研究领域(方向)
(1)胃癌,(2)结直肠癌,(3)整合素,(4)肿瘤转移与靶向治疗,(5)微创外科
个人及工作简历
外科学博士,美国加州大学博士后,美国加州大学Moores癌症中心高级访问学者,副教授,博士研究生导师,指导硕士生6人,博士生5人。
2023年度陕西省“青年科技新星”人才,入选西安交通大学第一附属医院首届“优青培育”计划、优秀教师。担任中国抗癌协会肿瘤胃肠病学专委会青年联盟副主任委员,美国癌症研究协会AACR会员,陕西省医师协会结直肠肛门外科分会委员,陕西省抗癌协会软组织肿瘤和肉瘤专委会委员。
主持国家自然科学基金2项,获中国博士后科学基金特别资助、一等资助,陕西省博士后科学基金一等资助。担任SCI期刊《Military Medical Research》科学编辑,《Frontiers in Oncology》客座主编。以第一或通讯作者发表医学SCI期刊论文20余篇,获省级高等学校科学技术奖本科高校类一等奖,合译临床专著1部。
科研项目
近5年主持国家级及省部级课题7项,校级课题2项
(1)国家自然科学基金面上项目 (82073271)
(2)国家自然科学基金青年基金 (81702362)
(3)中国博士后科学基金特别资助 (2019T120922)
(4)中国博士后科学基金一等资助 (2018M631176)
(5)陕西省博士后科学基金一等资助(2018BSHYDZZ49)
(6)陕西省创新人才攀登工程 (2023SR5078)
学术及科研成果、专利、论文
作为第一/通讯作者发表SCI论文18篇。
1) Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis. Journal of Clinical Investigation. 2018;128(1):531-544
(IF: 19.46,JCR Q1,Feature Article “亮点文章”)
2) Pontin Acts as a Potential Biomarker for Poor Clinical Outcome and Promotes Tumor Invasion in Hilar Cholangiocarcinoma. Biomed Res Int. 2018 May 13;2018:6135016
3) Combined Bcl-2/Src inhibition synergize to deplete stem-like breast cancer cells. Cancer Letters. 2019 Aug 10;457:40-46 (IF: 9.76,JCR Q1)
4) Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin β6 Upregulation in Colorectal Cancer. Oxid Med Cell Longev. 2020 Aug 13;2020:8032187 (IF: 7.31)
5) Integrin αvβ6 predicts poor prognosis and promotes resistance to cisplatin in hilar cholangiocarcinoma. Pathol Res Pract. 2020 Jul;216(7):153022
6) Development of a novel autophagy-related gene prognostic signature for gastric cancer. Transl Cancer Res. 2021 Jun;10(6):2790-2800
7) Stem-like breast cancer cells in the activated state resist genetic stress via TGFBI-ZEB1. NPJ Breast Cancer. 2022 Jan 13;8(1):5
(IF: 7.52,JCR Q1,Nature合作期刊)
8) Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway. Cells. 2022 Jun 30;11(13):2078 (IF: 7.67)
9) Development and Validation of a 6-Gene Hypoxia-Related Prognostic Signature For Cholangiocarcinoma. Front Oncol. 2022 Jul 18;12:954366 (IF: 6.2)
10) Comprehensive analysis of the prognostic value and immune infiltration of FGFR family members in gastric cancer. Front Oncol. 2022 Sep 6:12:936952(IF: 6.2)
11) Expression of Integrin β6 and HAX-1 Correlates with Aggressive Features and Poor Prognosis in Esophageal Squamous Cell Carcinoma. Cancer Manag Res. 2020 Oct 2;12:9599-9608
12) Integrin β6 deficiency protects mice from experimental colitis and colitis-associated carcinoma by altering macrophage polarization. Front Oncol. 2023 May 8;13:1190229(IF: 5.7)
13) Breast cancer stem cells tolerate chromosomal instability during tumor progression via c-Jun/AXL stress signaling. Heliyon. 2023 Sep 14;9(9):e20182(Cell旗下期刊)
14) Integrated Multi-omics Analyses Identify CDCA5 as a Novel Biomarker Associated with Alternative Splicing, Tumor Microenvironment, and Cell Proliferation in Colon Cancer Via Pan-cancer Analysis. J Cancer. 2024 Jan 1;15(3):825-840
15) Development of fatty acid metabolism score based on gene signature for predicting prognosis and immunotherapy response in colon cancer. Clin Transl Oncol. 2024 Mar;26(3):630-643
16) Expression patterns of E2Fs identify tumor microenvironment features in human gastric cancer. PeerJ. 2024 Feb 13;12:e16911
17) Integrative Multiomics Profiling Unveils the Protective Function of Ulinastatin against Dextran Sulfate Sodium-Induced Colitis. Antioxidants. 2024 Feb 8;13(2):214(IF: 7.0,最具学术影响力期刊)
18) Comprehensive analysis reveals TSPEAR as a prognostic biomarker in colorectal cancer. J Cancer. 2024 Jan 1;15(3):809-824
联系方式
电子邮箱:sunqi4875@163.com
联系电话:15529608720
个人主页:http://www.en.jdyfy.com/info/1011/2767.htm
联系地址:陕西省西安市雁塔西路277号西安交通大学第一附属医院外科大楼8楼