刘锦锋

  

    研究领域(方向)

    1.乙肝母婴阻断;

2. HCC发生机制研究

科研项目

主持国家自然科学基金2项,参与国家自然科学基金5项,参与国家“十一五”、“十二五”、“十三五”重大传染病专项:

1、国家自然科学基金面上项目,81670537、IL-6对NTCP介导HBV胎盘细胞感染及细胞间直接感染的调节、2017/1-2020/12、50万、在研、主持

2、国家自然科学基金青年项目,31100129、hRIP对HIV-1病毒基因的转录后调节、2012/01-2014/12、23万元、结题、主持

3、国家自然科学基金面上项目,81770594,细胞与线粒体自噬和滋养细胞损伤及其与HBV感染宫内传播的关系研究、2018/1-2021/12、54万、在研、参与

4、国家自然科学基金面上项目,81770594,细胞与线粒体自噬和滋养细胞损伤及其与HBV感染宫内传播的关系研究、2018/1-2021/12、54万、在研、参与

5、国家自然科学基金面上项目,81570528,磷酸化Atg13介导的线粒体自噬在肝星状细胞活化中的机制、2018/1-2021/12、62万、在研、参与

6、科技重大专项“十三五”课题,2017ZX10001-002、提高HBeAg阳性慢性乙型肝炎患者HBsAg阴转率抗病毒/免疫治疗新方案的研究、2017/1-2021/12、86万、在研、参与

7、科技重大专项“十二五”课题,2012ZX10002-007、病毒性肝炎转归预警机制的研究、2012/1-2016/12、180万、在研、参与

8、科技重大专项“十一五”课题,2008ZX10002-007、病毒性肝炎转归预警机制的研究、2008/1-2012/12、160万、结题、参与

9、国家自然科学基金,30872219、不良结局家族聚集性HBV感染NK细胞功能缺陷研究、2009/1-2011/12、35万、结题、参与

10、国家自然科学基金,30700712、不良结局家族聚集性HBV感染宿主因素研究、2008/1-2010/12、17万、结题、参与

11、国家自然科学基金,30671862,HBV前X基因致癌作用的体内外研究、2007/1-2009/12,30万、结题、参与

*学术集科研成果、专利、论文发表的第一作者及通讯作者SCI文章:

  1. Tianyan Chen, Jing Wang, Hongtao Qiu, Qiang Yu, Taotao Yan, Caijing Qi, Furong Cao, Zhen Tian, Dandan Guo, Naijuan Yao, Yuan Yang, Yingli He, Yingren Zhao,Jinfeng Liu(通讯作者).Different interventional criteria for chronic hepatitis B pregnant women with HBeAg(+) or HBeAg(-): Epidemiological data from Shaanxi, China. Medicine. 2018;97(24): e11406.

  2. Liu Jinfeng(第一作者),Yao Naijuan, Zhao Yingren.Improvement of telbivudine on renal function and massive proteinuria: A case report.Journal of Viral Hepatitis, 2017;24 Suppl 1:75-77.

  3. Liu Jinfeng(第一作者),Wang Jing, Qi Caijing,Cao Furong, Tian Zhen, Guo Dandan, Yan Taotao, Li Qian, Yang Shujuan, Fu Jianjun, Tang Xianmei, Kou Xiao Ni, Liu Na,Jiang Zicheng, Zhao Yingren*,Chen Tianyan*.Baseline Hepatitis B Virus Titer Predicts Initial Postpartum Hepatic Flare: A Multicenter Prospective Study.Journal of Clinical Gastroenterology, 2017.

    Liu Jingfeng(第一作者),Chen Tianyan, Zhao Yingren.Telbivudine therapy for gravidas with chronic hepatitis B infection and patients at risk of renal impairment.Journal of Viral Hepatitis, 2017;24 Suppl 1:6-11.

  4. Liu, Jinfeng#(第一作者),Wang, Jing#,Jin, Dongfang,Qi, Caijing,Yan, TaoTao,Cao, Furong,Jin, Li,Tian, Zhen,Guo, Dandan,Yuan, Ningxia,Feng, Weihong,Zhang, Shulin,Zhao, Yingren*,Chen, Tianyan*,Hepatic flare after telbivudine withdrawal and efficacy of postpartum antiviral therapy for pregnancies with chronic hepatitis B virus.Journal of Gastroenterology and Hepatology,2017.1.01,32(1):177~183

  5. Liu Jinfeng#(第一作者),Feng Yuling#, Wang Jing, Li Xuelan, Lei Chunmei, Jin Dongfang, Feng Weihong, Yang Yuan, He Yingli, Li Yuanyuan, Du Dan, Zhang X, Jin Li, Yan Taotao, Chen Tianyan*, Zhao Yingren*.An "immune barrier" is formed in the placenta by hepatitis B immunoglobulin to protect the fetus from hepatitis B virus infection from the mother. Human Vaccines & Immunotherapeutics. 2015;11(8):2068-76.

  6. Wang Jing#,Liu Jinfeng#(第一作者),Qi Caijing, Yan Taotao, Cao Furong, Jin Li, He Yingli, Yang Yuan, Zhang Shulin, Chen Tianyan*,Zhao Yingren*. Efficacy of tenofovir disoproxil fumarate to prevent vertical transmission in mothers with lamivudine-resistant HBV. Antivir Ther.2015;20(7):681-7.

  7. Liu, Jinfeng(第一作者);Henao-Mejia Jorge;Liu,Hao;*Zhao,Yingren;*He JohnnyJ.;Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.Journal of Neuroimmune Pharmacology,2011,6(2):308-21.

  8. Liu, Jinfeng(第一作者);Li, Yongqin; Chen, Tianyan; Yang, Yuan; Wang, Ke; He, Yingli; Yang, Qian; Ye, Feng; Jin, Yan; Qiu, Ting; Lin, Shumei; Liu, Min; Zhao, Yingren*,The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis,Archives of Virology, 2008, 153(11): 2157-2161.

  9. Yu Zhang, Hongli Liu, Ruitian Yi, Taotao Yan; Yingli He; Yingren Zhao*,Jinfeng Liu*(通讯作者).Hepatitis B virus whole-X and X protein play distinct roles in HBV-related hepatocellular carcinoma progression. Journal of Experimental & Clinical Cancer Research. Journal of Experimental& Clinical Cancer Research. 2016,35(7):87.

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