王亚楠，教授，博士研究生导师，国家级青年人才项目入选者，西安交通大学“青年拔尖人才（A）类”；西安交通大学第一附属医院内分泌科副主任（挂职），西安交通大学国际肥胖与代谢性疾病研究中心副主任，西安交通大学MED-X研究院免疫代谢性疾病研究所教授，荷兰莱顿大学医学研究中心客座高级研究员。
研究领域（方向）
肥胖与代谢性疾病相关研究领域：1.非酒精性脂肪肝炎的新型诊疗靶标的基础和临床研究；2.肠道菌群及代谢产物诊断和治疗肥胖和代谢性疾病（糖尿病、高血脂、动脉硬化性心血管疾病）。
个人及工作简历
2001.9 - 2006.6
北京大学
基础医学
本科
2006.10-2008.7
荷兰莱顿大学
生物药学
硕士
2008.8-2012.12
荷兰莱顿大学
医学（内分泌和代谢学)
博士
2012.12-2013.10
荷兰莱顿大学医学研究中心
人类遗传学系
博士后
2013.11-2016.10
荷兰格罗宁根大学医学研究中心
儿科代谢性肝病系
博士后
2016.11-2019.10
荷兰莱顿大学医学研究中心
内分泌和代谢学系
高级研
究人员
2019.10-至今
入选西安交大“青拔人才”计划
交大一附院内分泌代谢科和Med-X研究院免疫代谢性疾病研究所
内分泌和代谢学
教授
博士生导师
科研项目
项目名称
项目时间
项目来源
项目经费
抑制DHCR24治疗非酒精性脂肪肝炎新方案的机制研究
2022.01- 2025.12
国家自然科学基金（面上项目）
55万人民币
应用肠道菌群及其生物产物丁酸作为动脉粥样硬化和非酒精性脂肪炎的
个体化诊断和治疗
2019.02- 2022.02
国家级人才项目
（青年项目）
100万人民币
诊断非酒精性脂肪性肝炎的新型无创生物标记物的临床和基础研究
2021.01-
2022.12.
陕西省重点研发项目
7万人民币
脂蛋白代谢紊乱引起的代谢性疾病（动脉粥样硬化和非酒精性脂肪肝）的诊断和治疗
2018.12- 2023.12
陕西省人才项目
（青年项目）
150万人民币
DHCR24，可用于非酒精性脂肪肝病的新型治疗靶点
2018.04-
2019.09
荷兰健康研究与发展组织（ZonMw）青年科学家项目
3万欧元
棕色脂肪对血液和肝脏胆固醇脂质代谢关键作用的研究
2016.11-
2019.11
荷兰国家自然基金（NWO）创新研究计划Veni项目
24.9万欧元
肠道微生物对短链脂肪酸丁酸治疗肥胖和代谢综合征的潜在机制研究
2018.06-
2020.02
荷兰莱顿大学基金项目(LUF)
2.5万欧元
学术及科研成果、专利、论文（5年内）
1.Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, Gao Y, van den Heuvel JK, Meijer OC, Berbée JF, Heijink M, Giera M, Willems van Dijk K, Groen AK, Rensen PCN,Wang Y.Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit.Gut2018 Jul; 67(7): 1269-1279.（通讯作者）
2.Zhou E, Li Z, Nakashima H, Liu C, Ying Z, Foks AC, Berbee JFP, van Dijk KW, Rensen PCN,Wang Y. Hepatic Scavenger Receptor Class B Type 1 Knockdown Reduces Atherosclerosis and Enhances the Antiatherosclerotic Effect of Brown Fat Activation in APOE*3-Leiden.CETP Mice.Arterioscler Thromb Vasc Biol2021 Apr;41(4): 1474-1486.（通讯作者）
3.Zhou E, Li Z, Nakashima H, Choukoud A, Kooijman S, Berbee JFP, Rensen PCN,Wang Y. Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice. Pharmacol Res2021 Mar 2;167: 105524.（通讯作者）
4.Zhou E, Hoeke G, Li Z, Eibergen AC, Schonk AW, Koehorst M, Boverhof R, Havinga R, Kuipers F, Coskun T, Boon MR, Groen AK, Rensen PCN, Berbée JFP,Wang Y.Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidemia and atherosclerosis development.Cardiovasc Res2020 Aug 1;116(10): 1710-1720.（通讯作者）
5.Van der Tuin S, Li Z, Berbée JF, Verkouter I, Ringnalda LE, Neele AE, van Klinken JB, Rensen SS, Fu J, de Winther MPJ, Groen AK, Rensen PCN, Willems van Dijk K,Wang Y. Lipopolysaccharide lowers cholesteryl ester transfer protein by activating F4/80+Clec4f+Vsig4+Ly6C-Kupffer cell subsets.J Am Heart Assoc2018 Mar;10: 7(6).（通讯作者）
6.Van der Tuin SJ, Kühnast S, Berbée JF, Verschuren L, Pieterman EJ, Havekes LM, van der Hoorn JW, Rensen PC, Jukema JW, Princen HM, Willems van Dijk,Wang Y. Anacetrapib reduces (V) LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9.J Lipid Res2015 Nov; 56: 2085-2093.（通讯作者）
7.Wang Y, van der Tuin S, Tjeerdema N, van Dam AD, Rensen SS, Hendrikx T, Berbée JF, Atanasovska B, Fu J, Hoekstra M, Bekkering S, Riksen NP, Buurman WA, Greve JW, Hofker MH, Shiri-Sverdlov R, Meijer OC, Smit JW, Havekes LM, van Dijk KW, Rensen PC.Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.Hepatology2015 Dec; 62: 1710-1722.（第一作者）
8.Herrera Moro Chao D*,Wang Y*, Foppen E, Ottenhoff R, van Roomen C, Parlevliet ET, van Eijk M, Verhoek M, Boot R, Marques AR, Scheij S, Mirzaian M, Kooijman S, Jansen K, Wang D, Mergen C, Seeley RJ, Tschöp MH, Overkleeft H, Rensen PCN, Kalsbeek A, Aerts JMFG, Yi CX..Diabetes2019 Dec; 68(12): 2223-2234.[*Contributed equally]（共同一作）
9.Kooijman S*,Wang Y*, Parlevliet ET*, Boon MR, Edelschaap D, Snaterse G, Pijl H, Romijn JA, Rensen PC.Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice.Diabetologia2015 Nov; 58: 2637-2646 [*Contributed equally].（共同一作）
10.Rozendaal YJW*,Wang Y*, Paalvast Y, Tambyrajah LL, Li Z, Willems van Dijk K, Rensen PCN, Kuivenhoven JA, Groen AK, Hilbers PAJ, van Riel NAW.In vivoandin silicodynamics of the development of Metabolic Syndrome.PLoS Comput Biol2018 Jun; 14(6): e1006145.[*Contributed equally].（共同一作）
11.Wang Y, Parlevliet ET, Geerling JJ, Tuin SJL, Zhang H, Bieghs V, Jawad AHM, Shiri-Sverdlov R, Bot I, de Jager SC, Havekes LM, Romijn JA, Willems van Dijk K, Rensen PC. Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration.Br J Pharmacol2014 Feb; 171: 723-734.（第一作者）
12.Wang Y, Snel M, Jonker JT, Hammer S, Lamb HJ, de Roos A, Meinders AE, Pijl H, Romijn JA, Smit JW, Jazet IM, Rensen PC.Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases plasma CETP and increases apolipoprotein AI levels without improving the cholesterol efflux properties of HDL.Diabetes Care2011 Dec; 34: 2576-2580.（第一作者）
13.Wang Y, Berbée JF, Stroes ES, Smit JW, Havekes LM, Romijn JA, Rensen PC.CETP expression reverses the reconstituted HDL-induced increase in VLDL.J Lipid Res2011 Aug; 52: 1533-1541.（第一作者）
14.Trinder M,Wang Y, Madsen CM, Ponomarev T, Bohunek L, Daisely BA, Julia Kong H, Blauw LL, Nordestgaard BG, Tybjærg-Hansen A, Wurfel MM, Russell JA, Walley KR, Rensen PCN, Boyd JH, Brunham LR. Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis.Circulation. 2021 Mar 2;143(9):921-934.
15.Liu C, Schonke M, Zhou E, Li Z, Kooijman S, Boon MR, Larsson M, Wallenius K, Dekker N, Barlind L, Peng XR,Wang Y, Rensen PCN. Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis.Cardiovasc Res2022 Jan 29;118(2):489-502.
16.Körner A, Zhou E, Müller C, Mohammed Y, Herceg S, Bracher F, Rensen PCN,Wang Y, Mirakaj V, Giera M.Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution.Proc Natl Acad Sci U S A2019 Oct; 116(41): 20623-20634.
17.van Eenige R, Ying Z, Tambyrajah L, Pronk ACM, Blomberg N, Giera M,Wang Y, Coskun T, van der Stelt M, Rensen PCN and Kooijman S. Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE *3-Leiden.CETP mice.J Lipid Res2021;62:100070.
18.Blauw LL,Wang Y, Willems van Dijk K, Rensen PCN.A Novel Role for CETP as Immunological Gatekeeper: Raising HDL to Cure Sepsis?Trends Endocrinol Metab2020 May;31(5):334-343.
19.Li Z, de Jonge WJ,Wang Y, Rensen PCN, Kooijman S. Electrical Neurostimulation Promotes Brown Adipose Tissue Thermogenesis.Front Endocrinol (Lausanne)2020 Sep 30;11:567545.
20.Schilperoort M, van den Berg R, Coomans CP, Khedoe PPSJ, Ramkisoensing A, Boekestijn S,Wang Y, Berbée JFP, Meijer JH, Biermasz NR, Rensen PCN, Kooijman S. Continuous Light Does Not Affect Atherosclerosis in APOE*3-Leiden.CETP Mice.J Biol Rhythms2020 Dec;35(6):598-611.
21.Florijn BW, Duijs JMGJ, Levels JH, Dallinga-Thie GM,Wang Y, Boing AN, Yuana Y, Stam W, Limpens RWAL, Au YW, Nieuwland R, Rabelink TJ, Reinders MEJ, van Zonneveld AJ, Bijkerk R.DiabeticNephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2.Diabetes2019 Dec; 68(12): 2287-2300.
22.van Eyk HJ, Blauw LL, Bizino MB,Wang Y, van Dijk KW, de Mutsert R, Smit JWA, Lamb HJ, Jazet IM, Rensen PCN.Hepatic triglyceride content does not affect circulating CETP: lessons from a liraglutide intervention trial and a population-based cohort.Sci Rep2019 Jul; 9(1): 9996
23.Blauw LL, Noordam R, Soidinsalo S, Blauw CA, Li-Gao R, de Mutsert R, Berbée JFP,Wang Y,van Heemst D, Rosendaal FR, Jukema JW, Mook-Kanamori DO, Würtz P, Willems van Dijk K, Rensen PCN.Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile.Eur J Hum Genet2019 Mar; 27(3): 422-431.
24.Trinder M, Genga KR, Kong HJ, Blauw LL, Lo C, Li X, Cirstea M,Wang Y,Rensen PCN, Russell JA, Walley KR, Boyd JH, Brunham LR. Cholesteryl Ester Transfer Protein Influences High-Density Lipoprotein Levels and Survival in Sepsis.Am J Respir Crit Care Med2019 Apr; 199(7): 854-862.
25.Rozendaal YJW,Wang Y, Hilbers PAJ, van Riel NAW.Computational modelling of energy balance in individuals with Metabolic Syndrome.BMC Syst Biol2019 Feb 26;13(1):24.
26.Blauw LL, Li Z, Rensen SS, Greve JW, Verhoeven A, Derks RJ, Giera M,Wang Y, Rensen PCN.Metabolic liver inflammation in obesity does not robustly decrease hepatic and circulating CETP. Atherosclerosis2018 Aug; 275: 149-155.
27.Tahapary DL, de Ruiter K, Kurniawan F, Djuardi Y,Wang Y, Nurdin SME, Iskandar E, Minggu D, Yunir E, Guigas B, Supali T, Rensen PCN, Sartono E, Soewondo P, Harbuwono DS, Smit JWA, Yazdanbakhsh M.Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet.Sci Rep2018 May; 8(1): 8149.
28.Blauw LL, Li-Gao R, Noordam R, de Mutsert R, Trompet S, Berbée JFP,Wang Y, van Klinken JB, Christen T,van Heemst D, Mook-Kanamori DO, Rosendaal FR, Jukema JW, Rensen PCN, Willems van Dijk K.CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease.Circ Genom Precis Med2018 May; 11(5): e002034.
29.Hoeke G,Wang Y, van Dam AD, Mol IM, Gart E, Klop HG, van den Berg SM, Pieterman EH, Princen HMG, Groen AK, Rensen PCN, Berbée JFP, Boon MR.Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis.Atherosclerosis2017 Dec; 267: 116-126.
30.Paalvast Y, Gerding A,Wang Y, Bloks VW, van Dijk TH, Havinga R, Willems van Dijk K, Rensen PCN, Bakker BM, Kuivenhoven JA, Groen AK.Male apoE*3-Leiden.CETP mice on high-fat high-cholesterol diet exhibit a biphasic dyslipidemic response, mimicking the changes in plasma lipids observed through life in men.Physiol Rep2017 Oct; 5 (19).
联系方式
电子邮箱：y_wang@xjtufh.edu.cn或 yanan.wang@xjtu.edu.cn
联系电话：13359242141
个人主页：
https://orcid.org/0000-0002-0327-0458
https://scholar.google.cz/citations?user=omw25XQAAAAJ&hl=en
联系地址：陕西省咸阳市秦都区中国西部科技创新港21号楼2021室
