朱峰

朱峰,医学博士,博士研究生导师,教授,转化医学中心教授、西安交通大学第一附属医院精神心理科副主任

研究领域(方向)

1.微生物精神病学研究,关注精神神经疾病的肠-脑轴和免疫相关机制。

2.复杂疾病和表型的宏基因组基础:联合全基因组关联分析、全宏基因/转录组分析,代谢组和转录组技术识别复杂疾病的系统生物学机制;开发活体生物药。

3.常见脑疾病的生物学标记及其临床转化研究。

个人及工作简历:

朱峰,西安交通大学第一附属医院转化医学中心教授,精神科副主任,陕西省精神医学研究中心项目组长,西安交通大学青年拔尖人才。2018-2020年在美国麻省总医院做访问研究,2020年获得国家自然科学基金优秀青年基金资助,现任中国神经科学学会精神病学基础与临床分会青年委员,中华医学会医学遗传学分会生化与代谢学组组员,陕西省抗癌协会转化医学分化委员。主持国家自然科学基金2项,陕西省自然科学基金2项,西安交大一附院临床研究重点项目2项。目前发表SCI论文30余篇,在精神疾病遗传机制和肠脑轴机制上的研究发表于Nature,Nature Gentics,Molecular Psychiatry和Nature Communications等杂志。研究方向为人体微生物组与复杂疾病、生物精神病学和活菌药物开发。

科研项目:

1.陕西省重点研发计划项目,2021GXLH-Z-083,精神益生菌药物开发,2021 年 5 月至 2023年 4 月,30 万,在研,主持

2.西安交通大学第一附属医院临床研究重点项目,XJTU1AF2021CRF-008,基于深度学习方法的精神益生菌筛选和功能鉴定,2021-12 至 2024-12,40 万,在研,主持

3.国家自然科学基金优秀青年科学基金项目,“精神分裂症肠脑轴机制”,项目号:82022023,2021-1-1 至 2023-12-31,120 万,在研,主持;

学术及科研成果、专利、论文

1. Yuan Gao#, Yajuan Fan#, Zai Yang, Qingyan Ma, Binbin Zhao, Xiaoyan He,Fengjie Gao, Li Qian, Wei Wang, Ce Chen, Yunchun Chen, Chengge Gao, Xiancang Ma* & Feng Zhu*. Systems biological assessment of altered cytokine responses to bacteria and fungi reveals impaired immune functionality in schizophrenia.Molecular Psychiatry; (2021). https://doi.org/10.1038/s41380-021-01362-0

2. Feng Zhu#; Ruijin Guo#; Wei Wang#; Yanmei Ju#; Qi Wang#; Qingyan Ma; QiangSun; Yajuan Fan; Yuying Xie; Zai Yang; Zhuye Jie; Binbin Zhao; Liang Xiao; LinYang; Tao Zhang; Bing Liu; Liyang Guo; Xiaoyan He; Yunchun Chen; Ce Chen;Chengge Gao; Xun Xu; Huanming Yang; Jian Wang; Yonghui Dang; Lise Madsen;Susanne Brix; Karsten Kristiansen*; Huijue Jia*; Xiancang Ma*; Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice, Molecular Psychiatry; 2019.8; doi:10.1038/s41380-019-0475-4.

3. Feng Zhu#; Yanmei Ju#; Wei Wang#; Qi Wang#; Ruijin Guo#; Qingyan Ma;Qiang Sun; Yajuan Fan; Yuying Xie; Zai Yang; Zhuye Jie; Binbin Zhao; Liang Xiao; Lin Yang; Tao Zhang; Junqin Feng; Liyang Guo; Xiaoyan He; Yunchun Chen;Ce Chen; Chengge Gao; Xun Xu; Huanming Yang; Jian Wang; Yonghui Dang; Lise Madsen; Susanne Brix; Karsten Kristiansen*; Huijue Jia*; Xiancang Ma*; Metagenomewide association of gut microbiome features for schizophrenia, Nature Communications; 11(1):1612.

4. Li Liu#; Yan Wen#; Yujie Ning#; Ping Li; Bolun Cheng; Shiqiang Cheng; Lu Zhang; Mei Ma; Xin Qi; Chujun Liang; Tielin Yang; Xiangding Chen; Lijun Tan;Hui Shen; Qing Tian; Hong Wen Deng; Xiancang Ma; Feng Zhang*; Feng Zhu*; A transethnic two-stage polygenetic scoring analysis detects genetic correlation between

osteoporosis and schizophrenia, Clinical and Translational Medicine; 9(1):21; 2020.2.

5. Yan Zhao#; Xiao Liang#; Feng Zhu#; Yan Wen; Jiawen Xu; Jian Yang; Miao Ding; Bolun Cheng; Mei Ma; Lu Zhang; Shiqiang Cheng; Cuiyan Wu; Sen Wang; Xi Wang; Yujie Ning; Xiong Guo; Feng Zhang*; A large-scale integrative analysis of GWAS and common meQTLs across whole life course identifes genes, pathways and tissue/cell types for three major psychiatric disorders, Neuroscience and Biobehavioral Reviews; 95:347-352; 2018.12.

6. Wei Wang#; Junqin Feng#; Cui Ji; Xin Mu; Qingyan Ma; Yajuan Fan; Ce Chen; Chengge Gao; Xiancang Ma*; Feng Zhu*; Increased methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of patients with generalized anxiety disorder, Journal of Psychiatric Research; 91:18-25; 2017.8.

7. Feng Zhu; Chunxia Yan*; Yichong Wen; Jiayin Wang; Jinbo Bi; Yaling Zhao; Lai Wei; Chengge Gao; Wei Jia; Shengbin Li*; Dopamine D1 Receptor Gene Variation Modulates Opioid Dependence Risk by Affecting Transition to Addiction, PLos One; 8(8); 2013.8.

8. Feng Zhu; Chunxia Yan*; Yan Zhao; Yang Zhao; Pingping Li; Shengbin Li*; Effects of pre-training morphine on spatial memory acquisition and retrieval in mice, Physiology & Behavior; 104(5):754-760; 2011.10; doi:10.1016/j.physbeh.2011.07.014.

9. Feng Zhu; Chunxia Yan*; Qian Wang; Yongsheng Zhu; Yan Zhao; Jiong Huan; Hongbo Zhang; Chengge Gao; Shengbin Li*; An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia, Brain Research; 1420:106-113; 2011.10.

10. Yingxiang Sun#; Lijun Bai#*; Xuan Niu; Zhuonan Wang; Bo Yin; Guanghui Bai; Danbin Zhang; Shuoqiu Gan; Chuanzhu Sun; Shan Wang; Feng Zhu*; Ming Zhang*; Elevated Serum Levels of Inflammation-Related Cytokines in Mild Traumatic Brain Injury Are Associated With Cognitive Performance , Frontiers in Neurology, 10:1120;2019.10; doi:10.3389/fneur.2019.01120.

11. Jie Zhu; Feng Zhu*; Na Zhao; Xin Mu; Pingping Li; Wei Wang; Jian Liu; Xiancang Ma; Methylation of Glucocorticoid Receptor Gene Promoter Modulates Morphine Dependence and Accompanied Hypothalamus-Pituitary-Adrenal Axis Dysfunction, JOURNAL OF NEUROSCIENCE RESEARCH; 95(7):1459-1473; 2017.7.

12. Yanlong Zhao; Chenguang Ding; Wujun Xue; Xiaoming Ding; Jin Zheng; Yi Gao; Xinxin Xia; Sutong Li; Jing Liu; Feng Han; Feng Zhu*; Puxun Tian*; Genomewide DNA methylation analysis in renal ischemia reperfusion injury , Gene; 610:32-4;2017.4.

联系方式

电子邮箱:zhufeng1982@xjtu.edu.cn

联系电话:13571827380

个人主页:

联系地址:西安交通大学第一附属医院


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