研究领域（方向）
（1）胃肠道肿瘤的基础与临床研究，（2）肠道炎症与免疫的研究
个人及工作简历
外科学博士，博士生导师，普外科副主任。中国抗癌协会胃肠道间质瘤分会委员，陕西省保健协会胃肠疾病防治委员会常委，陕西省健康促进与教育协会基层卫生分会常委。长期从事胃肠外科的临床、教学与科研工作，主持参与国家及省自然科学基金等基金项目，主要研究代谢性疾病对肿瘤细胞及预后的影响。国内外发表论文20余篇，第一作者及通讯作者SCI收录10余篇，国际知名期刊收录1篇。自参加工作以来，一直从事临床教学工作，并参与住院医师规范化培训教学工作。多年来一直从事胃肠道肿瘤的综合治疗，近年开展腹腔镜手术，先后开展完成腹腔镜辅助胃癌、结直肠癌根治术，腹腔镜疝修补术。多次参加陕西省及西北地区腹腔镜结直肠大赛，并取得优异成绩。
科研项目
1.基于多组学数据迁移学习策略和cfDNA全基因组测序的胃癌早期筛查模型开发与应用（2024SF-ZDCYL-02-04），2024.01-2026.12，陕西省重点研发计划，70万元
2.探索早期结直肠癌根治术后利用血浆ctDNA基因组特征进行复发预测并提前实施预防治疗的意义（HX201979），2020.01，吴阶平医学基金，10万元
3.高糖微环境诱发胃癌患者化疗耐药的机制研究（2019SF-057），陕西省重点研发计划，2019.06，7万元
学术及科研成果、专利、论文
1.Wenbin Gong, Zhenni Liu, Yuqiu Wang, Wenbo Huang, Kui Yang, Zhenhai Gao, Kun Guo, Zhengtao Xiao,Wei Zhao*. Reprogramming of Treg cell-derived small extracellular vesicles effectively prevents intestinal inflammation from PANoptosis by blocking mitochondrial oxidative stress.Trends Biotechnol.2025;43(4):893-917. (IF=14.9)
2.Huiru Xu, Xin Zhao, Yuqing Liang, Jiaodi Zhang, Jiaxin Wang, Baolin Guo,Wei Zhao*. Macrochannel-aligned cryogels with oxygen release and antibacterial properties for MRSA-infected diabetic wound healing.Chem Eng J.2024; 495:153299 (IF=13.4)
3.Huilin Liu, Chao Huang, Zhenni Liu, Yuhan Li, Yanan Zhu, Min Gao, Jing Chen, Hui Zhang, Zhengtao Xiao,Wei Zhao*. Systematic drug screening and target analysis identify digitoxin as a potential therapy for uveal melanoma.Br J Pharmacol.2025;182(6):1275-1291 (IF=6.8)
4.Zhixian Lin, Jinmeng Wang, Yixin Ma, Yanan Zhu, Yuhan Li, Zhengtao Xiao,Wei Zhao*.Cancer-Associated Fibroblasts Establish Spatially Distinct Prognostic Niches in Subcutaneous Colorectal Cancer Mouse Model.Cancers (Basel). 2025;17(14):2402. (IF=4.4)
5.Wenbin Gong, Hangyu Fu, Kui Yang, Tao Zheng, Kun Guo,Wei Zhao*. 4-Octyl itaconate blocks GSDMB-mediated pyroptosis and restricts inflammation by inactivating granzyme A.Cell Prolif.2024;57(12):e13711. (IF=5.9)
6.Fanni Li, Jun Yan, Jing Leng, Tianyu Yu, Huayou Zhou, Chang Liu, Wenbo Huang, Qi Sun,Wei Zhao*. Expression patterns of E2Fs identify tumor microenvironment features in human gastric cancer.PeerJ. 2024:12:e16911. (IF=2.4)
7.Wei Zhao#, Huanye Mo, Runkun Liu, Tianxiang Chen, Nan Yang, Zhikui Liu. Matrix stiffness-induced upregulation of histone acetyltransferase KAT6A promotes hepatocellular carcinoma progression through regulating SOX2 expression.Br J Cancer.2022;127(2):202-210. (IF=6.4)
8.Ting Zhang, Jianbao Zheng, Lina Qiao,Wei Zhao*. Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein.Pathol Res Pract. 2022; 229:153705. (IF=3.2)
9.Jianjiang Wang, Runkun Liu, Huanye Mo, Xuelian Xiao, Qiuran Xu,Wei Zhao*. Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.Int J Biol Sci. 2021;17(13):3331-3342. (IF=10.0)
10.Xianzhen Jin, Lina Qiao, Hui Fan, Chunyan Liao, Jianbao Zheng, Wei Wang, Xiuqin Ma, Min Yang, Xuejun Sun,Wei Zhao*. Long non-coding RNA MSC-AS1 facilitates the proliferation and glycolysis of gastric cancer cells by regulating PFKFB3 expression.Int J Med Sci. 2021; 18(2):546-554. (IF=3.2)
联系方式
电子邮箱：zhaowei9803@126.com
联系电话：15291698780
个人主页：无
联系地址：西安交通大学第一附属医院普通外科
