薛丽

姓名:

薛丽

一级学科:

105120 (专业学位) 临床检验诊断学

照片:

研究领域(方向):

自身免疫性疾病和感染性疾病的实验室诊断和发病机制

个人及工作简历:

薛丽,医学博士,副主任技师/副研究员,硕士研究生导师/博士研究生合作导师,国家留学基金委公派英国伦敦大学学院风湿病研究中心访问学者。兼任中国医学装备协会基因检测分会委员、中国微生物学会临床微生物学专业委员会青年委员、中国检验检测学会委员、陕西省预防医学会病原微生物检验专业委员会委员、陕西省中西医结合学会检验医学专业委员会委员、西安医学会检验医学分会青年委员。主要从事临床分子生物学检验,研究方向为感染性疾病和自身免疫性疾病的实验室诊断和发病机制。主持国家自然科学基金青年项目1项,陕西省自然科学基金和社发基金各1项,校基金1项,院基金重点项目、院人才培养专项基金和院基金青年项目各1项。参与国家自然科学基金4项,省级、校级和院级课题多项。以第一或通讯作者发表学术论文20余篇,其中SCI论文15篇,包括Cell Death & Disease, Arthritis Research & Therapy, Clinical and Experimental Immunology等国际知名期刊。主持校级新技术1项,院级新技术2项。获陕西省高等院校科学技术二等奖,西安市自然科学优秀论文一等奖。

主要科研项目

1. 国家自然科学基金青年项目,81802129,肥大细胞多巴胺D3受体通过负调控TLR4延缓类风湿性关节炎软骨细胞凋亡的作用机制研究,2019/01-2021/12,结题,主持;

2. 陕西省重点研发计划一般项目,2025SF-YBXM-378,基于外周血DNA甲基化和机器学习的类风湿关节炎早期新标志物筛选验证及疾病活动度预测模型构建,2025/06-2027/06,在研,主持;

3. 陕西省重点研发计划一般项目,2022SF-280,类风湿关节炎发生发展相关的特征性环状RNA筛选与鉴定,2022/01-2023/12,结题,主持;

4. 陕西省自然科学基础研究计划,2017JQ8032,类风湿关节炎发生中滑膜肥大细胞多巴胺D3受体的作用研究,2017/01-2018/12,结题,主持。

代表性论著、科研获奖、人才称号

代表性论著:

[1] Xue L, Xu S, Li M, Wang B, Kang P, Zhu J, Clanchy FIL, Williams RO, Abraham D, Geng Y. The dopamine D3 receptor regulates dopamine-induced activation and glycolytic metabolism of synovial fibroblasts in rheumatoid arthritis. Clin Exp Immunol. 2026, 220(1):uxag008.

[2] Xue L, Zhu J, Lei K, Liu Z, Tang Y, Zhong B, Gao N, Xiong C, Lei J, Tian Y, Zhou W, Feng N, Zhang X, Chen D, Li J, Geng Y. Evaluation of the FPMC respiratory panel for detection of respiratory tract pathogens in nasopharyngeal swab and sputum specimens. Virol J. 2024, 21(1):156.

[3] Xue L, Wang B, Li X, Zhu J, Wang W, Huang F, Wang X, Jin Y, Xiong C, Tao L, Xu K, Wang J, Guo Y, Xu J, Yang X, Wang N, Gao N, Wang Y, Li Ke, Li M, Geng Y. Comprehensive analysis of serum exosome-derived lncRNAs and mRNAs from patients with rheumatoid arthritis, Arthritis Res Ther, 2023, 25(1): 201.

[4] Xue L, Wang B, Zhu J, He Q, Huang F, Wang W, Tao L, Wang Y, Xu N, Yang N, Jin L, Zhang H, Gao N, Lei K, Zhang Y, Xiong C, Lei J, Zhang T, Geng Y, Li M. Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis. Ann Med. 2023, 55(1):175-189.

[5] Wang B, Li X, Li M, Geng Y, Wang N, Jin Y, Zhang W, Xu K, Wang J, Tao L, Lai S, Wu K, Lei J, Wang J, Zhou T, Li K, Chen Y, and Xue L*. Dopamine D3 receptor signaling alleviates mouse rheumatoid arthritis by promoting Toll-like receptor 4 degradation in mast cells. Cell Death & Disease. 2022, 13:240.

[6] Sun H, Xue L, Guo Y, Du J, Nan K, Li M. Global, regional and national burden of non-Hodgkin lymphoma from 1990 to 2017: estimates from global burden of disease study in 2017. Ann Med. 2022, 54(1):633-645.

[7] Xue L, Tao L, Li X, Wang Y, Wang B, Zhang Y, Gao N, Dong Y, Xu N, Xiong C, Zhou T, Liu Z, Liu H, He J, Li K, Geng Y, Li M*. Plasma fibrinogen, D-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis. Sci Rep. 2021, 11(1): 16903.

[8] Li M, Xu S, Yan Y, Wang H, Zheng J, Li Y, Zhang Y, Hao J, Deng C, Zheng X, Liu M, Gao Y, Wang X, Xue L*. Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection. Sci Rep. 2021, 11(1):18775.

[9] Li M, Xu SC, Geng Y, Wang RL, Yan Y, Wang HC, Li YX, Yi QY, Zhang YJ, Hao JJ, Deng C, LiW, Xue L*. The protective effects of L-carnitine on myocardial ischemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-κB pathway and the activation of Nrf2 pathway. Clin Exp Pharmacol Physiol. 201946 (11): 1001-1012.

[10] Xue L, Li XY, Chen QP, He JT, Dong YY, Wang J, Shen SY, Jia R, Zang QJ, Zhang T, Li M, Geng Y*. Associations between D3R expression in synovial mast cells and disease activity and oxidant status in patients with rheumatoid arthritis. Clin Rheumatol. 2018, 37: 2621–2632.

[11] Xue L, Lu XL, He JT, Zhang T, Wu XK, Zhang YP, Wang NN, An Z, Xu JR, Geng Y*. Serum CK 18-M30 reflect liver pathological severity during NAFLD progression in a rat model. Pathol Res Pract. 2018, 214: 1778-1786.

[12] Xue L, He JT, Gao N, Lu XL, Li M, Wu XK, Liu ZS, Jin YF, Liu JL, Xu JR, Geng Y*. Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia. Sci Rep. 2017, 7: 45176.

[13] Xue L, Geng Y, Li M, Jin YF, Ren HX, Li X, Wu F, Wang B, Cheng WY, Chen T, Chen YJ*. The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation. International Immunopharmacology. 2016, 36(6): 187-198.

[14] Xue L, Li X, Ren HX, Wu F, Li M, Wang B, Chen FY, Cheng WY, Li JP, Chen YJ*, Chen T*. The dopamine D3 receptor regulates the effects of methamphetamine on LPS-induced cytokine production in murine mast cells. Immunobiology. 2015, 220(6): 744-752.

[15] Xue L, Li M, Chen T, Sun HF, Zhu J, Li X, Wu F, Wang B, Li JP, Chen  YJ*. PE-induced apoptosis in SMMC-7721 cells: Involvement of Erk and Stat signalling pathways. Int J Mol Med. 2014, 34 (1):119-29.

科研获奖:

陕西省高等学校科学技术二等奖,肠道微生态在代谢相关疾病中的作用及机制研究2018年,主要完成人。

联系方式

电子邮箱xuelially@163.com

联系电话:18049098658

个人主页:http://www.2yuan.xjtu.edu.cn/defsyy/info/8021/443231.htm

联系地址: 西安交通大学第二附属医院(西安市西五路157号)


下一篇:刘军辉

地址:陕西省西安市咸宁西路28号 邮编:710049
版权所有:西安交通大学 站点建设与维护: 网络信息中心 陕ICP备06008037号