研究领域（方向）：
个人及工作简历（个人受教育及工作经历）：
教育经历：
工作经历：
主要科研项目
项目名称：基于噬菌体尾丝蛋白Gp50靶向作用的抗菌药物构建及其对鲍曼不动杆菌的抑制作用研究，项目编号：82473817；起止日期：2025.01-2028.12；基金来源：国家自然科学基金-面上项目。
项目名称：Cas5关键磷酸化位点对白色念珠菌细胞壁压力应激通路的调控作用及机制研究，项目编号：81903733；起止日期：2020.01-2022.12；基金来源：国家自然科学基金-青年项目。
项目名称：Cas5介导的白色念珠菌细胞壁应激关键蛋白结构作用研究，项目编号：2018M643675；起止日期：2019.01-2020.12；基金来源：中国博士后科学基金-面上项目。
项目名称：白色念珠菌细胞壁完整性调控因子Cas5蛋白的结构解析，项目编号：2019JQ-954；起止日期：2019.01-2020.12；基金来源：陕西省自然科学基础研究计划一般项目青年项目。
项目名称：组蛋白去乙酰化酶Sir2介导白色念珠菌细胞壁重塑调控其与宿主间相互作用及机制研究，项目编号：xzy012023096；起止日期：2023.01-2025.12;基金来源：基本科研业务费。
学术及科研成果、专利、论文
近5年，发表论文
[1] Wenhui Bai, Yanmei Wang, Jia Ma, Guanglin Li, Yuchen Wang, Chen Yang, Qiyue Zhang, Qingqing Li, Jiye Zhang,Peipei Zhang*. Histone deacetylase Hos1 promotes the homeostasis of Candida albicans cell wall and membrane and its specific inhibitor has an antifungal activity in vivo.Microbiological Research. 2025,269:128132.
[2]Menghan Wang, Ying Yang, Dongdong Li, Yanmei Wang, Tailin Ji, Qingqing Li, Jiye Zhang,Peipei Zhang*, Jin Su*. Miconazole-splitomicin combinedβ-glucan hydrogel for effective prevention of Candida albicans periprosthetic joint infection.European Journal of Pharmaceutical Sciences.2025,204:106955.
[3] Chen Yang; Guanglin Li; Qiyue Zhang; Wenhui Bai; Qingqing Li;Peipei Zhang*; Jiye Zhang*; Histone deacetylase Sir2 promotes the systemic Candida albicans infection by facilitating its immune escape via remodeling the cell wall and maintaining the metabolic activity,Mbio.2024 Apr 29:e0044524.
[4]Peipei Zhang, Xiaohui Zhao, Yawen Wang, Ke Du, Zhihao Wang, Jianfeng Yu, Gang Chang, Steve Matthews, Hongliang Wang, Bing Liu. Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins.Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2022, 119 No. 9e2116278119.
[5]Peipei Zhang, Zhihao Wang, Yawen Wang, Steve Matthews, Ling Lan, Bing Liu. 1H, 13C and 15N NMR assignments of Bacillus subtilis bacteriophage SPO1 protein Gp46.Biomolecular NMR Assignments.2019,13(1):245-247
[6] Fei Mo,Peipei Zhang, Qingqing Li, Xianwei Yang, Jia Ma, Jiye Zhang. Development and evaluation of a film forming system containing myricetin and miconazole nitrate for preventing Candida albicans catheter-related infection.Microbial Drug Resistance. 2022. Accepted.
[7] Qingqing Li, Xiaofeng Yang,Peipei Zhang, Fei Mo, Peiru Si, Ximeng Kang, Menghang Wang, Jiye Zhang. Dasatinib loaded nanostructured lipid carriers for effective treatment of corneal neovascularization.Biomaterials Science. 2021,9(7):2571-2583.
[8] Fei Mo, Jia Ma, Xiaofeng Yang,Peipei Zhang, Oingqing Li, Jiye Zhang. In vitro and in vivo effects of the combination of myricetin and miconazole nitrate incorporated to thermosensitive hydrogels on C. albicans biofilms.Phytomedicine.2020,71(6):153223.
[9] Huihui Fan,Peipei Zhang, Li Zhou, Fei Mo, Zhen Jin, Jia Ma, Rong Lin, Jiye Zhang. Naringin-loaded polymeric micelles as buccal tablets: formulation, characterization, in vitro release, cytotoxicity and histopathology studies.Pharmcolocy and pharmacy. 2020,25(5):547-555.
[10] Fei Mo, Jia Ma,PeipeiZhang, Dawei Zhang, Huihui Fan, Xiaofeng Yang, Liqing Zhi, Jiye Zhang. Solubility and thermodynamic properties of baicalein in water and ethanol mixtures from 283.15 to 328.15 K.Chemical Engineering Communications, 2021, 208(2): 183-196.
[11] Jin Su, Jia Ma, Fei Mo, Xiaofeng Yang,PeipeiZhang, Jiye Zhang. Thermosensitive hydrogels as a controlled release system for alkannin to improve localized treatment of Candida vaginitis after external beam radiotherapy in vitro and in vivo.Pathogen and Disease, 2019, 77(4): ftz041.
[12] Zhihao Wang, Hongliang Wang, Mulvenna Nancy, anz-Hernandez Maximo;Peipei Zhang, Yanqing Li, Jia, Yawen Wang, Matthews Steve, Wigneshweraraj Sivaramesh, Bing Liu.A Bacteriophage DNA Mimic Protein Employs a Non-specific Strategy to Inhibit the Bacterial RNA Polymerase.Frontiers in microbiology, 2021, 12:692512.
专利
Bing Liu; Denghui Liu; Xin Wang;Peipei Zhang; Yawen Wang; Chi Xu; Nan Qiao; Use ofbelinostat or pharmaceutically acceptable salt thereof in preparation of drug for treating infection, 2023-11-28,美国, 17/860,889 (专利)
李清清;张继业;马骁;康曦萌;雷佳星;杨晨;张沛沛;王飞飞;一种抑制瘢痕形成的水凝胶组合物及其制备方法与应用, 2023-11-28,中国, CN202210314579.3 (专利)
张继业;莫菲;张沛沛;李清清;杨显伟;马佳;苏进;一种预防经皮置管导管外表面感染的联合杨梅素/唑类药物的涂膜剂及其应用, 2022-8-16,中国, ZL202110114115.3 (专利)
联系方式
电子邮箱：peipei2018@xjtu.edu.cn.
个人主页：
联系地址：陕西省西安市西咸新区西安交通大学创新港校区泓仁楼21-1042室
