2009.05—2015.01 德国马普所，分子药理学，博士 导师：Stefan Offermanns(院士)； Ingrid Fleming(院士)
2006.09—2009.04 西安交通大学，药理学，硕士导师：臧伟进(教授，博导)
2002.09—2006.05 西安交通大学，药学专业，学士
工作经历
2019.05 至今 西安交大一附院，心内科，特聘教授
2017.09 至今 西安交通大学，医学部基础医学院，教授，博士生导师
2014.12—2018.03 德国马普院心肺所，博士后，Group leader，导师：Stefan Offermanns 院士
荣誉与获奖
1. 欧洲循环协会 ESM ，ESM-SERVIER 奖
2. 德国心脏协会，Dieter-Klaus-Forde 奖
3. 德国微循环及血管生物协会，Young Inverstigator Award
4. 北美血管生物协会，(NAVBO)-Del Vecchio 奖
科研项目
1. 国家自然科学基金，重点项目，主持.
2. 国家自然科学基金，面上项目，主持.
3. 国家自然科学基金，优秀青年项目，主持.
4. 陕西省科技创新团队，负责人
5. 科技部，战略科技发展类，主持.
6. 陕西省科学技术厅，陕西省杰出青年科学基金项目，主持.
7. 陕西省科学技术厅，陕西省重点项目，主持.
8. 西安交通大学“青年拔尖人才项目 A 类计划”，主持.
9. 德国 ECCPS 的青年项目，主持.
10. 德国科学基金会 DFG 重点项目，核心科学家（Core Scientist）.
代表性论文
1. Zhang Y, Sun Y, Xu G, Wu Y, Shi Z, Chang Z, Liu J, Pang K, Liu S, Wang H, Rong W, Shao Z, Liu X, He Y, Yan Y, Zhou B, Yuan Z, Zhang XF, Offermanns S, Wang S. Zonated mechanosensing by PIEZO1 controls liver regeneration. Science. 2026.
2. Cao Y, Xu L, Zhang M, Su A, Wang S, Li T, Liu S, Mao Z, He Y, Shao Z, Zhang J, Wang Y, Tian H, Sun Y, Li Y, Yan L, Zhang G, Sun S, Mei N, Chen F, Xiong Y, Liang G, Offermanns S, Yan Y, Yuan Z, Wang S. PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism. Cardiovasc Res. 2026.
3. Xu L, Li T, Cao Y, He Y, Shao Z, Liu S, Wang B, Su A, Tian H, Li Y, Liang G, Wang C, Shyy J,Xiong Y, Chen F, Yuan JX, Liu J, Zhou B, Wettschureck N, Offermanns S, Yan Y, Yuan Z, Wang S. PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice. J Clin Invest. 2025.
4. Xu L, Yang C, Pang K, Zhang Y, He Y, Liu S, Tian H, Shao Z, Wang S, Liu X, Li T, Cao Y, Yan L, Liu J, Wang Y, Li Y, Zhao W, Wang Y, Yan Y, Wang S. Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity. Mol Metab. 2025.
5. Chen X, Shao J, Brandenburger I, Qian W, Hahnefeld L, Bonnavion R, Cho H, Wang S, Hidalgo J,Wettschureck N, Geisslinger G, Gurke R, Wang Z, Offermanns S. FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes. Nat Commun. 2025.
6. Cho H, Lai CC, Bonnavion R, Alnouri MW, Wang S, Roquid KA, Kawase H, Campos D, Chen M, Weinstein LS, Martínez A, Looso M, Sanda M, Offermanns S. Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Science. 2025.
7. Jin YJ, Liang G, Li R, Wang S, Alnouri MW, Bentsen M, Kuenne C, Günther S, Yan Y, Li Y,Wettschureck N, Offermanns S. Phosphorylation ofendothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. Nat Cardiovasc Res. 2025.
8. Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S. SPMs exert anti- inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. Proc Natl Acad Sci U S A. 2024.
9. Liang G, Wang S, Shao J, Jin YJ, Xu L, Yan Y, Günther S, Wang L, Offermanns S. Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. Circ Res. 2022.
10. Wang S, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, Vestweber D, Offermanns S. Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood. 2022.
11. Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S. Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. J Clin Invest. 2021.
12. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation ofACE 2. Circ Res. 2021.
13. Wang L, Rice M, Swist S, Kubin T, Wu F, Wang S, Kraut S, Weissmann N, Böttger T, Wheeler M, Schneider A, Braun T. BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State. Circulation. 2021.
14. Xu L, Wettschureck N, Bai Y, Yuan Z, Wang S. Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice. J Hepatol. 2021.
15. Wang L, Wang S, Shi Y, Li R, Günther S, Ong YT, Potente M, Yuan Z, Liu E, Offermanns S. YAP and TAZ protect against white adipocyte cell death during obesity. Nat Commun. 2020.
16. Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, HonoréE, Offermanns S. Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun. 2020.
17. Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019.
18. Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I,Kruse C, Brandes RP. The polarity protein Scrib limits atherosclerosis development in mice. Cardiovasc Res. 2019.
19. Yin W, Kim HT, Wang S, Gunawan F, Li R, Buettner C, Grohmann B, Sengle G, Sinner D,
Offermanns S, Stainier DYR. Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. Eur Respir J. 2019.
20. Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, AlthoffTF,Offermanns S. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018.
21. Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J,Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR. The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 2018.
22. Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016.
23. Kwon HB, Wang S, Helker CS, Rasouli SJ, Maischein HM, Offermanns S, Herzog W, Stainier DY. In vivo modulation of endothelial polarization by Apelin receptor signalling. Nat Commun. 2016.
24. Wirth A, Wang S, Takefuji M, Tang C, AlthoffTF, Schweda F, Wettschureck N, Offermanns S. Age- dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling. Cardiovasc Res. 2016.
25. Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE,Fleming I, Lundberg JO, Wettschureck N, Offermanns S. P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction. J Clin Invest. 2015.
26. Sivaraj KK, Li R, Albarran-Juarez J, Wang S, Tischner D, Grimm M, Swiercz JM, Offermanns S, Wettschureck N. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015.
27. AlthoffTF, Albarrán Juárez J, Troidl K, Tang C, Wang S, Wirth A, Takefuji M, Wettschureck N,Offermanns S. Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J Exp Med. 2012.
学术活动
组织会议
1. 西安交通大学 2019 心血管高端研讨会组织委员会委员 西安，中国 (2019. 12).
邀请报告
1. Piezo1 感知血流剪切力的作用，2019 长安国际心血管会，西安，中国（invited talk, 2019.05）
2. Piezo1 对血流剪切力的感知机制研究，中国病理生理学会血管医学专业委员会第三届学术研讨会，上海，中国（invited talk, 2018. 11）
3. Piezo1 介导的钙信号在血管机械传导中的作用，第 12 届国际钙信号和细胞功能研讨会，沈阳，中国（invited talk, 2018.07）
4. Piezo1 and P2Y2 mediated mechanotransduction in endothelial flow sensing ，Max-Planck Symposium 2017 ，Berline ，Germany（invited talk, 2017. 10）
5. Mechanotransduction in vascular endothelial cells ，Perspective in Vascular Biology 2016 ，Frankfurt， Germany（invited talk ，2017.09）
6. P2Y2 mediated mechanosignalling in regualtion blood pressure,International Conference on Purinergic Signaling, Hamburg, Germany（invited talk ，2015.07）
