个人信息：
西安交通大学医学部心血管研究中心，教授，博士生导师
邮箱：xiaolei0122@xjtu.edu.cn
电话：18609284536
教育、工作经历：
2024.01- 西安交通大学医学部，教授
2018.01-2023.12 西安交通大学医学部，副教授
2015.04-2016.04 美国佐治亚州立大学，进修
2014.04-2015.04 美国俄克拉荷马大学，进修
2012.07-2017.12 西安交通大学医学部，讲师
2007.09-2012.06 北京师范大学生命科学学院，生理学，博士
2003.09-2007.07 西北大学生命科学学院，生物技术，学士
研究方向：
心血管及代谢性疾病基础研究；受体与信号转导；天然营养素与血管功能；免疫炎症性皮肤病机制
学术兼职：
中国病理生理学会理事
中华医学会心血管病学分会代谢性心血管疾病学组委员
中国病理生理学会受体专业委员会委员
国际心脏研究会（ISHR）中国分会及中国病理生理学会心血管专业委员会委员
中国病理生理学会血管医学专业委员会青年委员
中国生物化学与分子生物学会脂质与脂蛋白专业委员会青年委员
主持科研项目情况：
1.国家自然科学基金重点项目（批准号82230012，260万），合作主持
2.国家自然科学基金重大研究计划培育项目（批准号91939108，45万），主持
3.国家自然科学基金面上项目（批准号81770497，60万），主持
4.国家自然科学基金青年项目（批准号81300242，23万），主持
5.西安交通大学医学“基础-临床”融合创新项目（批准号YXJLRH2022024，20万），合作主持
6.“医学攀登人才计划”﹣西安交通大学医学部首批国家级后备人选支持计划（批准号217，20万），主持
国际会议获奖情况：
1.2023国际皮肤病研究学会学术会议（ISID）旅行资助奖（日本东京）
2.2018亚洲血管生物学会（ASVB）青年优秀奖（中国上海）
3.2018南方国际心血管病学术会议（SCC）优秀论文二等奖（中国广州）
论文发表情况：
1. Cui, Q., Jiang,T., XieX.,Wang,H., Qian L., Cheng Y.,LiQ.,Lu,T.,Yao,Q.,Liu,J., Lai, B., Chen, C.,Xiao, L.*, Wang, N.*, 2024.S-nitrosylation Attenuates Pregnane X Receptor Hyperactivity andAcetaminophen-induced Liver Injury.JCI Insight.9(2):e172632.
2.Xie, X.#, Cui, Q.#, Jiang, T., Zhao, Z., Liu, Z., Liu, J., Yao, Q., Wang, Y., Dang, E., Wang, G.,Xiao, L.*, Wang, N., 2024. A Critical Role of Endothelial Skp2/PTEN Axis in Angiogenesis and Psoriasis.Br J Dermatol.190(2):244-257.
3.李畅#,姜婷婷#,汪南平*,校蕾*. 2024.核受体功能及其在银屑病中的病理生理学意义，《中国病理生理杂志》，40, 2160-2165.
4.崔琪,杜雄,校蕾*,汪南平*.2023.转录因子的巯基亚硝基化修饰及其生理学意义，《生理科学进展》，54, 26-32.
5.Xiao, L., Wang, N.*, 2022. PPAR-δ: A key nuclear receptor in vascular function and remodeling.J Mol Cell Cardiol.169, 1-9.
6.Liu,J.#, Du,X.#, Yao,Q.,Jiang, T.,Cui, Q.,Xie, X.,Zhao,Z., Lai, B.,Wang, N.,Xiao, L.*,2022.Procyanidin B2 ameliorates endothelial dysfunction induced by nicotine via the induction of tetrahydrobiopterin synthesis,J Funct Foods.,99,105306.
7.Lai, B#, Xie, X.#, Li, F.#, Cui, Q., Dang, E., Luo, W., Wang, N., Zheng, Y., Wang, G.,Xiao, L.*, Wang, N., 2021. Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation.J Invest Dermatol.141, 2895-2907.e2897.
8.Xiao, L., Nie, X., Cheng, Y., Wang, N.*, 2021. Sodium-Glucose Cotransporter-2 Inhibitors in Vascular Biology: Cellular and Molecular Mechanisms.Cardiovasc Drugs Ther.35, 1253-1267.
9.Nie, X.#, Tang, W.#, Zhang, Z., Yang, C., Qian, L., Xie, X., Qiang, E., Zhao, J., Zhao, W.,Xiao, L.*, Wang, N.*, 2020. Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism.Redox Biol.37, 101728.
10.Zhang, Z., Xie, X., Yao, Q., Liu, J., Tian, Y., Yang, C.,Xiao, L.*, Wang, N.*, 2019a. PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway.Br J Pharmacol.176, 2945-2961.
11.Xie, X.#, Yang, C.#, Cui, Q., Ma, W., Liu, J., Yao, Q., Zhang, Z.,Xiao, L.*, Wang, N.*, 2019b. Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells.J Agric Food Chem.67, 9805-9811.
12.Tian, Y., Yang, C., Yao, Q., Qian, L., Liu, J., Xie, X., Ma, W., Nie, X., Lai, B.,Xiao, L.*, Wang, N.*, 2019c. Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages.Front Immunol.10, 1895.
13.Zhang, M., Zhang, Z., Xie, X., Yao, Q., Liu, J., Lai, B.,Xiao, L.*, Wang, N.*, 2019d. Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries.J Cell Physiol.234, 4342-4351.
14.Li, C.#,Xiao, L.#, Jia, J., Li, F., Wang, X., Duan, Q., Jing, H., Yang, P., Chen, C., Wang, Q., Liu, J., Shao, Y., Wang, N.*, Zheng, Y.*, 2019e. Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.J Invest Dermatol.139, 71-80.
15.Xie, X., Zhang, Z., Wang, X., Luo, Z., Lai, B.,Xiao, L.*, Wang, N.*, 2018. Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine.Mol Med.24, 10.
16.李帆，张子绘，谢新雅，校蕾*，汪南平*.2018.增塑剂邻苯二甲酸二丁酯致血管内皮功能损伤及其机制，《中国科学生命科学》,48,535-543.
17.Wang, S., Xie, X., Lei, T., Zhang, K., Lai, B., Zhang, Z., Guan, Y., Mao, G.,Xiao, L.*, Wang, N.*, 2017a. Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism.Mol Pharmacol.92, 256-264.
18.Zhang, Z., Jiang, M., Xie, X., Yang, H., Wang, X.,Xiao, L.*, Wang, N.*, 2017b. Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation.Sci Rep.7, 40237.
19.张子绘，汤伟琦，李帆，校蕾*，汪南平.2017.异源物代谢核受体PXR和CAR在血管疾病中的作用，《生理科学进展》，48, 341-346.
20.Ni, J., Zhang, Z., Luo, X.,Xiao, L.*, Wang, N.*, 2016a. Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells.J Biochem Mol Toxicol.30, 178-185.
21.Xiao, L.#, Zhang, Z.#, Luo, X., Yang, H., Li, F., Wang, N.*, 2016b. Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα.Mol Immunol.80, 17-23.
22.Xiao, L.#, Wang, J.#, Li, J., Chen, X., Xu, P., Sun, S., He, D., Cong, Y., Zhai, Y.*, 2015. RORα inhibits adipocyte-conditioned medium-induced colorectal cancer cell proliferation and migration and chick embryo chorioallantoic membrane angiopoiesis.Am J Physiol Cell Physiol.308, C385-396.
23.Xiao, L., Liu, Y., Wang, N.*, 2014a. New paradigms in inflammatory signaling in vascular endothelial cells.Am J Physiol Heart Circ Physiol.306, H317-325.
24.Xiao, L.*, Zhang, Z., Luo, X., 2014b. Roles of xenobiotic receptors in vascular pathophysiology.Circ J.78, 1520-1530.
25.Xiao, L., Xie, X., Zhai, Y.*, 2010a. Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism.Adv Drug Deliv Rev.62, 1316-1321.
26.Xiao, L., Zhang, J., Li, H., Liu, J., He, L., Zhang, J., Zhai, Y.*, 2010b. Inhibition of adipocyte differentiation and adipogenesis by the traditional Chinese herb Sibiraea angustata.Exp Biol Med.235, 1442-1449.
27.Li, H.X.#,Xiao, L.#, Wang, C., Gao, J.L., Zhai, Y.G.*, 2010. Review: Epigenetic regulation of adipocyte differentiation and adipogenesis.J Zhejiang Univ Sci B.11, 784-791.
28.Yao, Q.#, Cui, Q.#, Liu, J., Xie, X., Jiang, T., Wang, H., Zhao, Z., Zhao, W., Du, X., Lai, B.,Xiao, L., Wang, N.*, 2023. Free fatty acids stabilize integrin β(1)via S-nitrosylation to promote monocyte-endothelial adhesion.J Biol Chem.299, 102765.
29.Yao, Q., Liu, J., Cui, Q., Jiang, T., Xie, X., Du, X., Zhao, Z., Lai, B.,Xiao, L., Wang, N.*, 2022a. CCN1/Integrin α(5)β(1) Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation.Nutrients.14.
30.Liu, J., Yao, Q., Xie, X., Cui, Q., Jiang, T., Zhao, Z., Du, X., Lai, B.,Xiao, L., Wang, N.*, 2022b. Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism.Nutrients.14.
31.Liu, J., Yao, Q.,Xiao, L., Li, F., Ma, W., Zhang, Z., Xie, X., Yang, C., Cui, Q., Tian, Y., Zhang, C., Lai, B., Wang, N.*, 2020a. APC/Cdh1 targets PECAM-1 for ubiquitination and degradation in endothelial cells.J Cell Physiol.235, 2521-2531.
32.Liu, J., Yao, Q.,Xiao, L., Ma, W., Li, F., Lai, B., Wang, N.*, 2020b. PPARγ induces NEDD4 gene expression to promote autophagy and insulin action.Febs j.287, 529-545.
33.Ban, Y.#, Liu, Y.#, Li, Y., Zhang, Y.,Xiao, L., Gu, Y., Chen, S., Zhao, B., Chen, C.*, Wang, N.*, 2019a. S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension.Redox Biol.21, 101099.
34.Yao, Q., Liu, J.,Xiao, L., Wang, N.*, 2019b. Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability.J Biol Chem.294, 3284-3293.
35.Yao, Q., Liu, J., Zhang, Z., Li, F., Zhang, C., Lai, B.,Xiao, L., Wang, N.*, 2018a. Peroxisome proliferator-activated receptor γ (PPARγ) induces the gene expression of integrin α(V)β(5) to promote macrophage M2 polarization.J Biol Chem.293, 16572-16582.
36.Zhang, C., Deng, J., Liu, D., Tuo, X.,Xiao, L., Lai, B., Yao, Q., Liu, J., Yang, H.*, Wang, N.*, 2018b. Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway.Br J Pharmacol.175, 4218-4228.
37.Yang, H.,Xiao, L., Wang, N.*, 2017. Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions.J Diabetes.9, 341-352.
38.Luo, X., Luo, Z., Zhang, Z., Yang, H., Lai, B., Yao, Q.,Xiao, L., Wang, N.*, 2016. Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes.Biochem Biophys Res Commun.471, 303-308.
39.Wang, X.#, Cheang, W.S.#, Yang, H.,Xiao, L., Lai, B., Zhang, M., Ni, J., Luo, Z., Zhang, Z., Huang, Y., Wang, N.*, 2015. Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms.Br J Pharmacol.172, 5609-5618.
40.Luo, X.,Xiao, L., Yang, H., Zhang, R., Jiang, M., Ni, J., Lei, T., Wang, N.*, 2014a. Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes.Nutr Metab.11, 55.
41.Wang, S., Lei, T., Zhang, K., Zhao, W., Fang, L., Lai, B., Han, J.,Xiao, L., Wang, N.*, 2014b. Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells.J Biol Chem.289, 30075-30081.
42.Yang, H.,Xiao, L., Yuan, Y., Luo, X., Jiang, M., Ni, J., Wang, N.*, 2014c. Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells.Biochem Pharmacol.92, 599-606.
43.Wang,X., Fang,X., Zhou,J., Chen,Z., Zhao,B.,Xiao,L., Liu,A., Li,YS., Shyy,JY., Guan,Y., Chien,S.*, Wang,N.*,2013.Shear stress activation of nuclear receptor PXR in endothelial detoxification.Proc Natl Acad Sci U S A.110,13174-9.
44.Xie, X., Wang, S.,Xiao, L., Zhang, J., Wang, J., Liu, J., Shen, X., He, D., Zheng, X., Zhai, Y.*, 2011. DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-ĸB.Cell Physiol Biochem.28, 649-662.
论著情况:
1.汪南平，校蕾.《血管生物学（第2版）》“核受体与血管病变”章节（北京大学医学出版社，2014，董尔丹等）.
2.Xiao,L.,Wang,J., Jiang,M., Xie,W., Zhai,Y.*,The emerging role of Constitutive Androstane Receptor and its cross talk with Liver X Receptors and Peroxisome Proliferator-Activated Receptors in lipid metabolism.Vitamins and Hormones,edited by Gerald Litwack, Academic Press, 2013.
3.校蕾（编委）.《病理生理学实验教程》（周新文、王玉芳主编），华中科技大学出版社，2024.
