寇博


*个人及工作简历

2003/09-2008/07,西安交通大学医学院,医学和英语翻译双学士

2008/09-2010/07,西安交通大学医学院,肿瘤学硕士

2010/09-2014/12,西安交通大学医学院,肿瘤学博士

2015/03-2017/12,西安交通大学第一附属医院心血管外科,助理研究员

2016/05-至今,西安交通大学管理学院,在职博士后

2018/01-至今,西安交通大学第一附属医院心血管外科,副研究员

*研究领域(方向

1、细胞自噬与肿瘤侵袭迁移的分子机制

2、医疗大数据研究

*科研项目

1、国家自然科学基金青年科学基金项目,81602562, mTOR介导的细胞自噬在粉防己碱抗前列腺癌侵袭迁移的作用机制研究,2017/01-2019/12,17万元,在研,主持

2、陕西省国际科技合作与交流计划,2017KW-063,mTOR介导的细胞自噬在粉防己碱抗前列腺癌侵袭迁移的作用机制研究,2018/01-2020/12,4.5万,在研,主持

3、西安交通大学校基金,1191329722,基于大数据方法的肿瘤科临床管理研究,2016/01-2019/01,12万,在研,主持

4、西安交通大学第一附属医院院基金2015YK17,粉防己碱通过调控mTOR介导的细胞自噬抑制前列腺癌侵袭转移的分子机制研究,2016/01-2019/01,2.5万,在研,主持

*学术集科研成果、专利、论文

[1] Kou BGao YDu CShi QXu SWang CQWang XYHe DLGuo P. miR-145 inhibits invasion of bladder cancer cells by targeting PAK1. Urol Oncol2014326):846-854. (IF: 3.7669)

[2] Kou BoLiu WeiHe WenboZhang YuanyuanZheng JianjjieYan YangZhang YongjianXu SuochunWang Haichen. Tetrandrine suppress metastatic phenotype of prostate cancer cells by regulatine Akt/MTOR/MMP-9 signaling pathway. ONCOL REP. 2016, 35 (5): 2880-2886. (一作) (IF:2.662

[3] Bo Kou, Wei Liu, Xu Xu, Yang Yang, Qiuyue Yi, Fengwei Guo, Jianpeng Li, Jinsong Zhou, Qingshan Kou. Autophagy induction enhances tetrandrine-induced apoptosis via AMPK/mTOR pathway in human bladder cancer cells. ONCOL REP. 2017, 38 (5): 3137-3143. (IF: 2.662

[4] Bo Kou, Wei Liu, Wei Zhao, Peng Duan, Yang Yang, Qiyue Yi, Fengwei Guo, Jianpeng Li, Jinsong Zhou, Qingshan Kou. Thymoquinone inhibits epithelial-mesenchymal transtition in prostate cancer cells by negatively regulating TGF-β/smad2/3 signaling pathway. ONCOL REP. 2017, 38 (6): 3592-3598.(IF: 2.662

[5] Bo Kou, Wei Liu, Xiaoshuang Tang, Qingshan Kou.HMGA2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating TGF-β/Samd2 signaling pathway. ONCOL REP. 2018, 39(1): 101-108. (IF: 2.662

[6] Bo Kou, Wei Liu, Bo Ma, Jing Zhang, Borui Sun, Yang Yang, Jianpeng Li, Jinsong Zhou, Qingshan Kou. Thymoquinone inhibits metastatic phenotype and epithelial-mesenchymal transition in renal cell carcinoma by regulating LKB1/AMPK signaling pathway. ONCOL REP. 2018, 40(3): 1443-1450. (IF: 2.662

[7] Zhang Yongjian Liu Wei He Wenbo Zhang YuanyuanDeng XiulingMa YanminZeng JinKou Bo. Tetrandrine reverses epithelial-mesenchymal transition in bladder cancer by downregulating Gli-1. INT J ONCOL. 2016, 48 (5): 2035-2042. IF:3.079

[8] Lv Ming, Kou Bo, Zhou Zhili, He Wenbo. A mathematical optimization model for efficient assignment of inpatients in an oncology center in China. JBUON. 2017, 22(3):790-800.  (IF:1.344)

[9]Yang Yan, Bo Kou, Luqin Yan. Thread-based microfluidic three channel device in combination with thermal lens detection for the determination of copper and zinc. Analytical Methods. 2015, 7: 8757-8762. (IF: 1.9)

[10] Liu WeiKou BoMa Zhen-KunTang Xiao-ShuangLv ChuanYe MinChen Jia-QiLi LeiWang Xin-YangHe Da-Lin. Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion in human prostate cancer cells. Asian J Androl2015175):850-853.IF:2.996

[11] Lv Ming, Li Yi, Kou Bo, Zhou Zhili. Integer programming for improving radiotherapy treatment efficiency. Plos One, 2017, 12(7): e0180564. IF: 2.806

出版刊物:

HISTOCHEMISTE,德国得古意特+西安交通大学出版,2017-08-01,ISBN号978-3-11-052482,副主编。

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