张义磊博士
教授博士生导师
西安交通大学基础医学院教授
西安交通大学第一附属医院特聘教授
zhangyilei@xjtu.edu.cn
课题组公众号：MetabodeathLab
【研究简介】
主要围绕肿瘤细胞营养依赖的代谢和细胞死亡调控机制及其在肿瘤靶向治疗中的应用开展系列研究工作，先后在Nature，NatureCell Biology, Nature Communications, Cell Research, Advanced Science, Cancer Research等专业期刊累计发表SCI论文43篇，引用超过12000次，h-index=31。以第一、或通讯作者（含共同）在NatureCell Biology, Nature Communications，CellResearch，AdvancedScience, Cell Death and Differentiation等期刊发表论文17篇，其中ESI高被引论文5篇。入选科睿唯安数据库2025全球高被引学者，连续三年入选全球2%科学家。主持国家自然科学基金(3项)、陕西省引才计划、秦创原创新创业计划等科研项目。担任中国细胞生物学细胞死亡分会委员，中国生物物理学会微量元素分会委员，中国抗癌协会肿瘤标志专业委员会青年委员等。
【研究经历】
·2009年9月-2014年12月，华中科技大学生命科学与技术学院，生物化学与分子生物学专业，硕博连读，获博士学位；
·2015年3月-2019年10月，美国德克萨斯大学MD安德森癌症中心放射肿瘤学系，博士后研究员；
·2019年10月至2021年1月，美国德克萨斯大学MD安德森癌症中心放射肿瘤学系，讲师；
·2021年3月至今，西安交通大学基础医学院，教授。
·2021年10月至今，西安交通大学第一附属医院，特聘教授。
【研究方向】
（1）肿瘤细胞胱氨酸代谢与铁死亡调控机制及其应用。发现抑癌基因BAP1通过表观调控基因表达促进胱氨酸依赖和铁死亡抑制肿瘤（2018，第一作者，NatureCell Biology；2019,第一作者， Cell Cycle; 2024,通讯，Oncogenesis；2025，末位通讯，CellDeath and Differentiation）；揭示胱氨酸代谢调控GPX4翻译表达新机制，证明胱氨酸依赖和铁死亡增敏肿瘤放、化疗的重要作用(2024, Journal of Advanced Research,末位通讯； 2020,共同第一作者,Cell Research; 2021,第一作者， Nature Communications; 2021,共同通讯，RedoxBiology；2025，末位通讯，Journal ofAdvancedResearch)。
（2）肿瘤细胞葡萄糖依赖与双硫死亡的调控机制。揭示胱氨酸转运蛋白SLC7A11调控葡萄糖依赖的关键作用，阐明胱氨酸代谢促进葡萄糖依赖的分子机制，发现葡萄糖依赖调控双硫死亡的机理（2017,共一和通讯 Journal of Biological Chemistry; 2020，共一，NatureCell Biology; 2023,第二作者，Nature Cell Biology）。发现内质网应激在葡萄糖缺乏诱导细胞死亡中的关键作用，揭示靶向内质网应激调控双硫死亡的分子机制（2020, 第一作者，Cancer Research; 2024,末位通讯,Advanced Science）。
【发表论文】
2025
Fan K, Zhou S, Ren Y, Xiong J, Wang H, Fu Y, Chen Y, Wang B, Fan K, Gao M, Guo T, Wei X, Jiao L, Shi J, Ding C,Zhang Y*. Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis.Cell Death Differ. 2025 Nov 27. doi: 10.1038/s41418-025-01624-2. Epub ahead of print. PMID: 41310183.
Emmanuel N, He Q, Kang Y, Gao M, Wang M, Fan K, Xiong J, Wu S, Fa B, Xiao Z, Niu Y, Kang Y, Zhang D, Yao Y,Zhang Y*. Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS-PAGE with Low Acrylamide Concentration.FEBSOpen Bio. FEBS Open bio 15 (6), 994-1008.
Fan Y, Wang Y, Dan W,Zhang Y, Nie L, Ma Z, Zhuang Y, Liu B, Li M, Liu T, Wang Z, Ye L, Wei Y, Lei Y, Guo C, An J, Wang C, Zhang Y, Zeng J, Wei W, Gan B, Li L. PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer.Nat Cell Biol. 2025 Apr;27(4):641-653. doi: 10.1038/s41556-025-01610-3. Epub 2025 Mar 3. PMID: 40033101.
Wang B, Huang C, Liu X, Liu Z,Zhang Y, Zhao W, Xu Q, Ho PC, Xiao Z. iMetAct: An integrated systematic inference of metabolic activity for dissecting tumor metabolic preference and tumor-immune microenvironment.Cell Rep. 2025 Mar 6;44(3):115375. doi: 10.1016/j.celrep.2025.115375. Epub ahead of print. PMID: 40053454.
Mao X, Xiong J, Cai M, Wang C, He Q, Wang B, Chen J, Xiao Z, Wang B, Han S,Zhang Y*. SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells.J Adv Res. 2025 Jan 18:S2090-1232(25)00045-1. doi: 10.1016/j.jare.2025.01.026. Epub ahead of print. PMID: 39832721
2024
Wang J, Chen J, Fan K, Wang M, Gao M, Ren Y, Wu S, He Q, Tu K, Xu Q,Zhang Y. Inhibition of Endoplasmic Reticulum Stress Cooperates with SLC7A11 to Promote Disulfidptosis and Suppress Tumor Growth upon Glucose Limitation.Adv Sci (Weinh). 2024 Dec 30:e2408789. doi: 10.1002/advs.202408789. Epub ahead of print. PMID: 39739602.
Wang J, Wang M, Wu S, Zhu Y, Fan K, Chen Y, Xiao Z, Chen J, Tu K, Huang D,Zhang Y*, Xu Q*. Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels.Oncogenesis. 2024 Sep 12;13(1):31. doi: 10.1038/s41389-024-00535-0. PMID: 39266549; PMCID: PMC11393423.
Wu S, Wang J, Wang M, Zhou K, Huang D*,Zhang Y*, Zhang H*. Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration.Biol Direct. 2024 Sep 12;19(1):81. doi: 10.1186/s13062-024-00528-4. PMID: 39267140; PMCID: PMC11396215.
Liu Z, Fan K, Abudukeremu A, Gao M, Tan X, Mao X, Li X, Ma W, Ma X, Li C, Yang Y, Tu K, Chen J,Zhang Y*, Guan Y*. LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism.Cell Death Discov. 2024 Jun 22;10(1):298. doi: 10.1038/s41420-024-02072-6. PubMed PMID: 38909032; PubMed Central PMCID: PMC11193757.
Mo H, Li R, Yang N, Han J, Xiao X,Zhang Y, Xiao Z, Jiao L, Xu Q, Tu K. USP40 promotes hepatocellular carcinoma progression through a YAP/USP40 positive feedback loop.Cancer Lett. 2024 May 1;589:216832. doi: 10.1016/j.canlet.2024.216832. Epub 2024 Mar 26. PubMed PMID: 38537774.
2023
Huang S, Zhang Q, Zhao M, Wang X,Zhang Y, Gan B, Zhang P. The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.J Cell Biol. 2023 Nov 6;222(11). doi: 10.1083/jcb.202212072. Epub 2023 Oct 13. PubMed PMID: 37831441; PubMed Central PMCID: PMC10570852.
Wang J, Wang H, Gao M,Zhang Y, Zhang L, Huang D, Tu K, Xu Q. The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions.Apoptosis. 2023 Oct;28(9-10):1304-1314. doi: 10.1007/s10495-023-01875-9. Epub 2023 Jul 31. Review. PubMed PMID: 37523039.
Guo T, Yan W, Cui X, Liu N, Wei X, Sun Y, Fan K, Liu J, Zhu Y, Wang Z,Zhang Y*, Chen L*. Liraglutide attenuates type 2 diabetes mellitus-associated non-alcoholic fatty liver disease by activating AMPK/ACC signaling and inhibiting ferroptosis.Mol Med. 2023 Sep 28;29(1):132. doi: 10.1186/s10020-023-00721-7. PubMed PMID: 37770820; PubMed Central PMCID: PMC10540362.
Guo L, Zhang W, Zhang X, Wang J, Nie J, Jin X, Ma Y, Wang S, Zhou X,Zhang Y, Xu Y, Tanaka Y, Yuan J, Liao XH, Gong Y, Su L. A novel transcription factor SIPA1: identification and verification in triple-negative breast cancer.Oncogene. 2023 Aug;42(35):2641-2654. doi: 10.1038/s41388-023-02787-3. Epub 2023 Jul 27. PubMed PMID: 37500797; PubMed Central PMCID: PMC10457189.
Zeng F, Ye L, Zhou Q, He Y,Zhang Y, Deng G, Chen X, Liu H. Inhibiting SCD expression by IGF1R during lorlatinib therapy sensitizes melanoma to ferroptosis.Redox Biol. 2023 May;61:102653. doi: 10.1016/j.redox.2023.102653. Epub 2023 Mar 1. PubMed PMID: 36889082; PubMed Central PMCID: PMC10009726.
Liu X, Nie L,Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis.Nat Cell Biol. 2023 Mar;25(3):404-414. doi: 10.1038/s41556-023-01091-2. Epub 2023 Feb 6. PubMed PMID: 36747082; PubMed Central PMCID: PMC10027392.
更多相关发表文献，请点击下面链接：
https://www.ncbi.nlm.nih.gov/myncbi/yilei.zhang.1/bibliography/public/
https://orcid.org/0000-0003-1407-0301
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