王楠

研究领域(方向):

专业:药物分析学/药理学

研究领域:

1.复杂体系物质基础分析

2.药物作用新靶点发现

3.基于新靶点的创新药物开发

个人及工作简历(个人受教育及工作经历):

1. 2025.01至今 西安交通大学教授/博士生导师

2. 2020.06至今 博士生导师

3. 2024.08至今 陕西省创新药物研究中心(药物分析装备)副主任

4. 2018.6-2024.12 西安交通大学副教授/硕导

5. 2014.12-2018.6 西安交通大学讲师

6. 2016.12-2017.12约翰∙霍普金斯大学访问学者

7. 2009.9-2014.12 西安交通大学,药物分析学,医学博士

主要科研项目

1.国家自然科学基金面上项目:基于MRGPRX2新靶点的小柴胡汤抗过敏性哮喘药效物质基础及机制研究(主持,2023-2026,82274063)

2.人工智能与数字经济广东省实验室医药智能分析中心自主部署项目子课题:医药智能分析中心-智能装备(主持,2021-2025,2020开放基金82)

3.陕西省自然科学基金面上项目:基于MrgX2新靶点的延胡索抗过敏性哮喘药效物质基础及作用机制研究(主持,2020-2022,2022JM-474)

4.陕西省中医药管理局中医药防治新冠科研攻关项目:中药柴胡抗新冠病毒成分筛选与研究(主持,2023-2024,ZYJXG-Y2315)

5.中国博士后科学基金面上项目:紫苏叶醇提物抗过敏性哮喘作用及与肥大细胞关系研究(主持,2019-2022,2019M653672)

6.国家自然科学基金青年项目:中药注射剂中黄芩苷致类过敏反应与hMRGPRX2受体关系研究(主持,2016-2018,81503321)

学术及科研成果、专利、论文

以第一及通讯作者发表SCI论文30余篇,申请国家发明专利15

部分论文:

[1][Haoyun Bai, Yongjing Zhang, Xinping Zhang, Chenjia Li, Mengyang Ma, Jie Gao, Tingting Deng, Chang Gao,Nan Wang*. Zyxin-a novel detrimental target, is inhibited by Saikosaponin A during allergic asthma. Phytomedicine. 2025; 138: 156434.

[2]Yongjing Zhang, Wen Zhang, Mengyang Ma, Xinping Zhang, Chenjia Li, Tingting Deng, Jie Gao, Chang Gao,Nan Wang*. Corydalis yanhusuo extract and its pharmacological substances alleviate food allergy by inhibiting mast cells activation via PLC/PKC/ STAT3 pathway. Journal of Ethnopharmacology. 2025, 337: 118809.

[3]Yongjing Zhang, Yingnan Zeng, Haoyun Bai, Wen Zhang, Zhuoyin Xue, Shiling Hu, Shemin Lu*,Nan Wang*. Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases. Journal of Pharmaceutical Analysis. 2024, 14: 101149.

[4]Haoyun Bai, Zhuoyin Xue, Wen Zhang, Chaohua Feng, Zhenqi Zhou, Shiling Hu, Yongjing Zhang, Qiaohong Qin, Yuanyuan Wu, Xiuzhen Sun, Yuhan Zhou,Nan Wang*. α-Asarone alleviates allergic asthma by stabilizing mast cells through inhibition of ERK/JAK2-STAT3 pathway. BioFactors. 2023; 49: 140–152.

[5]Nan Wang, Jue Wang, Yongjing Zhang, Shiling Hu, Haoyun Bai, Yajing Hou, Cheng Wang, Huaizhen He, Langchong He*. Imperatorin ameliorates mast cell-mediated allergic airway inflammation by inhibiting MRGPRX2 and CamKII/ERK signaling pathway. Biochemical Pharmacology. 2021; 184: 114401.

[6]Zhuoyin Xue, Yongjing Zhang, Yingnan Zeng, Shiling Hu, Haoyun Bai, Jue Wang, Huiling Jing,Nan Wang*. Licochalcone A inhibits MAS-related GPR family member X2-induced pseudo-allergic reaction by suppressing nuclear migration of nuclear factor-κB. Phytotherapy Research. 2021; 35: 6270-6280.

[7]Nan Wang, Jue Wang, Yongjing Zhang, Shiling Hu, Tianxiao Zhang, Yuanyuan Wu, Xiuzhen Sun, Tao Zhang, Shuanying Yang, Langchong He*. Substance P-induced lung inflammation in mice is mast cell dependent. Clinical & experimental allergy. 2021; 52: 46-58.

[8]Yongjing Zhang, Shiling Hu, Jue Wang, Zhuoyin Xue, Cheng Wang,Nan Wang*. Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2. Virology. 2021; 554: 83–88.

[9]Yongjing Zhang, Zhuoyin Xue, Shiling Hu, Haoyun Bai, Jue Wang,Nan Wang*. Chrysin Inhibits Pseudo-allergic Reaction by Suppressing Mitochondrial STAT3 Activation via MAS-Related GPR Family Member X2. Journal of Agricultural and Food Chemistry. 2021.69: 6569-6577.

[10]Jue Wang, Yongjing Zhang, Shiling Hu, Shuai Ge, Min Jia,Nan Wang*.Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway. International Immunopharmacology. 2021; 93: 107426.

[11]Shiling Hu, Jue Wang, Yongjing Zhang, Haoyun Bai, Cheng Wang,Nan Wang*, Langchong He*. Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2. Journal of Medical Virology. 2021; 93: 3143–3151.

部分授权专利:

[1]ZL 201910600151.3王楠,贺浪冲,贺怀贞,王程,王珏,张永竟.一种P物质诱导的过敏性哮喘动物模型的构建方法和筛选药物的方法

[2]ZL202010100384. X王楠,贺浪冲,吴媛媛,王程.维生素K3用于制备抗类过敏药物的应用

[3]ZL2021147968.9.贺浪冲,王楠,张化俊,贺怀贞,王程,胡时灵,卢闻,张涛,马维娜.三尖杉酯碱用于制备抗新型冠状病毒药物的应用.

[4]ZL201910468926.6.5. 贺浪冲,王楠,张涛,丁园园,刘瑞,韩省力.一种用于制备类过敏反应的双抗夹心试剂盒配对抗体的多肽及其应用.

联系方式

电子邮箱:wangnan2014@xjtu.edu.cn

个人主页:http://gr.xjtu.edu.cn/web/wangnan2014

联系地址:陕西省西安市长安区高桥街道中国西部创新港21号楼5103

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