研究领域（方向）
（1）耳鼻咽喉疾病的发病机制探索（2）甲状腺肿瘤及咽喉肿瘤的发病机制及治疗方法
个人及工作简历
许崇文，医学博士，副研究员，就职于西安交大一附院耳鼻咽喉头颈外科，现为陕西省甲状腺疾病临床研究中心秘书长。主要从事耳鼻咽喉常见疾病的诊治，甲状腺结节消融治疗，甲状腺肿瘤腔镜手术和开放手术治疗。
2013年-2014年曾在，美国托马斯杰斐逊大学“基梅尔肿瘤研究中心”从事肿瘤学研究。主持国家自然科学基金1项，参与国家自然科学基金5项，主持陕西省自然科学基金1项，西安市科技创新项目1项，第一或通讯作者发表SCI文章15篇，参与发表SCI论文40余篇。
现为中国抗癌协会甲状腺整合康复委员会委员，陕西省中西医结合学会耳鼻喉科专委会委员，西北腔镜甲状腺联盟委员，陕西省抗癌协会临床肿瘤大数据应用专委会委员，陕西省保健协会甲状腺专委会、头颈肿瘤专委会及眩晕专委会委员，长安医学会甲乳外科专委会委员。
科研项目
1.MGAT3通过催化平分型GlcNAc糖基化修饰LAMA3调控甲状腺微小乳头状癌颈侧淋巴结转移的作用及机制研究（82103568），国家自然科学基金委，2022/01/01-2024/12/31，30万，主持。
2.let-7a通过调节细胞焦亡介导乳腺癌紫杉醇耐药机制研究（2021JQ-386），陕西省自然科学基础研究计划，2021/01/01-2022/12/31，3万，主持。
3.影像学研究-术中利用近红外显像技术联合免疫胶体金法快速识别甲状旁腺临床研究（2019115413YX009SF042(5)），西安市科技计划项目，2019/10/01-2021/09/30，5万，主持。
4.术中利用近红外显像技术联合免疫胶体金法快速识别甲状旁腺临床研究（XJTU1AF-CRF-2020-020），西安交大一附院临床研究中心，2021/01/01-2024/12/31，6万，主持。
学术及科研成果、专利、论文
1)Feng Lei, Wang Rui, Zhao Qian, Wang Jun, Luo Gan*.,Xu Chongwen*. Racial disparities in metastatic colorectal cancer outcomes revealed by tumor microbiome and transcriptome analysis with bevacizumab treatment[J]. Frontiers in Pharmacology, 2024, 14: 1320028.
2)Zhu Jinxiang#, Guo Longwei#, Dai Hao, Zheng Zhiwei, Yan Jinfeng, Liu Junsong, Zhang Shaoqiang, Li Xiang, Sun Xin, Zhao Qian*,Xu Chongwen*.RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma[J]. CELL BIOLOGY AND TOXICOLOGY, 2024, 40(1):14.
3)Chongwen Xu#, Xiaoxia Wang#, Junsong Liu#, Jinfeng Yan1, Shaoqiang Zhang*, Zhiwei Zheng , Qian Zhao, Yi Feng , Yanxia Bai1, Ruimin Zhao, Honghui Li, Xiaobao Yao*. The Feasibility Study of Intraoperative RLN Monitoring Using Cricothyroid Membrane-Inserted Needle Electrodes During Thyroid Surgery[J]. OTOLARYNGOLOGY HEAD AND NECK SURGERY. 2023, 169(3):589-597.
4)Zhu Jinxiang#, Dai Hao#, Li Xiang, Guo Longwei, Sun Xin, Zheng Zhiwei*,Xu Chongwen*. LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis[J]. PATHOLOGY RESEARCH AND PRACTICE. 2023, 243:154360.
5)Shao Yuan#, Ren Wanli#, Dai Hao, Yang Fangli, Li Xiang, Zhang Shaoqiang, Liu Junsong, Yao Xiaobao, Zhao Qian, Sun Xin, Zheng Zhiwei,Xu Chongwen.SKP2 Contributes to AKT Activation by Ubiquitination Degradation of PHLPP1, Impedes Autophagy, and Facilitates the Survival of Thyroid Carcinoma[J]. MOLECULES AND CELLS. 2023, 46(6):360-373.
6)Jinxiang Zhu, Xiang Li, Shaoqiang Zhang, Junsong Liu, Xiaobao Yao, Qian Zhao, Bo Kou, Peng Han, Xuan Wang, Yanxia Bai, Zhiwei Zheng*andChongwen Xu*. Taraxasterol inhibits TGF-β1-induced epithelial-to-mesenchymal transition in papillary thyroid cancer cells through regulating the Wnt/β-catenin signaling [J]. Human and Experimental Toxicology, 2021:9603271211023792.
7)Ren Wanli#,Xu Chongwen#,Wang Shiyang, Li Huajing, Dai Hao, Yang Fangli, Shao Yuan, Bai Yanxia*. The effect of VAV3 polymorphisms on thyroid cancer[J].Endocrine, 2021:1-7.
8)Xu Chongwen#, Liu Junsong#, Yao Xiaobao, Bai Yanxia, Zhao Qian, Zhao Ruimin, Li Honghui, Guo Longwei, Wang Xuan, Zheng Zhiwei*, Zhang Shaoqiang*. Downregulation of microR-147b represses the proliferation and invasion of thyroid carcinoma cells by inhibiting Wnt/β-catenin signaling via targeting SOX15[J]. Molecular and Cellular Endocrinology, 2020, 501: 110662.
9)Chongwen Xu#, Yuan Shao#, Junsong Liu#, Xiaobao Yao, Fang Quan, Qian Zhao, Ruimin Zhao, Bo Kou, Honghui Li, Peng Han, Xuan Wang, Yanxia Bai, Zhiwei Zheng*, Shaoqiang Zhang*. Long non-coding RNA AGAP2-AS1 promotes proliferation and metastasis in papillary thyroid cancer by miR-628-5p/KLF12 axis[J]. Journal of bioenergetics and biomembranes. 2021, 53: 235-245.
10)Chongwen Xu, Peng Han, Wanli Ren, Hao Dai, Yanxia Bai, Zhen Shen, Baiya Li*, Yuan Shao*, The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population[J]. BioMed Research International, 2020, 2020:2329196.
11)Xu Chongwen#, Xiao Guodong#,Zhang Boxiang#,Wang Meng, Wang Jichang, Liu Dapeng, Zhang Jing, Ren Hong*, Sun Xin*.CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade[J].Gene Therapy, 2018, 25(1): 4-12.
12)Xu Chongwen，Sun Xin，Qin Sida，Wang Huangzhen，Zheng Zhiwei，Xu Shaohua，Luo Gang，Liu Peng，Liu Jian，Du Ning，Zhang Yunfeng，Liu Dapeng，Ren Hong*. Let-7a regulates mammosphere formation capacity through Ras/NF-kappaB and Ras/MAPK/ERK pathway in breast cancer stem cells[J]. Cell Cycle, 2015, 14（11）：1686-1697.
13)Xin Sun#,Chongwen Xu#, Shou-Ching Tang, Jichang Wang, Huangzhen Wang, Peili Wang, Ning Du, Sida Qin, Gang Li, Shaohua Xu, Zheng Tao, Dapeng Liu and Hong Ren*. Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells[J]. Cancer Gene Therapy, 2016, 23（4）: 83-89.
14)Junsong Liu#,Chongwen Xu#, Rui Wang, Peng Han, Qian Zhao, Honghui Li, Yanxia Bai, Lifeng Liu, Shaoqiang Zhang* and Xiaobao Yao*.Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data[J]. World Journal of Surgical Oncology, 2020, 18: 84.
15)Xin Sun#,Chongwen Xu#,Jinying Meng, Guodong Xiao, Jichang Wang, Shou-Ching Tang,Sida Qin, Ning Du, Gang Li, Henggang Zhang, Yunxia Niu,Hong Ren, Dapeng Liu. Breast Cancer stem-like cells are Sensitized to Tamoxifen Induction of Self-Renewal Inhibition with Enforced Let-7c[J].International Journal of Molecular Medicine,2018, 41(4): 1967-1975.
联系方式
电子邮箱：545999673@qq.com
联系电话：18991213556
个人主页：无
联系地址：陕西省西安市雁塔西路277号
