代表性论著、科研获奖、人才称号 |
Selected Publications(*Corresponding author,#co-first author) （1）Xin Y#, Xiong X#, Zhang Y, Zhang S, Zhang S, Yang Y, Liang Y, Zang L, Chen X, Li W, Halalmeh I, Zhou R, Li Z, Liu H, Geng J. Calhm6 Governs Macrophage Polarization Through Chp1-Camk4-Creb1 Axis and Ectosomal Delivery in Inflammatory Responses. Adv Sci. 2025 Sep 26:e02395. doi: 10.1002/advs.202502395. Epub ahead of print. PMID: 40999918. （2）Yan Zhang, Yingxue Liang, Wenjuan Li, Lulu Zang, Xi Chen, Xiaofan Xiong, Siyu Zhang, Yuhao Gu, Shuaijie Zhong, Yingnan Li, Jing Geng, Yanlong Xin, Tea seed-derived leucoside attenuates sepsis via inhibition of TLR4-MD2 complex formation,Biochemical Pharmacology,Volume 243, Part 1,2025 （3）Song D, Zhao X, Zhang Y, Wang M, Tang H, Fang J, Song Z, Ma Q, Geng J. The amelioration effect of sesamoside on inflammatory response in septic shock. BMC Immunol. 2025 Mar 6;26(1):15. （4）Zhang S, Xin Y, Yang Y, Zhang Y, Geng J. The Polarization of Macrophages Regulated by KCNG3 via the Activation of ASK1 Mediated by Potassium Ion Efflux. Cell Biol Int. 2025 Jul;49(7):810-823 （5）Dong W, Li Y, Fei Q, Li S, He X, Chai Y, Zhou J, Zong Y, Geng J*, Li Z*. Targeted spleen modulation: a novel strategy for next-generation disease immunotherapy. Theranostics. 2025 Mar 18;15(10):4416-4445. doi: 10.7150/thno.111116. PMID: 40225564; PMCID: PMC11984396. （6）Chen X, Fang K, Li B, Li Y, Ke Y, Ke W, Tian T, Zhao Y, Wang L, Geng J, Leake MC, Bai F. Macrophage-derived reactive oxygen species promote Salmonella aggresome formation contributing to bacterial antibiotic persistence. Imeta. 2025 Jun 22;4(4):e70059. （7）Jin Sun; Yingnan Li; Mengjiao Shi; Hongwei Tian; Jun Li; Kai Zhu; Ying Guo; Yanhua Mu; Jing Geng*; Zongfang Li* ; A Positive Feedback Loop of lncRNA HOXD-AS2 and SMYD3 Facilitates Hepatocellular Carcinoma Progression via the MEK/ERK Pathway, Journal of Hepatocellular Carcinoma, 2023, 2023:10 : 1237-1256 （8）Shaoying Zhang; Dan Wan; Mengchen Zhu; Guihu Wang; Xurui Zhang; Na Huang; Jian Zhang; Chongyu Zhang; Qi Shang; Chen Zhang; Xi Liu; Fanfan Liang; Chunyan Zhang; Guangyao Kong; Jing Geng; Libo Yao; Shemin Lu*; Yongyan Chen*; Zongfang Li*; CD11b+ CD43hi Ly6Clo splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis., Hepatology, 2022, 0(0) （9）Liu, Qingxu#; Li, Jiaxin#; Zhang, Weiji#; Xiao, Chen#; Zhang, Shihao#; Nian, Cheng; Li, Junhong; Su, Dongxue; Chen, Lihong; Zhao, Qian; Shao, Hui; Zhao, Hao; Chen, Qinghua; Li, Yuxi; Geng, Jing; Hong, Lixin; Lin, Shuhai; Wu, Qiao; Deng, Xianming; Ke, Rongqin; Ding, Jin; Johnson, Randy L.; Liu, Xiaolong; Chen, Lanfen*; Zhou, Dawang*; Glycogen accumulation and phase separation drives liver tumor initiation, Cell, 2021, 184(22): 5559-5576 （10）Geng, Jing#; Shi, Yiran#; Zhang, Jinjia#; Yang, Bingying; Wang, Ping; Yuan, Weihong; Zhao, Hao; Li, Junhong; Qin, Funiu; Hong, Lixin; Xie, Changchuan; Deng, Xianming; Sun, Yujie; Wu, Congying; Chen, Lanfen*; Zhou, Dawang*; TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection, Nature Communications, 2021, 2021(3519): 0-3519 （11）Wang, Ping#; Geng, Jing#; Gao, Jiahui; Zhao, Hao; Li, Junhong; Shi, Yiran; Yang, Bingying; Xiao, Chen; Linghu, Yueyue; Sun, Xiufeng; Chen, Xin; Hong, Lixin; Qin, Funiu; Li, Xun; Yu, Jau Song; You, Han; Yuan, Zengqiang; Zhou, Dawang; Johnson, Randy L; Chen, Lanfen*; Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis, Nature Communications, 2019, 10(755) （12）Ji, Suyuan#; Liu, Qingxu#; Zhang, Shihao#; Chen, Qinghua#; Wang, Cong; Zhang, Weiji; Xiao, Chen; Li, Yuxi; Nian, Cheng; Li, Jiaxin; Li, Junhong; Geng, Jing; Hong, Lixin; Xie, Changchuan; He, Ying; Chen, Xing; Li, Xun; Yin, Zhen Yu; You, Han; Lin, Kwang Huei; Wu, Qiao; Yu, Chundong; Johnson, Randy L; Wang, Li; Chen, Lanfen; Wang, Fen; Zhou, Dawang*; FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis, Developmental Cell, 2019, 48(4): 460-474 （13）Hong, Lixin; Li, Xun; Zhou, Dawang; Geng, Jing; Chen, Lanfen*; Role of Hippo signaling in regulating immunity, Cellular and Molecular Immunology, 2018, 15(12): 1003-109 （14）Geng, Jing#; Yu, Shujuan#; Zhao, Hao#; Sun, Xiufeng#; Li, Xun; Wang, Ping; Xiong, Xiaolin; Hong, Lixin; Xie, Changchuan; Gao, Jiahui; Shi, Yiran; Peng, Jiaqi; Johnson Randy L; Xiao, Nengming; Lu, Linrong; Han, Jiahuai; Zhou, Dawang*; Chen, Lanfen*; The transcriptional coactivator TAZ regulates reciprocal differentiation of T(H)17 cells and T-reg cells, Nature Immunology, 2017, 18(7): 800-812 （15）Zhang, Shihao#; Chen, Qinghua#; Liu, Qingxu#; Li, Yuxi; Sun, Xiufeng; Hong, Lixin; Ji, Suyuan; Liu, Chengyan; Geng, Jing; Zhang, Weiji; Lu, Zhonglei; Yin, Zhen Yu; Zeng, Yuanyuan; Lin Kwang Huei; Wu, Qiao; Li, Qiyuan; Nakayama Keiko; Nakayama Keiich I; Deng, Xianming; Johnson Randy L; Zhu, Liang; Gao, Daming; Chen, Lanfen*; Zhou, Dawang*; Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2, Cancer Cell, 2017, 31(5): 669-684 （16）Fan, Fuqin#; He, Zhixiang#; Kong, Lu Lu#; Chen, Qinghua#; Yuan, Quan#; Zhang, Shihao; Ye, Jinjin; Liu, Hao; Sun, Xiufeng; Geng, Jing; Yuan, Lunzhi; Hong, Lixin; Xiao, Chen; Zhang, Weiji; Sun, Xihuan; Li, Yunzhan; Wang, Ping; Huang, Lihong; Wu, Xinrui; Ji, Zhiliang; Wu, Qiao; Xia, Ning Shao; Gray Nathanael S; Chen, Lanfen; Yun, Cai Hong*; Deng, Xianming*; Zhou, Dawang*; Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration, Science Translational Medicine, 2016, 8(352) （17）Geng, Jing#; Sun, Xiufeng#; Wang, Ping; Zhang, Shihao; Wang, Xiaozhen; Wu, Hongtan; Hong, Lixin; Xie, Changchuan; Li, Xun; Zhao, Hao; Liu, Qingxu; Jiang, Mingting; Chen, Qinghua; Zhang, Jinjia; Li, Yang; Song, Siyang; Wang, Hong-Rui; Zhou, Rongbin; Johnson, Randy L; Chien, Kun-Yi; Lin, Sheng-Cai; Han, Jiahuai; Avruch, Joseph; Chen, Lanfen*; Zhou, Dawang*; Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity, Nature Immunology, 2015, 16(11): 1142-1152 （18）Wu, Hongtan#; Wei, Luyao#; Fan, Fuqin; Ji, Suyuan; Zhang, Shihao; Geng, Jing; Hong, Lixin; Fan, Xin; Chen, Qinghua; Tian, Jing; Jiang, Mingting; Sun, Xiufeng; Jin, Changnan; Yin, Zhen-Yu; Liu, Qingxu; Zhang, Jinjia; Qin, Funiu; Lin, Kwang-Huei; Yu, Jau-Song; Deng, Xianming; Wang, Hong-Rui; Zhao, Bin; Johnson, Randy L; Chen, Lanfen*; Zhou, Dawang*; Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis., Nature Communications, 2015, 6(6239) （19）Wu, Hongtan#; Xiao, Yubo#; Zhang, Shihao#; Ji, Suyuan; Wei, Luyao; Fan, Fuqin; Geng, Jing; Tian, Jing; Sun, Xiufeng; Qin, Funiu; Jin, Changnan; Lin, Jianjun; Yin, Zhen-Yu; Zhang, Ting; Luo, Lianzhong; Li, Yang; Song, Siyang; Lin, Sheng-Cai; Deng, Xianming; Camargo, Fernando; Avruch, Joseph; Chen, Lanfen*; Zhou, Dawang*; The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense, Cell Reports, 2013, 3(5): 1663-1677 （20）Geng, Jing; Xiao, Shuyan; Zheng, Zhonghui; Song, Siyang; Zhang, Lianru*; Gambogic acid protects from endotoxin shock by suppressing pro-inflammatory factors in vivo and in vitro, Inflammation Research, 2012, 62(2): 165-172 21）耿晶；陕西省“千人计划”青年项目；免疫分子功能与固有免疫应答，中共陕西省省委组织部，YJ0866，2021年1月； 22）周大旺；陈兰芬；邓贤明；耿晶；张世浩；器官尺寸大小调控机理与靶向干预，福建省科学技术奖（一等奖），2020年11月，2019-Z-1-002-04（第四完成人）； 23）耿晶，福建省第十三届自然科学优秀学术论文奖（一等奖），2018年10月（唯一完成人） |
