基本信息
佘刚
副教授，博士生导师
邮箱：shegang@mail.xjtu.edu.cn
工作及教育经历：
(1)2024-01至 今,西安交通大学,副教授
(2)2020-06至2023-12,西安交通大学,助理教授,合作导师:杜晓军教授
(3)2019-02至2020-02,莫纳什大学,药学与药理学系,访学博士研究生,导师: Chrishan Samuel教授
(4)2015-09至2020-05,西安交通大学,病理学与病理生理学专业,博士研究生，导师:邓秀玲教授
(5)2011-09至2015-07,天津医科大学,运动康复与健康专业,学士
研究方向：
(1)心肌Hippo信号通路激活所致心肌病的代谢调控机制
(2)钙激活钾离子通道在心血管疾病中的作用与调控机制
主持的基金项目/课题：
(1)国家自然科学基金面上项目, 82570325,49万元,在研,主持
(2)国家自然科学基金青年科学基金项目（C类）[原青年科学基金项目], 82200332, 30万元,结题,主持
(3)中国博士后科学基金特别资助（站中）, 2023T160518, 18万元,结题,主持
(4)陕西省自然科学基金青年项目, 2022JQ-839,5万元,结题,主持
(5)中国博士后科学基金面上项目, 2021M702592,8万元,结题,主持
已发表的SCI论文
(1)Jia LY, Hai XX, Wu ZQ, Li JJ, Yang YY, Hou MC, Wu LH, Han MZ, Zhang Yi, Xu YG, Deng J, Lai BC, Sadoshima J, Deng XL, Pang ZD*, Du XJ*,She G*. Inhibition of lactate-histone lactylation mediated cardiomyocyte-fibroblast communication mitigates cardiac fibrosis in cardiomyopathy models with Hippo pathway activation.Cell Death Dis. 2026.
(2)Wu LH, Bai RY, Chen JY, Pang ZD, Hai XX, Han MZ, Yang YY, Wang Y, Zhang Y, Zhang J,She G*, Du XJ*, Deng XL*. Dimethyl Fumarate Reverses beta-Adrenoceptor-Mediated Myocardial Fibrosis in Mice by Inhibiting Yes-Associated Protein-Regulated Expression of Intermediate-Conductance Ca(2+)-Activated K(+) Channel in Fibroblasts.J Am Heart Assoc. 2026;15(7):e046565.
(3)She G, Hai XX, Jia LY, Zhang YJ, Ren YJ, Pang ZD, Wu LH, Han MZ, Zhang Y, Li JJ, Bai RY, Lai BC, Yang YY, Sadoshima J, Du XJ, Deng XL, Zhang Y. Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1.Redox Biol. 2025;82:103597.
(4)She G, Du JC, Wu W, Pu TT, Zhang Y, Bai RY, Zhang Y, Pang ZD, Wang HF, Ren YJ, Sadoshima J, Deng XL, Du XJ. Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction.Theranostics. 2023;13(2):560–577.
(5)She G, Hou MC, Zhang Y, Zhang Y, Wang Y, Wang HF, Lai BC, Zhao WB, Du XJ, Deng XL. Gal-3 (Galectin-3) and KCa3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by betaAR (beta-Adrenoceptor) Activation.Hypertension. 2020;75(2):393–404.
(6)She G, Ren YJ, Wang Y, Hou MC, Wang HF, Gou W, Lai BC, Lei T, Du XJ, Deng XL. KCa3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II -Treated Rats.J Am Heart Assoc. 2019;8(1):e010418.
(7)Du XJ,She G, Pang ZD, Zhang Y, Deng XL. Expression, Localization and Actions of Galectin-3: Implications in the Pathophysiology and Therapy of Cardiovascular Disease.Int J Mol Sci. 2026;27(13).
(8)Wang Z,She G, Wang C, Ferens D, Salimova E, Widdop RE, Gaspari TA, Samuel CS. Serelaxin has greater anti-fibrotic potential than perindopril but maintains its anti-fibrotic efficacy in the presence of perindopril in normotensive mouse models of heart disease.Life Sci. 2026;399:124472.
(9)Zhao XY, Xu R, Li JJ, Chen YP, Liu PN, Yao JH, Wang XP, Hu YW, Lou J, Xu F,She G, Pang ZD, Huang N, Song Z, Deng XL, Du XJ, Zhang X, Zhang Y, Xie W. S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts.Hypertension. 2026;83(1):87–102.
(10)Zhang D, Li G, Liu X, Wang Y, Wu J, Ren Y,She G, Zheng D, Zhao Y, Deng XL, Li M, Zhao L. K(Ca)3.1 upregulation mediated by Ang II-induced JNK/AP-1 activation contributes to atrial fibrosis.Cell Signal. 2025;131:111731.
(11)Wu W, Huynh K, Du JC,She G, Duong T, Ziemann M, Zhao WB, Deng XL, Meikle PJ, Du XJ. Hippo pathway activation causes multiple lipid derangements in a murine model of cardiomyopathy.Biochim Biophys Acta Mol Cell Biol Lipids. 2025;1870(2):159590.
(12)Wang Z, Ren Y, Zhang D,She G, Wang Y, Li G, Sun X, Zheng D, Wang Z, Deng XL, Zhao Y, Zhao L. Elevated K(Ca)3.1 expression by angiotensin II via the ERK/NF-kappaB pathway contributes to atrial fibrosis.J Mol Cell Cardiol. 2025;202:133–143.
(13)Pang ZD, Wang Y, Han MZ,She G, Sun X, Bai RY, Lai BC, Zhang Y, Du XJ, Shyy JY, Deng XL. AMPK phosphorylation of K(Ca)2.3 alleviates angiotensin II-induced endothelial dysfunction.Biochem Pharmacol. 2025;236:116880.
(14)Han MZ, Wang Y, Sun KX, Zhang YJ, Bai RY, Wu LH, Hai XX, Lai BC, Li JJ,She G, Zhang Y, Du XJ, Pang ZD, Deng XL. Upregulating vascular endothelial K(Ca)2.3 channels alleviates pulmonary hypertension in mice.Mol Pharmacol. 2025;107(7):100048.
(15)Du XJ, Huynh K, Ziemann M,She G, Wu W, Duong T, Hai XX, Yang YY, Zhao WB, Lu Q, Zhang Y, Deng XL, Meikle PJ. Galectin-3 gene deletion alters lipid profile in healthy and cardiomyopathy mouse hearts.Biochim Biophys Acta Mol Cell Biol Lipids. 2025;1870(7):159676.
(16)Bai RY, Wu LH, Wang Y, Guo C,She G, Pang ZD, Li JJ, Zhao XY, Han MZ, Hai XX, Yang YY, Zhang Y, Zhao LM, Jiao LY, Du XJ, Deng XL. Glutaminolysis and alpha-ketoglutarate-stimulated K(Ca)3.1 expression contribute to beta-adrenoceptor activation-induced myocardial fibrosis in mice.Sci China Life Sci. 2025;68(7):2043–2057.
(17)Du XJ,She G, Wu W, Deng XL. Coupling of beta-adrenergic and Hippo pathway signaling: Implications for heart failure pathophysiology and metabolic therapy.Mitochondrion. 2024;78:101941.
(18)Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W,She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y. Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.Redox Biol. 2023;68:102944.
(19)Ma S, Bai L, Liu P,She G, Deng XL, Song AQ, Du XJ, Lu Q. Pathogenetic Link of Cardiac Rupture and Left Ventricular Thrombus Following Acute Myocardial Infarction: A Joint Preclinical and Clinical Study.Front Cardiovasc Med. 2022;9:858720.
(20)Wu W, Ziemann M, Huynh K,She G, Pang ZD, Zhang Y, Duong T, Kiriazis H, Pu TT, Bai RY, Li JJ, Zhang Y, Chen MX, Sadoshima J, Deng XL, Meikle PJ, Du XJ. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice.Theranostics. 2021;11(18):8993–9008.
(21)Pang ZD, Wang Y, Song Z,She G, Ma XZ, Sun X, Wu W, Lai BC, Zhang J, Zhang Y, Du XJ, Shyy JYJ, Deng XL. AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice.Biochem Pharmacol. 2021;183:114337.
(22)Zhang Y, Hou MC, Li JJ, Qi Y, Zhang Y,She G, Ren YJ, Wu W, Pang ZD, Xie W, Deng XL, Du XJ. Cardiac beta-adrenergic receptor activation mediates distinct and cell type-dependent changes in the expression and distribution of connexin 43.J Cell Mol Med. 2020;24(15):8505–8517.
(23)Wang Y, Wang XJ, Zhao LM, Pang ZD,She G, Song Z, Cheng X, Du XJ, Deng XL. Oxidative stress induced by palmitic acid modulates K(Ca)2.3 channels in vascular endothelium.Exp Cell Res. 2019;383(2):111552.
(24)Pang ZD, Wang Y, Wang XJ,She G, Ma XZ, Song Z, Zhao LM, Wang HF, Lai BC, Gou W, Du XJ, Deng XL. K(Ca)3.1 channel mediates inflammatory signaling of pancreatic beta cells and progression of type 2 diabetes mellitus.FASEB J. 2019;33(12):14760–14771.
(25)Wang Y, Sun HY, Liu YG, Song Z,She G, Xiao GS, Wang Y, Li GR, Deng XL. Tyrphostin AG556 increases the activity of large conductance Ca(2+) -activated K(+) channels by inhibiting epidermal growth factor receptor tyrosine kinase.J Cell Mol Med. 2017;21(9):1826–1834.
获得的学术奖励：
(1)佘刚;陕西省自然科学奖二等奖, 2024年
(2)佘刚;陕西高等学校科学技术研究优秀成果奖一等奖, 2023年
