校蕾
西安交通大学医学部,教授,博士生导师
血管医学与代谢生物学研究团队负责人
邮箱:xiaolei0122@xjtu.edu.cn
电话:18609284536
学习、工作经历:
2024.01~今西安交通大学医学部,教授
2018.01~2023.12 西安交通大学医学部,副教授
2012.07~2017.12 西安交通大学医学部,讲师
2014.04~2015.04 美国俄克拉荷马大学,进修
2015.05~2016.05 美国佐治亚州立大学,进修
2007.09~2012.07 北京师范大学,生理学博士
2003.09~2007.07 西北大学,生物学学士
研究方向:
心血管及代谢性疾病基础研究,受体与信号转导,天然营养素与血管功能,免疫炎症性皮肤病机制
1.主持科研项目情况:
[1]国家自然科学基金重点项目(批准号82230012),合作主持
[2]国家自然科学基金重大研究计划培育项目(批准号91939108),主持
[3]国家自然科学基金面上项目(批准号81770497),主持
[4]西安交通大学医学“基础-临床”融合创新项目(批准号YXJLRH2022024),合作主持
[5] “医学攀登人才计划”﹣医学部首批国家级后备人选支持计划(No.217),主持
2.近五年以第一/通讯作者发表论文情况:
[1] Cui, Q., Jiang,T., Xie X., Wang, H., Qian L., Cheng Y., Li Q., Lu, T., Yao, Q., Liu, J., Lai, B., Chen, C.,Xiao, L.*, Wang, N.*, 2023. S-nitrosylation Attenuates Pregnane X Receptor Hyperactivity and Acetaminophen-induced Liver Injury.JCI Insight.e172632. IF: 8
[2] Xie, X#, Cui, Q#, Jiang, T., Zhao, Z., Liu, Z., Liu, J., Yao, Q., Wang, Y., Dang, E., Wang, G.,Xiao, L.*, Wang, N., 2023. A Critical Role of Endothelial Skp2/PTEN Axis in Angiogenesis and Psoriasis.Br J Dermatol.Oct 18:ljad399.IF: 10.3
[3]崔琪,杜雄,校蕾*,汪南平*. 2023.转录因子的巯基亚硝基化修饰及其生理学意义,《生理科学进展》,54, 26-32.
[4]Xiao, L., Wang, N.*, 2022. PPAR-δ: A key nuclear receptor in vascular function and remodeling.J Mol Cell Cardiol.169, 1-9.IF: 5
[5] Liu, J.#, Du, X.#, Yao, Q., Jiang, T., Cui, Q., Xie, X., Zhao, Z., Lai, B., Wang, N.,Xiao, L.*,2022. Procyanidin B2 ameliorates endothelial dysfunction induced by nicotine via the induction of tetrahydrobiopterin synthesis,J Funct Foods.,99, 105306. IF: 6.1
[6] Lai, B#, Xie, X.#, Li, F.#, Cui, Q., Dang, E., Luo, W., Wang, N., Zheng, Y., Wang, G.,Xiao, L.*, Wang, N., 2021. Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation.J Invest Dermatol.141, 2895-2907.e2897. IF: 6.5
[7]Xiao, L., Nie, X., Cheng, Y., Wang, N.*, 2021. Sodium-Glucose Cotransporter-2 Inhibitors in Vascular Biology: Cellular and Molecular Mechanisms.Cardiovasc Drugs Ther.35, 1253-1267. IF: 3.4
[8] Nie, X.#, Tang, W.#, Zhang, Z., Yang, C., Qian, L., Xie, X., Qiang, E., Zhao, J., Zhao, W.,Xiao, L.*, Wang, N.*, 2020. Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism.Redox Biol.37, 101728. IF: 11.4
[9] Zhang, Z., Xie, X., Yao, Q., Liu, J., Tian, Y., Yang, C.,Xiao, L.*, Wang, N.*, 2019a. PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway.Br J Pharmacol.176, 2945-2961. IF:7.3
[10] Xie, X.#, Yang, C.#, Cui, Q., Ma, W., Liu, J., Yao, Q., Zhang, Z.,Xiao, L.*, Wang, N.*, 2019b. Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells.J Agric Food Chem.67, 9805-9811. IF:6.1
[11] Tian, Y., Yang, C., Yao, Q., Qian, L., Liu, J., Xie, X., Ma, W., Nie, X., Lai, B.,Xiao, L.*, Wang, N.*, 2019c. Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages.Front Immunol.10, 1895. IF:7.3
[12] Zhang, M., Zhang, Z., Xie, X., Yao, Q., Liu, J., Lai, B.,Xiao, L.*, Wang, N.*, 2019d. Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries.J Cell Physiol.234, 4342-4351. IF:5.6
3.论文获奖情况:
[1] 2023国际皮肤病研究学会学术会议(ISID)旅行资助奖(日本东京)
[2] 2018亚洲血管生物学会(ASVB)青年优秀奖第二名(中国上海)
[3] 2018南方国际心血管病学术会议优秀论文二等奖(中国广州)
4.学术兼职:
中国病理生理学会理事
中华医学会心血管病学分会代谢性心血管疾病学组委员
中国病理生理学会受体专业委员会委员
中国病理生理学会血管医学专业委员会青年委员
中国生物化学与分子生物学会脂质与脂蛋白专业委员会青年委员