韩亮，博士研究生导师，副教授，外科学博士
研究领域（方向）
（1）胰腺癌的神经浸润和疼痛机制，（2）急慢性胰腺炎的发病机制和疼痛控制。
个人及工作简历
韩亮，中共党员，博士研究生导师，外科学博士。西安交通大学第一附属医院肝胆外科副研究员，副教授。从事肝胆外科临床医疗工作，主攻胰腺肿瘤，急慢性胰腺炎等胰腺疾病的基础研究和外科手术治疗。美国胰腺协会(APA）会员，陕西省抗癌协会会员。主持国家级自然科学基金2项；主持陕西省基金，西安市基金，交大一附院基金各1项。主持西安交通大学和交大一附院教改项目各1项；分别获得西安交通大学和交大一附院教学竞赛一等奖，并荣获优秀教师，十佳医师，十佳教师等称号。
科研项目
国家级项目
• 主持国家自然科学基金项目2022年（No. 82172853）力-化耦合促进胰腺癌神经浸润和疼痛：Foxm1/β-catenin介导肿瘤细胞黏附力得失的机制研究。
• 主持国家自然科学基金项目2016年（No. 81502074）胰腺星状细胞-SHH-TRPV1在胰腺癌神经疼痛中的作用机制。
陕西省项目
• 陕西省自然科学基础研究计划2020年（2020JQ-510）旁分泌细胞sHH-施万细胞参与的神经导向作用促进胰腺癌疼痛。
西安市项目
• 主持“科技+”行动计划-（17）医学研究项目（XA2020-YXYJ-0009）
泛化痛阈状态下NOS/NF-κB “环状反馈”促进胰腺癌神经性疼痛的机制研究。
学术及科研成果、专利、论文
[1] Qian W, Chen K, Qin T, Xiao Y, Li J, Yue Y, Zhou C, Ma J, Duan W, Lei J,Han L, Li L, Shen X, Wu Z, Ma Q, Wang Z. The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer. J Exp Clin Cancer Res. 2021 Jan 9;40(1):25.
[2] Xue M,HanL, Qian W, Li J, Qin T, Xiao Y, Ma Q, Ma J, Shen X. Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF-κB Signaling Pathway and Inhibiting the Kappa Opioid Receptor. Oxid Med Cell Longev. 2020 May 7;2020:9230958.
[3] Jiang J, Bai J, Qin T, Wang Z,Han L. NGF from pancreatic stellate cells induces pancreatic cancer proliferation and invasion by PI3K/AKT/GSK signal pathway. J Cell Mol Med. 2020 May;24(10):5901-5910.
[4] Shao S, Qin T, Qian W, Li X, Li W,Han L, Zhang D, Wang Z, Ma Q, Wu Z, Wu E, Lei J. Cav-1 Ablation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Growth through Nrf2-Induced shh Signaling. Oxid Med Cell Longev. 2020 Apr 20;2020:1868764.
[5] Han L, Jiang J, Xue M, Qin T, Xiao Y, Wu E, Shen X, Ma Q, Ma J. Sonic hedgehog signaling pathway promotes pancreatic cancer pain via nerve growth factor. Reg Anesth Pain Med. 2020 Feb;45(2):137-144.
[6] Cheng L, Qin T, Ma J, Duan W, Xu Q, Li X,Han L, Li W, Wang Z, Zhang D, Ma Q, Lei J. Hypoxia-inducible Factor-1α Mediates Hyperglycemia-induced Pancreatic Cancer Glycolysis. Anticancer Agents Med Chem. 2019;19(12):1503-1512.
[7] 韩亮,武帅,尚佩强,王铮,仵正.胰十二指肠前动脉弓的解剖及其在微创保留十二指肠胰头切除术中的作用[J].腹腔镜外科杂志,2019,24(09):675-679.
[8] Wang Z, Jiang J, Qin T, Xiao Y,Han L. EIF5A regulates proliferation and chemoresistance in pancreatic cancer through the sHH signalling pathway. J Cell Mol Med. 2019 Apr;23(4):2678-2688.
[9] 蒋洁,张静,韩亮.血红素氧合酶-1对胰腺癌细胞增殖的促进作用[J].西安交通大学学报(医学版),2019,40(04):517-520.
[10]钱伟琨,李杰,严彬,曹俊宇,肖莹,秦涛,马清涌,韩亮.转基因小鼠源性胰腺癌组织块皮下移植瘤模型的构建与评价[J].西安交通大学学报(医学版),2019,40(03):368-373.
[11]Cao J, Li J, Sun L, Qin T, Xiao Y, Chen K, Qian W, Duan W, Lei J, Ma J, Ma Q,Han L. Hypoxia-driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating forkhead box protein M1. Mol Oncol. 2019 Feb;13(2):228-245.
[12]Shao S, Duan W, Xu Q, Li X,Han L, Li W, Zhang D, Wang Z, Lei J. Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis and Invasion through Downregulating CTGF. Oxid Med Cell Longev. 2019 Jan 16;2019:8148510.
[13]Li W, Wang Z, Xiao X,Han L, Wu Z, Ma Q, Cao L. Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. Oncol Rep. 2019 Jan;41(1):650-658.
[14]Yu Y, Cheng L, Yan B, Zhou C, Qian W, Xiao Y, Qin T, Cao J,Han L, Ma Q, Ma J. Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression. Int J Oncol. 2018 Dec;53(6):2445-2457.
[15]Cao J, Ma J, Sun L, Li J, Qin T, Zhou C, Cheng L, Chen K, Qian W, Duan W, Wang F, Wu E, Wang Z, Ma Q,Han L. Targeting glypican-4 overcomes 5-FU resistance and attenuates stem cell-like properties via suppression of Wnt/β-catenin pathway in pancreatic cancer cells. J Cell Biochem. 2018 Nov;119(11):9498-9512.
[16]Li W, Liu H, Qian W, Cheng L, Yan B,Han L, Xu Q, Ma Q, Ma J. Hyperglycemia aggravates microenvironment hypoxia and promotes the metastatic ability of pancreatic cancer. Comput Struct Biotechnol J. 2018 Oct 29;16:479-487.
[17]沙焕臣,雷建军,王铮,段万星,徐勤鸿,黎韡,韩亮,马清涌,张东.β_2肾上腺素受体通过HIF-1α调控NNK诱导的胰腺癌细胞进展[J].西安交通大学学报(医学版),2018,39(05):670-674+697.
[18]Han L, Jiang J, Ma Q, Wu Z, Wang Z. The inhibition of heme oxygenase-1 enhances the chemosensitivity and suppresses the proliferation of pancreatic cancer cells through the SHH signaling pathway. Int J Oncol. 2018 Jun;52(6):2101-2109.
[19]韩亮,马清涌.吲哚美辛通过E-Cad逆转高糖诱导的胰腺癌细胞增殖作用[J].现代肿瘤医学,2018,26(13):1998-2002.
[20]Wang Z, Wei Q,Han L, Cao K, Lan T, Xu Z, Wang Y, Gao Y, Xue J, Shan F, Feng J, Xie X. Tenascin-c renders a proangiogenic phenotype in macrophage via annexin II. J Cell Mol Med. 2018 Jan;22(1):429-438.
[21]蒋洁,张彦兵,宗伟,曹菲,韩亮.血红素加氧酶-1在胃癌顺铂化疗敏感性中的作用[J].西安交通大学学报(医学版),2018,39(01):53-56.
[22]韩亮,耿智敏,王林,白纪刚.腹腔镜下胆总管探查取石不同术式的疗效分析[J].陕西医学杂志,2016,45(12):1628-1630.
[23]Zong L, Chen K, Jiang Z, Chen X, Sun L, Ma J, Zhou C, Xu Q, Duan W,Han L, Lei J, Li X, Ma Q, Wang Z. Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer. J Exp Clin Cancer Res. 2017 Dec 11;36(1):181.
[24]Duan W, Chen K, Jiang Z, Chen X, Sun L, Li J, Lei J, Xu Q, Ma J, Li X,Han L, Wang Z, Wu Z, Wang F, Wu E, Ma Q, Ma Z. Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression. Cancer Lett. 2017 Jan 28;385:225-233.
[25]Li J, Ma J,Han L, Xu Q, Lei J, Duan W, Li W, Wang F, Wu E, Ma Q, Huo X. Hyperglycemic tumor microenvironment induces perineural invasion in pancreatic cancer. Cancer Biol Ther. 2015;16(6):912-21.
[26]Li W, Cao L,Han L, Xu Q, Ma Q. Superoxide dismutase promotes the epithelial-mesenchymal transition of pancreatic cancer cells via activation of the H2O2/ERK/NF-κB axis. Int J Oncol. 2015;46(6):2613-20.
[27]Liu J, Ma J, Wu Z, Li W, Zhang D,Han L, Wang F, Reindl KM, Wu E, Ma Q. Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling. BMC Cancer. 2014 Sep 20;14:686.
[28]Li X, Wang Z, Ma Q, Xu Q, Liu H, Duan W, Lei J, Ma J, Wang X, Lv S,Han L, Li W, Guo J, Guo K, Zhang D, Wu E, Xie K. Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer. Clin Cancer Res. 2014 Aug 15;20(16):4326-38.
[29]Duan W, Ma J, Ma Q, Xu Q, Lei J,Han L, Li X, Wang Z, Wu Z, Lv S, Ma Z, Liu M, Wang F, Wu E. The Activation of β1-integrin by Type I Collagen Coupling with the Hedgehog Pathway Promotes the Epithelial-Mesenchymal Transition in Pancreatic Cancer. Curr Cancer Drug Targets. 2014;14(5):446-57.
[30]Li W, Wu Z, Ma Q, Liu J, Xu Q,Han L, Duan W, Lv Y, Wang F, Reindl KM, Wu E. Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer. Curr Cancer Drug Targets. 2014;14(4):348-56.
[31]Lei J, Huo X, Duan W, Xu Q, Li R, Ma J, Li X,Han L, Li W, Sun H, Wu E, Ma Q. α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion. Cancer Lett. 2014 May 28;347(1):129-38.
[32]Li P, Xu Q, Zhang D, Li X,Han L, Lei J, Duan W, Ma Q, Wu Z, Wang Z. Upregulated miR-106a plays an oncogenic role in pancreatic cancer. FEBS Lett. 2014 Mar 3;588(5):705-12.
[33]Han L, Peng B, Ma Q, Ma J, Li J, Li W, Duan W, Chen C, Liu J, Xu Q, Laporte K, Li Z, Wu E. Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells. Curr Med Chem. 2013;20(33):4142-4152.
[34]Li W, Ma J, Ma Q, Li B,Han L, Liu J, Xu Q, Duan W, Yu S, Wang F, Wu E. Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway. Curr Med Chem. 2013;20(33):4185-4194.
[35]Shen X,Han L, Ma Z, Chen C, Duan W, Yu S, Li P, Zhang L, Li W, Xu Q, Ma Q. Aspirin: a potential therapeutic approach in pancreatic cancer. Curr Med Chem. 2013;20(33):4153-62.
[36]Li X, Ma G, Ma Q, Li W, Liu J,Han L, Duan W, Xu Q, Liu H, Wang Z, Sun Q, Wang F, Wu E. Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells. Mol Cancer Res. 2013 Mar;11(3):294-302.
[37]Li J, Cao G, Ma Q, Liu H, Li W,Han L. The bidirectional interation between pancreatic cancer and diabetes. World J Surg Oncol. 2012 Aug 24;10:171.
[38]Han L, Ma Q, Li J, Liu H, Li W, Ma G, Xu Q, Zhou S, Wu E. High glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFR. PLoS One. 2011;6(11):e27074.
[39]Li W, Ma Q, Li J, Guo K, Liu H,Han L, Ma G. Hyperglycemia enhances the invasive and migratory activity of pancreatic cancer cells via hydrogen peroxide. Oncol Rep. 2011 May;25(5):1279-87.
[40]Li J, Ma Q, Liu H, Guo K, Li F, Li W,Han L, Wang F, Wu E. Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia. PLoS One. 2011 Feb 28;6(2):e17385.
[41]胡恒通,彭波,马清涌,张东,韩亮,张珉,沙焕臣.HIF-1α与NF-κB通路对胰腺癌缺氧调节及肿瘤进展的作用[J].西安交通大学学报(医学版),2010,31(03):274-278.
[42]Hu HT, Ma QY, Zhang D, Shen SG,Han L, Ma YD, Li RF, Xie KP. HIF-1alpha links beta-adrenoceptor agonists and pancreatic cancer cells under normoxic condition. Acta Pharmacol Sin. 2010 Jan;31(1):102-10.
联系方式
电子邮箱：hanliangxjtu@163.com
联系电话：15029973398
联系地址：西安交通大学第一附属医院，西安市雁塔区雁塔西路277号
