研究领域（方向）
（1）不同生理与病理应激下能量代谢与免疫系统的协同整合机制，（2）器官间互作调控免疫代谢稳态的时空交互网络研究，（3）免疫代谢稳态调控衰老及肥胖、糖尿病、炎症等慢性免疫代谢疾病的机制。
个人及工作简历
赵晓，男，西安交通大学医学部教授/博士生导师，2006-2011年中山大学生命科学学院遗传学专业获博士学位，2011-2014年任山东农业大学讲师，2014-2015年在堪萨斯大学医学院任博士后、2015-2022年在Texas A&M University医学院从事博士后研究，2022年8月入职西安交通大学医学部第一附属医院，获西安交通大学“青年拔尖人才支持计划”A类的支持，聘为教授。本课题组主要研究方向为器官交流互作（Inter-organ communication）调控免疫代谢稳态（Immune-metabolic homeostasis）的时空交互机理，拟从组织器官间互作网络的维度系统性探索机体衰老及肥胖、糖尿病、炎症等慢性免疫代谢疾病的发病机理,为相关疾病的预防和治疗研究提供理论基础。
科研项目
1.肌肉分泌MDIF调控胰岛素合成及能量代谢稳态的组织器官互作机制研究（32271192）,国家自然科学基金面上项目，2023-2026,主持
2.西安交通大学青年拔尖人才支持计划A类，2022-2028，主持
学术及科研成果、专利、论文
目前已发表SCI论文25篇，总计他引近1000次，其中以第一作者发表SCI论文10篇，总计影响因子73.75，单篇最高引用142次，h指数为12。近年来，以第一作者在领域内顶级期刊发表论文多篇，例如Cell Metabolism（2021），Current Biology（2017），Aging Cell（2020），Current Opinion In Insect Science（2020），BMC Genomics（2015）等，相关研究引起了国内外学者的广泛关注和认可，其中Cell Metabolism杂志邀请著名学者Irene Miguel-Aliaga教授为Cell Metabolism（2021）文章被撰写专题评论文章，另外Cell Metabolism（2021）和Current Biology（2017）的文章获得Faculty Opinions（F1000Prime）推荐。
主要代表作：
1. XiaoZhao#and Jason Karpac*.Glutamate Metabolism Directs Energetic Trade-offs to Shape Host-Pathogen Susceptibility in Drosophila.Cell Metabolism,2021, 33: 1-17.
2. XiaoZhao#and Jason Karpac*.The Drosophila midgut and the systemic coordination of lipid-dependent energy homeostasis (Review).Current Opinion Insect Science, 2020, 41:100-105.
3. ZhaoXiao#, Li X#., Shi X., Karpac J*. (2020). Diet-MEF2 interactions shape lipid droplet diversification in muscle to influence Drosophila lifespan.Aging Cell, 2020, e13172.
4. Xiao Zhao#and Jason Karpac*. Muscle directs diurnal energy homeostasis through a myokine-dependent hormone module in Drosophila.Current Biology, 2017, 27 (13): 1941-1955.e6.
5. Xiao Zhao#, Zhaoyang Liu, Qing-Xin Liu*. Gene coexpression networks reveal key drivers of phenotypic divergence in porcine muscle.BMC genomics,2015, 16(1):50.
6. Xiao Zhao#, Qi Yu, Ling Huang and Qing-Xin Liu*. Patterns of positive selection of the complete myogenic regulatory factor gene family in vertebrates.PLoS ONE,2014, 9(3): e92873.
7. Xiao Zhao#, Zheng Huang, Xiaohong Liu, Yaosheng Chen,Wen Gong, Kaifan Yu, Lijun Qin, Hu Chen, Delin Mo*. The switch role of the Tmod4 in the regulation of balanced development between myogenesis and adipogenesis.Gene, 2013, 532 (12): 263-271.
8. Ling Huang#,Xiao Zhao#, Qi Yu, Wei-Zheng Cui and Qing-Xin Liu*.Evidence for the Coevolution of Axon Guidance Molecule Netrin and its Receptor Frazzled.Gene,2014, 544 (1): 25-31.
9. Xiao Zhao#, Delin Mo, Anning Li, Wen Gong, Shuqi Xiao, Yue Zhang, Limei Qin, Yuna Niu, Yunxue Guo, Xiaohong Liu, Peiqing Cong, Zuyong He, Chong Wang, Jiaqi Li, Yaosheng Chen*. Comparative analyses by deep-sequencing of transcriptome during skeletal muscle development between two swine breeds differing in muscle growth and fatness.PLoS ONE, 2011, 6(5): e19774.
10. Xiao Zhao#, Delin Mo, Anning Li, Wen Gong, Yue Zhang, Weiwei Qian, Weiquan Chen, Shuqi Xiao, Yaosheng Chen*. Characterization and transcriptional regulation analysis of the porcine PAQR6 gene.DNA and CELL BIOLOGY, 2011, 30 (11): 1-8.
11. Chi G. Weindel; Eduardo L. Martinez;Xiao Zhao; Cory J. Mabry; Samantha L. Bell; Krystal J. Vail; Aja K. Coleman; Jordyn J. VanPortfliet; Baoyu Zhao; Allison R. Wagner; Sikandar Azam; Ha ley M. Scott; Pingwei Li; A. Phillip West; Jason Karpac; Kristin L. Patrick; Robert O. Watson ; M itochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis,Cell, 2022, 185(17): 1-18
12. Zhao Xiao#, Mo De-Lin, Zhang Yue, Chen Yao-Sheng*. Progress in research on skeletal muscle growth and development in swine (Review).Chinese Bulletin of Life Sciences, 2011, 23 (1): 1-8.
13. MA Karim Rumi, Prabhakar Singh, Katherine F. Roby,Xiao Zhao, Khursheed Iqbal, Anamika Ratri, Tianhua Lei, Wei Cui, Shaon Borosha, Pramod Dhakal, Kaiyu Kubota, Damayanti Chakraborty, Jay L. Vivian, Michael W. Wolfe, Michael J. Soares.Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility.Endocrinology,2017 en.2016-1916.
14. Qi Yu, Xiao-Tong Li,Xiao Zhao, Xun-Li Liu and Qing-Xin Liu. Coevolution of Axon Guidance Molecule Slit and its Receptor Robo.PLoS ONE,2014, 10.1371/journal.pone.0094970.
15. Anning Li,Delin Mo,Xiao Zhao,Wei Jiang,Peiqing Cong,Zuyong He,Shuqi Xiao,Xiaohong Liu,Yaosheng Chen. Comparison of the longissimus muscle proteome between obese and lean pigs at 180 days.Mamm Genome, 2013, 24(1-2):72-9.
16. Yu Qi,Zhou QiSheng,Zhao Xiao,Liu QingXin. Current progress in functions of axon guidance molecule Slit and underlying molecular mechanism.Sheng Li Xue Bao, 2012, 64(2):220-30.
17. Anning Li, Yaosheng Chen,Xiao Zhao, Yuna Niu, Peiqing Cong, Zongwu Zhang, Weiquan Chen, Wei Jiang, Delin Mo. Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene.Mol Genet Genomics, 2010.284(3):185-95
18. Xiao-Tong Li, Qi Yu, Qi-Sheng Zhou,Xiao Zhao, Zhao-Yang Liu, Wei-Zheng Cui, Qing-Xin Liu. BmRobo1a and BmRobo1b control axon repulsion in the silkworm Bombyx mori.Gene, 2016, 577(2): 215-220.
19. Xiao-Tong Li, Qi Yu, Qi-Sheng Zhou,Xiao Zhao, ZY Liu, WZ Cui, Qing-Xin Liu. BmRobo2/3 is required for axon guidance in the silkworm Bombyx mori.Gene, 2016, 577(2): 174-179.
20. Qi Yu, Xiao-Tong Li, Chun Liu, Wei-Zheng Cui, Zhi-Mei Mu,Xiao Zhao, Qing-Xin Liu. Evolutionarily Conserved Repulsive Guidance Role of Slit in the Silkworm Bombyx mori. PLoS ONE, 2014, Oct 6;9(10):e109377.
21. Li Xiao-Tong, Zhou Qi-Sheng, Yu Qi,Zhao Xiao, Liu Qing-Xin. Current progress in functions of axon guidance molecule Robo and underlying molecular mechanism.Acta Physiologica Sinica, June 25, 2014, 66(3): 373–385
22. Weiquan Chen, Yaosheng Chen, Limei Qin, Anning Li,Xiao Zhao, Xiaoying Wang, Shuqi Xiao, Delin Mo. Transcription Factor Sp1 is Essential for the Regulation of the Porcine Caveolin-1 Gene.DNA and CELL BIOL, 2011, 30 (7): 491-497.
23. Niu Y, Mo D, Qin L, Wang C, Li A,Zhao X, Wang X, Xiao S, Wang Q, Xie Y, He Z, Cong P, Chen Y. LPS-induced miR-1224 negatively regulates tumor necrosis factor-alpha gene expression by modulating Sp1.Immunology, 2010.10.1111.
24. Zongwu Zhang, Delin Mo, Fei Ling, Chong Wang, Anning Li,Xiao Zhao, Yanfang Li, and Yaosheng Chen. Characterization and promoter activity analysis of a new porcine gene: NICE-3.DNA Cell Biol, 2010. 29 (3):141-147.
25. Shuqi Xiao, Jianyu Jia, Delin Mo, Qiwei Wang, Limei Qin, Zuyong He,Xiao Zhao, Yuankai Huang, Anning Li, Jingwei Yu, Yuna Niu, Xiaohong Liu, Yaosheng Chen. Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing.PLoS ONE, 2010.5(6):e11377.
26. Shuqi Xiao, Delin M, Qiwei W, Jianyu J, Limei Q, Xiangchun Y, Yuna N,Xiao Zhao, Xiaohong L, Yaosheng Chen. Aberrant immune response in infection of pigs with the highly virulent PRRSV (H-PRRSV) identified by high-throughput Solexa sequencing.BMC Genomics, 2010,11:544.
27. Zhisheng Zhang, Delin Mo, Peiqing Cong, Zuyong He, Fei Ling, Anning Li, Yuna Niu,Xiao Zhao, Chunyan Zhou, Yaosheng Chen. Molecular cloning, expression patterns and subcellular localization of porcine TMCO1 gene.Mol. Biol. Rep, 2010. 37(3):1611-1618.
28. Limei Qin, Yaosheng Chen, Yuna Niu, Weiquan Chen, Qiwei Wang, Shuqi Xiao, Anning Li, Ying Xie, Jing Li,Xiao Zhao, Zuyong He and Delin Mo. A deep investigation into the adipogenesis mechanism: Profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway.BMC Genomics, 2010.11:320.
联系方式
电子邮箱：xiaozhao@xjtu.edu.cn或xzhao02282@gmail.com
联系电话：19829837917
个人主页：https://gr.xjtu.edu.cn/web/1100012347
联系地址： 陕西省西安市西咸新区西安交通大学创新港校区21号 楼2018室
