屈秋民，医学博士，主任医师、二级教授。博士研究生导师，第一附属医院神经内科主任
研究领域（方向）
（1）认知障碍，（2）帕金森病
个人及工作简历
1981.09-1986.06 西安医科大学医疗系本科学习
1986.06-1993.05 西安医科大学第一附属医院神经内科住院医师
1993.06-1997.09 西安医科大学第一附属医院神经内科主治医师
1996.06-1997.06 日本医科大学第二内科研修
1997.10-2005.12 西安交通大学第一附属医院神经内科副主任医师
1998.09-2002.10 西安交通大学第一附属医院神经内科研究生
2002.10-2004.03 日本北海道大学医学部攻读博士学位
2005.02-2006.03 美国加州大学洛杉矶分校（UCLA）博士后研究
2006.01-至今 西安交通大学第一附属医院神经内科主任医师
2010.12-至今 西安交通大学第一附属医院神经内科教授
科研项目
(1) 石药集团恩必普药业有限公司横向课题：丁苯酞治疗迟发性卒中后认知障碍的有效性和安全性：一项为期 24 周的随机病例对照研究，2020-01至2023-12，152.25万元，主持。
(2) 西安交通大学第一附属医院临床研究课题重点项目，XJTU1AF-CRF-2018-004，慢性脑血流灌注不足对脑内β淀粉样蛋白沉积的影响及其与类淋巴系统功能的关系：一项前瞻性、非随机、自身对照研究，2019-01至2022-12，50.00万元，主持。
(3) 齐鲁制药有限公司横向课题，艾地苯醌对轻度阿尔茨海默病患者脑葡萄糖代谢的影响：一项12周随机、双盲、安慰剂对照研究，2018-08至2020-12，24.28万元，主持。
(4) 陕西省重点研发计划，2018ZDXM-SF-052，西安市农村中老年人认知功能障碍队列研究，2018-07至2021-06，30.00万元，主持。
(5) 石药集团恩必普药业有限公司横向课题，多奈哌齐联合丁苯酞治疗对轻-中度阿尔茨海默病患者脑葡萄糖代谢及Aβ沉积的影响：一项为期48周的随机病例对照研究，2018-03至2020-12，30.00万元，主持。
(6) 国家自然科学基金面上项目，81771168，糖尿病引起AQP4错位分布的分子机制及其对Aβ清除的影响，2018-01至2021-12，54.00万元，主持。
学术及科研成果、专利、论文
(1) Shang S†, Liu Z†, Gao J, Wang J, Lu W, Fei Y, Zhang B, Mi B, Li P, Ma L, Jiang Y, Chen Ch, Dang L, Liu J andQu Q*. The Relationship Between Pre-existing Coronary Heart Disease and Cognitive Impairment Is Partly Explained by Reduced Left Ventricular Ejection Fraction in the Subjects Without Clinical Heart Failure: A Cross-Sectional Study. Front. Hum. Neurosci. 16:835900.
(2) Wang J†,Gao Ling†, Liu J, Lu W, Dang L, Wei S, Hu N, Gao Y, Peng W, Shang S, Huo K, Wang J,Qu Q*. High level of plasma amyloid-β1-42is associated with significant cognitive decline: a two years follow-up study in Xi’an rural area. Clinical Interventions in Aging 2022:17 555-65.
(3) Gao L#,Dang L#, Wei S, Hu N, Gao F, Peng W, Shang S,Zhao Y, Chen C, Guo X, Huo K, Wang J, Wang J*andQu Q*. Peripheral Transport Proteins Were Associated with 4-Year Cognitive Decline in APOEε4 Non-Carriers: A Longitudinal, Population-Based Study.J Alzheimers Dis.2022; 86: 801-12.
(4) Wang Y†, Wei S†, Zhou R, Shang S, Dang L, Gao L, Chen C, Huo K, Wang J, Wang J* andQu Q*. The Relationships Between Lipid Accumulation Product Levels and Cognitive Decline Over 4 Years in a Rural Area of Xi’an, China.Front. Aging Neurosci. 2021;13: 761886.
(5) Wei S#, Shang S#, Dang L, Gao F, Gao Y, Gao L, Chen C, Huo K, Wang J, Wang J*andQu Q*. Blood triglyceride and high-density lipoprotein levels are associated with plasma amyloid-β transport: a population-based cross-sectional study.J Alzheimers Dis.2021; 84: 303-14.
(6) She M†, Shang S†, Hu N, Chen C, Dang L, Gao L, Wei S, Huo K, Wang J, Wang J*andQu Q*. Blood Pressure Level Is Associated With Changes in Plasma Ab1-40 and Ab1-42 Levels: A ross-sectional Study Conducted in the Suburbs of Xi’an, China.Front. Aging Neurosci.2021; 13: 650679
(7) Wang J, Guo X, Lu W, Liu J, Zhang H, Quan Q, Su H, Ma L, Gao F,Qu Q*. DL-3-n-butylphthalide delays cognitive decline in patients with mild to moderate Alzheimer's disease already receiving donepezil: a multicenter, prospective cohort study.J Alzheimers Dis.2021; 80(1): 1-9.
(8) Gao Y#, Wei S#, Gao F, Gao L, Dang L, Shang S, Chen C, Huo K, Wang J, Wang J*andQu Q*. Sleep disturbance is associated with higher plasma Aβ levels-A population-based cross-sectional study.Front. Aging Neurosci.2020; 12: 615838
(9) Gao L#, Wang J#, Jiang Y, Wei S, Shang S, Chen C, Dang L, Huo K, Deng M, Wang J,Qu Q*. Relationship Between Peripheral Transport Proteins and Plasma Amyloid-β in Patients with Alzheimer’s Disease Were Different from Cognitively Normal Controls: A Propensity Score Matching Analysis.J Alzheimers Dis.2020; 78(2): 699-709.
(10) Gao F, Shang S, Chen C, Dang L, Gao L, Wei S, Wang J, Huo K, Deng M, Wang J and Qu Q*. Non-linear Relationship Between Plasma Amyloid-β 40 Level and Cognitive Decline in a Cognitively Normal Population.Front. Aging Neurosci. 2020; 12: 557005
(11) Wei S, Gao L, Jiang Y, Shang S, Chen C, Dang L, Wang J, Huo K, Wang J, Zhang R,Qu Q*. The Apolipoprotein Eε4 Allele-Dependent Relationship Between Serum Lipid Levels and Cognitive Function: A Population-Based Cross-sectional Study.Front. Aging Neurosci.2020; 12: 44.
(12) Liu P#, Zhao B#, Wei M, Li Y, Liu J, Ma L, Shang S, Huo K, Wang J, Li R,Qu Q*. Activation of Inflammation is Associated with Aβ Accumulation Induced by Chronic Sleep Restriction in Rats.J Alzheimers Dis.2020; 74(3): 759-73.
(13) Wei S#, Gao L#, Jiang Y, Shang S, Chen C, Dang L, Zhao B, Zhang J, Wang J, Huo K, Wang J, Zhang R,Qu Q*. Apolipoprotein E ε4 Allele is Associated With Plasma Amyloid Beta and Amyloid Beta Transporter Levels: A Cross-sectional Study in a Rural Area of Xi'an, China.Am J Geriatr Psychiatry. 2020; 28(2): 194-204.
(14) Hu N#, Gao L#, Jiang Y, Wei S, Shang S, Chen C, Dang L, Wang J, Huo K, Deng M, Wang J,Qu Q*. The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study.Lipids Health Dis.2020; 19(1): 8.
(15) Zhao B#, Liu P#, Wei M, Li Y, Liu J, Ma L, Shang S, Jiang Y, Huo K, Wang J,Qu Q*. Chronic Sleep Restriction Induces Aβ Accumulation by Disrupting the Balance of Aβ Production and Clearance in Rats.Neurochem Res. 2019; 44(4): 859-73..
(16) Zhao B#, Shang S#, Li P, Chen C, Dang L, Jiang Y, Wang J, Huo K, Deng M, Wang J,Qu Q*. The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi'an, China.Lipids Health Dis.2019; 18(1): 4.
(17) Piao XY, Li W, Li Z, Zhang N, Fang H, Zahid D,Qu Q*. Forced FoxO1:S249V expression suppressed glioma cell proliferation through G2/M cell cycle arrests and increased apoptosis.Neurol Res.2019; 41(2): 189-98.
(18) An Q, Chen Z, Huo K, Su H,Qu QM*. Risk factors for ischemic stroke post bone fracture.J Clin Neurosci.2019; 59: 224-8.
(19) Zhang M#, Deng YN#, Zhang JY, Liu J, Li YB, Su H, Qu QM*. SIRT3 protects rotenone induced injury in SH-SY5Y cells via promoting autophagy through LKB1-AMPK-mTOR pathway.Aging Dis.2018; 9(2): 273-86.
(20) Jiang Y#, Shang S#, Li P, Chen C, Dang L, Wang J, Huo K, Deng M, Wang J, Qu Q*. Pulse Pressure Is Associated With Plasma Amyloid-β Transport Dysfunction.J Hypertens.2018; 36(3): 569-79.
(21) Wang J, Qiao F, Shang S, Li P, Chen C, Dang L, Jiang Y, Huo K, Deng M, Wang J,Qu Q*. Elevation of Plasma Amyloid-β Level is More Significant in Early Stage of Cognitive Impairment: A Population-Based Cross-Sectional Study.J Alzheimers Dis. 2018; 64(1): 61-9.
(22) Gao L#, Jiang Y#, Wei S, Shang S, Li P, Chen C, Dang L, Wang J, Huo K, Deng M, Wang J, Zhang R,Qu Q*. The Level of Plasma Amyloid-β40Is Correlated with Peripheral Transport Proteins in Cognitively Normal Adults: A Population-Based Cross-Sectional Study.J Alzheimers Dis. 2018; 65(3): 951-61.
(23) LiY#, Shang S#, Fei Y, Chen C, Jiang Y, Dang L, Liu J, Ma L, Wei M, Qu Q*. Interaction of Obesity and Type 2 Diabetes to Cognitive Impairment：A Cross-Sectional Study in a Rural Area of Xi'an, China.J Diabetes Complications. 2018; 32(1): 48-55.
(24) PiaoX, Wu G, Yang P, Shen J, De A, Wu J,Qu Q*. Association between Homocysteine and Cerebral Small Vessel Disease: A Meta-Analysis.J Stroke Cerebrovasc Dis. 2018; 27(9): 2423-30.
(25) Cao H, Wang R, Luo X, Li X, Hallett M, Thompson-Westra J, Yang J,Qu Q*, Yang X. A Voxel-Based Magnetic Resonance Imaging Morphometric Study of Cerebral and Cerebellar Gray Matter in Patients Under 65 Years with Essential Tremor.Med Sci Monit. 2018; 24: 3127-35.
(26) Wei M#, Zhao B#, Huo K, Deng Y, Shang S, Liu J, Li Y, Ma L, Jiang Y, Dang L, Chen C, Wei S, Zhang J, Yang H, Gao F,Qu Q*. Sleep Deprivation Induced Plasma Amyloid-β Transport Disturbance in Healthy Young Adults.J Alzheimers Dis. 2017; 57(3):899-906.
(27) Ma LY, Lv YL, Huo K, Liu J, Shang SH, Fei YL, Li YB, Zhao BY, Wei M, Deng YN,Qu QM*. Autophagy-lysosome dysfunction is involved in Aβ deposition in STZ-induced diabetic rats.Behav Brain Res.2017; 320: 484-93.
(28) Fei YL, Lv HJ, Li YB, Liu J, Qian YH, Yang WN, Ma KG, Li HB,Qu QM*. Tongxinluo improves the cognition by reducing β-amyloid accumulation in spontaneous hypertensive rats.Brain Res.2017; 1663: 151-60.
(29) MaLY, Fei YL, Wang XY, Wu SD, Du JH, Zhu M, Jin L, Li M, Li HL, Zhai JJ, Ji LP, Ma RR, Liu SF, Li M, Ma L, Ma XR, Qu QM*, Lv YL. The Research on the Relationship of RAGE, LRP-1, and Aβ Accumulation in the Hippocampus, Prefrontal Lobe, and Amygdala of STZ-Induced Diabetic Rats.J Mol Neurosci. 2017; 62:1-10.
(30) Liu J#, Shang S#, Li P, Deng M, Chen C, Jiang Y, Dang L,Qu Q*. Association between current smoking and cognitive impairment depends on age: A cross- sectional study in Xi'an, China.Med Clin(Barc).2017; 149(5): 203-8..
(31) Ma Q, Liu Y, Shang L, Yu J,Qu Q*. The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma.Oncol Rep. 2017; 38(6): 3367-75.
(32)CaoH, Shi J, Cao B, Kang B, Zhang M,Qu Q*.Evaluation of the Braak staging of brain pathology with1H-MRS in patients with Parkinson’s disease.Neuroscience Letters. 2017; 660: 57-62.
联系方式
电子邮箱：quqiumin@xjtufh.edu.cn
联系电话：029-85324083
个人主页：
联系地址：西安市雁塔西路277号西安交通大学第一附属医院神经内科
