国家级领军人才、陕西省领军人才
西安交通大学基础医学院院长
中国西部科技创新港转化医学研究院院长
中国免疫学会副理事长
Life Sci/BMC Immunol/Int Immunopharmacol杂志副主编
陕西省免疫健康重点实验室主任
陕西省科技创新团队负责人
西安交通大学研究生教育优秀导师
西安交通大学首届“青年优秀导师”（全校10人）
2.0拔尖班、强基计划、珠峰计划优秀指导教师
学习与研究经历
2004年9月－2009年1月：博士，移植免疫学，中科院动物所；
2009年2月－2014年1月：博士后，免疫学，美国杜克大学；
2014年2月－2015年8月：Research Associate Senior，免疫学，美国杜克大学；
2015年9月－2016年9月：Research Scientist，免疫学，美国杜克大学；
2016年9月－至今：教授、博导，西安交通大学。
主要业绩
已在Immunity、JCI、Sci Adv(2篇)、PNAS、CMI、J Immunother Cancer、STTT、J Adv Res、Elife、Plos Genetics、J Immunol等杂志发表SCI论文70余篇，共被引用2600余次；主编人卫、科学出版社等教材8部，主持国家级等6项教改项目，荣获省级教学成果奖1项，发表7篇教学论文。
在研基金项目
主持国家重点研发计划课题、国家自然科学基金委国际（地区）合作与交流重点项目、重大研究计划、面上项目、陕西省创新能力支撑计划、陕西省重点研发计划等项目。
研究方向
研究免疫细胞谱系起源、发育分化及功能调控的分子机制，筛选并研发肿瘤、自身免疫病、免疫缺陷等疾病的免疫治疗靶点、药物和策略，具体包括：
1）免疫细胞发育及免疫重建的调控机制；
2）免疫细胞分化及抗肿瘤的分子机制；
3）自身免疫病的发生机制及治疗靶点；
4）多组学解析免疫力和疾病早期诊断与免疫治疗。
主要业绩：
已在Immunity、JCI、Sci Adv、PNAS、CMI、J Immunother Cancer、STTT、J Adv Res、Elife、Plos Genetics、J Immunol等杂志发表SCI论文60余篇，共被引用1800余次；主编人卫、科学出版社等教材8部，主持国家级等6项教改项目，荣获省级教学成果奖1项，发表7篇教学论文。
代表性论文：
26.Su, Y.; Jiao, A.; Zhang, X.; Xu, Y.; Ping, H.; Zhu, K.; Wang, Q.; Yuan, N.; Gao, Y.; Ju, B.; Ding, R.; Wang, N.; He, L.; Lei, L.; Zhao, Y.; Zhang, M.;Zhang, B., Helicase A determines the transcription program of Th17 lineage differentiation and Autoimmunity.Sci Adv2026(Accepted).
25.Zhang, T.; Yang, B.; Li, W.; Jiao, A.; Zhang, X.; Ge, Y.; Yang, C.; Zheng, R.; Sun, C.; Yang, X.; Lei, L.; Zhou, X.;Zhang, B., Systematic transcriptome analysis reveals the function of alternative promoters in hematopoietic lineages.Stem Cell Reports2026, 21(3): 102791. doi: 10.1016/j.stemcr.2026.102791. Epub 2026 Feb 5.
24.Sun, L.; Zhang, C.; Jiao, A.; Su, Y.; Zhang, T.; Wang, Q.; Ge, Y.; Yang, C.; Yuan, N.; Zhang, L.; Sun, C.; Chen, L.; Ye, L.;Zhang, B., CCR2+ monocytes promote memory CD8+ T-cell differentiation via membrane-bound TGF-β.Cell Mol Immunol2025, 22(8): 869-888.
23.Sun,L.; Zhang, T.; Ge, Y.; Yao, Z.; Su, Y.; Wang, Q.; Chen, Y.; He, B.; Ding, R.; Zhang, C.; Lan, L.; Liu, R.; Ping, H.; Zhang, D.; Shi, L.; Zhou, X.; Jia, X.; Sun, C.; Liang, L.; Zhang, L.;Zhang, B., FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas.Cell Death Dis2025, 16(1): 301. doi: 10.1038/s41419-025-07606-z.
22.Liu, J.; Yang, B.; Hu, D.; Yuan, N.; Li, W.; Feng, Z.; Su, Y.; Zhang, D.; Yang, X.;Zhang, B., Lineage Tracking Dissects the Fate of Neonatal iNKT Cells Later in Life.Immunology2025, 175(1): 103-111.
21.Yang, B.; Li, W.; Wang, X.; Yuan, N.; Gao, Y.; Song, J.; Liu, J.; Zhang, T.; Liu, H.; Ren, Y.; Chen, P.; Yang, X.; Lei, L.; Zhou, X.; Zhang, H.;Zhang, B., Zinc finger protein Zfp335 is required for T cell homeostatic proliferation through regulating Lmnb1.Cell Biosci2025, 15(1): 139. doi: 10.1186/s13578-025-01483-x.
20.Sun, L.; Jiao, A.; Liu, H.; Ding, R.; Yuan, N.; Yang, B.; Zhang, C.; Jia, X.; Wang, G.; Su, Y.; Zhang, D.; Shi, L.; Sun, C.; Zhang, A.; Zhang, L.;Zhang, B., Targeting A Disintegrin and Metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity.Signal Transduct Target Ther2024,9(1): 152.
19.Wang, X.; Sun, L.; Yang, B.; Li, W.; Zhang, C.; Yang, X.; Sun, Y.; Shen, X.; Gao, Y.; Ju, B.; Gao, Y.; Liu, D.; Song, J.; Su, Y.; Jiao, A.; Liu, H.; Zhang, L.; He, L.; Lei, L.; Chen, W.;Zhang, B., Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation.J Clin Invest2023, 133 (20): e166628.
18.Jiao, A.; Zhang, C.; Wang, X.; Sun, L.; Liu, H.; Su, Y.; Lei, L.; Li, W.; Ding, R.; Ding, C.; Dou, M.; Tian, P.; Sun, C.; Yang, X.; Zhang, L.;Zhang, B., Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species.J Adv Res2023,55: 73-87.
17.Sun, L.; Su, Y.; Jiao, A.; Wang, X.;Zhang, B., T cells in health and disease.Signal Transduct Target Ther2023, 8 (1): 235.
16.Gao, Y.; Li, W.; Wang, Z.; Zhang, C.; He, Y.; Liu, X.; Tang, K.; Zhang, W.; Long, Q.; Liu, Y.; Zhang, J.;Zhang, B.; Zhang, L., SEL1L preserves CD8+ T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis.Cell Mol Immunol2023,20 (10): 1232-50.
15.Jiao, A.; Sun, C.; Wang, X.; Lei, L.; Liu, H.; Li, W.; Yang, X.; Zheng, H.; Ding, R.; Zhu, K.; Su, Y.; Zhang, C.; Zhang, L.;Zhang, B., DExD/H-box helicase 9 intrinsically controls CD8(+) T cell-mediated antiviral response through noncanonical mechanisms.Sci Adv2022, 8 (6): eabk2691.
14.Zhang, C.; Lei, L.; Yang, X.; Ma, K.; Zheng, H.; Su, Y.; Jiao, A.; Wang, X.; Liu, H.; Zou, Y.; Shi, L.; Zhou, X.; Sun, C.; Hou, Y.; Xiao, Z.; Zhang, L.;Zhang, B., Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice.J Immunother Cancer2021, 9 (10): e002809.
13.Wang, X.; Jiao, A.; Sun, L.; Li, W.; Yang, B.; Su, Y.; Ding, R.; Zhang, C.; Liu, H.; Yang, X.; Sun, C.;Zhang, B., Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms.Elife2022, 11:e75508.
12.Liu, J.; Yang, B.; Hu, D.; Yuan, N.; Li, W.; Feng, Z.; Su, Y.; Zhang, D.; Yang, X.;Zhang, B., Lineage Tracking Dissects the Fate of Neonatal iNKT Cells Later in Life.Immunology2025, Epub ahead of print. doi: 10.1111/imm.13909.
11.Liu, H.; Feng, Z.; Jiao, A.; Lan, L.; Ding, R.; Li, W.; Zheng, H.; Su, Y.; Jia, X.; Zhang, D.; Yang, X.; Zhang, L.; Sun, L.;Zhang, B., The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression.J Immunol2024, 212(11): 1714-21.
10.Yuan,N.; Su, Y.; Gao, Y.; Yang, B.; Zhang, T.; Wang, Q.; Zhang, D.; Shi, L.; Jiao, A.; Lei, L.; Sun, L.;Zhang, B., Med1 controls thymic T-cell migration into lymph node through enhancer-based Foxo1-Klf2 transcription program.Eur J Immunol2024, 54(10): e2350887.
9.Liu, H.; Wang, X.; Ding, R.; Jiao, A.; Zheng, H.; Zhang, C.; Feng, Z.; Su, Y.; Yang, X.; Lei, L.; Sun, L.; Zhang, L.; Sun, C.;Zhang, B., The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1.J Immunol2022, 209 (5): 886-95.
8.Jiao, A.; Liu, H.; Ding, R.; Zheng, H.; Zhang, C.; Feng, Z.; Lei, L.; Wang, X.; Su, Y.; Yang, X.; Sun, C.; Zhang, L.; Bai, L.; Sun, L.;Zhang, B., Med1 Controls Effector CD8(+) T Cell Differentiation and Survival through C/EBPβ-Mediated Transcriptional Control of T-bet.J Immunol2022, 209 (5): 855-63.
7.Zhang, B.; Liu, S. Q.; Li, C.; Lykken, E.; Jiang, S.; Wong, E.; Gong, Z.; Tao, Z.; Zhu, B.; Wan, Y.; Li, Q. J., MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium.Immunity2016, 44 (3): 568-81.
6.Zhang, B.; Jia, Q.; Bock, C.; Chen, G.; Yu, H.; Ni, Q.; Wan, Y.; Li, Q.; Zhuang, Y., Glimpse of natural selection of long-lived T-cell clones in healthy life.Proc Natl Acad Sci U S A2016, 113 (35): 9858-63.
5.Zhang, B.; Jiao, A.; Dai, M.; Wiest, D. L.; Zhuang, Y., Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.J Immunol2018, 201 (5): 1452-9.
4.Zhang, B.; Wu, J.; Jiao, Y.; Bock, C.; Dai, M.; Chen, B.; Chao, N.; Zhang, W.; Zhuang, Y., Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.J Immunol2015, 195 (9): 4282-91.
3.Zhang, B.; Lin, Y. Y.; Dai, M.; Zhuang, Y., Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells.J Immunol2014, 192 (3): 1055-63.
2.Liu, J.; Zhang, H.; Su, Y.;Zhang, B., Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases.Cell Biosci2022, 12 (1): 68.
1.Yang, X.; Wang, X.; Lei, L.; Su, Y.; Zou, Y.; Liu, H.; Jiao, A.; Zhang, C.; Liu, J.; Li, W.; Ding, R.; Zhou, X.; Shi, L.; Zhang, D.; Sun, C.;Zhang, B., Arid1a promotes thymocyte development through β-selection-dependent and β-selection-independent mechanisms.Immunology2022, 165 (4): 402-13.
已公开发表全部SCI论文的链接（PubMed）：
https://pubmed.ncbi.nlm.nih.gov/?term=baojun+zhang%2C+xi%27an+jiaotong+university
https://pubmed.ncbi.nlm.nih.gov/?term=baojun+zhang%2C+duke+university&sort=date
团队建设：
T细胞生物学（TCB）研究团队，包括教授1名、副教授6名、博士后6名、研究生10名。团队由国家领军人才领衔，团结协作，尊重个性，秉承个人成才与团队发展同频共振的理念，开展基础原创课题研究，解决生命医学科学难题和临床疾病问题。
欢迎副教授、博士后、研究生加入TCB研究团队！
欢迎研究生报考TCB研究团队！
电子邮箱：bj.zhang@mail.xjtu.edu.cn
联系电话：029-8265 6681、189 9190 6676
个人主页：https://gr.xjtu.edu.cn/en/web/bj.zhang/home
联系地址：雁塔西路76号交大医学部微免楼
