yihan Huang, Na Wang, Xiaolan Ji, Shiqiong Luo, Ling Gong, Chenrui Zhao, Guodong Zheng,Rui Liu#, Tao Zhang#. Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP-MRGPRX2 feedback loop, Phytomedicine, 2025, 140: e156564.
[3]Youfa Qin, Yihan Huang, Xiaolan J, Ling Gong, Shiqiong Luo, Jiapan Gao,Rui Liu#, Tao Zhang#. N-demethylsinomenine metabolite and its prototype sinomenine activate mast cells via MRGPRX2 and aggravate anaphylaxis, Frontiers in Pharmacology, 2024, 15:1389761.
[4]Yonghui Zhang, Yihan Huang, Baowen Dang, Shiting Hu, Chenrui Zhao, Yuejin Wang, Yujuan Yuan,Rui Liu#. Fisetin alleviates chronic urticaria by inhibiting mast cell activation via MRGPRX2, Journal of Pharmacy and Pharmacology, 2023 Oct 5;75(10):1310-1321.
[5]Rui Liu, Yonghui Zhang, Yuejin Wang, Yihan Huang, Jiapan Gao, Xi Tian, Tianyou Ma, Tao Zhang*. Anti‐inflammatory effect of dictamnine on allergic rhinitis via suppression of the LYN kinase‐mediated molecular signaling pathway during mast cell activation, Phytotherapy Research, 2023, 37(9): 4236-4250.
[6]Jiapan Gao, Yuanyuan Ding, Yuejin Wang, Peida Liang, Liyang Zhang,Rui Liu#. Oroxylin A is a severe acute respiratory syndrome coronavirus 2-spiked pseudotyped virus blocker obtained from Radix Scutellariae using angiotensin-converting enzyme II/cell membrane chromatography. Phytotherapy Research, 2021, 35(6):3194-3204.
[7]Chuchu Qiao, Shiling Hu, Delu Che, Jue Wang, Jiapan Gao, Ruiping Ma, Wenjun Jiang, Tao Zhang,Rui Liu*. The anti-anaphylactoid effects of Piperine through regulating MAS-related G protein-coupled receptor X2 activation, Phytotherapy Research, 2020, 34(6): 1409-1420.
[8]Rui Liu, Shiling Hu, Yuanyuan Ding, Jue Wang, Yuejin Wang, Jiapan Gao, Langchong He. Dictamnine is an effective anti-anaphylactoid compound acting via the MrgX2 receptor located on mast cells, Phytotherapy Research, 2021, 35(6):3181-3193.
[9]Rui Liu, Tingting Zhao, Delu Che, Jiao Cao, Jue Wang, Yanni Lv, Pengyu Ma, Yuanyuan Ding, Nana Wang, Xiaoyang Wang, Nan Wang, Jianli Wang, Zijun Gao, Tao Zhang*. The anti-anaphylactoid effects of hydroxysafflor yellow A on the suppression of mast cell Ca2+influx and degranulation, Phytomedicine, 2018, 48: 43-50.
[10]Rui Liu, Delu Che, Tingting Zhao, Priyanka Pundir, Jiao Cao, Yanni Lv, Jue Wang, Pengyu Ma, Jia Fu, Nana Wang, Xiaoyang Wang, Tao Zhang, Xinzhong Dong, Langchong He*. MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions, Biochemical Pharmacology, 2017, 146: 214-223.
代表性专利：
[1]张涛,丁园园,刘瑞,贺浪冲,王楠,马维娜,李超美.一种用于制备ELISA鼠单克隆包被抗体和兔检测抗体的多肽及其应用, ZL 2019 1 0468919.6, 2021年05月28日.
[2]贺浪冲,王楠,张涛,丁园园,刘瑞,韩省力.一种用于制备类过敏反应的双抗夹心试剂盒体的多肽及其应用, ZL 2019 1 0468926.6, 2021年05月28日.
[3]张涛,丁园园,刘瑞,贺浪冲,马维娜,韩省力.一种对类过敏反应特异性受体MRGPRX2蛋白的具有免疫原性的多肽及其应用, ZL 2019 1 0468920.9, 2021年05月28日.
[4]刘瑞,马维娜,贺浪冲,丁园园,张涛,曹娇,李超美.一种用于制备兔多克隆抗体的多肽及其应用, ZL 2019 1 0469462.0, 2021年04月20日.
[5]贺浪冲,韩省力,张涛,丁园园,刘瑞,王楠.一种抗Mrgprx2抗体的优势抗原表位多肽及其应用, ZL 2019 1 0469478.1, 2021年04月20日.
联系方式
电子邮箱：rliu2018@xjtu.edu.cn
联系电话：18092186746
个人主页：https://gr.xjtu.edu.cn/web/rliu2018
联系地址：西安交通大学创新港校区21号楼5106办公室
