研究领域（方向）
（1）肿瘤免疫微环境（2）肿瘤染色质不稳定与放化疗敏感性
个人及工作简历
李娟,女, 博士,西安交通大学第一附属医院转化医学中心副研究员。2017年获得西安交通大学生物化学与分子生物学博士学位,后期主要从事基因组不稳定与肿瘤的关系及肿瘤转移及肿瘤微环境的机制研究。近年来以第一作者和通讯作者在国际著名刊物《Journal of Experimental & Clinical Cancer Research》、《Cell Death and Disease》、《Am J Cancer Res》等杂志发表SCI文章12余篇，所发表文章已被引用近三百次。获得陕西省科学技术一等奖和二等奖各一项，主持国家自然科学基金面上项目及青年项目各一项、陕西省重点研发一般项目两项。现任陕西省抗癌协会生物样本库专业委员会委员，陕西省抗癌协会肿瘤标志物委员会委员。
科研项目
1、2021年获得陕西省社会发展一般项目资助项目编号2021SF-121
2、2023年获得国家自然科学基金面上项目资助项目编号82373389
学术及科研成果、专利、论文
发表论文：
1.Li J*，Liu J，Ren Y，Yang J，Liu P. Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors.Int J Biol Sci, 2014, 10;142-148
2.Li J*，Liu J*，Li P，Mao X，Li W，Yang J，Liu P. Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.J Exp Clin Cancer Res, 2014,33;170-183
3.Li J*，Liu J，Ren Y，Liu P. Roles of the WWOX in pathogenesis and endocrine therapy of breast cancer. Exp Biol Med, 2014,1;1-6
4.Juan Li*,Jie Liu*,Zheyong Liang,Fang He,Lu Yang,Pingping Li,Yina Jiang,Bo Wang,Can Zhou,Yaochun Wang,Yu Ren,Jin Yang,Jianmin Zhang,Zhijun Luo, Cyrus Vaziri, Peijun Liu.Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB deficient tumors growth. Cell death and disease. 2017, 8(3):e2673
5. Jie Liu*, Juan Li*, Pingping Li, Yaochun Wang, Zheyong Liang, Yina Jiang, Jing Li, Chen Feng, Ruiqi Wang, He Chen, Can Zhou, Jianmin Zhang, Jin Yang# & Peijun Liu. Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway. Scientific report. Sci Rep. 2017 Feb 7:7:42125
6.Li J,Liu J,Li P,Zhou C,Liu P. The downregulation of WWOX induces
epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer. Experimental Biology and Medicine, 2018, 243(1): 1066-1073.
7.Juan Li#; Xuefei Feng# ; Canyu Li; Jie Liu; Pingping Li; Ruiqi Wang; He Chen; Peijun Liu* ; Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling , Experimental Biology and Medicine, 2019, 244(12): 972-982.
8.Juan Li; Jie Liu; Riqi Wang; He Chen; Cui Li; Minggang Zhao; Fang H; Yaochun Wang; Peijun Liu* ; Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple-negative breast cancer, American Journal of Cancer Research, 2020, 10(2):507-522.
9.Shaoran Song #, Bixia Tian #, Miao Zhang, Xiaoqian Gao, Liu Jie, Peijun Liu,Juan Li*. High expression of Thymodylate synthase in breast cancer: Significance in prognostic value. Clin Exp Pharmacol Physiol.2021 Feb;48(2):279-287.
10.Shaoran Song, Jie Liu, Miao Zhang, Xiaoqian Gao, Wei Sun, Peijun Liu*, Yaochun Wang*,Juan Li*. Translation initiation factor EIF3B could serve as a potential prognostic predictor for breast cancer. Bioengineered 2022,vol 13, 2762-2776.
11.Jie Liu, Huxia Wang, Miao Zhang, Yazhao Li, Ruiqi Wang, He Chen, Bo Wang, Xiaoqian Gao, Shaoran Song, Yaochun Wang, Yu Ren*,Juan Li*,Peijun Liu*. Metformin and simvastatin synergistically suppress endothelin 1-induced hypoxia and angiogenesis in multiple cancer types. Cancer Science. 2023;114:640–653
12.Siyuan Zhang, Zejian Yang, Pei Qiu,Juan Li*,Can Zhou*. Research on the Role of Marriage Status Among Women Underwent Breast Reconstruction Following
Mastectomy: A Competing Risk Analysis Model Based on the SEER Database,
1998-2015.Frontiers in Surgery. January 2022 | Volume 8 | Article 803223
授权专利：
国家发明专利三氟胸苷在制备治疗三阴性乳腺癌药物中的应用授权公告号：CN109771437B第一完成人
联系方式
电子邮箱：lijuanxjtu@xjtu.edu.cn
联系电话：18092695587
个人主页：
联系地址：陕西省西安市雁塔区雁塔西路277号
