魏瑾

研究领域(方向)

心肌病、心衰;地方性心肌病(克山病);心脏康复治疗

个人及工作简历

1988年于西安交通大学医学部本科毕业后,留校在二附院心内科工作至今,1999年获内科学博士学位(MD,PhD),2008年晋升主任医师,教授,并通过博士生导师遴选。

科研项目

[1] 国家“12.5”科技支撑项目横向课题,病毒性心肌炎演变扩张型心肌病的监测和防治策略研究,已结题,子课题负责人。

[2] 国家自然科学基金项目,Calreticulin-STAT3/PKC 信号通路介导的线粒体损伤在扩张型心肌病发病中的分子机制研究,已结题,主持。

[3]国家自然科学基金项目:PINK1/Parkin介导线粒体自噬参与病理性心肌肥厚的机制及其分子调控研究,在研,主持。

学术及科研成果、专利、论文

(1) Inhibition of drp1 attenuates mitochondrial damage and myocardial injury in coxsackievirus b3 induced myocarditis. Biochem Biophys Res Commun 2017 550~556 484(3)

(2) Chronic resveratrol treatment improves cardiac function in a rat model of diabetic cardiomyopathy via attenuation of mitochondrial injury and myocardial apoptosis. Int J Clin Exp Med 2016 9(11)21156~21167

(3) Rosmarinic Acid suppressed high glucose-induced apoptosis in H9c2 cells by ameliorating the mitochondrial function and activating STAT3.Biochem Biophys Res Commun 2016 477(4) : 1024~1030

(4) Involvement of caspases and their upstreamregulators in myocardial apoptosis in a rat model of endemic dilatedcardiomyopathy Journal of Trace Elements in Medicine and Biology 2015.7.1 31(2015) : 85~91

(5) Suppression of PKCε-medicated mitochondrial connexin 43 phosphorylation at serine 368 isinvolved in myocardial mitochondrial dysfunction in a rat model of dilated cardiomyopathy Molecular Medicine Reports 2015.3.6 11(6) : 4720~4726

(6) Impairment of myocardial mitochondria in viralmyocardial disease and its reflective window in peripheral cellsPLos One 2014.12.31 9(12) : 1~18

(7) Calreticulin is localized at mitochondria of rat cardiomyocytes and affected by furazolidoneMolecular and Cellular Biochemistry 2014.8.3 397(1-2) : 125~130

(8) Novel distribution of calreticulin to cardiomyocyte mitochondria and its increase in a rat model of dilated cardiomyopathyBioch emical and Biophysical Research Communications 2014.6.20 449(1) : 62~68

(9) Calreticulin-STAT3 signaling pathway modulates mitochondrialfunction in a rat model of furazolidone-induced dilated cardiomyopathy PLos One 2013.6.20 8(6)

(10) Selenium deficiency induces apoptosis through endoplasmic reticulum stress in a rat model of endemic dilated cardiomyopathy Experimental & clinical cardiology 2014.4.10 20(8) : 3076~3081

联系方式

联系电话:13572140118

电子邮箱:weijin@mail.xjtu.edu.cn



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