南冠君

研究领域(方向):

(1)中药外源性有害物质分析及健康风险评估;

(2)非生物胁迫对药用植物次生代谢产物合成、积累和分布的影响。


个人及工作简历(个人受教育及工作经历):

教育经历

2007.9-2011.6西安交通大学药学学士

2012.9-2019.3西安交通大学药物分析学博士

2017.9-2018.9美国马萨诸塞大学食品科学访问学者

工作经历

2019.5~2023.9西安交通大学医学部药学院助理教授

2023.10~至今西安交通大学医学部药学院副教授

 

主要科研项目

纵向项目

(1)国家自然科学基金青年项目:Cd/Hg复合胁迫通过甘草ABCG10转运蛋白调控甘草苷的合成积累及机制。批准号:82304655,2024.1-2026.12,30万,主持。

(2)陕西省中医药管理局:陕西省中医药中青年骨干人才支持计划。批准号:TZKN-CXRC-25,2025.1-2026.12,20万,主持。

(3)陕西省中医药管理局:基于PBET/Caco-2和PBPK模型及概率分布的古代经典名方桃红四物汤中重金属的风险评估和限量标准制定。批准号:SZY-KJCYC-2025-ZY-008,2025.1-2026.12,5万,主持。

(4)陕西省重点研发计划一般项目:基于PBET/Caco-2和PBPK模型及概率分布的古代经典名方身痛逐瘀汤中重金属的风险评估和限量标准制定。批准号:2024SF-YBXM-493,2024.1-2025.12,6万,主持。

(5)陕西省重点研发计划一般项目:陕西十大秦药中重金属的形态分析、风险评估及重金属限量标准制定。批准号:2020SF-319,2020.1-2021.12,8万,主持。

横向项目

(1)新疆荣成哈克制药有限公司:民族药资源评估和新药筛选,50万,2023.6-2024.12

 


学术及科研成果、专利、论文

获奖情况

(1)2022年度陕西省科学技术进步二等奖:SIRT1/6为靶点的抗动脉粥样硬化药物筛选体系的建立和应用(排名第五)。

发表论文

  1. Guanjun Nan, Bo Wang, Xiaohan Lv, Weirong Wang, Zhimin Luo, Guangde Yang, Rongcheng Ding, Jianjiang Wang, Rong Lin, Haichen Wang. Effects of Rhaponticum carthamoides (Willd.) Iljin on endothelial dysfunction and the inflammatory response in type 2 diabetes mellitus mice.Phytomedicine, 2024, 135: 156134

  2. Zhen Jin, Bo Wang, Lingxuan Ren, Jianjun Yang, Zihan Zheng, Feng Yao, Rongcheng Ding, Jianjiang Wang, Jianyu He, Weirong Wang,Guanjun Nan*, Rong Lin*. 20-Hydroxyecdysone inhibits inflammation via SIRT6-mediated NF-κB signaling in endothelial cells.BBA - Molecular Cell Research, 2023, 1870: 119460. (通讯作者).

  3. Guanjun Nan, Yanru Huang, Zhengzheng Liu, Yu Liu, Yunzhe Li, Guangde Yang, Dissolution thermodynamics and preferential solvation of genistein in some (ethanol + water) mixtures at different temperatures.Drug Development and Industrial Pharmacy, 2022, 48:575-584

  4. Guanjun Nan, Lina Zhang, Zhengzheng Liu, Yu Liu, Yan Du, Hongwen Zhao, Hongxia Zheng, Rong Lin, Guangde Yang, Shaohua Zheng. Quantitative determination of p-cymene, thymol, neryl acetate, and β-caryophyllene in different growth periods and parts of eupatorium fortunei turcz. by GC-MS/MS.Journal of Analytical Methods in Chemistry, 2021, 2021: 2174667.

  5. Guanjun Nan, Xianxin Meng, Ning Song, Zhengzheng Liu, Yu Liu, Yunzhe Li, Guangde Yang Shaohua Zheng. Uptake and distribution characteristic and health risk assessment of heavy metal(loid)s in Platycodon Grandiflorum (Jacq.) A.DC. with growth from a medicinal herb garden of Xi’an, China.Biological Trace Element Research, 2021, 199:2 770-2778.

  6. Guanjun Nan, Xianxin Meng, Ning Song, Zhengzheng Liu, Yu Liu, Guangde Yang. Fractionation analysis and health risk assessment of heavy metals in six traditional Chinese medicines.Environmental Science and Pollution Research, 2020, 27: 10308-10316.

  7. Guanjun Nan, Liying Guo, Yuqiong Gao, Xianxin Meng, Lina Zhang, Ning Song, Guangde Yang. Speciation analysis and dynamic absorption characteristics of heavy metals and deleterious element during growing period of Chinese peony.International Journal of Phytoremediation, 2019, 21: 1407-1414.

  8. Guanjun Nan, Yuqiong Gao, Liying Guo, Xianxin Meng, Guangde Yang. Solid-liquid extraction of Daidzein and Genistein from Soybean: Kinetic modeling of influential factors.Preparative Biochemistry & Biotechnology, 2018, 48: 946-953.

  9. Lijuan Yang#,Guanjun Nan#, Xianxin Meng, Lina Zhang, Ning Song, Yu Liu, Zhengzheng Liu, Yu Wang, Guangde Yang. Study on the interaction between lovastatin and three digestive enzymes and the effect of naringin and vitamin C on it by spectroscopy and docking methods.International Journal of Biological Macromolecules, 2020, 155:1440-1449.(共同一作)

  10. Xianxin Meng#,Guanjun Nan#, Yunzhe Li, Yan Du, Hongwen Zhao, Hongxia Zheng, Wanlu Li, Henglin Liu, Yiping Li, Guangde Yang. Study on the interaction between nimodipine and five proteinases and the effects of naringin and vitamin C on these interactions by spectroscopic and molecular docking methods.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 272:120982. (共同一作)

  11. Guanjun Nan, Jing Sun, Meiwen Ding, Xin Yang, Guangde Yang.Interaction behavior between myricetin and dihydromyricetin with pepsin by spectroscopic and docking methods.Journal of Molecular Liquids, 2016, 223:128-135.

  12. Guanjun Nan, Ping Wang, Jing Sun, Jianhua Lv, Meiwen Ding, Liu Yang, Yiping Li Guangde Yang. Spectroscopy and molecular docking study on the interaction of daidzein and genistein with pepsin.Luminescence, 2016, 31:1524-1531.

  13. Guanjun Nan, Jiao Shi, Yanru Huang, Jing Sun, Jianhua Lv, Guangde Yang, Yiping Li. Dissociation constants and solubility of daidzein and genistein in different solvents.Journal of Chemical & Engineering Data, 2014, 59:1304-1311.

  14. Xianxin Meng,Guanjun Nan, Bowen Shi, Wanlu Li, Henglin Liu, Rong Lin, Guangde Yang, Shaohua Zheng. Investigation on the interaction between myricetin and dihydromyricetin with trypsin, α-chymotrypsin, lysozyme by spectroscopy and molecular docking methods.Luminescence, 2021, 37:810-821.

  15. Fei Mao,Guanjun Nan, Meng Cao, Yuqiong Gao, Liying Guo, Xianxin Meng, Guangde Yang. The metal distribution and the change of physiological and biochemical process in soybean and mung bean plants under heavy metal stress.International Journal of Phytoremediation, 2018, 20:1113-1120.

     


    联系方式

    电子邮箱:nanguanjun@xjtu.edu.cn

    联系电话:15091671327

    个人主页:https://gr.xjtu.edu.cn/en/web/nanguanjun

    联系地址:西安市雁塔区雁塔西路76号

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