任娟

任娟,博士,博士/硕士研究生导师,主任医师、三级教授、研究员

研究方向:

(1)肿瘤免疫逃逸机制;(2)放射免疫机制;(3)肿瘤血管生成机制;(4)肿瘤转移机制;

个人及工作简历

一. 临床上:现任西安交通大学第一附属医院肿瘤放疗科主任医师、三级教授、研究员。博导。曾在美国Cleveland Clinic进修,具有很好的临床业务能力。

① 熟悉立体定向头部放射外科SRS(头部X刀)、立体定向体部放射治疗SBRT/SABR、图像引导放射治疗(超声引导放射治疗技术、4D-CBCT定位及放疗监控技术)、深吸气屏气门控放射治疗技术、动态适形拉弧放疗技术、全身照射技术;

② 主持校级新医疗新技术4项:局晚期宫颈癌图像引导的三维后装放疗、保乳术后四维CT的靶区动度测定及剂量优化、肺癌图像引导下的大分割放疗、III-IV型门静脉癌栓的术前转化放疗;

③ 主持2项临床研究:局晚期直肠癌术前放疗分割剂量研究、肺癌静态调强与容积调强的剂量学比较;

④ 参加两个国家级治疗指南的编写:肿瘤放射外科学指南、放射性口腔黏膜炎防治指南;

⑤ 以副主编编写医疗专著3部:《肿瘤学》、《胸部恶性肿瘤诊疗及研究进展》、《肿瘤患者心身疾病诊治指南》,参编两部:《妇科肿瘤术中放疗》、美国《Field Cancerization: Basic Science and Clinical Applications》;

⑥ 学术任职:陕西省预防医学会放射卫生委员会主委;陕西省预防医学会第六届理事会理事;中华医学会放射肿瘤治疗学委员会肝胆胰肿瘤放疗学组委员;中华医学会心身医学分会心身肿瘤协作组委员;中国医师协会结直肠肿瘤专业委员会MDT专委会 委员;中国研究型学会 放疗专委会 委员;中国民族卫生协会 放射外科技术推广学组 委员;中国抗癌协会 胃癌专委会 委员;中国抗癌协会 大肠癌专业委员会 委员;中国抗癌协会 神经肿瘤专业委员会 委员;中国抗癌协会 肿瘤微创治疗专业委员会 委员;中国抗癌协会 肿瘤放射治疗专业委员会 委员;中国抗癌协会 中枢神经肿瘤分会 脑转移瘤分组 委员;中国老年医学会 肿瘤康复分会 食道癌专家委员会 委员;

⑦ 获中华医学会第12次全国放射治疗学学术会议优秀论文奖、第十三届中国西部肿瘤放疗学会议优秀论文奖;

二. 科研工作:

① .发表论文:第一/通讯作者论文69篇,其中SCI论文:47篇;影响因子共:194分;5分以上:14篇;单篇最高SCI他引频次:391次;第一作者Medline收录2篇;核心期刊20篇;第一/通讯论文:H因子:15;

② .以第一完成人获陕西省科学技术奖二等奖;陕西省高校科学技术奖一等奖;

③ 主持科研项目:国家自然科学基金4项、教育部新世纪人才项目1项、部级1项、省级3项、厅级2项;

④ 担任2种国际杂志主编、担任20种国际杂志编委;担任17种国际杂志审稿人;

⑤ 七次在国际学术会议上发言;6次作为国际学术会议大会组委会的成员;

三. 教学上:

② 发表3篇 第一/通讯作者教学论文;

②被聘为临床技能操作指导教师、被聘为PBL教学指导教师;

③已独立指导研究生:博士生 12名(7届);硕士生 22名(9届);

④完成了八年制PBL教学任务;完成五年制本科生《肿瘤学》课教学任务;⑤教学效果评估优秀;

科研项目:

国科金 4 项、教育部新世纪人才项目 1 项、部级 2 项、省级 3 项、厅级 2 项

国家自然科学基金
面上项目

2018

52万

主持

国家自然科学基金
面上项目
2013
57万

主持

国家自然科学基金
青年项目
2012
23万

主持

国家自然科学基金
面上项目
2010
34万

主持

教育部 新世纪优秀人才支持计划

2012
25万

主持

陕西省科技计划项目
面上项目
2020
5万

主持

陕西省科技计划项目
面上项目
2012
4万

主持

陕西省科技计划项目
面上项目
2007
4万

主持

中央高校青年教师跟踪计划杰青培育项目
面上项目
2012
30万

主持

申请人员近五年主要学术成就与工作业绩(包括临床专业技术能力、人才培育、学术研究、学科建设、社会服务和发展潜力)

第一/通讯作者SCI论文25篇,影响因子约92分,5分以上7篇。

近5年主持项目:

近5年主持国家自然科学基金面上项目一项,陕西省科技计划项目一项;

在国内外学术刊物发表论文情况:

一.近五年发表第一或通信作者文章:

1. Shuheng Bai , Ling Chen, Yanli Yan, Xuan Wang, Aimin Jiang, Rong Li, Haojing Kang, Zhaode Feng, Guangzu Li, Wen Ma, Jiangzhou Zhang and Juan Ren,(通讯作者),Identification of Hypoxia–Immune-Related Gene Signatures and Construction of a Prognostic Model in Kidney Renal Clear Cell Carcinoma. Front. Cell Dev. Biol. (2022) 9:796156. (SCI收录,影响因子7.731分)

2. Shuheng Bai, Ling Chen, Yanli Yan, Rong Li, Yun Zhou, Wang Xuan, Haojing Kang, Zhaode Feng, Guangzu Li, Shuling Zhou,Emmanuel Kwateng Drokow,Juan Ren,(通讯作者). Exploration of different hypoxia patterns and construction of a hypoxia-related gene prognostic index in colorectal cancer. Frontiers Immunology, Cancer Immunity and Immunotherapy, 2022,(SCI收录,影响因子7.5分)

3. Yinying Wu,Bo Zhu, Yanli Yan, Shuheng Bai, Haojing Kang, Jiangzhou Zhang, Wen Ma, Ying Gao, Beina Hui, Rong Li, Xiaozhi Zhang, and Juan Ren,(通讯作者). Long non-coding RNA SNHG1 stimulates ovarian cancer progression by modulating expression of miR-454 and ZEB1. Molecular Oncology,2021;15(5)1584-1596(SCI收录,影响因子6.603分)

4. Zhuanli Bai, YinYing Wu, Shuheng Bai, Yanli Yan, Haojing Kang, Wen Ma, Jiangzhou Zhang, Ying Gao, Beina Hui, Hailin Ma, Rong Li, Xiaozhi Zhang, Juan Ren(通讯作者),Long non-coding RNA SNGH7 Is activated by SP1 and exerts oncogenic properties by interacting with EZH2 in ovarian cancer. J Cell Mol Med. 2020; 24(13):7479-7489. (SCI收录,影响因子5.310分)

5. Shuheng Bai, YinYing Wu, Yanli Yan, Shuai Shao, Jiangzhou Zhang, Jiaxin Liu, Beina Hui, Rui Liu, Hailin Ma, Xiaozhi Zhang, Juan Ren,(通讯作者)Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma. Scientific Reports | (2020) 10:13659(SCI收录,影响因子5.228分)

6. Juan Ren(第一/通讯作者), Yuelang Zhang, Hui Cai, Hongbing Ma, Dongli Zhao, Xiaozhi Zhang, Zongfang Li, Shufeng Wang, Jiangsheng Wang, Rui Liu, Yi Li, Jiansheng Qian, Hongxia Wei, Liying Niu, Yan Liu, Lisha Xiao, Muyang Ding, Shiwen Jiang. Human GPR4 and the Notch signaling pathway in endothelial cell tube formation. Molecular Medcine Report. 2016 Aug;14(2):1235-40(SCI收录,影响因子2.952),

7:Shuwen Wang, Juan Ren(第一/通讯作者), Li Tan, Yanli Yan, Chaofan Xue, Xiaowei Ma. Effect of image guided hypofractionated stereotactic radiotherapy for peripheral non small cell lung cancer, OncoTargets and Therapy 2016:9 1–11,(SCI收录,影响因子4.147)

8:Yi Li, Ji Wang, Xiaowei Ma, Li Tan, Yanli Yan, Chaofan Xue, Beina Hui, Rui Liu, Hailin Ma and Juan Ren(通讯作者). A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer. International Journal of Biological Sciences, 2016; 12(8): 1022-1031.(SCI收录,影响因子6.580)

9. Juan Ren(第一/通讯作者), Wei Yuan, Ruihua Wang, Qiuping Wang, Yi Li, Chaofan Xue, Yanli Yan, Xiaowei Ma, Li Tan, Zi Liu. Dosimetric Comparison between Three-dimensional Magnetic Resonance Imaging-guided and Conventional Two-dimensional Point A-based Intracavitary Brachytherapy Planning for Cervical Cancer. PLOS ONE ,| 2016, 11(9):1-14. DOI:10.1371/journal.pone.0161932 (SCI收录,影响因子3.240)

10. Liang Liang, Lei Zhao, Ying Zan, Qing Zhu, Juan Ren(并列通讯作者), Xinhan Zhao, MiR-93-5p enhances growth and angiogenesis capacity of HUVECs by down-regulating EPLIN,Oncotarget,2017,8: 107033-107043 .(SCI收录,影响因子5.2)

11. Shuheng Bai, YinYing Wu, Yanli Yan, Haojing Kang, Jiangzhou Zhang, Wen Ma, Ying Gao, Beina Hui, Rong Li, Xiaozhi Zhang, Juan Ren(通讯作者). The effect of CCL5 on the immune cells infiltration and the prognosis of patients with kidney renal clear cell carcinoma. International Journal of Medical Sciences. 2020; 17(18): 2917-2925.(SCI收录,影响因子3.738分)

12. Zhuanli Bai, YinYing Wu, Yanli Yan, Shuheng Bai, Haojing Kang, Wen Ma, Jiangzhou Zhang, Ying Gao, Beina Hui, Hailin Ma , Rong Li, Xiaozhi Zhang, Juan Ren,(通讯作者),Downregulation of GPR4 and TCF7 Promotes Apoptosis and Inhibits Growth and Invasion of Ovarian Cancer Cells,Anticancer Agents Med Chem, 2021;21(12)1544-1550, (SCI收录,影响因子3.04分)

13. Shuheng Bai, YinYing Wu, Yanli Yan, Rong Li, Haojing Kang, Jiangzhou Zhang, Wen Ma, Ying Gao, Beina Hui, Hailin Ma, Xiaozhi Zhang, and Juan Ren,(通讯作者). Evaluation of the Efficacy and Toxicity of Radiotherapy for Type III-IV Portal Vein Tumor Thrombi. Technology in Cancer Research & Treatment. 2021, Volume 20: 1-7. (SCI收录,影响因子3.399分)

14. Yi Li, Ji Wang, Li Tan, BeiNa Hui, XiaoWei Ma, YanLi Yan, ChaoFan Xue, XiaoTing Shi, Emmanuel Kwateng Drokow and Juan Ren(通讯作者), Dosimetric comparison between IMRT and VMAT inirradiation for peripheral and central lung cancer. ONCOLOGY LETTERS,2018 15: 3735-3745, (SCI收录,影响因子2.967)

15. Zhuan-Li Bai, Vincent Tay, Shu-Zhong Guo,1 Juan Ren(并列通讯作者), and Mao-Guo Shu(通讯作者),Silibinin Induced Human Glioblastoma Cell Apoptosis Concomitant with Autophagy through Simultaneous Inhibition of mTOR and YAP. BioMed Research International, 2018, Article ID 6165192, 10 pages (SCI收录,影响因子3.411)

16. Jiangzhou Zhang, Shuheng Bai, Xingzhou Zhang, Yanli Yan, Haojing Kang, Guangzu Li, Zhaode Feng, Wen Ma, Hong Sun(并列通讯), Juan Ren,(通讯作者)* Clinical Study of 2 Radiotherapy Techniques for Semi-Hepatic Alternating Radiotherapy on Diffuse Liver Metastasis in Patients with Breast Cancer. Technol Cancer Res Treat. Technology in Cancer Research & Treatment, 2021;20: 1-10. (SCI收录,影响因子1.7分)

17.Jiangzhou Zhang, Shuheng Bai, Yanli Yan, Haojing Kang, Guangzu Li, Zhaode Feng, Wen Ma, Xuan Wang, Juan Ren,(通讯作者). Comprehensive analysis of m6A regulator signature for prediction of prognosis and immune cell infiltration in lung adenocarcinoma,Journal of biological regulators and Homeostatic Agents, 2022, 36(2):157(SCI收录,影响因子1.71分)

18. Li Tan, Long Zhang, Xiaowei Ma, Yanli Yan, Shuai Shao, Jiaxin Liu, Juan Ren(通讯作者),Skeletal muscle and brain metastases arising from primary squamous cell carcinoma of the parotid gland: a case report and review of the literature. International Journal of Clinical and Experimental Medicine 2018; 2018;11(12):13880-13886(SCI收录,影响因子1.422)

19. Li Tan,Yinying Wu(并列第一),Xiaowei Ma,Yanli Yan,Shuai Shao,Jiaxin Liu,HailinMa,Rui Liu,Linyan Chai,Juan Ren(通讯作者),A Comprehensive Meta-Analysis of Association between EGFR Mutation,Status and Brain Metastases in NSCLC,Pathology & Oncology Research,2019,25:791–799。(SCI收录,影响因子3.201)

20. YanLi Yan, Zhou Lu, Zi Liu, Wei Luo, Shuai Shao, Li Tan, XiaoWei Ma, JiaXin Liu, Emmanuel Kwateng Drokow and Juan Ren,(通讯作者)Dosimetric comparison between three‑and four‑dimensional computerised tomography radiotherapy for breast cancer,ONCOLOGY LETTERS,2019,18: 1800-1814,(SCI收录,影响因子2.967)

21. Yanli Yan,Long Zhang,Li Tan,Xiaowei Ma,Yong Zhang,Shuai Shao,Jiaxin Liu,Chaofan Xue,Zongfang Li,Xiaozhi Zhang,Emmanuel Kwateng Drokow,Xiaoting Shi,Juan Ren(通讯作者),Endocrine Therapy for Ductal Carcinoma In Situ (DCIS) of the Breast with Breast Conserving Surgery (BCS) and Radiotherapy (RT): a Meta-Analysis,Pathology & Oncology Research,(2020) 26:521–531,(SCI收录,影响因子3.201)

22.Chaofan Xue, Shuai Shao, Yanli Yan, Si Yang, Shuheng Bai, Yinying Wu, Jiangzhou Zhang, Rui Liu, Hailin Ma, Linyan Chai, Xiaozhi Zhang and Juan Ren(通讯作者),Association between G‑protein coupled receptor 4 expression and microvessel density, clinicopathological characteristics and survival in hepatocellular carcinoma ONCOLOGY LETTERS,2020 19: 2609-2620

23. Jiangzhou Zhang, Yanli Yan, Beina Hui, Shuheng Bai, Wen Ma, Juan Ren,(通讯作者). Clinicopathological Characteristics and Prognosis of Pulmonary Spindle Cell Carcinoma: a Population-based Retrospective Study. Annals of Palliative Medicine, 2021,2021;10(4)3793-3803,(SCI收录,影响因子1.7分)

24. Xiaowei Ma, Ling Chen, Li Tan, Yanli Yan, Shuai Shao, Jiaxin Liu, Rui Liu, Hailin Ma, BeiNa Hui, Linyan Chai, Juan Ren,(并列通讯作者),Hong Sun(通讯作者),A meta-analysis of the prognostic value of abnormally expressed lncRNAs and correlation with clinicopathological characteristics in glioma. Eurasian Journal of Medicine and Oncology (EJMO),(SCI收录,)2021, 2021;5(2):144–156

联系方式

电子邮箱:869491533@qq.com

联系电话:18991232257

个人主页:

联系地址:西交大一附院放疗科

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