王瑾，博士，硕士研究生导师，副主任医师
研究领域（方向）
痴呆与认知障碍
个人及工作简历
1、从大学开始受教育经历
1999/09-2004/09 西安交通大学医学院，医学学士
2004/09-2006/07 西安交通大学医学院，医学硕士
2010/09-2019/06 西安交通大学医学院，临床医学博士
2、研究工作经历
2006/07-2009/05 西安交通大学第一医院神经内科 住院医师
2009/05-2018/12 西安交通大学第一医院神经内科 主治医师
2019/01-今 西安交通大学第一医院神经内科 副主任医师
科研项目
[1]陕西省科技厅一般项目-社会发展领域:睡眠剥夺对脑组织内环境稳定的影响
及其机制研究。项目编号：2022SF-177.2022.3.1-2024.3.1.
[2]西安交通大学第一附属医院横向课题：中重度阿尔茨海默病患者单用或联合使用美金刚与甘露特钠胶囊的疗效及安全性研究。项目编号：HX202259.2022.1.1-2024.12.31.
[3]西安交通大学第一附属医院院基金：血浆转运蛋白sLRP1影响脑内Aβ沉积
分子机制研究。项目编号：2019QN-22. 2020.1-2022.12.
[4]陕西省科技厅一般项目-社会发展领域:糖尿病促进AQP4内化影响Aβ清除的
机制研究.项目编号：2017SF-260. 2017.01.01-2018.12.31.
[5]西安交通大学第一附属医院临床研究基金：多奈哌齐联合丁苯酞治疗对轻中
度阿尔茨海默病进展的影响.课题编号：XJTU1AF-CRF-2015-027.
2016.01-2017.12.
学术及科研成果、专利、论文
英文期刊论文
[1] Jin Wang, Ling Gao, Jie Liu, Liangjun Dang, Shan Wei, Ningwei Hu, Yao Gao, Wei Peng, Suhang Shang, Kang Huo, Jingyi Wang, Qiumin Qu.The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population.Clinical Interventions in Aging. 2022;17:555–565. (IF=4.458)
[2] Wang J, Guo X, Lu W, Liu J, Zhang H, Quan Q, Su H, Ma L, Gao F, Qu Q*.Donepezil Combined with DL-3-n-Butylphthalide Delays Cognitive Decline in Patients with Mild to Moderate Alzheimer’s Disease: A Multicenter, Prospective Cohort Study.J Alzheimers Dis. 2021;80(2):673-681. (IF=4.472)
[3] Jin Wang, Fan Qiao, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Yu Jiang, Kang Huo, Meiying Deng, Jingyi Wang and Qiumin Qu. Elevation of Plasma Amyloid-βLevel is More Significant in Early Stage of Cognitive Impairment: A Population-Based Cross-Sectional Study.Journal of Alzheimer’s Disease，2018，64:61–69.(IF=3.517)
[4] Gao, L.,Wang J., Jiang Y.,Wei S.,Shang S., Chen C., Dang L.,Huo K., Deng M., Wang J.,Qu Q. Relationship Between Peripheral Transport Proteins and Plasma Amyloid-β in Patients with Alzheimer's Disease were Different from Cognitively Normal Controls: A Propensity Score Matching Analysis. J Alzheimers Dis. 2020;78(2):699-709.（IF=3.909）
[5] Ping Li, Yongning Deng, Xiaojuan Guo,Jin Wang. Nursing effects of finger exercise on cognitive function and others for cerebral ischemic stroke patients. Am J Transl Res 2021;13(4):3759-3765.（IF=4.06）
[6] Ling Gao, Liangjun Dang, Shan Wei, Ningwei Hu, Fan Gao, Wei Peng, Suhang Shang,Yi Zhao, Chen Chen, Xiaojuan Guo, Kang Huo, Jingyi Wang,Jin Wang∗and Qiumin Qu.Peripheral Transport Proteins Were Associated with 4-Year Cognitive Decline in APOE 4 Non-Carriers: A Longitudinal, Population-Based Study.Journal of Alzheimer’s Disease. 2022; 86: 801–812.(IF=4.472)
[7] She M, Shang S, Hu N, Chen C, Dang L, Gao L, Wei S, Huo K, Wang J,Wang J*and Qu Q*. Blood Pressure Level Is Associated With Changes in Plasma Abeta1 -40 and Abeta1-42 Levels: A Cross-sectional Study Conducted in the Suburbs of Xi'an, China. Front Aging Neurosci 2021;13:650679.(IF=5.75)
[8] Wei S, Shang S, Dang L, Gao F, Gao Y, Gao L,Chen C, Huo K, Wang J,Wang J*and Qu Q*. Blood Triglyceride and High-Density Lipoprotein Levels Are Associated with Plasma Amyloid-beta Transport: A Population-Based Cross-Sectional Study. J Alzheimers Dis 2021;84:303-314. (IF=4.472)
[9] Wang Y, Wei S, Zhou R, Shang S, Dang L, Gao L, Chen C, Huo K, Wang J,Wang J*and Qu Q*.The Relationships Between Lipid Accumulation Product Levels and Cognitive Decline Over 4 Years in a Rural Area of Xi’an, China. Front Aging Neurosci 2021;13:761886. (IF=5.75)
[10]Gao Y#, Wei S #, Gao F, Gao L, Dang L, Shang S, Chen C, Huo K, Wang J,Wang J*and Qu Q*. Sleep disturbance is associated with higher plasma Aß levels - A population-based cross-sectional study. Front. Aging Neurosci. 2020; 12: 44(IF=4.362)
[11]Shang S, Liu Z, Gao J,Wang J，et al. The Relationship Between Pre-existing Coronary Heart Disease and Cognitive Impairment Is Partly Explained by Reduced Left Ventricular Ejection Fraction in the Subjects Without Clinical Heart Failure: A Cross-Sectional Study. Front Hum Neurosci. 2022;16:835900.（IF=3.16）
[12]Gao, F.,Shang S., Chen C, Dang L., Gao L , Wei S.,Wang J., Huo K., Deng M., Wang J., Qu Q. Non-linear Relationship Between Plasma Amyloid-β 40Level and Cognitive Decline in a Cognitively Normal Population. Front Aging Neurosci, 2020. 12: p. 557005.（IF=4.362）
[13]Wei S, Gao L, Jiang Y, Shang S, Chen C, Dang L, Wang J, Huo K, Wang J, Zhang R, Qu Q*. The Apolipoprotein Eε4 Allele-Dependent Relationship Between Serum Lipid Levels and Cognitive Function: A Population-Based Cross-sectional Study. Front. Aging Neurosci. 2020; 12: 44. (IF=4.362)
[14]Liu P#, Zhao B#, Wei M, Li Y, Liu J, Ma L, Shang S, Huo K, Wang J, Li R, Qu Q*. Activation of Inflammation is Associated with Aβ Accumulation Induced by Chronic Sleep Restriction in Rats. J Alzheimers Dis. 2020; 74(3): 759-773.(IF=3.909)
[15]Wei S, Gao L, Jiang Y, Shang S, Chen C, Dang L, Zhao B, Zhang J,Wang J, Huo K, Wang J, Zhang R, Qu Q.Apolipoprotein E ε4 Allele is Associated With Plasma Amyloid Beta and Amyloid Beta Transporter Levels: A Cross-sectional Study in a Rural Area of Xi'an, China.Am J Geriatr Psychiatry. 2020；28（2）：194-204.（IF=3.488）
[16]Hu N , Gao L , Jiang Y, Wei S, Shang S, Chen C, Dang L,Wang J, Huo K, Deng M, Wang J, Qu Q . The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study. Lipids Health Dis. 2020 Jan 14; 19(1): 8. (IF=2.651)
[17]Zhao B, Liu P, Wei M, Li Y, Liu J, Ma L, Shang S, Jiang Y, Huo K,Wang J, Qu Q.Chronic Sleep Restriction Induces Aβ Accumulation by Disrupting the Balance of Aβ Production and Clearance in Rats.Neurochem Res. 2019;44(4):859-873. (IF=2.782)
[18]Zhao B, Shang S, Li P, Chen C, Dang L, Jiang Y,Wang J, Huo K, Deng M, Wang J, Qu Q.The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi'an, China.Lipids Health Dis. 2019;18(1):4. (IF=2.651)
[19]Jiang Y, Shang S, Li P, Chen C, Dang L,Wang J, Huo K, Deng M, Wang J, Qu Q. Pulse Pressure Is Associated With Plasma Amyloid-β Transport Dysfunction. J Hypertens. 2018; 36(3): 569-579. (IF=4.092)
[20]Gao L, Jiang Y, Wei S, Shang S, Li P, Chen C, Dang L,Wang J,Huo K, Deng M, Wang J, Zhang R, Qu Q.The Level of Plasma Amyloid-β40 Is Correlated with Peripheral Transport Proteins in Cognitively Normal Adults: A Population-Based Cross-Sectional Study.J Alzheimers Dis. 2018; 65(3): 951- 961. (IF=3.517)
[21]Jin Qiao, Wen-Hui Lu,Jin Wang, Xiao-Juan Guo, Qiu-Min Qu. Vascular Risk Factors Aggravate the Progression of Alzheimer's Disease: A 3-Year Follow-Up Study of Chinese Population. American Journal of Alzheimer's Disease and Other Dementias.2014; 29(6):521-5. (IF=1.614)
中文期刊论文
[1] 王瑾，张彬艳，商苏杭，李珮，邓美英，江毓，陈晨，屈秋民.西安市农村居民高血压与血脂水平的相关性研究.兰州大学学报（医学版）.2018,44(6):14-19.
[2] 王瑾，李再利，颜飞，商苏杭，李珮，陈晨，邓美英，屈秋民.脑卒中高危人群认知功能障碍血管性危险因素筛查.中国现代神经疾病杂志.2017;17(2):138-142.
[3] 王瑾，商清，刘蕊，屈秋民.脑血管反应性降低与高血压认知功能减退的相关性研究.医学研究生学报.2016;29(12):1260-1264.
[4] 王瑾，王莹，叶雯，乔晋，屈秋民.新编痴呆自查问卷在痴呆筛查中的应用价值初探.中国现代神经疾病杂志.2015;15(7):554-559.
[5] 郜锦英,商苏杭,霍康,王瑾,屈秋民.左心室射血分数与认知损害的关系.中华老年心脑血管病杂志. 2015;17(12): 1271-4.
[6] 何芸,霍康,王瑾,屈秋民.高血压患者直立性低血压与认知功能减退相关.中华高血压杂志. 2015;23(7):639-43.
[7] 贾蕊,刘蕊,杜亚娟,王瑾,罗国刚.卵圆孔未闭导致反复跌倒发作2例.中国临 床神经科学2014;04: 430-432.
联系方式
电子邮箱：drwangjin@xjtufh.edu.cn
联系电话：13572208524
个人主页：
联系地址：西安市雁塔西路277号
