党永辉

    研究领域(方向)

 1. 法医精神病学与心理学

 2. 法医毒理学与毒物分析

 3. 重性精神障碍的神经生物学


个人及工作简历


累计主持各级各类科研基金10项,其中国家自然科学基金面上项目3项;目前发表SCI收录期刊论文65篇,其中通讯作者文章34篇,第一作者文章8篇;参编教材、专著著作10部。2014年获高等教育国家级教学成果奖二等奖(排名第四)及“第七批中央和国家机关、中央企业优秀援疆干部人才”称号,荣记二等功。

SCI收录期刊PLoS ONE, Medicine, Frontiers in Behavioral Neuroscience, Experimental and Therapeutic Medicine, Frontiers in Psychiatry编委;Medline收录期刊《法医学杂志》编委;《中国医学伦理学》杂志第一届青年编辑委员会委员。中华医学会精神医学分会司法精神医学组委员,西安市医学会精神病学分会委员;陕西省法医学会理事;中国解剖学会人类学分委会委员;陕西省司法鉴定协会法医类临床精神病专业委员;中国药物滥用防治协会青年专家委员会委员。


  

  科研项目


1. 主持2011年陕西省科学技术研究发展计划项目《甲基苯丙胺依赖大鼠腹外侧眶皮层表观遗传机制研究》(No.2011K15-01-03);

2. 主持2011年西安交通大学基本科研业务费国际科技合作项目《HINT1基因敲除小鼠甲基苯丙胺成瘾行为的神经可塑性机制》(No.2011JDHZ59);

3. 主持2012年国家自然科学基金资助面上项目《HINT1蛋白缺乏影响甲基苯丙胺成瘾行为的细胞与分子机制》(No.81171262);

4. 主持2014年国家自然科学基金资助面上项目《Hint-/-小鼠精神分裂样表型筛选及其VTA-NAc-PFC通路神经可塑性机制研究》(No.81371473);

5. 主持2016年陕西省自然科学基础研究计划面上项目《氧化锆金属泡沫3D细胞培养体系在实验性帕金森病模型中的应用》(No.2016JM8078);

6. 主持2017年机械制造系统工程国家重点实验室开放课题研究基金《面向帕金森病实验干预的神经营养因子3D培养体系研究》(No.sklms2017002);

7. 主持2018年国家自然科学基金资助面上项目《BDNF及GDNF干预吗啡成瘾行为的基因治疗策略与机制研究》(No.81771435);

8. 主持2020年国家卫健委毒品依赖和戒治重点实验室开放课题《HINT1 蛋白介导吗啡成瘾中MOR与NMDAR交互作用的机制研究》(No.2020DAMPO-0011)。


学术及科研成果、专利、论文


选择性发表物:

1. Yang L, Shen M, Xiang P, Shen B, Deng H, Qiang H, Dang Y*, Shi Y*. Application of a Validated UPLC-MS-MS Method for the Determination of Diphenidol in Biological Samples in 15 Authentic Lethal Cases. J Anal Toxicol. 2020, bkaa160.

2. Chu Z, Liu P, Li X, Liu Y, Liu F, Lei G, Yang L, Deng L, Dang Y*. Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antinociceptive effect in a rat of neuropathic pain. Psychopharmacology (Berl). 2020, 237(8): 2509-2516.

3. Lei G, Liu F, Liu P, Jiao T, Yang L, Chu Z, Deng LS, Li Y, Dang YH*. Does genetic mouse model of constitutive Hint1 deficiency exhibit schizophrenia-like behaviors? Schizophr Res. 2020, 222: 304-318.

4. Liu P, Lei G, Chu Z, Deng LS, Yang L, He JL, Dang YH*. The role of HINT1 in methamphetamine-induced behavioral sensitization. Psychopharmacology (Berl). 2020, 237(8): 2345-2351.

5. Liu P, Chu Z, Lei G, Deng LS, Yang L, Dang YH*. The role of HINT1 protein in morphine addiction: An animal model-based study. Addict Biol. 2020, e12897.

6. Wang X, Huang S, Liu Y, Li D, Dang Y, Yang L. Effects of ketogenic diet on cognitive function in pentylenetetrazol-kindled rats. Epilepsy Res. 2020. 170:106534.

7. Lei G, Liu F, Liu P, Zhou Y, Jiao T, Dang YH*. Worldwide Tendency and Focused Research in Forensic Anthropology: A Bibliometric Analysis of Decade (2008-2017). Leg Med (Tokyo). 2019, 37: 67-75.

8. Lei G, Liu F, Liu P, Zhou Y, Jiao T, Dang YH*. A Bibliometric Analysis of Forensic Entomology Trends and Perspectives Worldwide Over the Last Two Decades (1998-2017). Forensic Sci Int. 2019, 295: 72-82.

9. Liu F, Wen YF, Zhou Y, Lei G, Guo QY, Dang YH*. A meta-analysis of emotional disorders as possible risk factors for chronic periodontitis. Medicine. 2018, 97(28): e11434

10. Zhou Y, Zhang HK, Liu F, Lei G, Liu P, Jiao T, Dang YH*. Altered Light Conditions Contribute to Abnormalities in Emotion and Cognition Through HINT1 Dysfunction in C57BL/6 Mice. Front Behav Neurosci. 2018, 12: 110

11. Liu P, Liu Z, Wang J, Ma X, Dang Y*. HINT1 in Neuropsychiatric Diseases: A Potential Neuroplastic Mediator. Neural Plast. 2017: 5181925.

12. Sun LK, Liu P, Liu F, Zhou Y, Chu Z, Li YQ, Chu G, Zhang Y, Wang JB, Dang YH*. Effects of Hint1 deficiency on emotional-like behaviors in mice under chronic immobilization stress. Brain Behav. 2017, 23; 7(10): e00831.

13.   Liu P, Xing B, Chu Z, Liu F, Lei G, Zhu L, Gao Y, Chen T, Dang YH*. The DopamineD3 Receptor Knockout Mice Exhibit Abnormal Nociception in a Sex-Different Manner. J Neurosci Res. 2017, 95(7): 1438-1445.

14.   Liu F, Ma J, Liu P, Chu Z, Lei G, Jia XD, Wang JB, Dang YH*. Hint1 gene deficiency enhances the supraspinal nociceptive sensitivity in mice. Brain Behav. 2016, 6 (8): e00496.

15.   Zhao Y, Liu P, Chu Z, Liu F, Han W, Xun X, Dang YH*. Electrolytic Lesions of the bilateral ventrolateral orbital cortex inhibit methamphetamine-associated contextual memory formation in rats. Brain Res. 2015, 22: 1624: 214-21.

16.   Liu ZW, Li WQ, Wang JK, Ma XC, Liang C, Liu P, Chu Z, Dang YH*. Zirconium oxide ceramic foam: a promising supporting biomaterial for massive production of glial cell line-derived neurotrophic factor. J Zhejiang UnivSci B. 2014, 15(12): 1013-22.

17.   Xing B, Liu P, Xu WJ, Xu FY, Dang YH*. Effect of Microinjecting of 5-aza-2-deoxycytidine into Ventrolateral Orbital Cortex on Depressive-like Behavior in Rats. Neurosci Lett. 2014, 574: 11-4.

18.   Liu F, Ma J, Zhang H, Liu P, Liu YP, Xing B, Dang YH*. Fluoride exposure during development affects both cognition and emotion in mice. Physiol Behav. 2014, 124: 1-7.

19.   Xing B, Liu P, Jiang WH, Liu F, Zhang H, Cao GF, Chen T, Dang YH*. Effects of immobilization stress on emotional behaviors in dopamine D3 receptor knockout mice.Behav Brain Res. 2013, 243: 261-6.

20.   Jin J, Hu F, Qin X, Liu X, Li M, Dang Y*, Dang J*. Very Early Neurophysiological Study in Guillain-Barre Syndrome. Eur Neurol. 2018, 80(1-2): 100-105.

21.   Li JP, Liu P, Lei G, Chu Z, Liu F, Shi CF, Dang YH*, Chen T*. The Role of HINT1 in Methamphetamine-induced Conditioned Place Preference. Neurotox Res. 2017, 33(2): 353-361.

22.   Li BJ, Liu P, Chu Z, Shang Y, Huan MX, Dang YH*, Gao CG*. Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor 1, and dopamine receptor 2. Neuroreport. 2017, 28(8): 462-469.

23.   Ma XC, Chu Z, Zhang XL, Jiang WH, Jia M, Dang YH*, Gao CG*. Intranasal Delivery of Recombinant NT4-NAP/AAV Exerts Potential Antidepressant Effect. Neurochem Res. 2016, 41(6): 1375-80.

24.   Ma J, Liu F, Liu P, Dong YY, Chu Z, Hou TZ*, Dang YH*. Impact of early developmental fluoride exposure on the peripheral pain sensitivity in mice. Int J Dev Neurosci. 2015, 47(Pt B): 165-71.

25.   Liu Z, Cai H, Zhu H, Toque H, Zhao N, Qiu C, Guan G, Dang Y*, Wang J*. Protein kinase RNA-like endoplasmic reticulum kinase (PERK)/calcineurin signaling is a novel pathway regulating intracellular calcium accumulation which might be involved in ventricular arrhythmias in diabetic cardiomyopathy. Cell Signal. 2014, 26(12): 2591-2600.

26.   Xing B, Zhao Y, Zhang H, Dang Y*, Chen T*, Huang J, Luo Q. Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antidepressant-like effect in the rat forced swim test. Brain Res Bull, 2011, 85(3-4): 153-157.

27.   Dang YH, Liu P, Ma R, Chu Z, Liu YP, Wang JB, Ma XC, Gao CG. HINT1 is involved in the behavioral abnormalities induced by social isolation rearing. Neurosci Lett. 2015, 21: 607: 40-5.

28.   Dang YH, Ma XC, Zhang JC, Ren Q, Wu J, Gao CG, Hashimoto K.Targeting of NMDA Receptors in the Treatment of Major Depression. Curr Pharm Des. 2014, 20(32): 5151-9.

29.   Dang YH, Zhao Y, Xing B, Zhao XJ, Huo FQ, Tang JS, Qu CL, Chen T. The role of dopamine receptors in ventrolateral orbital cortex-evoked anti-nociception in a rat model of neuropathic pain. Neuroscience, 2010, 169(4): 1872-80.

30.   Dang YH, Xing B, Zhao Y, Zhao XJ, Huo FQ, Tang JS, Qu CL, Chen T. The role of dopamine receptors in ventrolateral orbital cortex-evoked antinociceptionin a rat formalin test model. Eur J Pharmacol, 2011, 657 (1-3): 97-103.

教材与专著:

1. 与活体有关的鉴定——司法精神病学鉴定(1~11). 见:张秦初主编.临床法医学鉴定问答.北京:人民卫生出版社,2002. 142~154.

2. 心理保健方法;学习和工作中的心理保健;现代生活现象与心理保健. 见:姚斌主编. 现代人的心理保健——走出心理困惑. 北京:人民卫生出版社,2001. 75~105,320~375.

3.干细胞的应用;治疗性克隆之争.见:郑月茂、张雅蓉主编.干细胞、克隆与转基因. 北京:北京科学技术出版社,2011. 92~121,260~262.

4.基因与基因工程. 见:郑月茂主编. 转基因克隆动物理论与实践. 北京:科学出版社,2012. 13~62.

5.光遗传学技术在成瘾研究中的应用;精神外科治疗. 见:李生斌主编. 成瘾基因组学. 西安:西安交通大学出版社, 2016. 165~172, 410~416.

6. 精神疾病的司法鉴定. 见:李生斌主编. 现代实用法医学. 西安:西安交通大学出版社,2010. 309~320.

7.毒品中毒. 见:朱少华主编. 法医毒理学实验指导. 北京:人民卫生出版社,2016. 38~48.

8.法医心理学. 见:李生斌主编. 法医学. 北京:人民卫生出版社,2017.

9.民族精神病学;医学人类学与行为医学. 见:席焕久主编. 生物医学人类学. 北京:科学出版社,2018. 376~389, 450~471


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