王亭忠

*研究领域（方向）

心血管离子通道病分子遗传学机制；

慢性心力衰竭精准医学研究。

1. *科研项目 国家自然科学基金（面上项目）：No. 81870256，心脏钠通道Nav1.5的SUMOylation化在心肌缺血致心律失常中的作用及其机制研究，2019年~2022年，主持人

2. 国家自然科学基金（面上项目）：No. 81570672，尿毒症毒素降低hERG通道功能介导慢性肾衰竭心律失常发生的机制研究，2016年~2019年，主持人

3. 国家自然科学基金（青年基金）：No. 30800455，在体内微环境下骨髓间充质干细胞源性心肌细胞的电生理特征及致心律失常性，2008年~2011年，主持人

4. 陕西省重点研发计划（国际科技合作项目）：No. 2018KW-061，采用iPSC模型研究SNTA1-D242G突变导致长QT综合征的分子机制及药物纠正作用，2018年~2020年，主持人

   陕西省重点研发计划（国际科技合作项目）：No. 2014KW23-05，hERG钾通道突变的分子遗传学机制及纠正，2014年~2016年，主持人

5. 高等学校博士学科点专项科研基金（新教师项目）：No. 200806981027，在体内微环境下骨髓间充质干细胞源性心肌细胞的电生理特征及致心律失常性，2008年-2011年，主持人

    

   *学术集科研成果、专利、论文

    

  近年来主要相关文章（*通讯作者）：

1. Wang X, Fan X, Ji S, Ma A*, Wang T*. Prognostic value of neutrophil to lymphocyte ratio in heart failure patients. Clin Chim Acta. 2018;485:44-49.

2. Luo L, Ning F, Du Y, Song B, Yang D, Salvage SC, Wang Y, Fraser JA, Zhang S, Ma A*, Wang T*. Calcium-dependent Nedd4-2 upregulation mediates degradation of the cardiac sodium channel Nav1.5: implications for heart failure. Acta Physiol (Oxf). 2017 Sep;221(1): 44-58.

3. Yang G, Chen S, Ma A, Lu J, Wang T*. Identification of the difference in the pathogenesis in heart failure arising from different etiologies using a microarray dataset. Clinics (Sao Paulo). 2017; 72(10): 600-608.

4. Luo L, Hu P, Miao C, Ma A, Wang T*. Clenbuterol attenuates hERG channel by promoting the mature channel degradation. Int J Toxicol. 2017;36(4):314-324.

   Zhao Y, Wang T, Guo J, Yang T, Li W, Koichopolos J, Lamothe SM, Kang Y, Ma A, Zhang S. Febrile temperature facilitates hERG/I_Kr degradation through an altered K⁺ dependence. Heart Rhythm. 2016; 13(10):2004-2011.

   Du Y, Zhang J, Xi Y, Wu G, Han K, Huang X, Ma A, Wang T*. β1-Adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats. J Physiol Biochem. 2016;72(2): 293-302.

5. Ning F, Luo L, Ahmad S, Valli H, Jeevaratnam K, Wang T, Guzadhur L, Yang D, Fraser JA, Huang CL, Ma A, Salvage SC. The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles. Pflugers Arch. 2016; 468(4):655-65.

6. Song B, Li T, Chen S, Yang D, Luo L, Wang T, Han X, Bai L, Ma A. Correlations between MTP and ROS levels of peripheral blood lymphocytes and readmission in patients with chronic heart failure. Heart Lung Circ. 2016;25(3):296-302.

7. Yang D, Wang T, Ni Y, Song B, Ning F, Hu P, Luo L, Wang Y, Ma A. Apamin-sensitive K⁺ current upregulation in volume- overload heart failure is associated with the decreased interaction of CK2 with SK2. J Membr Biol. 2015;248(6): 1181-1189.

   Wang T, Hogan-Cann A, Kang Y, Cui Z, Guo J, Yang T, Lamothe SM, Li W, Ma A, Fisher JT, Zhang S. Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2. Mol Pharmacol. 2014; 85(6):877-886.

   Song W, Oosten EV, Wang T, Lamothe S, Hamilton A, Petsikas D, Payne D, Redfearn D, Zhang S, Baranchuk A. Alterations in HERG potassium channel expression in patients with obstructive sleep apnea. Exp Clin Cardiol. 2014; 20(8): 3455-3475.

8. Ni Y, Wang T, Zhuo X, Song B, Zhang J, Wei F, Bai H, Wang X, Yang D, Gao L, Ma A. Bisoprolol reversed small conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat model. Mol Cell Biochem. 2013; 384(1-2): 95-103.

9. Bai X, Tian H, Wang T, Du Y, Xi Y, Wu Y, Gao J, Ma A. Oleic acid inhibits the K_ATP channel sSubunit Kir6.1 and the K_ATP current in human umbilical artery smooth muscle cells. Am J Med Sci. 2013; 346(3):204-10.

10. Zhuo X, Wu Y, Ni Y, Liu J, Gong M, Wang X, Wei F, Wang T, Yuan Z, Ma A, Song P. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013; 18(7): 800-810.

11. Guo J^#, Wang T^#, Li X, Shallow H, Yang T, Li W, Xu J, Fridman MD, Yang X, Zhang S. Cell surface expression of hERG channels is regulated by caveolin-3 via Nedd4-2. J Biol Chem. 2012;287(40): 33132-33141.（^#并列第一作者）

12. Wei F^#, Wang T^#, Zhang J, Yuan Z, Tian H, Ni Y, Zhuo X, Han K, Liu Y, Lu Q, Bai H, Ma A. Mesenchymal stem cells neither fully acquire the electrophysiological properties of mature cardiomyocytes nor promote ventricular arrhythmias in infarcted rats. Basic Res Cardiol. 2012; 107(4):274. doi: 10.1007/s00395- 012-0274-4（^#并列第一作者）

13. Wang X, Zhuo X, Ni Y, Gong M, Wang T, Lu Q, Ma A. Improvement of cardiac function and reversal of gap junction remodeling by Neuregulin-1β in volume-overloaded rats with heart failure. J Geriatr Cardiol. 2012;9(2): 172-179.

14. Wei F, Wang T, Liu J, Du Y, Ma A. The subpopulation of mesenchymal stem cells that differentiate toward cardiomyocytes is cardiac progenitor cells. Exp Cell Res. 2011; 317(18): 2661- 2670.

15. Guo J, Wang T, Yang T, Xu J, Li W, Fridman MD, Fisher JT, Zhang S. Interaction between the cardiac rapidly (I_Kr) and slowly (I_Ks) activating delayed rectifier potassium channels revealed by low K⁺-induced hERG endocytic degradation. J Biol Chem. 2011; 286(40): 34664-34674.

16. Zhang H*, Zhang L, Zhang Q, Yang X, Yu J, Shun S, Wu Y, Zeng Q, Wang T*. Puerarin: a novel antagonist to inward rectifier potassium channel (I_K1). Mol Cell Biochem. 2011; 352(1-2): 117-123.

17. Xi Y, Wu G, Yang L, Han K, Du Y, Wang T, Lei X, Bai X, Ma A. Increased late sodium currents are related to transcription of neuronal isoforms in a pressure-overload model. Eur J Heart Fail. 2009; 11(8): 749-757.

18. Wang T, Xu Z, Jiang W, Ma A. Cell-to-cell contact induces mesenchymal stem cell to differentiate into cardiomyocyte and smooth muscle cell. Int J Cardiol. 2006;109(1):74-81.

19. Du Y, Huang X, Wang T, Han K, Zhang J, Xi Y, Wu G, Ma A. Down-regulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat. Pflugers Arch. 2007; 454(3):451–459.

     

    联系方式

    电子邮箱：tingzhong.wang@xjtu.edu.cn