研究领域（方向）
1.法医临床学
2.毒品成瘾的神经生物学机制与治疗
3.脑损伤后认知与情感障碍的神经生物学机制
个人及工作简历
1982年3月出生，医学博士，副教授，硕士研究生导师，法医学院副院长兼法医临床系主任，中国毒理学会特种医学毒理专业委员会青年委员（2022.01-2026.01），中国药物滥用防治协会青年专家委员会委员（2017.05-2022.05），海峡两岸医药卫生交流协会法医学分会委员（2021.01-2024.01），陕西省司法鉴定协会法医类司法鉴定专业委员会委员（2021.04至今）。
工作经历:
2012.08-2016.09: 西安交通大学法医学院，讲师
2015.08-2016.08: 渥太华大学，加拿大皇家精神卫生研究所，访问学者
2016.10-至今 : 西安交通大学法医学院，副教授
2018.10-至今 : 西安交通大学法医学院，副院长
学习经历:
2001.08-2006.07: 西安交通大学，临床医学、法医学，本科
2006.08-2012.07: 西安交通大学，法医学，硕士、博士研究生
科研项目
主持国家自然科学基金项目2项，陕西省重点研发计划项目1项，西安交通大学新教师科研支持计划项目1项。作为项目组主要成员，参与国家自然科学基金重点项目、科技部国际科技合作与交流专项项目、西安交通大学创新团队培育项目等多项科研项目的申报和研究工作。
1.内源性大麻素通过VTA-NAc环路调控甲基苯丙胺成瘾的机制研究。国家自然科学基金面上项目。在研。主持。
2.多巴胺受体通过调节伏隔核BDNF参与甲基苯丙胺成瘾机制的研究。国家自然科学基金青年项目。结题。主持。
3.内源性大麻素系统对脑损伤后认知与情感障碍的调节作用及其机制研究。陕西省重点研发计划项目。在研。主持。
4.甲基苯丙胺成瘾小鼠伏隔核突触可塑性改变以及BDNF调节作用的研究。西安交通大学“新教师科研支持计划”项目。结题。主持。
5.伏隔核miR-29/Dnmt3/Meg3通路参与甲基苯丙胺成瘾的机制研究。国家自然科学基金重点项目。结题。参与。
6.延胡索乙素对甲基苯丙胺依赖的治疗作用研究。科技部国家国际科技合作与交流专项项目。结题。参与。
学术及科研成果、专利、论文
1.第一作者/通讯作者论文
(1) Shuai Wang, Ming Li, Linlan Su, Yu Wang, Dongliang Ma, Hongyan Wang, Jie Zhu* and Teng Chen*. Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice. Frontiers in Cellular Neuroscience. 2022. 16: 89319.
(2) Zhu Jie, Zhao Na, Chen Yanjiong, Zhu Li, Zhong Qing, Liu Jian, ChenTeng*. Sodium butyrate modulates a methamphetamine-induced conditioned place preference. Journal of Neuroscience Research. 2017. 95(4): 1044-1052.
(3) Zhu Jie, Zhu Feng*, Zhao Na, Mu Xin, Li Pingping, Wang Wei, Liu Jian, Ma Xiancang. Methylation of glucocorticoid receptor gene promoter modulates morphine dependence and accompanied hypothalamus-pituitary-adrenal axis dysfunction. Journal of Neuroscience Research, 2017.95(7): 1459-1473.
(4) Zhu Li#, Zhu Jie#, Liu Yufeng, Chen Yanjiong, Li Yanlin, Chen Sisi, Li Tao, Dang Yonghui, Chen Teng*. Chronic methamphetamine regulates the expression of MicroRNAs and putative target genes in the nucleus accumbens of mice. Journal of Neuroscience Research, 2015. 93(10): 1600-1610.
(5) Zhu Li#, Zhu Jie#, Liu Yufeng, Chen Yanjiong, Li Yanlin, Huang Liren, Chen Sisi, Li Tao, Dang Yonghui, Chen Teng*. Methamphetamine induces alterations in the long non-coding RNAs expression profile in the nucleus accumbens of the mouse. BMC Neuroscience, 2015. 16: 18.
(6) Zhu Jie, Chen Yanjiong, Zhao Na, Cao Guofen, Dang Yonghui, Han Wei, Xu Ming, Chen Teng*. Distinct roles of dopamine D3 receptors in modulating methamphetamine-induced behavioral sensitization and ultrastructural plasticity in the shell of the nucleus accumbens. Journal of Neuroscience Research, 2012. 90(4): 895-904.
(7) Zhu Jie, Cao Guofen, Dang Yong-hui, Chen Teng*. Structural plasticity associated with drugs addiction. Sheng Li Ke Xue Jin Zhan, 2011. 42(6): 413-418.
(8) Zhu Jie, Chen Yanjiong, Lai Jianghua, Dang Yonghui, Yan Chunxia, Xu Ming, Chen Teng*. Dopamine D3 receptor regulates basal but not amphetamine-induced changes in pain sensitivity in mice. Neuroscience Letters, 2010. 477(3): 134-137.
(9)秦新潮，刘丹，李佳琦，朱杰*. 多层螺旋CT三维重建在肋骨骨折诊断及法医临床鉴定中的应用，临床医学研究与实践，2017. 2（6）：1-3.
(10)Jie Zhu，Ning Gu，Xia Zhang*. Faah inhibitors induces anti-anxiety responsethrough astroglial-mediated LTD，26th Annual Symposium of the International Cannabinoid Research Society，Bukovina，2016.6.26-2016.7.1(会议论文)。
2.其他作者论文
(1)Dong N, Zhu J, Wang R, Wang S, Chen Y, Wang C, Goh ELK, Chen T*. Maternal Methamphetamine Exposure Influences Behavioral Sensitization and Nucleus Accumbens DNA Methylation in Subsequent Generation. Front Pharmacol. 2022. 19;13:940798.
(2)Cao G, Meng G, Zhu L, Zhu J, Dong N, Zhou X, Zhang S, Zhang Y*. Susceptibility to chronic immobilization stress-induced depressive-like behaviour in middle-aged female mice and accompanying changes in dopamine D1 and GABAA receptors in related brain regions. Behav Brain Funct. 2021.17(1):2.
(3)韩青，阎春霞，张毛影，朱杰，顾珊智*.胶原纤维、Ⅳ型胶原及CD34诊断外伤性迟发性脾破裂.刑事技术. 2021,46(02)：204-207.
(4)Hao R, You H, Zhu J, Chen T, Fang J*. "Burning Lamp"-like Robust Molecular Enrichment for Ultrasensitive Plasmonic Nanosensors. ACS Sens. 2020.5(3):781-788.
(5)Su H, Sun T, Wang X, Du Y, Zhao N, Zhu J, Yan J, Chen T, Yun K*. Levo-tetrahydropalmatine attenuates methamphetamine reward behavior and the accompanying activation of ERK phosphorylation in mice.Neurosci Lett. 2020, 714:134416.
(6)曹国芬*，张永爱，朱莉，朱杰，陈艳炯，陈腾*.甲基苯丙胺重复暴露诱导小鼠空间学习记忆损伤的可能分子机制中国药物依赖性杂志. 2019,28(03):189-194.
(7)曹国芬*，张永爱，张苏梅，张海苗，朱莉，朱杰，周小兰，陈腾.不同剂量甲基苯丙胺对小鼠空间学习记忆能力的影响及其机制.西安交通大学学报(医学版). 2019,40(04):559-563.
(8)Dong N, Zhu J, Han W, Wang S, Yan Z, Ma D, Goh ELK, Chen T*. Maternal methamphetamine exposure causes cognitive impairment and alteration of neurodevelopment-related genes in adult offspring mice. Neuropharmacology. 2018.140:25-34.
(9)Cao G, Zhang Y, Zhu L, Zhu J, Zhao N, Dong N, Dang Y, Chen Y, Chen T*.The inhibitory effect of levo-tetrahydropalmatine on the methamphetamine-induced spatial memory impairment in mice.Neurosci Lett. 2018. 672:34-39.
(10)谭清斌，朱虹，贺斌慷，朱杰。强行注射HIV血液致他人感染的法医学鉴定分析1例。中国法医学杂志。2017，32（4）：435-436。
(11) Duan Tingting# ，Gu Ning# ，Wang Ying# ，Wang Feng，Zhu Jie，Fang Yiru，Shen Yuan，Han Jing ，Zhang Xia*. Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents. J Psychiatry Neurosci. 2017. 42(4):230-241.
(12) Zhao N, Chen Y, Zhu J, Wang L, Cao G, Dang Y, Yan C, Wang J, Chen T*. Levo-tetrahydropalmatine attenuates the development and expression of methamphetamine-induced locomotor sensitization and the accompanying activation of ERK in the nucleus accumbens and caudate putamen in mice. Neuroscience, 2014. 258: 101-110.
(13)Xue L, Li M, Chen T, Sun H, Zhu J, Li X, Wu F, Wang B, Li J, Chen Y*.PE‑induced apoptosis in SMMC‑7721 cells: involvement of Erk and Stat signalling pathways. Int J Mol Med. 2014. 34(1):119-129.
(14)Cao Guofen, Zhu Jie, Zhong Qing, Shi Chaofeng, Dang Yonghui, Han Wei, Liu Xinshe, Xu Ming, Chen Teng*. Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex. Neuropharmacology, 2013. 67:144-154.
(15)Su HongLiang, Zhu Jie, Chen YanJiong, Zhao Na, Han Wei, Dang YongHui, Xu Ming, Chen Teng*. Roles of levo-tetrahydropa
lmatine in modulating methamphetamine reward behavior. Physiology & Behavior, 2013. 118:195-200.
(16)孔晗，刘彦玲，朱杰，阎春霞，魏曙光，张洪波，李生斌，陈腾*.甲基苯丙胺诱导的小鼠条件性位置偏爱及多巴胺D3受体的调制作用.中国药物依赖性杂志. 2009,18(03):175-179.
(17)朱俊艳，陈腾*，孔晗，朱杰.盲眼损伤后临床法医学鉴定1例.法医学杂志.2007.(03):231-232.
联系方式
联系电话：029-82657378
电子邮箱：zhujie.xjtu@xjtu.edu.cn
联系地址：陕西省西安市雁塔西路76号，西安交通大学医学部，710061
