王健
博士，副教授，博士生导师
西安交通大学 基础医学院
生物物理学系 / 转化医学研究院 医学工程研究所
陕西省 西安市 中国西部科技创新港 21号楼 1090
邮箱：jian.wang@xjtu.edu.cn
个人简介
王健，西安交通大学基础医学院副教授、博士生导师，研究领域主要为生物医学传感与检测技术及其应用研究，在光电化学成像与传感技术、单细胞成像、超微电极均相电化学检测、纳米功能材料制备与应用等方面积累了丰富的经验。主持国家自然科学基金项目、陕西省自然科学基金青年/面上项目、中国博士后基金面上项目、横向科研项目等，作为骨干成员参与了国家科技部重点研发计划项目以及多项项目的执行。已在国内外学术期刊发表多篇论文，其中以第一作者或通讯作者在Analytical Chemistry，Biosensors and Bioelectronics，ACS Sensors等国际知名学术期刊发表SCI收录论文19篇，授权国家发明专利1项，软件著作权2项，《国家生物安全工程丛书》编委。荣获2023年度陕西省科学技术奖自然科学二等奖（5/6），2023年陕西省陕西高等学校科学技术研究优秀成果一等奖（4/6）。
教育经历：
2011/09-2015/08，伦敦玛丽女王大学，工程与材料科学，博士，导师：Prof. Steffi Krause
2009/09-2011/09，中南大学，材料学专业，硕士，导师：余志明 教授
2005/09-2009/06，中南大学，材料科学与工程专业，学士
科研与学术工作：
2020/08-至今， 西安交通大学，基础医学院医学工程研究所，副教授
2016/09-2020/08，西安交通大学，基础医学院医学工程研究所，讲师
2015/08-2016/01，伦敦玛丽女王大学，工程与材料科学，博士后，导师：Prof. Alvaro Mata
研究方向：
1、光电化学成像系统的开发与应用
基于光寻址电位传感（LAPS）原理，通过对半导体材料、光源、驱动系统及信号采集系统的优化与集成，研制多模态、高时空分辨率的光电化学成像与传感通用仪器平台，应用于生物医学传感与成像领域，包括活体单细胞的电化学行为及电生理活动的无损免标记二维成像表征与可视化监测，以及生物分子的高通量传感与检测。
2、电化学生物医学传感
结合功能材料和生物工程技术，构建多种类型微纳仿生传感器，包括仿生嗅觉与味觉传感器，化学敏感的仿生分子器件及免标记DNA传感器，用于微环境中化学与生物分析信号。
发表论文：
2024
(1) Qiaoyu Yang; Jiaming Liao; Luyao Feng; Sen Wang; Zhibin Zhao; Jian Wang*; Yazhong Bu*; Jian Zhuang; De-Wen Zhang*, One-step construction of multiplexed enzymatic biosensors using light-addressable electrochemistry on a single silicon photoelectrode. Biosensors and Bioelectronics 2024, 253, 116194. https://doi.org/10.1016/j.bios.2024.116194 (IF =12.6)
2023
(1) Fangming Chen#, Qian Guo#, Qiaoyu Yang, Yao Meng, Mingrui Jiang, Jian Wang*, De-Wen Zhang*. Label-Free Imaging of Cell Apoptosis by a Light-Addressable Electrochemical Sensor. Analytical Chemistry 2023, 95(23): 8898-8905. https://pubs.acs.org/doi/10.1021/acs.analchem.3c00566 (IF = 7.4)
(2) Mingrui Jiang, Fangming Chen, Yao Meng, Qiaoyu Yang, Jian Wang, De-Wen Zhang*, Yaqiong Wang*. Carbonized polydopamine layer-protected silicon substrates for light-addressable electrochemical sensing and imaging. Talanta 2023, 254: 124124. https://doi.org/10.1016/j.talanta.2022.124124 (IF = 6.1)
(3) Jian Wang, Fangming Chen, Qiaoyu Yang, Yao Meng, Mingrui Jiang, Yaqiong Wang, De-wen Zhang*, Liping Du*. Light-addressable electrochemical immunoassay for multiplexed detection of antigen. Sensors and Actuators B: Chemical 2023, 374: 132821. https://doi.org/10.1016/j.snb.2022.132821（IF =8.4）
(4) Chen, Wei, Miaomiao Chi, Miaomiao Wang, Yage Liu, Shu Kong, Liping Du*, Jian Wang*, Chunsheng Wu*. 2023. Label-Free Detection of CA19-9 Using a BSA/Graphene-Based Antifouling Electrochemical Immunosensor. Sensors 23, 24: 9693. https://doi.org/10.3390/s23249693 (IF=3.9)
2022
(1) Fangming Chen, Qiaoyu Yang, MingRui Jiang, Yao Meng, De-wen Zhang*, Jian Wang*. Visualization of electrochemical reactions on microelectrodes using light-addressable potentiometric sensor imaging. Analytica Chimica Acta 2022, 1224: 340237. https://doi.org/10.1016/j.aca.2022.340237（IF = 6.2）
(2) Yao Meng, Fangming Chen, Chunsheng Wu, Steffi Krause, Jian Wang*, De-wen Zhang*. Light-Addressable Electrochemical Sensors toward Spatially Resolved Biosensing and Imaging Applications. ACS Sensors 2022, 7(7): 1791-1807. https://doi.org/10.1021/acssensors.2c00940 (IF =8.9)
(3) Liping Du#, Jian Wang#, Wei Chen, Ping Zhu, Yulan Tian, Shu Kong, Chunsheng Wu, Comparative investigation of neuronal development on nano- and micro-topographic continuous silicon substrates, Materials Letters, Volume 316, 2022, 132017. (IF =3)
2021
(1) Yao Meng, Fangming Chen, Mingrui Jiang, Qin Guo, Yaqiong Wang, Jian Wang*, De-wen Zhang*. A Homogeneous Label-Free Electrochemical microRNA Biosensor Coupling With G-Triplex/Methylene Blue Complex and λ-Exonuclease-Assisted Recycling Amplification. Frontiers in Chemistry 2021, 9(975). (IF =5.5)
(2) Jian Wang, Fangming Chen, Qin Guo, Yao Meng, Mingrui Jiang, Chunsheng Wu, Jian Zhuang, De-wen Zhang*. Light-Addressable Square Wave Voltammetry (LASWV) Based on a Field-Effect Structure for Electrochemical Sensing and Imaging. ACS Sensors 2021, 6(4): 1636-1642. (IF =8.9)
(3) Fangming Chen, Xingchuang Fu, Yao Meng, Mingrui Jiang, Jian Wang*, Ying-Lin Zhou*, De-wen Zhang*. A novel miniaturized homogeneous label-free electrochemical biosensing platform combining integrated microelectrode and functional nucleic acids. Analytica Chimica Acta 2021, 1158: 338415. (IF = 6.2)
(4) Yun-Chong Li, Bo Jiao*, Yi-Jun Zhang, Jian Wang*, Wei Ren, De-wen Zhang, Xun Hou, Zhao-Xin Wu*. Bipolar Light-Addressable Potentiometric Sensor Based on Fullerene Photosensitive Layer. Advanced Materials Technologies 2021, 6(8): 2001221. (IF =6.8)
2020
(1) Jian Wang#, Yulan Tian#, Fangming Chen, Wei Chen, Liping Du, Zhiyuan He, Chunsheng Wu*, De-wen Zhang*. Scanning Electrochemical Photometric Sensors for Label-Free Single-Cell Imaging and Quantitative Absorption Analysis. Analytical Chemistry 2020, 92(14): 9739-9744. (IF = 7.4)
2019
(1) Jian Wang, Zhao Yang, Wei Chen, Liping Du, Bo Jiao, Steffi Krause, Ping Wang, Qiuping Wei, De-wen Zhang*, Chunsheng Wu*. Modulated light-activated electrochemistry at silicon functionalized with metal-organic frameworks towards addressable DNA chips. Biosensors and Bioelectronics 2019, 146: 111750.
(2) Jian Wang, Shu Kong, Fangming Chen, Wei Chen, Liping Du, Wen Cai, Liquan Huang, Chunsheng Wu*, De-Wen Zhang*. A bioelectronic taste sensor based on bioengineered Escherichia coli cells combined with ITO-constructed electrochemical sensors. Analytica Chimica Acta 2019, 1079: 73-78.
(3) Fan Wu, Bo Zhou, Jian Wang, Muchun Zhong, Anirban Das, Michael Watkinson, Karin Hing, De-wen Zhang*, Steffi Krause*. Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges. Analytical Chemistry 2019, 91(9): 5896-5903.
Before 2018
(1) Jian Wang*, Liping Du, Steffi Krause, Chunsheng Wu*, Ping Wang*, Surface modification and construction of LAPS towards biosensing applications, Sensors & Actuators: B. Chemical 2018, 265, 161-173.
(2) Fangming Chen#, Jian Wang#, Liping Du, Xu Zhang, Fan Zhang, Chunsheng Wu*, Ping Wang*, Functional expression of olfactory receptors using cell-free expression system for biomimetic sensors towards odorant detection, Biosensors and Bioelectronics 2019, 130: 382-388.
(3) Jian Wang, Inmaculada Campos, Fan Wu, Jingyuan Zhu, Gleb B. Sukhorukov, Matteo Palma, Michael Watkinson*, Steffi Krause*, The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy, Electrochimica Acta 2016, 208: 39-46.
(4) Jian Wang, Yinglin Zhou, Michael Watkinson, Julien Gautrota, Steffi Krause*, High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers, Sensors & Actuators: B. Chemical 2015, 209: 230-236.
(5) Jian Wang, Fan, et al. "Click" Patterning of Self-Assembled Monolayers on Hydrogen-Terminated Silicon Surfaces and Their Characterization Using Light-Addressable Potentiometric Sensors[J]. Langmuir 2015, 31(35):9646-9654.
教学课程：
本科课程：
1 全校通识课：《基因的奥秘》
2 未来技术学院：《设计思维》、《医工学基础》
3 医学部专业选修课：《生物物理学》
4 基础医学院课程：《学科交叉专题》
研究生课程：
1 医学部：《智能医学工程》
2 医学部英语课程：《高级医学研究英语实践》
招生信息：
本课题组研究方向为多学科交叉领域。
欢迎化学、生物学、物理学、材料科学、生物医学工程、基础医学、医学技术等专业方向的同学加入！
欢迎推免或报考本课题组的硕士和博士。
欢迎本科生加入课题组进行创新创业训练。
015 医学部 基础医学院
【学术型】
硕士研究生
071000生物学 06(全日制)生物物理学
博士研究生
071011生物物理学 10(全日制)单细胞光寻址检测及成像
