侯玉柱 教授 博士研究生导师
研究领域（方向）
主要从事肿瘤免疫学研究，从分子、细胞及机体整体水平上，研究肿瘤发生、发展及治疗过程中的免疫学机制，主要包括：（1）研究肿瘤发生、发展过程中的免疫监视与免疫逃逸；（2）研究放疗与免疫治疗过程中肿瘤免疫微环境以及系统性免疫反应。
工作经历
2011年9月－2014年12月：博士后，免疫学，中科院动物所；
2015年1月－2017年12月：博士后，肿瘤免疫学，美国芝加哥大学；
2018年1月－2019年12月：讲师，肿瘤免疫学，美国芝加哥大学；
2020年1月－至今：教授、博导，西安交通大学。
科研项目
主持国家自然基金面上项目、西安交大学青年拔尖人才项目、基本科研业务费等项目。
学术及科研成果、专利、论文
在Immunity、Science Translational Medicine、Science Immunology、Journal of Hematology and Oncology, Protein Cell等学术期刊公开发表SCI论文20余篇，被引用1600余次。
代表性论文
1. Yuanyuan Zhang, Yujie Zhang, Yonghong Li, Yuhan Fu, Yuanru Zhao, Wei Zhao, Runqing Li, Yao Xian, Kangsheng Tu, Feng Wu, Cheng Li*,Yuzhu Hou*, Mingzhen Zhang*. Harnessing Ag2S quantum dots with immune adjuvant for NIR-II fluorescence imaging-guided sonodynamic immunotherapy of colon cancer.Chemical Engineering Journal, 2023; 474. doi: 10.1016/j.cej.2023.145685 (IF: 15.100)
2. Liangliang Xu#, Chang Zou#, Shanshan Zhang#, Timothy Shun Man Chu, Yan Zhang, Weiwei Chen, Caining Zhao, Li Yang, Zhiyuan Xu, Shaowei Dong, Hao Yu, Bo Li, Xinyuan Guan,Yuzhu Hou*, Feng-Ming Kong*. Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors.Journal of Hematology and Oncology,2022; 15(1):87. doi: 10.1186/s13045-022-01307-2 (IF: 23.186)
3.Yuzhu Hou#*, Hua L Liang#, Xinshuang Yu#, Zhida Liu, Xuezhi Cao, Enyu Rao, Xiaona Huang, Liangliang Wang, Lei Li, Jason Bugno, Yanbin Fu, Steven J Chmura, Wenjun Wu, Sean Z Luo, Wenxin Zheng, Ainhoa Arina, Jessica Jutzy, Anne R McCall, Everett E Vokes, Sean P Pitroda, Yang-Xin Fu, Ralph R Weichselbaum*. Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity.Science Translational Medicine, 2021; 13(528):eabb0130. doi: 10.1126/scitranslmed.abb013 0 (IF: 19.319)
4. Enyu Rao#,Yuzhu Hou#, Xiaona Huang, Liangliang Wang, Jiaai Wang, Wenxin Zheng, Hengjin Yang, Xinshuang Yu, Kaiting Yang, Jason Bugno, Xingchen Ding, Everett Vokes, Yang-Xin Fu, Ralph R Weichselbaum*, Hua L Liang*. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages.Science Immunology, 2021; 6(60):eaba8426. doi: 10.1126/sciimmunol.aba8426 (IF: 30.630)
5.Yuzhu Hou, Hua Liang, Enyu Rao, Wenxin Zheng, Xiaona Huang, Liufu Deng, Yuan Zhang, Xinshuang Yu, Meng Xu, Helena Mauceri, Ainhoa Arina, Ralph R Weichselbaum*, Yang-Xin Fu*. Non-canonical NF-κB antagonizes STING sensor-mediated DNA sensing in radiotherapy.Immunity, 2018; 49(3): 490-503. (IF: 22.553)
6.Yuzhu Hou#, Linnan Zhu#, Hongling Tian#, Haixi Sun, Lianfeng Zhang, Ruoyu Wang, Yong Zhao*. IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis.Protein Cell. 2018; doi: 10.1007/s13238-018-0505-z (IF: 10.164)
7.Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Huifang Guo, Lianfeng Zhang, Qiang Wang, Zhanguo Li, Yong Zhao*. The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.Journal of Immunology, 2014;193(1):130-8 (IF: 4.886)
8.Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Mingzhao Zhu, Bernard F Godley, Qiang Wang, Zhanguo Li, Yong Zhao*. LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression.Arthritis & Rheumatism. 2013; 65(11): 2835-46. (IF: 9.586)
联系方式
电子邮箱：houyuzhu@xjtu.edu.cn
联系地址：陕西省西安市雁塔西路76号
