研究领域（方向）
（1）消化道黏膜屏障损伤，（2）炎癌转化，（3）胃肠肿瘤，（4）等离子体医学
个人及工作简历
教育背景
2012.09-2015.09，西安交通大学，肿瘤学，博士（西安交通大学优秀博士标兵）
2013.12-2014.1，美国University of Massachusetts Medical School，访问学者
2005.09-2012.06，西安交通大学，肿瘤学，学士+硕士（本硕连读，优秀毕业生）
工作经历
2024.01-至今，西安交通大学第一附属医院肿瘤外科，副主任/副教授/副主任医师/副研究员
2022.08-2023.12，西安交通大学第一附属医院肿瘤外科，副主任/副研究员/主治医师
2021.10-2022.08，西安交通大学第一附属医院肿瘤外科，东院区临时负责人/副研究员/主治医师
2020.09-2021.09，陕西省宝鸡高新医院，副院长(挂职)，陕西省委组织部博士服务团
2015.09-2020.08，西安交通大学第一附属医院肿瘤外科，团支部书记/副研究员/主治医师
科研项目
国家社会科学基金，一般项目，23BRK014，气候变化视角下老年人口健康风险测度与预警研究
国家自然科学基金，青年项目，81502442，幽门螺杆菌诱导Mist1基因启动子区甲基化及表达沉默在胃癌发生发展中的作用
陕西省自然科学基础研究计划, 青年项目, 2019JQ-948, Mist1基因介导胃主细胞源性胃癌的发病机制研究
中央高校基本科研业务费, 一般项目, xjj2018106, 基于机器学习的直肠癌新辅助治疗能量多普勒超声评价体系构建
学术及科研成果、专利、论文
1.Ma, R., Wang, X., Ren, K., Ma, Y., Min, T., Yang, Y., Xie, X., Li, K., Zhu, K., Yuan, D., Mo, C., Deng, X., Zhang, Y., Dang, C.,Zhang, H., & Sun, T. (2024). Chronic low-dose deltamethrin exposure induces colon injury and aggravates DSS-induced colitis via promoting cellular senescence. Ecotoxicology and environmental safety, 274, 116214. Advance online publication. https://doi.org/10.1016/j.ecoenv.2024.116214
2.Ma, R., Sun, T., Wang, X., Ren, K., Min, T., Xie, X., Wang, D., Li, K., Zhang, Y., Zhu, K., Mo, C., Dang, C., Yang, Y., &Zhang, H. (2023). Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis. Ecotoxicology and environmental safety, 264, 115475. https://doi.org/10.1016/j.ecoenv.2023.115475
3.Ma, Y., Sun, T., Ren, K., Min, T., Xie, X., Wang, H., Xu, G., Dang, C., &Zhang, H. (2023). Applications of cold atmospheric plasma in immune-mediated inflammatory diseases via redox homeostasis: evidence and prospects. Heliyon, 9(12), e22568. https://doi.org/10.1016/j.heliyon.2023.e22568
4.Sun, T., Ren, K., Xu, G., Ma, R., Wang, X., Min, T., Xie, X., Sun, A., Ma, Y., Wang, H., Zhang, Y., Zhu, K., Dang, C., Zhang, G., &Zhang, H.(2023). Plasma-Activated Solutions Mitigates DSS-Induced Colitis via Restoring Redox Homeostasis and Reversing Microbiota Dysbiosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(34), e2304044. https://doi.org/10.1002/advs.202304044
5.Ren, K., Xie, X., Min, T., Sun, T., Wang, H., Zhang, Y., Dang, C., &Zhang, H. (2022). Development of the Peritoneal Metastasis: A Review of Back-Grounds, Mechanisms, Treatments and Prospects. Journal of clinical medicine, 12(1), 103. https://doi.org/10.3390/jcm12010103
6.Min, T., Xie, X., Ren, K., Sun, T., Wang, H., Dang, C., &Zhang, H. (2022). Therapeutic Effects of Cold Atmospheric Plasma on Solid Tumor. Frontiers in medicine, 9, 884887. https://doi.org/10.3389/fmed.2022.884887
7.Xie, X., Ren, K., Zhou, Z., Dang, C., &Zhang, H. (2022). The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study. BMC gastroenterology, 22(1), 58. https://doi.org/10.1186/s12876-022-02130-2
8.Xie, X., Zhou, Z., Song, Y., Zhang, X., Dang, C., &Zhang, H. (2021). Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/β-catenin Pathway. Journal of Cancer, 12(15), 4574–4584. https://doi.org/10.7150/jca.59138
9.Wang, W., Xie, X., Yuan, T., Wang, Y., Zhao, F., Zhou, Z., &Zhang, H. (2021). Epidemiological trends of maternal hypertensive disorders of pregnancy at the global, regional, and national levels: a population-based study. BMC pregnancy and childbirth, 21(1), 364. https://doi.org/10.1186/s12884-021-03809-2
10.Wang, W., Xie, X., Zhou, Z., &Zhang, H. (2021). Expression Analysis of MIST1 and EMT Markers in Primary Tumor Samples Points to MIST1 as a Biomarker of Cervical Cancer. International journal of general medicine, 14, 1293–1300. https://doi.org/10.2147/IJGM.S307367
11.Zhou, Z., Xie, X., Wang, X., Zhang, X., Li, W., Sun, T., Cai, Y., Wu, J., Dang, C., &Zhang, H. (2021). Correlations Between Tumor Mutation Burden and Immunocyte Infiltration and Their Prognostic Value in Colon Cancer. Frontiers in genetics, 12, 623424. https://doi.org/10.3389/fgene.2021.623424
12.Zhang, H., Yin, J., Wang, X., Yuan, D., Zhu, K., Li, K., Xu, G., Dang, C., Jia, R., & Zhang, Y. (2021). Patients' Responses to the Sudden Interruption of Chemotherapy During the Outbreak of the Novel Coronavirus: A Cross-Sectional Study. Cancer management and research, 13, 351–358. https://doi.org/10.2147/CMAR.S274525
13.Xie, X., Zhou, Z., Song, Y., Wang, W., Dang, C., &Zhang, H. (2018). Differences between carcinoma of the cecum and ascending colon: Evidence based on clinical and embryological data. International journal of oncology, 53(1), 87–98. https://doi.org/10.3892/ijo.2018.4366
14.Zhou, Z., Wang, W., Xie, X., Song, Y., Dang, C., &Zhang, H. (2018). Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway. Biochemical and biophysical research communications, 500(2), 411–417. https://doi.org/10.1016/j.bbrc.2018.04.089
15.Xie, X., Zhou, Z., Song, Y., Dang, C., &Zhang, H. (2017). Surgical Management and Prognostic Prediction of Adenocarcinoma of Jejunum and Ileum. Scientific reports, 7(1), 15163. https://doi.org/10.1038/s41598-017-15633-w
16.Hao, N., Xie, X., Zhou, Z., Li, J., Kang, L., Wu, H., Guo, P., Dang, C., &Zhang, H. (2017). Nomogram predicted risk of peripherally inserted central catheter related thrombosis. Scientific reports, 7(1), 6344. https://doi.org/10.1038/s41598-017-06609-x
17.Xie, X., Zhou, Z., Song, Y., Li, W., Diao, D., Dang, C., &Zhang, H. (2016). The Management and Prognostic Prediction of Adenocarcinoma of Appendix. Scientific reports, 6, 39027. https://doi.org/10.1038/srep39027
联系方式
电子邮箱：hao.zhang@xjtu.edu.cn
联系电话：029-85324610
个人主页：
联系地址：西安交通大学第一附属医院外科大楼6楼
