高鹏

单细胞---高鹏 (3)

高鹏:研究员,博士研究生导师

研究领域

1. 高通量测序技术的开发(单细胞水平&三代测序)

2. 血细胞发育及相关疾病

个人简介

西安交通大学第一附属医院特聘研究员,博士生导师,陕西省高层次人才引进计划(青年项目)和西安交通大学青年拔尖人才支持计划入选者。本、硕、博均毕业于东南大学医学院,专业分别是临床医学、病理学和免疫学。2011年博士毕业后先后在美国爱荷华大学和费城儿童医院/宾夕法尼亚大学任博士后研究员和研究科学家。2021年全职回国后加入西安交通大学第一附属医院单细胞测序平台,任职特聘研究员和博士研究生导师。主要从事高通量测序技术的开发、胚胎造血干细胞发育的转录调控机制、自身免疫性疾病发病机制、癌症发生发展和耐药机制等研究。主持西安交通大学青年拔尖人才支持计划项目、陕西省高层次人才引进计划(青年项目)项目和东南大学优秀博士论文基金,参与多项国家自然科学基金、教育部博士点基金、美国NIH基金以及癌症登月计划中的HTAN项目。迄今在NatureCellCancer DiscoveryImmunityBloodPNASScience AdvancesNucleic Acids ResearchGenes & DevelopmentNature Communications等期刊发表SCI论文29篇(其中第一和通讯作者论文7篇)。SCI引用1000多次,h-index为17。

教育经历

2007.09-2011.09:博士,免疫学,东南大学

2005.09-2007.06:硕士,病理学,东南大学(2007年9月起提前攻读博士学位)

2000.09-2005.06:学士,临床医学,东南大学

工作经历

2021.08-至今:特聘研究员,博士研究生导师,西安交通大学第一附属医院

2020.01-2021.02:研究科学家,费城儿童医院/宾夕法尼亚大学

2015.12-2020.01:博士后,费城儿童医院/宾夕法尼亚大学

2011.07-2015.12:博士后,爱荷华大学

科研项目(近5年主持项目)

1. 陕西省高层次人才引进计划(青年项目),2022-2025

2. 西安交通大学青年拔尖人才支持计划,2021-2026

发表论文(#第一或并列第一,*通讯作者)

第一作者

1. Gao P#,Chen C#, Howell E#, Li Y#, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann A, Speck N*, and Tan K*. (2020) Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells.Genes & Development. 34(13-14):950-964.

2. Zhu Q#,Gao P#, Tober J#, Bennett L, Chen C, Uzun Y, Li Y, Howell E, Mumau M, Yu W, He B, Speck N*, and Tan K*. (2020) Developmental trajectory of pre-Hematopoietic stem cell formation from endothelium.Blood.136(7):845-856.

3. Gao P#, Uzun Y#, He B, Salamati SE, Coffey JKM, Tsalikian E, Tan K. (2019) Risk variants disrupting enhancers of TH1 and TREGcells in type 1 diabetes.Proc Natl Acad Sci USA. 116(15):7581-7590.

4. Gao P, Zhai F, Guan L, Zheng J. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21.Oncology Letters. 2(1): 123-128.

5. Gao P, Zheng J. (2011) Oncogenic virus-mediated cell fusion: new insights into initiation and progression of oncogenic viruses-associated cancers.Cancer Letters. 303(1): 1-8.

6. Gao P, Guan L, Zheng J. (2010) Role of leukotriene B4 in celecoxib-mediated anticancer effect.Biochemical and Biophysical Research Communications. 402(2): 308-311.

7. Gao P#, Zheng J. (2010) High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer.Virology Journal. 7(1): 238.

共同作者

1. Yang Y, Mumau M, Tober J, Zhu Q, Bennett L, Hong C, Sung DC, Keller T, Uzun Y,Gao P, Shewale S, Chen M, Yang J, Chen X, Thomas SA, Tan K, Speck NA, Kahn ML. (2022) Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis.Blood,139(19):2942-2957.

2. Melenhorst JJ#*, Chen GM#, Wang M#, Porter DL#, Chen C, Collins MA,Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, Gill SI, Tian L, Kulikovskaya I, Gupta M, Ambrose DE, Davis MM, Fraietta JA, Brogdon JL, Young RM, Chew A, Levine BL, Siegel DL, Alanio C, Wherry EJ, Bushman FD, Lacey SF, Tan K*, June CH*. (2022) Decade-long leukaemia remissions with persistence of CD4+CAR T cells.Nature, 602(7897):503-509.

3. Chen GM#, Chen C#, Das RK#,Gao P, Chen C, Bandyopadhyay S, Ding Y, Uzun Y, Yu W, Zhu Q, Myers RM, Grupp SA, Barrett DM, Tan K. (2021) Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy.Cancer Discovery, 11(9):2186-2199.

4. Chen C#, Yu W#, Alikarami F#, Qiu Q, Chen C, Flournoy J,Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding Y, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM*, Bernt KM*, Tan K*. (2021) Single-cell multiomics reveals increased plasticity, resistant populations and stem-cell-like blasts in KMT2A-rearranged leukemia.Blood. doi: 10.1182/blood.2021013442. Online ahead of print.

5. Howell ED, Yzaguirre AD,Gao P, Lis R, He B, Lakadamyali M, Rafii S, Tan K*, Speck NA*. (2021) Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes Dev, 35(21-22):1475-1489.

6. Estevez B, Borst S, Jarocha D, Sudunagunta V, Gonzalez M, Garifallou J, Hakonarson H,Gao P, Tan K, Liu P, Sumedha Bagga S, Holdreith N, Tong W, Speck N, French D, Gadue P, and Poncz M. (2021) RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells: Mechanistic studies and drug correction.Blood, 137(19):2662-2675.

7. Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J,Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA*, Zon LI*. (2020) CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.Proc Natl Acad Sci USA, 117(38):23626-23635.

8. He B,Gao P, Ding Y, Chen C, Chen G, Chen C, Kim H, Tasian S, Hunger S, Tan K. (2020) Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers.Science Advances, 6(30):eaba3064.

9. The HTAN consortium. (2020) The Human Tumor Atlas Network: Charting tumor transitions across space and time at single-cell resolution.Cell. 181(2):236-249.

10.Chen C#, Yu W#, Tober J,Gao P, He B, Lee K, Trieu T, Blobel G, Speck N, Tan K. (2019)Spatial genome re-organization between fetal and adult hematopoietic stem cells.Cell Reports. 29(12):4200-4211.e7.

11.Zheng J,Gao P. (2019) Towards normalization of the tumor microenvironment for cancer therapy.Integrative Cancer Therapies.18:1534735419862352.

12.Liu K#, Du S#,Gao P, Zheng J. (2019) Verteporfin inhibits the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1.Journal of Cancer. 10(18):4196-4207.

13.Gao L, Tober J,Gao P, Chen C, Tan K, Speck NA. (2018) RUNX1 and the endothelial origin of blood.Experimental Hematology. 68:2-9.

14.Du S#, Liu K#,Gao P, Li Z, Zheng J. (2018)Differential anticancer activities of arsenic trioxide on head and neck cancer cells with different human papillomavirus status.Life Sciences. 212:182-193.

15.Gao L#, Uzun Y#,Gao P, He B, Ma X, Wang J, Han S, Tan K. (2018) Identifying noncoding risk variants using disease-relevant gene regulatory networks.Nature Communications.9(1):702.

16.Tober J, Maijenburg MMW, Li Y, Gao L, Hadland BK,Gao P, Minoura K, Bernstein ID, Tan K, Speck NA. (2018) Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.Journal of Experimental Medicine. 215(2):645-659.

17.He B#, Xing S#, Chen C,Gao P, Teng L, Shan Q, Gullicksrud JA, Martin MD, Yu S, Harty JT, Badovinac VP, Tan K, and Xue HH. (2016) CD8+T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections.Immunity. 45(6):1341-1354.

18.Ma X, Gao L, Karamanlidis G,Gao P, Lee CF, Garcia-Menendez L, Tian R, Tan K. (2015) Revealing Pathway Dynamics in Heart Diseases by Analyzing Multiple Differential Networks.PLoS Computational Biology. 11(6):e1004332.

19.Wang H,Gao P, Zheng J. (2014) Arsenic trioxide inhibits cell proliferation and human papillomavirus oncogene expression in cervical cancer cells.Biochemical and Biophysical Research Communications.451(4):556-561.

20.Zheng J,Gao P. (2013) Biosynthetic and Metabolic Alterations in Cancer Growth.Current Angiogenesis. 2, 149-156.

21.Teng L, He B,Gao P, Gao L, Tan K. (2014) Discover context-specific combinatorialtranscription factor interactions by integrating diverse ChIP-Seq data sets.Nucleic Acids Research. 42(4):e24.

22.Fan R, Bonde S,Gao P, Sotomayor B, Chen C, Mouw T, Zavazava N, Tan K. (2012) Dynamic HoxB4 Regulatory Network During Hematopoietic Stem Cell Development.Blood. 119(19): e139-147.

联系方式

联系邮箱:gaopeng@xjtu.edu.cn

联系电话:18182621983

个人主页:https://gr.xjtu.edu.cn/web/gaopeng

联系地址:西安交通大学彭康楼,西安交大一附院科研楼

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