刘娜

研究领域（方向）

1.消化道肿瘤个体化诊治

2.胃肠动力障碍相关性疾病

3.慢性肝病无创监测

工作简历

2021-至今西安交通大学第二附属医院消化内科主任医师

2019-至今西安交通大学博士生导师

2017-2021 西安交通大学第二附属医院消化内科副主任医师、副教授

2004-2016西京医院消化内科主治医师、讲师

2014-2016瑞典林雪平大学博士后

2009年美国华盛顿大学、内布拉斯加大学医学中心访问学者

科研项目

1. 国家自然科学基金面上项目，No. 81872397，RhoB/Arl14小G蛋白中心功能聚合体通过Slit2/Robo1-Wnt/β-catenin通路轴调节大肠癌EMT，2019/01-2022/12，57万

2. 国家自然科学基金面上项目, No. 81370484，miR-92a在胃粘膜肠上皮化生中调控CDX2的作用机制研究，2014/01-2017/12，70万

3. 国家自然科学基金面上项目, No. 30973423,基于文库筛选的miR-483-3p介导c-Myc转录通路调控胃癌发生的新机制研究，2010/01-2012/12，31万

4. 国家自然科学基金青年项目，No. 30400535，小G蛋白RhoC调控胃癌转移的新机制研究，2005/01-2007/12，21万

学术及科研成果、专利、论文

现任中华医学会消化内镜分会儿科协作组委员、中国老年医学学会肿瘤分会副总干事、中国抗癌协会康复专业委员会委员、中国医师协会整合医学分会肿瘤专业委员会委员、陕西省预防学会消化专委会常委，陕西省医学会消化病分会青年委员会副主任委员等。发表SCI文章60篇，多个国际知名期刊审稿人，2008年作为主要完成人荣获国家科学技术进步一等奖1项。

1.Xie N, Bai Y, Qiao L, Bai Y, Wu J, Li Y, Jiang M, Xu B, Ni Z, Yuan T, Shi Y, Wu K, Xu F, Wang J, Dong L,Liu N(corresponding author).ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments. J Cell Mol Med, 2021 Apr;25(8):4014-4027.

2.Xie N, Pan Y, Wu J, Bai Y, Xiao C, Gao X, Wang J,Liu N(corresponding author).MicroRNA-302s might regulate ARL4C-mediated gastric cancer progression via p53 signaling: bioinformatics analysis and experiments validation. Onco Targets Ther, 2021 Apr 13;14:2541-2553.

3.Li Y, Qiao L, Bai Y, Xiao C, Wu J, Gao X, Qiao C, Shi Y, Hou W, Wang J, Xie N,Liu N(corresponding author).Identification of SRGAP2 as a Potential Oncogene and a Prognostic Biomarker in Hepatocellular Carcinoma. Life Sciences, 2021,doi.org/10.1016/j.lfs.2021.119592.

4.Wei ZC, Yang Q,Yang Q, Yang J,TantaiX, Xing X, Xiao CL, Pan YL,LiuN(corresponding author), Wang JH. Rome III, Rome IV, and Potential Asia Symptom Criteria for Functional Dyspepsia Do Not Reliably Distinguish Functional From Organic Disease. Clin and Transl Gastroenterol. 2020 Dec;11(12):e00278.DOI:10.14309/ctg.0000000000000278.

5.WeiZC,YangQ,YangJ,TantaiX, Xing X,XiaoCL,PanYL,WangJH,LiuN. Predictive value of alarm symptoms in patients with Rome IV dyspepsia: A cross-sectional study. World J of Gastroenterol. 2020 Aug;26(30):4523-4536.

6.Bai Y, Qiao L, Xie N, Li Y, Nie Y, Pan Y, Shi Y, Wang J, Liu N (corresponding author). TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer. Cancer Med. 2020 Feb;9(4):1503-1514. doi: 10.1002/cam4.2756. Epub 2019 Dec 31.

7.Tantai XX, Yang LB, Wei ZC, Xiao CL, Chen LR, Wang JH, Liu N (corresponding author). Association of proton pump inhibitors with risk of hepatic encephalopathy in advanced liver disease: A meta-analysis. World J Gastroenterol. 2019 Jun;25(21):2683-2698. doi: 10.3748/wjg.v25.i21.2683.

8.Qiao L, Xie N, Bai Y, Li Y, Shi Y, Wang J, Liu N (corresponding author). Identification of upregulated HNRNPs associated with poor prognosis in pancreatic cancer. BioMed Res Int. 2019 Jul;2019:5134050. doi: 10.1155/2019/5134050.

9.Liu N, Cui W, Jiang X, Zhang Z, Gnosa S, Ali Z, Jensen L, Jönsson JI, Blockhuys S, Lam EW, Zhao Z, Ping J, Xie N, Kopsida M, Wang X, Sun XF. The critical role of dysregulated RhoB signaling pathway in radio-resistance of rectal cancer. Int J Radiat Oncol Biol Phys. 2019 Apr 27. pii: S0360-3016(19)30653-4. doi: 10.1016/j.ijrobp.2019.04.021.

10.Wei Z, Liu N (corresponding author), Tantai X, Xing X, Xiao C, Chen L, Wang J. The effects of curcumin on the metabolic parameters of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Hepatol Int. 2018 Nov 16. doi: 10.1007/s12072-018-9910-x.

11.Tantai X, Yang L, Wei L, Xiao C, Chen L, Wang J, Liu N. Systematic Review with Meta-Analysis: Effects of Statins on the Hepatic Decompensation, Complications, Mortality and Drug Safety in Liver Cirrhosis. Gastroenterology, 154 (6) , S-1247. DOI: 10.1016/S0016-5085(18)34097-6（会议论文）

12.Kang X, Zhao L, Liu N (co-first author), Wang X, Zhang R, Liu Z, Liang S, Yao S, Tao Q, Jia H, Pan Y, Guo X.Activities in a social networking-based discussion group by endoscopic retrograde cholangiopancreatography doctors. Eur J Gastroenterol Hepatol. 2017 Oct;29(10):1131-1135.

13.Bai Y, Qiao L, Xie N, Shi Y, Liu N (corresponding author), Wang J. Expression and prognosis analyses of the Tob/BTG antiproliferative (APRO) protein family in human cancers. PLoS One. 2017 Sep 18;12(9):e0184902. doi: 10.1371/journal.pone.0184902. eCollection 2017

14.Liu N, Cox TR, Cui W, Homlund B, Ping J, Erler JT, Sun XF. Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients. Oncotarget. 2017;8(36):60015-60024.

15.Liu Q, Yao L, Xie H, Zhang DX, Zhang H, Guo C, Wu K, Liu N (corresponding author).High-resolution manometry and endoscopic ultrasonography are important for diagnosing congenital esophageal stenosis. J Dig Dis. 2015;16(8):479-82.

16.Zhang Z, Liu X, Feng B, Liu N (co-first author), Wu Q, Han Y, Nie Y, Wu K, Shi Y, Fan D. STIM1, a direct target of microRNA -185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer. Oncogene. 2015;34(37):4808-20.

17.Liu N, Pan Y, Li Z, Shi Y, Zhang X, Wu G, Wu K, Wang X. Neuromuscular and vascular hamartoma: a rare entity or special phase of Crohn's disease. J Dig Dis. 2015 Jan;16(1):52-4.

18.Liu N，Liu L, Zhang H, Gyawali CP, Zhang D, Yao L, Yang Y, Wu K, Ding J, Fan D. Effect of intravenous proton pump inhibitor regimens and timing of endoscopy on clinical outcomes of peptic ulcer bleeding. J of Gastroenterol Hepatol. 2012 Sep;27(9):1473-9.

19.Liu N, Zhang G, Bi F, Pan Y, Xue Y, Shi Y, Yao L, Zhao L, Zheng Y, Fan D.RhoC is essential for the metastasis of gastric cancer. J Mol Med. 2007 Oct;85(10):1149-56.

20.Liu N, Bi F, Pan Y, Sun L, Xue Y, Shi Y, Yao X, Zheng Y, Fan D.Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin Cancer Res. 2004 Sep;10(18 Pt 1):6239-47.

联系方式

电子邮箱：liunafmmu@163.com

个人主页：https://www.researchgate.net/profile/Na_Liu68

联系地址：西安交通大学第二附属医院消化内科