王胜鹏，博士
教授，博导，国家级青年人才
陕西省杰出青年基金获得者
西安交通大学‘A 类青年拔尖人才’
德国马普所心肺所客座科学家
西安交通大学
基础医学院教授; 西安交大一附院心内科特聘教授
联系电话：18066720583
Email: shengpeng.wang@xjtu.edu.cn
个人主页：http://bms.xjtu.edu.cn/info/1090/1838.htm
通讯地址：陕西省西安市雁塔区雁塔西路76号西安交通大学医学部, 西安，710061
个人简介
王胜鹏， 2006年于西安交通大学药学院获理学学士学位；2009年于西安交通大学医学部获药理学硕士学位；2015年于德国马普所及法兰克福大学获分子医学博士学位；2014-2018年于德国马普所心肺所从事博士后研究，担任Group leader。2015年获得北美血管生物协会(NAVBO) Del Vecchio奖；2016获得德国微循环及血管生物协会Young Inverstigator Award和德国心脏协会Dieter-Klaus-Forde奖；2017年获得欧洲循环协会(ESM) ESM-SERVIER奖；2017年入选西安交通大学‘青年拔尖人才A类’计划；2020年获得陕西省杰出青年基金，并担任西安交通大学中德心血管联合研究中心主任；主持一项国家自然科学基金面上项目，1项科技部战略发展项目，并在国内外重要学术会议上应邀报告12次。
主要研究方向包括：1）血管稳态及代谢调控，揭示了血管稳态及血压维持的新的力学调控机制；2）肥胖发生的力学机制，证明Piezo1是脂肪细胞感知膜张力的机械受体，率先从力学角度阐述了脂肪增生、炎症及肥胖发生的新机制。长期致力于血管力学生物学研究，聚焦血管稳态调控的力学感知瓶颈问题，在机械力受体发现、高血压及肥胖的力学调控方面取得了一系列突破进展。
在国际权威学术期刊发表研究论文33篇，14篇影响因子>10，被Nature、Cell、Science等杂志他引600余次，；以第一或共同通讯作者在Blood (2022, 影响因子22.1 ) 、 Journal of Hepatology (2021影响因子25.4) 、Circulation Research (2021影响因子17.5) 、Nature Communications 2020 (2篇, 影响因子14.9)、Journal of Clinical Investigation 2015/2016 (2篇，影响因子14.7)等杂志发表论文14篇。以参与作者在Circulation, European Respiratory Journal, Nature Communications, Journal of Clinical Investigation, Cardiovascular Research, Journal of Experimental Medicine等国际权威杂志发表论文21篇，多次受邀担任elife, Nature Communications, Journal of Clinical Investigation等杂志审稿人。
教育经历
2009.05—2015.01 德国马普所，分子药理学，博士
导师：Stefan Offermanns(院士)； Ingrid Fleming(院士)
2006.09—2009.04 西安交通大学，药理学，硕士
导师：臧伟进(教授，博导)
2002.09—2006.05 西安交通大学，药学专业，学士
工作经历
2019.05至今 西安交大一附院，心内科，特聘教授
2017.09至今 西安交通大学，医学部基础医学院，教授，博士生导师
2014.12—2018.03 德国马普院心肺所，博士后，Group leader，导师：Stefan Offermanns院士
荣誉与获奖
1. 欧洲循环协会ESM，ESM-SERVIER奖
2. 德国心脏协会，Dieter-Klaus-Forde奖
3. 德国微循环及血管生物协会，Young Inverstigator Award
4. 北美血管生物协会，(NAVBO)-Del Vecchio奖
科研项目
1. 国家优青项目
2. 科技部，战略科技发展类，主持
3. 国家自然科学基金，面上项目，主持
4. 陕西省科学技术厅，陕西省杰出青年科学基金项目，主持
5. 陕西省科学技术厅，陕西省重点项目，主持.
6. 西安交通大学“青年拔尖人才项目A 类计划”
7. 科技部，战略科技发展类，主持
8. 德国ECCPS的青年项目，主持
9. 德国科学基金会DFG重点项目，核心科学家
代表性论文
1. ShengPeng Wang* , Bianbian Wang , Yue Shi, Tanja Möller, Rebekka I Stegmeyer, Boris Strilic, Ting Li , Zuyi Yuan , Changhe Wang, Nina Wettschureck , Dietmar Vestweber, Stefan Offermanns*, Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood 2022（IF=25.25，First & Corresponding author, 封面文章）
2. Liran Xu；Nina Wettschureck；Yongping Bai*； Zuyi Yuan*；Shengpeng Wang*；Myofibroblast is dispensable for liver fibrosis，Journal of Hepatology，2021.Mar 3:S0168-8278(21)00160-4.（IF=30.08，Corresponding author）
3. Yuyang Lei*, Jiao Zhang*, Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X.-J. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang*, Zu-Yi Yuan*, and John Y-J. Shyy*，SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2，Circulation Research，2020 Dec 4:2020.12.04.409144.（IF=17.5，Corresponding author）
4. Wang Shengpeng*; Cao Shuang; Arhatte Shuang; Li Dahui; Shi Yue; KurzSabrina; Hu Jiong; Wang Lei; Shao Jingchen; Atzberger Ann; Wang Zheng; WangChanghe; Zang Weijin; Fleming Ingrid; Wettschureck Nina; Honoré Eric;Offermanns Stefan*; Adipocyte Piezo1 mediates obesogenic adipogenesis throughthe FGF1/FGFR1 signaling pathway in mice，Nature Communications，2020，11(1):2023.（IF=14.9，First & Corresponding author）
5. Lei Wang*, ShengPeng Wang*#, Yue Shi, Rui Li, Stefan Günther, Zuyi Yuan, Enqi Liu, Stefan Offermanns*，#，YAP and TAZ protect against white adipocyte cell death during obesity，Nature Communications，2020.（IF=14.9，Corresponding author）
6. Wang Shengpeng; Chennupati Ramesh; Kaur Harmandeep; Iring Andras;Wettschureck Andras; Offermanns Stefan*; Endothelial cation channel PIEZO1controls blood pressure by mediating flow-induced ATP release，Journal of Clinical Investigation，2016，126(12)：4527-4536. （IF=14.7，First author）Nature Review Nephrology亮点评述
7. Wang Shengpeng; Iring Andras; Strilic Boris; Juarez Julian Albarran;Kaur Harmandeep; Troidl Kerstin; Tonack Sarah; Burbie Joachim C.; MuellerChrista E.; Fleming Ingrid; Lundberg Jon O.; Wettschureck Nina; Offermanns Stefan*; P2Y₂ and GqG₁₁ control blood pressure by mediating endothelialmechanotransduction，Journal of Clinical Investigation，2015，125(8)：3077-3086. （IF=13.2，First author） Faculty1000特别推荐
8. Chengzhuo Li, Jin Yang, Fengshuo Xu, Didi Han, Shuai Zheng, Rahel Elishilia Kaaya,Shengpeng Wang* and Jun Lyu，A prognostic nomogram for the cancerspecific survival of patients with upper-tract urothelial carcinoma based on the Surveillance, Epidemiology, and End Results Database，BMC Cancer，2020，20:534.（IF=2.933，Corresponding author）
9. Wang Shengpeng; Zhang Yan; Wier W. Gil; Yu Xiaojiang; ZhaoMing; Hu Hao;Sun Lei; He Xi; Wang Youhua; Wang Bing; Zang Weijin*; Role of store-operated Ca2+ entry in adenosine-induced vasodilatation of rat small mesenteric artery,AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY，2009，297(1):H347-H354. （IF=4.048，First author）
10. Kwon Hyouk Bum;Wang Shengpeng; Helker Christian S. M.; Rasouli S.Javad; Maischein Hans-Martin; Offermanns Stefan; Herzog Wiebke; Stainier DidierY. R.*; In vivo modulation of endothelial polarization by Apelin receptorsignalling，Nature Communications.，2016，7(11805)：1-12.（IF=11.878）
11. Wang Shengpeng; Zang Weijin*; Kong Shanshan; Yu Xiaojiang; Sun Lei; Zhao Xinfeng; Wang Shixiang; Zheng Xiaohui*; Vasorelaxant effect of isopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate, a novel metabolite from Salvia miltiorrhiza, on isolated rat mesenteric artery, Eur J Pharmacol., 2008, 579(1- 3): 283-288. （IF=3.17，First author）
其它论文 (按时间倒序排列)
1. Wang L, Rice M, Swist S, Kubin T, Wu F, Shengpeng Wang, Kraut S, Weissmann N, Böttger T, Wheeler M, Schneider A, Braun T. BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State. Circulation. 2020 Dec 18. （IF=23.603）
2. Wang L, Chennupati R, Jin YJ, Li R, Shengpeng Wang, Günther S, Offermanns S. YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells. iScience. 2020 Nov 26;23(12):101860. （IF=4.447）
3. Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Shengpeng Wang, Offermanns S, Ercanoglu MS, Kwon HB, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA. Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. Communications Biology. 2020 May 26;3(1):265. （IF=4.165）
4. Li C, Yang J, Zheng S, Xu F, Han D, Bai L, Wei YL, Wang S, Lyu J. Establishment and Validation of a Nomogram for Tonsil Squamous Cell Carcinoma: A Retrospective Study Based on the SEER Database. Cancer Control. 2020 Jan-Dec;27(1):1073274820960481. （IF=3.103）
5. Han D, Yang J, Xu F, Huang Q, Bai L, Wei YL, Kaaya RE, Shengpeng Wang, Lyu J. Prognostic factors in patients with gallbladder adenocarcinoma identified using competing-risks analysis: A study of cases in the SEER database. Medicine (Baltimore). 2020 Jul 31;99(31):e21322. （IF=1.552）
6. Wu Jiayuan; Zhou Quan; Pan Zhenyu; Wang Yufeng; Hu Liren; Chen Guanghua; Shengpeng Wang *; Lyu Jun*; Development and validation of a nomogram for predicting long-term overall survival in nasopharyngeal carcinoma A population-based study, Medicine, 2019, 99:4(e18974). （IF=1.552，Corresponding author）
7. Yin Wenguang; Kim Hyun Taek; Shengpeng Wang; Gunawan Felix; Li Rui; Buettner Carmen; Grohmann Beate; Sengle Gerhard; Sinner Debora; Offermanns Stefan; Stainier Didier Y R*; Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis, European Respiratory Journal，2019 53(3): 0-1800840. （IF=11.807）
8. Iring Andras; Jin Young June; Albarran Juarez Julian; Siragusa Mauro; ShengPeng Wang; Dancs Peter T; Nakayama Akiko; Tonack Sarah; Chen Min; Kuenne Carsten; Sokol Anna M; Guenther Stefan; Martinez Alfredo; Fleming Ingrid;Wettschureck Nina; Graumann Johannes; Weinstein Lee S; Offermanns Stefan*; Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure, Journal of Clinical Investigation, 2019, 129(7): 2775-2791. （IF=12.282）
9. Yin Wenguang*; Kim Hyun Taek; ShengPeng Wang; Gunawan Felix; Wang Lei; Kishimoto Keishi; Zhong Hua; Roman Dany; Preussner Jens; Guenther Stefan; Graef Viola; Buettner Carmen; Grohmann Beate; Looso Mario; Morimoto Mitsuru; Mardon Graeme; Offermanns Stefan; Stainier Didier Y R*; The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis, Nature Communications, 2018, 9(1): 0-2815. （IF=11.878）
10. Schürmann Christoph; Dienst Franziska L.; Pálfi Katalin; VasconezAndrea E.; Oo James A.; ShengPeng Wang; Buchmann Giulia K.; Offermanns Stefan;Sluis Bart van de; Leisegang Matthias S.; Günther Stefan; Humbert Patrick O.;Lee Eunjee; Zhu Jun; Weigert Andreas; Mathoor Praveen; Wittig Ilka; Kruse Christoph; Brandes Ralf P.*; The Polarity Protein Scrib Limits Atherosclerosis Development in Mice, Cardiovascular Research, 2019, 115(14): 1963-1974. （IF=7.014）
11. Liu Longzhu; He Xi; Zhao Ming; Yang Si; Shengpeng Wang; Yu Xiaojiang; Liu Jiankang; Zang Weijin*; Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats., Journal of Molecular and Cellular Cardiology, 2019, 128: 26-37. （IF=5.055）
12. Juárez Julián Albarrán; Iring Andras; Shengpeng Wang; Joseph Sayali;Grimm Myriam; Strilic Boris; Wettschureck Nina; Althoff Till F; Offermanns Stefan*; Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation, Journal of Experimental Medicine, 2018, 215(10 ): 2655-2672. （IF=10.892）
13. Wirth Angela*; Shengpeng Wang; Takefuji Mikito; Tang Cong; Althoff Till F.; Schweda Frank; Wettschureck Nina; Offermanns Stefan*; Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling, Cardiovascular Research，2016,109(1): 131-140. （IF=7.014）
14. Wang Youhua; Tian Zhenjun; Zang Weijin; Jiang Hongke; Li Youyou; Shengpeng Wang; Chen Shengfeng*; Exercise training reduces insulin resistance in postmyocardial infarction rats, Physiological Reports, 2015, 3(4). （IF=1.005）
15. Sivaraj Kishor K.; Li Rui; Juarez Julian Albarran; ShengPeng Wang; Tischner Denise; Grimm Myriam; Swiercz Jakub M.; Offermanns Stefan; Wettschureck Nina*; Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis, Cardiovascular Research, 2015, 108(1): 171-180. （IF=7.014）
16. Althoff Till F.; Juarez Julian Albarran; Troidl Kerstin; Tang Cong; Shengpeng Wang; Wirth Angela; Takefuji Mikito; Wettschureck Nina; Offermanns Stefan*; Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling, Journal of Experimental Medicine, 2012, 209(12): 2277-2290. （IF=10.892）
17. Wang Youhua; Shengpeng Wang; Wier W. Gil; Zhang Quanjiang; JiangHongke; Li Qiuxia; Chen Shengfeng; Tian Zhenjun; Li Youyou; Yu Xiaojiang; Zhao Ming; Liu Jinjun; Yang Jing; Zhang Jing; Zang Weijin*; Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction ratsvia a PI3K/Akt/eNOS pathway-mediated mechanism, American Journal of Physiology-Heart and Circulatory Physiology, 2010, 299(6):H2097-H2106. （IF=4.048）
18. Wang YH, Hu H, Wang SP, Tian ZJ, Zhang QJ, Li QX, Li YY, Yu XJ, Sun L, Li DL, Jia B, Liu BH, Zang WJ. Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve. Eur J Appl Physiol. 2010 Feb;108(3):459-68. doi: 10.1007/s00421-009-1232-1. Epub 2009 Oct 15. （IF=2.58）
19. Hu H, Li DL, Fan L, Ren J, Shengpeng Wang, Jia B, Liu BH, Sun L, Yu XJ, Zang WJ. Involvement of volume-sensitive Cl- channels in the proliferation of human subcutaneous pre-adipocytes. Clin Exp Pharmacol Physiol. 2010 Jan;37(1):29-34. doi: 10.1111/j.1440-1681.2009.05223.x. （IF=2.456）
20. Wang SP, Zang WJ, Kong SS, Yu XJ, Sun L, Zhao XF, Wang SX, Zheng XH. Vasorelaxant effect of isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate, a novel metabolite from Salvia miltiorrhiza, on isolated rat mesenteric artery. Eur J Pharmacol. 2008 Jan 28;579(1-3):283-8. doi: 10.1016/j.ejphar.2007.10.009. （IF=3.263）
21. Lu Jun; Zhu Shuming; Zang Weijin; Xu Xiaoli; Luo Hongli; Yu Xiaojiang; Shengpeng Wang; Kong Shanshan; Wu Jie; Horie Minoru; Sun Lei*; Protective mechanism of adenosine to the rat arterial endothelial dysfunction induced by hydrogen peroxide, Biology & Pharmaceutical Bulletin, 2007, 30(7): 1206-1211. （IF=1.540）
学术活动
组织会议
1. 西安交通大学2019心血管高端研讨会组织委员会委员, 西安, 中国 (2019.12).
邀请报告
1. Piezo1感知血流剪切力的作用，2019长安国际心血管会，西安，中国（invited talk, 2019.05）
2. Piezo1对血流剪切力的感知机制研究，中国病理生理学会血管医学专业委员会第三届学术研讨会，上海，中国（invited talk, 2018.11）
3. Piezo1介导的钙信号在血管机械传导中的作用，第12届国际钙信号和细胞功能研讨会，沈阳，中国（invited talk, 2018.07）
4. Piezo1 and P2Y2 mediated mechanotransduction in endothelial flow sensing，Max-Planck Symposium 2017 ，Berline，Germany（invited talk, 2017.10）
5. Mechanotransduction in vascular endothelial cells，Perspective in Vascular Biology 2016，Frankfurt，Germany（invited talk，2017.09）
6. P2Y2 mediated mechanosignalling in regualtion blood pressure,International Conference on Purinergic Signaling, Hamburg, Germany（invited talk，2015.07）
