研究员，博士研究生导师
个人简介
高鹏博士，西安交通大学第一附属医院特聘研究员，博士生导师。陕西省高层次人才引进计划（青年项目）和西安交通大学青年拔尖人才支持计划入选者。以第一或通讯作者在PNAS、Blood、Genes&Development、Cancer Letter和HLA等期刊发表论文11篇，在Nature、Cell、Cancer Discovery、Immunity、Blood、PNAS、Science Advances和Nucleic Acids Research等期刊发表SCI论文22篇。SCI引用1,900多次，h-index为21。
研究领域
主要从事运用单细胞测序等高通量测序技术研究血细胞发育及相关疾病过程中的转录调控机制，具体方向如下。更多详细内容请浏览https://gr.xjtu.edu.cn/web/gaopeng。
1.胚胎造血干细胞发育机制
2.白血病发生及进展机制
3.疾病相关变异体的筛选与鉴定
4.HLA基因的转录调控机制
5.基于HLA的新配型体系建立与临床应用
实验室长期招收科研人员，包括青年优秀人才、各级博士后、研究生及本科生！欢迎感兴趣的青年学者和同学加入。如有意愿，请发送简历至邮箱gaopeng@xjtu.edu.cn。
教育经历
2007-2011：博士，免疫学，东南大学
2005-2007：硕士，病理学，东南大学
2000-2005：学士，临床医学，东南大学
工作经历
2021-至今：特聘研究员，博士研究生导师，西安交通大学第一附属医院
2020-2021：研究科学家，费城儿童医院/宾夕法尼亚大学
2015-2020：博士后，费城儿童医院/宾夕法尼亚大学
2011-2015：博士后，爱荷华大学
科研项目
1.科技部国家重点研发计划，2023-2027，参与
2.陕西省高层次人才引进计划（青年项目），2022-2025，主持
3.西安交通大学青年拔尖人才支持计划，2021-2026，主持
发表论文
第一/通讯作者
1.Li Z, Zhao Y, Yang L, Wang X,Gao P*.(2024)The novel HLA-C*14:02:01:33 allele identified by Pacific Biosciences HiFi sequencing in a Chinese individual.HLA. 103(2):e15417. (IF=8)(通讯作者)
2.Li Z, Xu T, Li X, Wang T, Tang G, Zhao H, Zhao Y, Ye K*,Gao P*. (2023)Viral integration promotes SV40T-induced immortalization by disturbing the expression of DNA/chromosome- and ECM-associated functional genes.Gene. 896:148060. (IF=3.5) (通讯作者)
3.Gao H,Gao P*, and Ye N*. (2023) A method for evaluating of RNA’s coding potential using the interaction effects of open reading frames and high-energy scalogram.Computers in Biology and Medicine. 168:107752. (IF=7.7) (通讯作者)
4.Gao H,Gao P*, and Ye N*. (2023)Prelnc2: A prediction tool for lncRNAs with enhanced multi-level features of RNAs.PloS One. 18(6):e0286377. (IF=3.7) (通讯作者)
5.Gao P#,Chen C#, Howell E#, Li Y#, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann A, Speck N*, and Tan K*. (2020) Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells.Genes & Development. 34(13-14):950-964.(IF=10.5) (第一作者)
6.Zhu Q#,Gao P#, Tober J#, Bennett L, Chen C, Uzun Y, Li Y, Howell E, Mumau M, Yu W, He B, Speck N*, and Tan K*. (2020)Developmental trajectory of pre-Hematopoietic stem cell formation from endothelium.Blood.136(7):845-856. (IF=20.3)(第一作者)
7.Gao P#, Uzun Y#, He B, Salamati SE, Coffey JKM, Tsalikian E, Tan K*. (2019) Risk variants disrupting enhancers of TH1 and TREGcells in type 1 diabetes.Proc Natl Acad Sci USA. 116(15):7581-7590.(IF=11.1) (第一作者)
8.Gao P, Zhai F, Guan L, Zheng J*. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21.Oncology Letters. 2(1):123-128. (IF=2.9) (第一作者)
9.Gao P, Zheng J. (2011) Oncogenic virus-mediated cell fusion: new insights into initiation and progression of oncogenic viruses-associated cancers.Cancer Letters. 303(1):1-8. (IF=9.7) (第一作者)
10.Gao P, Guan L, Zheng J*. (2010) Role of leukotriene B4 in celecoxib-mediated anticancer effect.Biochemical and Biophysical Research Communications. 402(2):308-311. (IF=3.1) (第一作者)
11.Gao P#*, Zheng J. (2010) High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer.Virology Journal. 7(1):238. (IF=4.8) (第一作者、通讯作者)
共同作者
1.Yang Y, Mumau M, Tober J, Zhu Q, Bennett L, Hong C, Sung DC, Keller T, Uzun Y,Gao P, Shewale S, Chen M, Yang J, Chen X, Thomas SA, Tan K, Speck NA, Kahn ML. (2022)Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis.Blood.139(19):2942-2957.(IF=20.3)
2.Chen C#, Yu W#, Alikarami F#, Qiu Q, Chen C, Flournoy J,Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding Y, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM*, Bernt KM*, Tan K*. (2022) Single-cell multiomics reveals increased plasticity, resistant populations and stem-cell-like blasts in KMT2A-rearranged leukemia.Blood. 139(14):2198-2211. (IF=20.3)
3.Melenhorst JJ#*, Chen GM#, Wang M#, Porter DL#, Chen C, Collins MA,Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, Gill SI, Tian L, Kulikovskaya I, Gupta M, Ambrose DE, Davis MM, Fraietta JA, Brogdon JL, Young RM, Chew A, Levine BL, Siegel DL, Alanio C, Wherry EJ, Bushman FD, Lacey SF, Tan K*, June CH*. (2022) Decade-long leukaemia remissions with persistence of CD4+CAR T cells.Nature. 602(7897):503-509. (IF=64.8)
4.Chen GM#, Chen C#, Das RK#,Gao P, Chen C, Bandyopadhyay S, Ding Y, Uzun Y, Yu W, Zhu Q,Myers RM, Grupp SA, Barrett DM, Tan K. (2021) Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy.Cancer Discovery. 11(9):2186-2199. (IF=29.1)
5.Howell ED, Yzaguirre AD,Gao P, Lis R, He B, Lakadamyali M, Rafii S, Tan K*, Speck NA*. (2021) Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes.Genes &Development. 35(21-22):1475-1489. (IF=10.5)
6.Estevez B, Borst S, Jarocha D, Sudunagunta V, Gonzalez M, Garifallou J, Hakonarson H,Gao P,Tan K, Liu P, Sumedha Bagga S, Holdreith N, Tong W, Speck N, French D, Gadue P, and Poncz M. (2021) RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoieticprogenitor cells: Mechanistic studies and drug correction.Blood. 137(19):2662-2675. (IF=20.3)
7.Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J,Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA*, Zon LI*. (2020) CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.Proc Natl Acad Sci USA. 117(38):23626-23635. (IF=11.1)
8.He B,Gao P, Ding Y, Chen C, Chen G, Chen C, Kim H, Tasian S, Hunger S, Tan K. (2020) Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers.Science Advances. 6(30):eaba3064. (IF=13.6)
9.The HTAN consortium. (2020) The Human Tumor Atlas Network: Charting tumor transitions across space and time at single-cell resolution.Cell. 181(2):236-249. (IF=64.5)
10.Chen C#, Yu W#, Tober J,Gao P, He B, Lee K, Trieu T, Blobel G, Speck N, Tan K. (2019)Spatial genome re-organization between fetal and adult hematopoietic stem cells.Cell Reports. 29(12):4200-4211.e7. (IF=8.8)
11.Zheng J,Gao P. (2019)Towards normalization of the tumor microenvironment for cancer therapy.Integrative Cancer Therapies.18:1534735419862352.
12.Liu K#, Du S#,Gao P, Zheng J. (2019) Verteporfin inhibits the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1.Journal of Cancer. 10(18):4196-4207. (IF=3.9)
13.Gao L, Tober J,Gao P, Chen C, Tan K, Speck NA. (2018) RUNX1 and the endothelial origin of blood.Experimental Hematology. 68:2-9. (IF=2.6)
14.Du S#, Liu K#,Gao P, Li Z, Zheng J. (2018)Differential anticancer activities of arsenic trioxide on head and neck cancer cells with different human papillomavirus status.Life Sciences. 212:182-193. (IF=6.1)
15.Gao L#, Uzun Y#,Gao P, He B, Ma X, Wang J, Han S, Tan K. (2018) Identifying noncoding risk variants using disease-relevant gene regulatory networks.Nature Communications.9(1):702. (IF=16.6)
16.Tober J, Maijenburg MMW, Li Y, Gao L, Hadland BK,Gao P, Minoura K, Bernstein ID, Tan K, Speck NA. (2018) Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.Journal of Experimental Medicine. 215(2):645-659. (IF=15.3)
17.He B#, Xing S#, Chen C,Gao P, Teng L, Shan Q, Gullicksrud JA, Martin MD, Yu S, Harty JT, Badovinac VP, Tan K, and Xue HH. (2016) CD8+T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections.Immunity. 45(6):1341-1354. (IF=32.4)
18.Ma X, Gao L, Karamanlidis G,Gao P, Lee CF, Garcia-Menendez L, Tian R, Tan K. (2015) Revealing Pathway Dynamics in Heart Diseases by Analyzing Multiple Differential Networks.PLoS Computational Biology. 11(6):e1004332. (IF=4.3)
19.Wang H,Gao P, Zheng J. (2014) Arsenic trioxide inhibits cell proliferation and human papillomavirus oncogene expression in cervical cancer cells.Biochemical and Biophysical Research Communications.451(4):556-561. (IF=3.1)
20.Zheng J,Gao P. (2013) Biosynthetic and Metabolic Alterations in Cancer Growth.Current Angiogenesis. 2, 149-156.
21.Teng L, He B,Gao P, Gao L, Tan K. (2014) Discover context-specific combinatorial transcription factor interactions by integrating diverse ChIP-Seq data sets.Nucleic Acids Research. 42(4):e24. (IF=14.9)
22.Fan R, Bonde S,Gao P, Sotomayor B, Chen C, Mouw T, Zavazava N, Tan K. (2012) Dynamic HoxB4 Regulatory Network During Hematopoietic Stem Cell Development.Blood. 119(19): e139-147. (IF=20.3)
联系方式
联系邮箱：gaopeng@xjtu.edu.cn
联系地址：陕西省西安市雁塔西路277号 西安交通大学第一附属医院科研楼
