主要科研项目 |
(1)国家自然科学基金委员会,面上项目,82571968,mTORC1介导GDNF/SCFAs序贯干预促进肠神经突触形成及细胞移植治疗先天性巨结肠的机制研究, 2026-01-01至2029-12-31,49万元,在研,主持 (2)河南省人力资源和社会保障厅, 2026年度河南省引进国外智力项目-高端外国专家计划, HNGD2026008, Lincon Stamp博士引进及肠神经系统可塑性研究, 2026-01-01至2026-12-31, 10万元,在研,主持 (3)西安交通大学第二附属医院，育英计划(新星培养人选)No.6，HSCR的临床转化研究，2024-01-01至2029-12-31,180万,在研,主持 (4)Australian Government -MRFF Stem Cell Therapies Mission ($AUD: 583,614), Basic research, APP 2009049, Stem cell therapy for digestive disease, 2023-01-01至2025-12-31, 270万元,结题,参与 (5)国家自然科学基金委员会,面上项目, 82071692,肠道固有孢子形成菌在肠神经嵴前体细胞移植治疗先天性巨结肠中的作用与机制研究, 2021-01-01至2024-12-31, 52万元,结题,主持 (6)国家自然科学基金委员会,应急管理项目, 81741096,基于肠道炎症调控探讨肠神经嵴前体细胞移植修复肠神经系统的实验研究, 2018-01-01至2018-12-31, 20万元,结题,主持 (7)西安交通大学,基础-临床融合创新项目, YXJLRH2022053,探讨菌群产物在细胞移植治疗先天性巨结肠中的作用与机制研究, 2022-08-01至2024-07-31, 20万元,结题,主持 (8)陕西省科学技术厅,创新人才推进计划-青年科技新星项目, 2019KJXX-044,基于“粪菌移植”重建肠道菌群促进ENCCs移植修复肠神经系统的实验研究, 2019-01-01至2021-07-31, 10万元,结题,主持 (9)陕西省科学技术厅,一般项目-社会发展领域, 2022SF-133, 5-HT4受体激动剂通过MEK/MAPK诱导神经再生在肠神经嵴前体细胞移植修复肠神经系统的机制研究, 2022-01-01至2023-12-31, 6万元,结题,主持 (10)陕西省科学技术厅,创新人才推进计划-青年科技新星项目, 2019KJXX-044,基于“粪菌移植”重建肠道菌群促进ENCCs移植修复肠神经系统的实验研究, 2019-01-01至2021-07-31, 10万元,结题,主持 (11)陕西省科学技术厅,一般项目-面上项目, 2020JM-407,基于FMT提高SCFAs水平协同ENCCs移植修复ENS研究, 2020-01-01至2021-06-30, 3万元,结题,主持 |
代表性论著、科研获奖、人才称号 |
(1)Jia W#, Yan H, Huang J, Liu W, Fu Z, Tian D, Xu W, Chen X, Gao Y*,Yu H*. Dual roles of GDNF in enteric glial cell plasticity: direct transdifferentiation via the CaMKII/NeuroD1 pathway and cooperative regulation in a neural stem cell-inducing medium.Stem Cell Res Ther. 2026 Mar 11;17(1):144. (2)Liu W#, Xu W#, Huang J, Xu J, Fu Z, Yan H, Jia W,Yu H, Zheng B, Pan W, Chen X, Gao Y*, Tian D*. DNER as a novel protein contributes to HSCR pathogenesis: multi-omics combined Mendelian randomization analysis.Pediatr Res. 2026 Feb 25. (3)Van Mechelen K#, Zhao J, Di Natale MR, Jiang L, Lai DK,Yu H, Oviedo Querejazu M, Furness JB, Vanden Berghe P, Hao MM, Stamp LA*. Unlocking the Neurogenic Potential of Enteric Glial Cells for Hirschsprung Disease Therapy.Cell Mol Gastroenterol Hepatol. 2026;20(5):101693. (4)Luan Y#, Zhang H, Liu Y, Zhou J, Li W, Ma K, Zheng X, Huang C, Chen X, Lu H,Yu H, Bjørås M, Klungland A, Zhang Z*. Inverse and dynamic levels of H3K4me3 and H3K27me3 regulate mouse postnatal dental gyrus development.Cell Death Differ. 2026 Jan;33(1):219-235. (5)Yu H*, Pan W, Tian D, Gao Y*. Deciphering the complexity of enteric niches in Hirschsprung disease: from metaphorical insights to therapeutic transformation.Front Pediatr. 2025 Jun 19;13:1579290. (6)Jia W, Liu W, Tian D, Yan H, Huang J, Fu Z, Xu W, Chen X, Gao Y*,Yu H*. Sodium Butyrate Promotes Enteric Glial Cells Neurogenesis by Inhibiting Kdm2a and Inducing Klf4 Expression.J Pediatr Surg. 2025 Jun 24:162428. (7) Tian DH#; Xu WY#; Pan WK; Zheng BJ; Yang WL; Jia WY; Liu Y; Garstka MA; Gao Y*;Yu H*. Fecal microbiota transplantation enhances cell therapy in a rat model of hypoganglionosis by SCFA-induced MEK1/2 signaling pathway,The EMBO Journal, 2023, 42(1) (8) Tian DH#; Qin CH#; Xu WY#; Pan WK; Zhao YY; Zheng BJ; Chen XL;LiuY; Gao Y*;Yu H*. Phenotypic and functional comparison of rat enteric neural crest-derived cells during fetal and early postnatal stages,Neural Regen Res, 2021,16(11): 2310- 2315 (9)Yu H#; Cao NJ; Pan WK; Su L; Zhao YY; Tian DH; Xu WY; Gao Y*; Zheng BJ. Correlation of spatio-temporal characteristics of intestinal inflammation with IL-17 in a rat model of hypoganglionosis,Biochem Biophys Res Commun, 2018,506(4): 956- 961 (10)Yu H#; Pan WK; Wang HJ; Gao Y*. A Time-Limited and Partially Reversible Model of Hypoganglionosis Induced by Benzalkonium Chloride Treatment,NEUROCHEM RES, 2016, 41(5): 1138- 1144 (11)Yu H#; Zheng BJ; Pan WK; Wang HJ; Xie C; Zhao YY; Chen XL; Liu Y; Gao Y*. Combination of exogenous cell transplantation and 5-HT4receptor agonism induce endogenous enteric neural crest-derived cells in a rat hypoganglionosis model,Exp Cell Res, 2016, 351(1): 36-42 (12)Yu H#, Pan WK, Zheng BJ, Wang HJ，Chen XL，Liu Y，Gao Y*. Decreased proliferative，migrative and neuro-differentiative potential of postnatal rat enteric neural crest-derived cells during culture in vitro.Exp Cell Res. 2016 May 1;343(2):218-222. (13)Yu H#, Pan WK#, Ge X, Wang H, Huang Q, Chen X, Liu Y, Gao Y*. Nontoxicity of lentiviral vector infection to viability, migration, apoptosis, and differentiation of postnatal rat enteric neural crest-derived cells.Neuroreport. 2015 Oct 21;26(15):883-9. (14)许文耀#,田东浩,贾婉莹,闫寒蕾,黄晶晶,刘威,余辉*,高亚.短链脂肪酸对先天性巨结肠模型小鼠的神经再生/保护效应[J].中华小儿外科杂志,2023,44(08): 742-748. (15)余辉#,潘伟康,高亚*.先天性巨结肠肠道微环境异常及其临床转化潜能[J].中华小儿外科杂志,2023,44(08) :752-758. |
