秦思达

    *研究领域（方向）：肺癌的临床与转化性研究。

*科研项目 主持课题：

1.国家自然科学基金：去泛素酶OTUD7B抑制Smac类似物介导的肺癌细胞侵袭转移的实验研究。

2.院基金项目：LCL161激活NK细胞增敏派姆单抗治疗 肺癌的作用及机制研究。

3.院临床研究项目：NAR对NSCLC患者预后评估的多中心前瞻性队列研究。

第二负责人参与课题：

1.国家自然科学基金：FoxF1/整合素αvβ3正反馈环路介导非小细胞肺癌EGFR-TKI继发耐药的机制研究。

2.陕西省国际科技合作与交流计划：MiR-367通过FBXW7调控NSCLC恶性进展的作用及其机制研究。

3.院基金项目：CDK4/6抑制剂在肺癌干细胞中抗肿瘤作用及其免疫机制的研究。

1. *学术集科研成果、专利、论文Guodong Xiao, Xiao Gao, Xin Sun, Chengcheng Yang, Boxiang Zhang, RuiYing Sun, Guanghong Huang, Xiang Li, Jian Liu, Ning Du, Dapeng Liu, Rui Liang, Hong Ren,Sida Qin*.miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC. Oncol Rep. 2017;38(2):1190-1198.

2. Guanghong Huang, Xin Sun, Dapeng Liu, Yunfeng Zhang, Boxiang Zhang, Guodong Xiao, Xiang Li, Xiao Gao, Chenhao Hu, Meng Wang, Hong Ren,Sida Qin*.The efficacy and safety of anti-PD-1/PD-L1 antibody therapy versus docetaxel for pretreated advanced NSCLC: a meta-analysis. Oncotarget. 2017;9(3):4239-4248.

3. Chengcheng Yang, Huangzhen Wang, Boxiang Zhang, Yimeng Chen, Yamin Zhang, Xin Sun, Guodong Xiao, Kejun Nan, Hong Ren,Sida Qin*. LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC. J Exp Clin Cancer Res. 2016 Sep 30;35(1):158-175.

4. Sida Qin, Chengcheng Yang, Boxiang Zhang, Xiang Li, Xin Sun, Gang Li, Jing Zhang, Guodong Xiao, Xiao Gao, Guanghong Huang, Peili Wang, Hong Ren. XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC. Int J Oncol. 2016 Oct;49(4):1289-96.

5. Sida Qin, Boxiang Zhang, Guodong Xiao, Xin Sun, Gang Li, Guanghong Huang, Xiao Gao, Xiang Li, Huangzhen Wang, Chengcheng Yang, Hong Ren. Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation. Tumour Biol. 2016 Oct;37(10):13509-13520.

6. Boxiang Zhang, Huangzhen Wang, Litao Yang, Yiwen Zhang, Peili Wang, Guanghong Huang, Jie Zheng, Hong Ren,Sida Qin*. OTUD7B and NIK expression in non-small cell lung cancer: Association with clinicopathological features and prognostic implications. Pathol Res Pract. 2016 Oct;212(10):893-898.

7. Sida Qin,Chongwen Xu, Shuo Li, Chengcheng Yang, Xin Sun, Xifang Wang, Shou-ching Tang, Hong Ren. Hyperthermia induces apoptosis by targeting Survivin in esophageal cancer[J]. Oncology reports, 2015, 34(5): 2656-2664.

8. Sida Qin,Chongwen Xu, Shuo Li, Xifang Wang, Xin Sun, Peili Wang, Boxiang Zhang, Hong Ren. Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3[J]. Molecular medicine reports, 2015, 11(6): 4694-4700.

9. Sida Qin,Chengcheng Yang, Xifang Wang, Chongwen Xu, Shuo Li, Boxiang Zhang, Hong Ren. Overexpression of Smac promotes cisplatin induced apoptosis by activating caspase-3 and caspase-9 in lung cancer A549 cells[J]. Cancer Biotherapy and Radiopharmaceuticals, 2013, 28(2): 177-182.

10. Sida Qin, Chengcheng Yang, Shuo Li, Chongwen Xu, Yang Zhao, Hong Ren. Smac: Its role in apoptosis induction and use in lung cancer diagnosis and treatment[J]. Cancer Letters. 2012, 318(1):9-13.

电子邮箱：qinsida@xjtu.edu.cn

联系地址：陕西省西安市雁塔西路277号