*研究领域（方向）
牙齿硬组织疾病和发育性疾病； 氟化物与牙齿健康
*个人及工作简历
于1983和1987年 获西安医科大学口腔系口腔医学学士和硕士学位。2006年2月 获挪威卑尔根大学牙医系牙医学博士学位。自1983年毕业留校工作至今，先后在口腔内科牙体病及儿童牙病专业组、口腔预防教研室、特诊科任住院医师、主治医师及主任医师，并曾参加苏丹医疗队援外工作两年。在对牙体病（龋病、牙髓及根尖周病、发育异常、外伤及慢性损伤）进行临床治疗的过程中，对其病因和治疗措施进行了较深入的研究。
*科研项目
1.国家自然科学基金面上项目，81470034，氟化物通过转录因子FoxO1调控釉基质蛋白酶表达影响氟牙症发生的分子机制研究，2015/01-2016/12，在研，主持
2.陕西省科技统筹创新工程计划资源主导型产业关键技术（链）项目，2013KTCL03-03，早期龋和釉质脱矿类改变的仿生学治疗--新型仿生修复凝胶的研发，2013/01-2015/1，在研，主持
3.国家自然科学基金面上项目，30972558，氟化物对釉基质蛋白酶的表达及活性的影响，2010/01-2012/12，已结题，主持
4.国家自然科学基金面上项目，81670985，氟通过调控PI3K-Akt-FoxO1信号途径影响成熟成釉细胞KLK4表达的机制研究，2017.01-2018.12，主持
5.陕西省攻关项目，2015SF153，Lin28参与牙髓损伤修复的机制研究，2015/01-2016/12，在研，主持
6.国家自然科学基金青年基金项目，81602812，钙通过调节氟诱导的内质网应激反应上调成釉细胞器细胞中KLK4和AMTN表达，2017.01-2019.12，参与
*学术及科研成果、专利、论文
1.第一作者论文
(1) Jianping Ruan ，Asgeir Bardsen，Anne Nordrehaug Astrom，Ruizhe Huang，Zhilun Wang，Kjell Bjorvatn，Dental fluorosis in children in areas with fluoride-polluted air, high-fluoride water, and low-fluoride water as well as low-fluoride air: A study of deciduous and permanent teeth in the Shaanxi province, China，Acta Odontologica Scandinavica，2007，65（2）：65-71。
(2) 阮建平 ，王治伦，黄虹，黄瑞哲，余波，刘志红，汤星红，宝鸡市农村儿童乳牙氟斑牙调查分析，中国地方病防治杂志，2006，（01）：46-48。
(3) 阮建平 ，李红杏，黄瑞哲，妊娠期大鼠摄入氟化物对子代鼠血液和骨氟浓度的影响，陕西医学杂志，2006，35（12）：1620-1622。
(4) Jianping Ruan ，Zhilun Wang，Zhuangqun Yang，Asgeir Bardsen，Anne Nordrehaug Astrom，Kjell Bjorvatn，Dental fluorosis in primary teeth: a study in rural schoolchildren in Shaanxi Province, China，International Journal of Paediatric Dentistry，2005，15（6）：412-419。
(5) Jianping Ruan ，Zhuangqun Yang，Zhilun Wang，Anne Nordrehaug Astrom，Asgeir Bardsen，Kjell Bjorvatn，Dental fluorosis and dental caries in permanent teeth: rural schoolchildren in high-fluoride areas in the Shaanxi province, China，Acta Odontologica Scandinavica，2005，63（5）：258-265。
(6) 阮建平 ，刘忠岐，宋健玲，Kjell Bjorvatn，阮梅生，陕西大荔县改水对氟牙症患病情况的影响，中华口腔医学杂志，2004，（02）：53-55。
2. 通讯作者论文
（1）Lin Zhao, Juedan Li, Jiali Su, Sneed Malcolm L, Jianpng Ruan. LS8 cell apoptosis induced by NaF through p-ERK and p-JNK—a mechanism study of dental fluorosis, Acta Odontologica Scandinavica,2016;74(7):539-549.
（2）Lin Zhao, Jiali Su, Ning Dong, Juedan Li, Peng Wang, Jianping Ruan. Impact of fluoride on ameloblasts and MAPKs and caspase-12 activity in the tooth germ of rat offspring. Int J Clin Exp Pathol, 2017;10(3):3609-3616.
（3）Juedan Li; Lin Zhao; Xiaomeng Zhao; Peng Wang; Yan Liu; Jianping Ruan*; Foxo1 Attenuates NaF-Induced Apoptosis of LS8 Cells through the JNK and Mitochondrial Pathways, Biol Trace Elem Res, 2017, 181(1): 104-111.
（4）Peng Wang, Jianghong Gao, Danyang Wang, Malcolm L. Snead, Juedan Li,Jianping Ruan*. Optimizing concentration of titanium tetrafluoride solution for human dentine remineralization, Archives of Oral Biology, 2017(83): 7–12
（5）Ning Dong, Yan Liu, Tiantian Zhang, Lin Zhao, Jiangang Tian, Jianping Ruan*. Different expression patterns of Lin28 and Lin28b in mouse molar development, Archives of Oral Biology, 2017(82): 280-285.
（6）Lei Mi, Huaiqin Liu, Yu Gao, Hui Miao, Jianping Ruan*. Injectable nanoparticles/hydrogels composite as sustained release system with stromal cell-derived factor-1 for calvarial bone regeneration, International Journal of Biological Macromolecules, 2017, 101: 341–347.
（7）Juedan Li; Peng Wang; Jianghong Gao; Xiuzhi Fei; Yan Liu; Jianping Ruan*; NaF Reduces KLK4 Gene Expression by Decreasing Foxo1 in LS8 Cells, Biological Trace Element Research, 2018, 186(2): 498-504.
（8）Yan Liu, Ning Dong, Juedan Li, Lin Zhao, Liping Gao, Yurong Zhang, Jianping Ruan. RNA-binding protein Lin28 is associated with njured dentin-dental pulp complex in Sprague-Dawley rats. Int J Clin Exp Pathol, 2018;11(9):4385-4394.
（9）Nan Jiang, Lu Chen, Qianli Ma, Jianping Ruan*. Nanostructured Ti surfaces and retinoic acid/dexamethasone present a spatial framework for the maturation and amelogenesis of LS-8 cells, International Journal of Nanomedicine, 2018,19/25 13:3949-3964.
（10）Yan Liu, Ning Dong, Jiyu Miao, Chenxing Li, Xiaofei Wang, Jianping Ruan*; Lin28 promotes dental pulp cell proliferation via upregulation of cyclindependent proteins and interaction with let-7a/IGF2BP2 pathways, Biomedicine & Pharmacotherapy, 2019, 113: 108742.
（11）Xiaojing Liu, Meili Gao, Jianping Ruan, Qun Lu. Root Canal Anatomy of Maxilary First premolar by Microscopic Computed Tomography in a Chinese Adolescent Subpopulation. BioMed Research International,2019,DOI: 10.1155/2019/4327046.
（12）Xiuzhi Fei, Yuncong Li, Michael D Weir, Bashayer H Baras, Haohao Wang, Suping Wang, Jirun Sun, Mary A S Melo, Jianping Ruan*, Hockin H K Xu*. Novel pit and fissure sealant containing nano-CaF 2 and dimethylaminohexadecyl methacrylate with double benefits of fluoride release and antibacterial function, Dental Materials, 2020, 36:1241-1253.
（13）Jianghong Gao, Zhen Gao, Fan Dang, Xinmei Li, Hao Liu, Xiaojing Liu, Meili Gao, Jianping Ruan. Calcium Promotes differentiation in ameloblast-like LS8 cells by downregulation of phosphatidylinositol 3 kinase/protein kinase B pathway. Archives of Oral Biology, 2020, 109:104579.
（14）Jianghong Gao, Xinmei Li, Liping Gao, Haiyan Chen, Bashayer H. Baras, Xiaojing Liu, Hao Liu, Ayesha Rana, Meili Gao, Jianping Ruan. Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikrein-related peptidase-4 and tight junction proteins in ameloblasts. Internatinal Journal of Molecular Medicine, 2020,46:179-190.
（15）Jialing Li, Min Huag, Yonglin Xie, Ruizhe Huang, Jianping Ruan. Role of EZH2/ pd-l1 / hif-1a in the progression of oral squamous cell carcinoma. Drug Design, Development and Therapy , 2020, https://doi.org/10.2147/DDDT.S267982
（16）Xiaojing Liu, Evaluation of palatal furcation groove and root canal anatomy of maxillary first premolar: a CBCT and micro-CT study. BioMed Research International,2020,DOI
*联系方式
电子邮箱：ruanjp@mail.xjtu.edu.cn
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