王一东

 

研究领域

器官发育与再生修复

教育及工作经历

2023-至今 西安交通大学第一附属医院 特聘教授

2018-至今 西安交通大学基础医学院,教授

2016-2018 美国阿尔伯特爱因斯坦医学院,遗传系,研究助理

2012-2016 美国阿尔伯特爱因斯坦医学院,遗传系,博士后,导师:周滨

2006-2011 四川大学,细胞生物学,博士,导师:魏于全

2008-2011 美国阿尔伯特爱因斯坦医学院,遗传学系,访问学者

2002-2006 西南交通大学,生物工程,学士

科研项目

2024-2026 陕西省杰出青年基金项目,主持。

2019-2024 科技部重点专项,子课题负责人。

2020-2023 国家自然科学基金面上项目,主持。

2019-2022 陕西省人社厅重点项目,主持。

2018-2021 陕西省青年项目,主持。

2018-2024 西安交通大学“青年拔尖人才计划”A类项目, 主持。

2013-2015 国心脏协会博士后基金, 主持。

2011-2016 美国国立卫生研究院R1项目, 参与。

发表论文情况(*通讯作者;#并列一作)

  1. Huahua Liu#, Rui Zhou#, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J Shyy, Bin Zhou, Zuyi Yuan*,Yidong Wang*.Epigentic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development.iScience. 2024.

  2. Huahua Liu#, Pengfei Lu#, Shan He, Yuru Luo, Yuan Fang, Sonia Benkaci, Bingruo Wu,Yidong Wang*, Bin Zhou*.β-Cateninregulates endocardial cushion growth by suppressing p21.Life Science Alliance. 2023.

  3. Bingruo Wu#, Brian Wu#, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice Morrow,Yidong Wang*, Bin Zhou*. Crk and Crkl are required in the endocardial lineage for heart valve development.Journal of the American Heart Association. 2023.

  4. Wangge Ma#, Wei Zhang#, Huahua Liu, Benheng Qian, Rongguang Lai, Zijun Yao,Yidong Wang, Yang Yan*, Zuyi Yuan*. Plasma Cell-free DNA is a potential biomarker for diagnosis of calcific aortic valve disease.Cardiology. 2023.

  5. Pengfei Lu, Bingruo Wu,Yidong Wang,Megan Russell, Yang Liu, Daniel J. Bernard, Deyou Zheng, Bin Zhou*. Prerequisite endocardial-mesenchymal transition for murine cardiac trabecular angiogenesis.Developmental Cell. 2023.

  6. Benheng Qian, Kexin Li, Xiaoying Lou, Ye Guo,Yidong Wang*, Lianpin Wu*, Donghong Zhang*. Plasma Cell-Free DNA as a Novel Biomarker for the Diagnosis and Monitoring of Atherosclerosis.Cells. 2022.

  7. Pengfei Lu, Ping Wang, Bingruo Wu,Yidong Wang, Yang Liu, Wei Cheng, Xuhui Feng, Xinchun Yuan, Miriam M Atteya, Haleigh Ferro, Yukiko Sugi, Grant Rydquist, Mahdi Esmaily, Jonathan T Butcher, Ching-Pin Chang, Jack Lenz, Deyou Zheng, Bin Zhou.Nature communications. 2022

  8. Pengfei Lu#;Yidong Wang#; Yang Liu; Yifeng Wang; Bingruo Wu; Deyou Zheng, Richard P. Harvey; Bin Zhou*; Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signaling.Nature Cell Biology. 2021.

  9. Yidong Wang*; Yuan Fang; Pengfei Lu; Bingruo Wu; Bin Zhou*. NOTCH signaling in aortic valve development and calcific aortic valve disease.Front Cardiovasc Med.2021.

  10. Yidong Wang*, Pengfei Lu, Liping Jiang, Bingruo Wu, Bin Zhou*. Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1.Cardiovasc Res.2020.

  11. Terence Gee,Emily Farrar,Yidong Wang,Bingruo Wu,Kevin Hsu,Bin Zhou,Jonathan Butcher*. NFκB (Nuclear Factor κ-Light-Chain Enhancer of Activated B Cells) Activity Regulates Cell-Type–Specific and Context-Specific Susceptibility to Calcification in the Aortic Valve.Arterioscler Thromb Vasc Biol.2020.

  12. Dongying Chen, Xiaolong Zhu, Natalie Kofler,Yidong Wang, Bin Zhou,Michael Simons*. FRS2-dependent cell fate transition during endocardial cushion morphogenesis.DevBiol.2019.

  13. Yang Liu, Pengfei Lu,Yidong Wang, Bernice Morrow, Bin Zhou, Deyou Zheng*. Spatiotemporal gene Coexpression and regulation in mouse cardiomyocytes of early cardiac morphogenesis.J Am Heart Assoc. 2019.

  14. Yidong Wang*,#, Pengfei Lu#, Bingruo Wu, Bernice Morrow, Bin Zhou*. NOTCH maintains developmental cardiac gene network through WNT5A.J Mol Cell Cardiol.2018.

  15. Yidong Wang*, Pengfei Lu, Bingruo Wu, Dario F. Riascos-Bernal, Nicholas E.S Sibinga, Tomas Valenta, Konrad Basler, Bin Zhou*. Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.J Mol Cell Cardiol.2018.

  16. Yidong Wang, Bingruo Wu, Pengfei Lu, Donghong Zhang, Feng Xiao, Shweta Vashney, Zhenwu Zhuang, Nicholas E.S Sibinga, Nikolaos G. Frangogiannis, Kitsis Richard, David Sharp, Pamela Stanley, Bin Zhou*.Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lackingPofut1.Nature Communications.2017.

  17. Yidong Wang, Bingruo Wu, Emily Farrar, Wendy Lui, Pengfei Lu, Donghong Zhang, Christina M. Alfieri, Kai Mao, Ming Chu, Di Yang, Di Xu, Michael Rauchman, Verdon Taylor, Simon Conway, Katherine E. Yutzey, Jonathan T. Butcher, Bin Zhou*. Notch-Tnf signaling is required for development and homeostasis of arterial valves.European Heart Journal.2017.

  18. Bingruo Wu#,Yidong Wang#, Feng Xiao, Jonathan T. Butcher*, Katherine E. Yutzey*, Bin Zhou*. Development mechanisms of aortic valve malformation and disease.Annual Review of Physiology. 2017.

联系方式

邮箱:yidwang119@xjtu.edu.cn

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