靶向性多肽联合多谱段分子内窥镜原位实时诊断胃癌的基础研究(国家自然科学基金,81472747,在研)
筛选多肽组合探针联合分子影像学技术早期诊断胃癌的研究(国家自然科学基金,81172359,结题)
二甲双胍通过激活抑癌基因LKB1正常化肿瘤血管系统的机制研究(陕西省社会发展科技攻关,2016SF-196,结题)
一、期刊论文
(1) Weiming Li#, Huan Jia#, Jichang Wang, Hao Guan, Yan Li, Dan Zhang, Yanan Tang, Thomas D Wang, Shaoying Lu*, A CD44-specific peptide, RP-1, exhibits capacities of assisting diagnosis and predicting prognosis of gastric cancer, Oncotarget, 8 (2017) 30063-30076.
(2) JichangWang, Guangyue Li, Pingping Li, Xin Sun, Weiming Li, Yan Li, Shaoying Lu*, Peijun Liu*, Suppression of hypoxia-induced excessive angiogenesis by metformin via elevating tumor blood perfusion, Oncotarget, 8 (2017) 73892.
(3) Hao Guan, Weiming Li, Yuanyuan Li, Jichang Wang, Yan Li, Yanan Tang, Shaoying Lu*, MicroRNA-93 promotes proliferation and metastasis of gastric cancer via targeting TIMP2, PloS one, 12 (2017) e0189490.
(4) Dan Zhang, Huan Jia, Weiming Li, Yingchun Hou, Shaoying Lu*, Shuixiang He*, Screening and Identification of a Phage Display Derived Peptide That Specifically Binds to the CD44 Protein Region Encoded by Variable Exons, Journal of biomolecular screening, 21 (2016) 44-53.
(5) Dan Zhang, Huan Jia, Yan Wang, Weiming Li, Yingchun Hou, Shiwei Yin, Thomas D Wang, Shuixiang He, Shaoying Lu*, A CD44 specific peptide developed by phage display for targeting gastric cancer, Biotechnology letters, 37 (2015) 2311-2320.
(6) Matthew B. Sturm#, Bishnu P. Joshi#, Shaoying Lu#, Cyrus Piraka, Supang Khondee, Badih Joseph Elmunzer, Richard S. Kwon, David G. Beer, Henry D. Appelman, Danielle Kim Turgeon, Thomas D Wang*, Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human results, Science translational medicine, 5 (2013) 184ra161.
二、授权发明专利
(1) 禄韶英, 贾环, 王燕, 张丹, 李伟明, 关昊. CD44靶向性多肽及其在制备用于筛选早期胃癌的亲和探针中的应用. 国家发明专利. 专利号: ZL201410497787.7.
(2) 禄韶英, 张文杰. 一种胃癌靶向性多肽及其应用. 国家发明专利. 专利号: ZL201110264377.4.
(3) Thomas D Wang, Shaoying LU, Neoplasia targeting peptides and methods of the use, 美国专利, US 8247529, Aug.21.2012