王飞，特聘研究员·博士生导师·西安交通大学青年拔尖人才
教育及工作简历
2021年1月于中国科学院大学获得博士学位，丹麦奥胡斯大学博士联合培养。博士毕业后继续在丹麦奥胡斯大学生物医学系从事博士后研究。2024年2月加入西安交通大学第一附属医院，
工作经历：
2024.02-至今,西安交通大学，第一附属医院
2020.10-2024.01,丹麦奥胡斯大学，博士后
2014.09-2017.09,深圳华大生命科学研究院，助研/副研
教育经历：
2019.10-2020.10,丹麦奥胡斯大学，生物医学
2017.09-2020.01,中国科学院大学，基因组学
2011.09-2014.07,西南大学，发育生物学
2007.09-2011.07,西北农林科技大学，生物工程
研究领域（方向）
课题组从事单细胞组学大数据解析肿瘤免疫微环境，移植免疫，泛血管疾病等；单细胞组学技术开发；并开展肿瘤免疫靶点发现与新型治疗技术开发，具有丰富的基础研究和临床转化研究经验。主要研究方向：
（1）单细胞组学大数据分析，肿瘤免疫，移植免疫，泛血管疾病
（2）单细胞组学实验技术开发
（3）肿瘤免疫靶点发现，新型免疫治疗技术开发
科研成果：
发表一作/通讯（含共同）论文多篇，包括Nature Genetics（接收），Nature Communications，Cellular&Molecular Immunology，Communicatons bilogy，Clinical and Translational Medicine等杂志。在肿瘤免疫治疗，基因与细胞治疗领域申请国内外专利20余项，已授权8项；开发肿瘤免疫治疗技术多项，部分产品已实现临床转化。
学术及科研成果、专利、论文：
[1]. Wang, F., Ding, P., Liang, X. et al. Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level. Nat Commun 13, 3620 (2022). https://doi.org/10.1038/s41467-022-31388-z. (First-author, IF=17.694, Highlighted in Nature Communications, top 50 papers in “from molecules and cells to organisms” topic).
[2]. Wang, F., Xu, Q., Zhuang, Z. et al. A single-cell approach to engineer CD8+ T cells targeting cytomegalovirus. Cell Mol Immunol (2020). doi: 10.1038/s41423-020-0466-z. (First author, IF=22.096).
[3]. Li Z*, Sun C*, Wang F*, et al. Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single-cell sequencing. Clin Transl Med. 2022; 12: e689. (IF=8.554, Co-first author).
[4]. Chai C, Liang L, Mikkelsen N S, et al., Wang F#, Luo Y#. Single-cell transcriptome analysis of epithelial, immune, and stromal signatures and interactions in human ovarian cancer [J]. Commun Biol, 2024, 7(1): 131.（IF=5.9, Co-responding author）
[5]. Xiao, J.*, Wang, F.*, Hu, X., Li, D., Liu, G., Xu, Q., Chen, C., Xiang, H., Dong, X., Zhu, L., Yang, D., Gao, Y., Wang, M., Luo, Y., Chao, C.-C., Li, G., Guo, Q., Engineering In Vitro Organ-Structured Tumor Model for Evaluating Neoantigen-Specific T Cell Responses in Hepatocellular Carcinoma. Adv. Mater. Interfaces 2023, 10, 2300155. https://doi.org/10.1002/admi.202300155.(IF=4.996, co-first and co-corresponding author).
[6]. Wang, S., Ding, P., Yuan, J. et al., Wang, F. Integrative cross-species analysis of GABAergic neuron cell types and their functions in Alzheimer’s disease. Sci Rep 12, 19358 (2022). https://doi.org/10.1038/s41598-022-21496-7. (IF=4.996, Corresponding author).
[7]. Wu, Y., Su, K., Zhang, Y.et al.A spatiotemporal transcriptomic atlas of mouse placentation.Cell Discov10, 110 (2024).https://doi.org/10.1038/s41421-024-00740-6. (IF=12.5)
[8]. Chen C, Guo Q, Liu Y, Hou Q, Liao M, Guo Y, Zang Y, Wang F, Liu H, Luan X, Liang Y, Guan Z, Li Y, Liu H, Dong X, Zhang X, Liu J, Xu Q. Single-cell and spatial transcriptomics reveal POSTN+cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer. Clin Transl Med. 2023 Dec;13(12):e1515. doi: 10.1002/ctm2.1515. (IF=8.554)
[9]. Chen Y, Zhang X, Peng X, Jin Y, Ding P, Xiao J, Li C, Wang F, Chang A, Yue Q, Pu M, Chen P, Shen J, Li M, Jia T, Wang H, Huang L, Guo G, Zhang W, Liu H, Wang X, Chen D. SPEED: Single-cell Pan-species atlas in the light of Ecology and Evolution for Development and Diseases. Nucleic Acids Res. 2022 Oct 28: gkac930. doi: 10.1093/nar/gkac930. (IF=13.1)
[10]. Liang Y, Xu Q, Liu S, Li J, Wang F, Li Z, Liao L, Lu Y, Li Y, Mu F, Sun H-X and Zhu L (2022) Single-Cell Transcriptomics Reveals Killing Mechanisms of Antitumor Cytotoxic CD4+ TCR-T Cells. Front. Immunol. 13:939940. doi: 10.3389/fimmu.2022.939940. (IF=7.97).
[11]. Xi Xiang, Xiaoying Zhao, Xiaoguang Pan, Fei Wang et al. Efficient correction of Duchenne muscular dystrophy mutations by SpCas9 and dual gRNAs. Mol Ther Nucleic Acids.2021 Mar 13; 24:403-415. doi: 10.1016/j.omtn.2021.03.005. (IF=12.91).
[12]. Ding R, Liu S, Wang S, Chen H, Wang F, Xu Q, Zhu L, Dong X, Gu Y, Zhang X, Chao CC, Gao Q. Single-cell transcriptome analysis of the heterogeneous effects of differential expression of tumor PD-L1 on responding TCR-T cells. Theranostics 2021; 11(10):4957-4974. doi:10.7150/thno.55075. (IF=11.6).
[13]. Qumiao Xu1, Ziyi Li, Fei Wang, Zhenkun Zhuang, Yanling Liang, Qianqian Gao, Xuan Dong, Linnan Zhu. Single-cell approach to generate functional TCR-Ts: a potential accelerator of TCR-T cell therapy for infectious diseases. Journal of cellular immunology. (2020) Volume 2, Issue 6. (IF=4.178).
[14]. Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, Li Y, Wang F, Huang L, Chen L, Wang D, Dong X, Zhang Z, Li Y, Ze B, Hou Y, Yang H, Ma Y, Gu Y, Chao CC. Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Theranostics, 2020; 10(11):5137-5153. (IF=11.6).
[15]. Gao Q, Dong X, Xu Q, Zhu L, Wang F, Hou Y, Chao CC. Therapeutic potential of CRISPR/Cas9 gene editing in engineered T-cell therapy. Cancer Medicine. 2019, Aug; 8(9):4254-4264. (IF=4.711)
授权/公开专利:
1.一种靶向巨细胞病毒抗原的特异性T细胞受体及其应用，P2019-1-0081.CN,中国授权
2.抗BCMA一本鎖抗体scFv、並びにその作製方法及びその使用，P2018-1-0162.JP，日本授权
3. Anti-bcma single-chain antibody scfv, preparation method therefor and application thereof，P2018-1-0162.EP，欧洲公开
4.抗BCMA单链抗体scFv及其制备方法和应用，P2018-1-0162.CN，中国授权
5.不同启动子启动多个串联sgRNA表达的质粒构建方法，P2018-1-0121.CN，中国授权
6. EBV表位高亲和力T细胞受体，P2017-1-0261.CN，中国授权
7. Mart-1(27-35) epitope-specific t cell receptor，P2017-1-0218.US，美国授权
8. MART-1(27-35)表位特异性T细胞受体，P2017-1-0218.CN，中国授权
9.一种扩增TCR全长序列的试剂盒及其应用，P2017-1-0084.CN，中国授权
联系方式
电子邮箱：feiwangxjtu@xjtu.edu.cn
wfv5314@126.com
联系电话：13798219204
个人主页：https://gr.xjtu.edu.cn/en/web/feiwangxjtu
联系地址：西安交通大学第一附属医院
陕西省西安市雁塔西路277号
