刘静

6E0CA

刘静教授博导

西安交通大学青年拔尖人才(A类)

国家级人才

研究领域/方向

临床医学、肿瘤学(报考学科代码100214):

1.新型PROTAC靶向蛋白降解药物研发

2.肿瘤代谢及肿瘤免疫

教育及工作经历

2023.4-至今,西安交通大学第一附属医院,青年拔尖人才(A类),教授

2018-2023,美国哈佛大学医学院贝斯以色列女执事医疗中心,博士后

2017-2018,西安交通大学,生命学院,讲师

2010-2016,西安交通大学,生命学院,生物学博士

2006-2010,西安交通大学,生命科学人才基地班,本科

科研资助

国家自然科学基金优秀青年科学基金(海外)项目(2023-2025)

西安交通大学青年拔尖人才启动(2023-2028)

国家自然科学基金青年项目(2017-2019)

学术及科研成果、专利、论文

长期致力于肿瘤及蛋白质翻译后修饰相关研究,针对肿瘤靶向治疗及免疫治疗开展了系统性工作,以第一/通讯作者在Science Advances,Nature Communications(2篇),Cell Research(3篇),Journal of the American Chemical Society(4篇),Trends inCell Biology及Seminar in Cancer Biology(2篇)等杂志发表论文16篇,他引超过2000次,H因子29。研究成果被Nature Review Cancer,Nature Review Drug Discovery及Trends in Cell Biology等引用。

代表性论文

(*共同第一作者,#通讯作者)

1.J Wang*, Z Wang*, H Inuzuka, W Wei, J Liu#. PRMT1 methylates METTL14 to modulate its oncogenic function.Neoplasia, 2023, 42, 100912

2.Liu J*, Bu, X*, Chu, C. Dai X, Asara J. et al. PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity.Nature Communications. 2023, 14, 2806.

3.Wang Z*,Liu J*, Chen H, Qiu X, Xie L, et al. Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins,Journal of the American Chemical Society. 2023, 17;145(19):10872-10879.

4.Liu J*, Yu X*, Chen H, Kaniskan H, Xie L, et al. TF-DUBTACs stabilize tumor suppressor transcription factors.Journal of the American Chemical Society. 2022, 144 (28), 12934-12941.

5.Liu J*, Peng Y*, Wei W#. Cell cycle on the crossroad of tumorigenesis and cancer therapy.Trends in Cell Biology. 2022, 32(1): 30-44.

6.Liu J*, Peng Y*, Inuzuka H, Wei W#. Targeting micro-environmental pathways by PROTACs as a therapeutic strategy.Seminars in Cancer Biology. 2022, 86(2): 269-279.

7.Liu J*, Peng Y*, Shi L*, Wan L, Inuzuka H, et al. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle.Cell Research. 2021, 31(1): 80-93.

8.Liu J*, Tokheim C*, Lee JD, Gan W, North BJ, et al. Genetic fusions favor tumorigenesis through degron loss in oncogenes.Nature Communications. 2021, 12(1): 6704.

9.Liu J*, Chen H*, Kaniskan H, Xie L, Chen X, et al. TF-PROTACs enable targeted degradation of transcription factors.Journal of the American Chemical Society. 2021, 143(23): 8902-8910.

10.Liu J*, Chen H*, Liu Y, Shen Y, Meng F, et al. Cancer selective target degradation by folate-caged PROTACs.Journal of the American Chemical Society. 2021, 143(19): 7380-7387.

11.Liu J*, MaJ *, LiuY *, XiaJ, LiY, et al. PROTACs: A novel strategy for cancer therapy.Seminars in Cancer Biology. 2020, 67, 171-179.

12.Liu J*, Chen H*, Ma L, He Z, Wang D, et al. Light-induced control of protein destruction by opto-PROTAC.Science advances.2020, 6 (8), eaay5154

联系方式

电子邮箱:jingliu@xjtu.edu.cn

实验室主页:https://gr.xjtu.edu.cn/en/web/jingliu

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