
研究领域(方向):
研究方向集中于智能响应型药物递送系统的设计与开发,重点探索其在炎症性疾病和肿瘤治疗中的应用。具体研究内容包括:(1)基于天然多糖的功能化药物载体构建及其靶向递送机制;(2)多功能纳米酶系统的设计及其在疾病微环境调控中的应用;(3)仿生药物递送系统的构建及其生物学效应评价。
个人及工作简历(个人受教育及工作经历):
2021.05-至今西安交通大学药学院副教授
2016.12-2021.04西北工业大学生命学院讲师
2011.09-2016.12西安交通大学医学部硕博连读(硕士:药剂学/博士:药物分析学)
2006.09-2010.07陕西中医药大学药学院中药学学士
主要科研项目
国家自然科学基金青年基金:81803491,双探针共载肿瘤渗透性纳米荧光检测系统的构建及其在乳腺癌PDT精准治疗中的应用,主持。
陕西省重点研发计划—社会发展领域项目:2025SF-YBXM-346,基于去磷酸化调控TLR4/MyD88/NF-κB通路抑制炎症反应的递药系统的构建及其治疗UC的研究,主持。
陕西省重点研发计划—社会发展领域项目:2022SF-081,基于“铁死亡”机制的纳米诊疗系统的构建及其在肿瘤化学动力学疗法中的应用,主持。
陕西省自然科学基金青年基金:2019JQ-320,肿瘤渗透性纳米检测系统在三阴性乳腺癌PDT精准治疗中的应用,主持。
中国博士后科学基金面上项目:2021M702633,可监测肿瘤化学动力学疗法的逐级靶向纳米诊疗系统的构建及应用,主持。
中国博士后科学基金面上项目:2018M633584,肿瘤渗透性纳米检测系统对乳腺癌PDT治疗的指导研究,主持。
陕西省博士后科研资助项目:2018BSHQYXMZZ43,靶向EGFR智能纳米诊疗系统的构建及其在TNBC精准治疗中的应用,主持。
学术及科研成果、专利、论文
近五年论文:
Therapeutic systems based on natural gut microbiota modulators: the latest advances in the treatment of inflammatory bowel disease.Materials Advances, 2025, 6, 1578-1607(通讯作者)
Construction and evaluation of a nanosystem that combines acidification promoted chemodynamic therapy and intracellular drug release monitoring.Journal of Biotechnology, 2024, 383, 13-26.(第一作者)
Dexamethasone-Loaded Lipid Calcium Phosphate Nanoparticles Treat Experimental Colitis by Regulating Macrophage Polarization in Inflammatory Sites.InternationalJournal of Nanomedicine, 2024, 19, 993–1016.(第一作者)
Metal-Phenolic Networks for Chronic Wounds Therapy.International Journal of Nanomedicine, 2023, 18, 6425-6448.(通讯作者)
Restoration of dysregulated intestinal barrier and inflammatory regulation through synergistically ameliorating hypoxia and scavenging reactive oxygen species using ceria nanozymes in ulcerative colitis,Biomaterials Research, 2023, 27:75.(通讯作者)
Hyaluronic acid-based M1 macrophage targeting and environmental responsive drug releasing nanoparticle for enhanced treatment of rheumatoid arthritis,Carbohydrate Polymers, 2023, 316, 121018.(通讯作者)
Co-loading Nanodetection System in the Process Monitoring and Efficacy Assessment of Photodynamic Therapy: An In Vitro Study.ACS Biomaterials Science & Engineering, 2023, 9, 1089-1103.(第一作者)
Recent molecular design strategies for efficient photodynamic therapy and its synergistic therapy based on AIE photosensitizers.European Journal of Medicinal Chemistry, 2022, 244:114843.(通讯作者)
Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification.International Journal of Nanomedicine, 2022,17 2611-2628.(通讯作者)
Multifunctional nanosystems sequentially regulating intratumor Fenton chemistry by remodeling the tumor microenvironment to reinforce chemodynamic therapy.Biomaterials Advances, 2022,138:212957.(第一作者)
Cinnamaldehyde and doxorubicin co-loaded graphene oxide wrapped mesoporous silica nanoparticles for enhanced MCF-7 cell apoptosis.International Journal of Nanomedicine, 2020:15 10285-10304.(第一作者)
Regulating intracellular ROS signal by a dual pH/reducing-responsive nanogels system promotes tumor cell apoptosis.International Journal of Nanomedicine, 2019, 14: 5713-5728.(第一作者)
Amplification of Oxidative Stress in MCF-7 Cells by a Novel pH-Responsive Amphiphilic Micellar System Enhances Anticancer Therapy.Molecular Pharmaceutics, 2019, 16 (2): 689-700.(第一作者)
Construction and Mechanism of IL-15-Based Coactivated Polymeric Micelles for NK Cell Immunotherapy.Advanced Healthcare Materials. 2024;13(4).2302589(其他)
Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC.Journal of Nanobiotechnology. 2024; 22(1): 98.(其他)
专利(第一申请人)
董凯,邢元铭,关泽林,王丹阳,邓淑婧,谭祈超.一种硫辛酸接枝透明质酸衍生物、制备方法及应用:中国,申请号202510709760.8[P].申请日期2025-05-29.
董凯,卢婷利,叶仙育,赵壮壮. pH响应性氧化石墨烯纳米片包覆介孔二氧化硅药物双载复合纳米粒子及制备方法:中国,ZL201910732152.3[P]. 2022-12-09.
联系方式:
电子邮箱:dongkai120@xjtu.edu.cn
联系电话:+86-15209281970
个人主页:https://pharm.xjtu.edu.cn/info/1187/2815.htm
联系地址:陕西省咸阳市秦都区钓台街道西安交通大学创新港C区21号楼(泓仁楼)