王楠

研究领域(方向)

1.复杂体系中抗过敏活性成分筛选发现

2.抗过敏性药物发现与机制研究

3.过敏性疾病的发生发展机制

4.抗新冠病毒药物筛选与发现

个人及工作简历

个人受教育及工作经历

1.2009.9-2014.12西安交通大学博士

2.2014.12-2018.6西安交通大学讲师

3.2016.12-2017.12约翰∙霍普金斯大学访问学者

4.2018.6至今,西安交通大学副教授

科研项目

1.82274063.基于MRGPRX2新靶点的小柴胡汤抗过敏性哮喘药效物质基础及机制研究. 国家自然科学面上项目 2023.1-2026.12

2.2022JM-474.基于MrgX2新靶点的延胡索抗过敏性哮喘药效物质基础及作用机制研究.陕西省自然科学基金面上项目 2022.1-2023.12.31

3.ZYJXG-Y23015中药柴胡抗新冠病毒成分筛选与研究. 陕西省中医药管理局中医药防治新冠病毒科研攻关项目 2023.1-2024.12

学术及科研成果、专利、论文

发表部分论文:

1.Haoyun Bai, Zhuoyin Xue, Wen Zhang, Chaohua Feng, Zhenqi Zhou, Shiling Hu, Yongjing Zhang, Qiaohong Qin, Yuanyuan Wu, Xiuzhen Sun, Yuhan Zhou,Nan Wang*. α-Asarone alleviates allergic asthma by stabilizing mast cells through inhibition of ERK/JAK2-STAT3 pathway. BioFactors. 2023; 49: 140–152.

2.Nan Wang, Jue Wang, Yongjing Zhang, Shiling Hu, Haoyun Bai, Yajing Hou, Cheng Wang, Huaizhen He, Langchong He*. Imperatorin ameliorates mast cell-mediated allergic airway inflammation by inhibiting MRGPRX2 and CamKII/ERK signaling pathway. Biochemical Pharmacology. 2021; 184: 114401.

3.Zhuoyin Xue, Yongjing Zhang, Yingnan Zeng, Shiling Hu, Haoyun Bai, Jue Wang, Huiling Jing,Nan Wang*. Licochalcone A inhibits MAS-related GPR family member X2-induced pseudo-allergic reaction by suppressing nuclear migration of nuclear factor-κB. Phytotherapy Research. 2021; 35: 6270-6280.

4.Nan Wang,Jue Wang, Yongjing Zhang, Shiling Hu, Tianxiao Zhang, Yuanyuan Wu, Xiuzhen Sun, Tao Zhang, Shuanying Yang, Langchong He*. Substance P-induced lung inflammation in mice is mast cell dependent. Clinical & experimental allergy. 2021; 52: 46-58.

5.Yongjing Zhang, Shiling Hu, Jue Wang, Zhuoyin Xue, Cheng Wang,Nan Wang*.Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2. Virology. 2021; 554: 83–88.

6.Yongjing Zhang, Zhuoyin Xue, Shiling Hu, Haoyun Bai, Jue Wang,Nan Wang*.Chrysin Inhibits Pseudo-allergic Reaction by Suppressing Mitochondrial STAT3 Activation via MAS-Related GPR Family Member X2. Journal of Agricultural and Food Chemistry. 2021.69: 6569-6577.

7.Jue Wang, Yongjing Zhang, Shiling Hu, Shuai Ge, Min Jia,Nan Wang*.Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway. International Immunopharmacology. 2021; 93: 107426.

8.Jiapan Gao, Delu Che, Xueshan Du, Yi Zheng, Huiling Jing,Nan Wang*. Imidazolidinyl urea activates mast cells via MRGPRX2 to induce non-histaminergic allergy. Toxicology Research. 2021; doi: 10.1093/toxres/tfab035.

9.Shiling Hu, Jue Wang, Yongjing Zhang, Haoyun Bai, |Cheng Wang,Nan Wang*, Langchong He*. Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2.journal of Medical Virology. 2021; 93: 3143–3151.

部分授权专利:

1.ZL 201910600151.3王楠 贺浪冲 贺怀贞 王程 王珏 张永竟 一种P物质诱导的过敏性哮喘动物模型的构建方法和筛选药物的方法

2.ZL202010100384.X王楠 贺浪冲 吴媛媛 王程 维生素K3用于制备抗类过敏药物的应用

联系方式

电子邮箱:wangnan2014@xjtu.edu.cn

联系电话:029-82656264

个人主页:http://gr.xjtu.edu.cn/web/wangnan2014

联系地址:陕西省西安市长安区高桥街道中国西部创新港21号楼5103

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