个人简介
王正辉，男，博士学位，主任医师/教授，博士生导师。2009年毕业于西安交通大学，获评优秀博士毕业生。2016年获评“陕西省第11届青年科技奖”.西安交通大学第二附属医院第一批青年拔尖人才。2016年至2018年曾在哈佛大学附属医院BIDMC从事博士后研究工作，任陕西省耳鼻咽喉分会、陕西省抗癌协会耳鼻喉分会等多个学会委员。兼任《Archives of Otolaryngology and Rhinology》、《Annals of clinical otolaryngology》等10余个国际杂志编委。以第1负责人主持国家自然基金项目2项，省级科研项目3项，校级项目多项。获陕西省科技进步三等奖2项。参编教材3部，在国内外发表专业论文50余篇，其中SCI收录30余篇。
研究方向：
头颈部肿瘤生物学研究；肿瘤术后功能重建；组织工程
工作经历：
(1) 2021.1-至今,西安交通大学,第二附属医院,教授/博士生导师
(2) 2018.3-至今,西安交通大学,第二附属医院,副教授/博士生导师
(3) 2016.8-2018.2,哈佛大学Beth Israel Deaconess Medical Center,博士后.
(4) 2013.2-2016.7,西安交通大学,第二附属医院,副教授/硕士生导师.
(5) 2009.11-2013.2,西安交通大学,第二附属医院,主治医师.
教育经历：
(1) 2006.9–2009.9,西安交通大学,外科学,博士.
(2) 2001.9–2004.7,西安交通大学,颌面外科,硕士.
(3) 1996.9–2001.7,西安交通大学,口腔医学,学士.
研究成果：
王正辉，杨壮群,等.组织工程软骨构建中相关性问题研究. 2015年陕西省教育厅科学进步奖一等奖。
王正辉，杨壮群,等.组织工程软骨构建中相关性问题研究.2015年陕西省人民政府科学进步奖三等奖。
主持科研项目情况：
(1)国家自然科学基金面上项目，81670917，多聚蛋白聚糖酶调控的信号通路在软骨细胞去分化中的作用与分子机制研究，2017.01-2020.12，58万元，在研，主持.
(2)陕西省科技攻关项目，2018SX-192，Aggrecanase与软骨细胞分化机制研究，2019.01-2020.12，5万元，在研，主持.
(3)中央高校基本科研业务费专项资金，2014QNZZ0102，组织工程软骨构建相关问题研究，2014.06-2017.06，15万元，已结题，主持.
(4)国家自然科学基金青年项目，81000416，Sox9诱导人脐血间充质干细胞向软骨细胞分化的关键蛋白筛选及功能分析，2011.01-2013.12，20万元，已结题，主持.
代表性论著(第1作者或通讯作者)：
1.Liangliang Liu, Tianxi Gao,Zhenghui Wang.Anterior wall resection plus radiofrequency ablation versus simple aspiration in the treatment of auricular pseudocyst: a retrospective study.Journal of International Medical Research, 2020, 48(9). http://dx.doi.org/10.1177/0300060520950930 (SCI Index, Corresponding author)
2. Xiaoli Li , Dingwei Zhang , Jiahui Ding , Li Li, Zhenghui Wang. Identification of ATP2C1 mutations in the patients of Hailey-Hailey disease. BMC Med Genet, 2020;21(1):120(SCI Index, Corresponding author)
3. Tianxi Gao , Qing Zhang, Jin Hou, Kang Zhu, Bin Sun, Jingguo Chen, Cui Xia, Xiaoyong Ren, Ying Cheng,Zhenghui Wang. Vestibular-evoked myogenic potentials in patients with severe obstructive sleep apnea. Journal of International Medical Research, 2020, 48(3):300060520909717(SCI Index, Corresponding author)
4.Xiaoli Li, Jingjing Li, Yanxia Shi, Ting Wang, Aling Zhang, Na Shao,Zhenghui Wang. Psychological intervention improves life quality of patients with laryngeal cancer. Patient Preference and Adherence, 2017,11:1723-1727(SCI Index, Corresponding author)
5. Xiaoli Li, Xiaoyong Ren, Jianmin Liang, Weijun Ma,Zhenghui Wang,Zhuangqun Yang. Delivery of sodium morrhuate to hemangioma endothelial cells using immunoliposomes conjugated with anti-VEGFR2/KDR antibody. International Journal of Nanomedicine 2017:12 6963-6972(SCI Index, Corresponding author)
6. Caiqin Wu, Huanan Luo, Weijun Ma, Xiaoyong Ren, Chuangxin Lu, Ni Li,Zhenghui Wang.Polysaccharides isolated from Hedyotis diffusa inhibits the aggressive phenotypes of laryngeal squamous carcinoma cells via inhibition of Bcl-2, MMP-2, and μPA. Gene, 2017,637: 124-129(SCI Index, Corresponding author)
7.Tianxi Gao, Xiaoli Li, Juan Hu, Weijun Ma, Jingjing Li, Na Shao,Zhenghui Wang.Management of traumatic tympanic membrane perforation: a comparative study. Therapeutics and Clinical Risk Management, 2017;13:927–931(SCI Index, Corresponding author)
8.Xiaoli Li, Xiaoyong Ren, Sisi Li,Jianmin Liang, Xiaoyan Zhao, Ting Wang,Zhenghui Wang. Morphological, Immunocytochemical, and Biochemical Studies of Rat Costal Chondrocytes Exposed to IL-1β and TGF-β1. Journal of Healthcare Engineering, 2017, Article ID 9747264(SCI Index, Corresponding author)
9.Xiaoli Li, Jun Zhang, Huanan Luo, Xiaoyan Zhao, Aling Zhang,Zhenghui Wang. Characterization of Sox9-overexpressing human umbilical cord blood-derived mesenchymal stem cells-based engineered cartilage both in vitro and in vivo. J Biomed Mater Res Part A 2017:105A:1150–1155(SCI Index, Corresponding author)
10.Zhenghui Wang, Minjie Fan, Xiaoli Li, Qing Zhang, Huanan Luo, Ying Gao, Guoxi Zheng, Jin Hou, Botao Wang, Xiaopeng Li, Jianmin Liang, Xiaoyan Zhao, Min Xu.Biocompatibility between phbhhx films modified by phap-rgd fusion protein and human nasal septum chondrocytes. Int J Clin Exp Med 2016;9(2):944-951(SCI Index)
11.ZH Wang, J. Zhang, Q. Zhang, Y. Gao, J. Yan, X.Y. Zhao, Y.Y. Yang, D.M. Kong, J. Zhao, Y.X. Shi and X.L. Li. Evaluation of bone matrix gelatin/fibrin glue and chitosan/gelatin composite scaffolds for cartilage tissue engineering. Genetics and Molecular Research 2016,15 (3): gmr.15038431(SCI Index)
12.Li XL, Chang HM, Luo HN,Wang ZH, Zheng GX, Lu XY, He XJ, Chen F, Wang T, Liang JM, Xu M. Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds coated with PhaP-RGD fusion protein promotes the proliferation and chondrogenic differentiation of human umbilical cord mesenchymal stem cells in vitro. J Biomed Mater Res Part A, 2015:103A:1169–1175(SCI Index, Corresponding author)
13.Dingwei Zhang , Xiaoli Li,Zhenghui Wang, Yanfei Zhang, Kun Guo, Shuang Wang, Chen Tu ,Jia Huo. Shengxiang Xiao. Hailey–Hailey disease: investigation of a possible compensatory SERCA2 up-regulation and analysis of SPCA1, p63, and IRF6 expression. Arch Dermatol Res,2015;307:143-149(SCI Index, Corresponding author)
14. Jianmin Liang, Juan Hu, Huimin Chang, Ying Gao, Huanan Luo,Zhenghui Wang, Guoxi Zheng, Fang Chen, Ting Wang, Yeye Yang, Xiaohui Kou, Min Xu. Tracheobronchial foreign bodies in children –a retrospective study of 2,000 cases in Northwestern China. Therapeutics and Clinical Risk Management, 2015,11:1291–1295(SCI Index, Corresponding author)
15.Zhenghui Wang, Xiaoli Li, Xijing He, Xianghong Zhang, Zhuangqun Yang. Experimental study of tissue-engineered cartilage allograft with RNAi chondrocytes in vivo. Therapeutics and Clinical Risk Management, 2014,10:335–340(SCI Index)
16.Zhenghui Wang,Chuangxin Lu, Caiqin Wu, Min Xu, Xiaohui Kou, Demin Kong, Gangli Jing. Polysaccharide of Boschniakia rossica induces apoptosis on laryngeal carcinoma Hep2 cells. Gene, 2014,56:203-206( SCI Index)
17. HM Chang,ZH Wang, HN Luo, M Xu, XY Ren, GX Zheng, BJ Wu, XH Zhang, XY Lu, F Chen, XH Jing, L Wang. Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-based scaffolds for tissue engineering. Brazilian Journal of Medical and Biological Research ,2014, 47(7): 533-539(SCI Index ,corresponding author)
18.Zhenghui Wang, Xiaoli Li, XiJing He, Min Xu, Baojun Wu, Huanan Luo, Zhe Xing. Delivery of the Sox9 gene promotes chondrogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells in an in vitro model. Brazilian Journal of Medical and Biological Research, 2014, 47(4): 279-286(SCI Index)
19.Zhenghui Wang, Baojun Wu, Xianghong Zhang, Min Xu, Huimin Chang, Xiaoyun Lu, Xiaoyong Ren. Purification of a polysaccharide from Boschniakia rossica and its synergistic antitumor effect combined with 5-Fluorouracil. Carbohydrate Polymers, 2012,89:31-35(SCI Index)
20.Zhenghui Wang, Xiaoli Li, Baojun Wu, Dingwei Zhang, Min Xu, Xiaoyong Ren, Caiqin Wu, Jingjing Li. Liposome-loaded pingyangmycin: A new possible agent to treat hemangioma. African Journal of Pharmacy and Pharmacology, 2012, 6(27): 2088-2090 (SCI Index)
21.Zhenghui Wang, Xianghong Zhang, Baoshu Li, et al. The role of intralesional Pingyangmycin in the treatment of nasal polyp in aged population. African Journal of Pharmacy and Pharmacology, 2012, 6(30): 2281-22843(SCI Index)
22.Xiaoli Li,Zhenghui Wang, Yongxi Zhao, Suju Luo, Dingwei Zhang, Shengxiang Xiao, Zhenhui Peng. Isolation and antitumor activities of acidic polysaccharide from Gynostemma pentaphyllum Makino. Carbohydrate Polymers, 2012,89:942-947(SCI Index, Corresponding author)
23.Xiaoli Li,Zhenghui Wang, Yongxi Zhao, Suju Luo, Dingwei Zhang, Shengxiang Xiao, Zhenhui Peng. Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis. Carbohydrate Polymers, 2012,89:1232-1237 (SCI Index, Corresponding author)
24.Zhenghui Wang, Zhuangqun Yang, Xijing He, B. Elnour Kamal, Zhe Xing. Lentivirus-mediated knockdown of aggrecanase-1 and -2 promotes chondrocyte-engineered cartilage formation in vitro. Biotechnology and Bioengineering, 2010, 107(4): 730-736 (SCI Index)
25.Zhenghui Wang, Zhuangqun Yang, Xijing He, Junbo Tu. Aggrecanases gene inhibition in chondrocytes: a new possible strategy to relieve immune rejection of transplants. Medical Hypotheses, 2009, 72(2):196-198(SCI Index)
26.Zhenghui Wang, Xijing He, Zhuangqun Yang, Junbo Tu. Cartilage tissue engineering with demineralized bone matrix gelatin and fibrin glue hybrid scaffold : an in vitro study. Artificial Organs , 2010,34(2):161-166(SCI Index)
27.Zhenghui Wang, Zhuangqun Yang, Zhe Xing, Min Xu. Fluorine induced apoptosis and lipid peroxidation in cultured human hair follicle in vitro. Biol Trace Elem Res,2010, 137:280-288(SCI Index)
28.Zhenghui Wang, Zhuangqun Yang, Xijing He, Li Wang, Lixia Li, Junbo Tu. Effects of RNAi- mediated inhibition of aggrecanase-1 and aggrecanase-2 on rat costochondral chondrocytes in vitro. Acta Pharmacol Sin, 2008,29 (10):1215 -1226(SCI Index)
29.Wang ZH, Li XL, Yang Z,He X, Tu J, Zhang T. Effects of aloesin on melanogenesis in pigmented skin equivalents. International Journal of Cosmetic Science, 2008,30:121-130(Pubmed)
30.Wang Zhenghui, Wu Baojun, Kamal Mustafa. Tissue engineered cartilage using chitosan/gelatin and normal or post-RNA interference-chondrocytes in vitro. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(1):106-111(Pubmed)
31.Wang Zhenghui, He Xijing, Yang Zhuangqun, Wang li, Li Lixia, Tu Junbo. Effects of RNA interference against aggrecanase 1 gene on extracellular matrix metabolism of cultured chondrocytes in vitro. J South Med Univ, 2009;29(9):1766-1769(Pubmed)
发明专利：
1.一种电动弹出式可折叠手术刀(专利号ZL 2017 1 1209278.X)已授权
ESCO2抑制剂在制备用于治疗下咽癌的药物中的用途实审阶段
检测下咽癌IcRNA标志物的试剂在制备诊断下咽癌产品中的应用实审阶段
联系方式：
ehui4298@163.com, wangzhenghui77@xjtu.edu.cn
