主持研究课题:
1. PPAR-γ通路在股骨头坏死病理机制中的作用研究(西安交通大学校长科研基金)
2. 骨髓基质干细胞复合异种脱细胞神经基质构建组织工程神经的研究(中央高校基本科研业务费-自由探索项目)
3. HIF-1α和BMP-7基因共转染骨髓间充质干细胞移植治疗股骨头坏死的实验研究(国家自然科学基金-青年项目)
4. 基于3D微结构打印技术构建掺锂β-TCP复合骨髓间充质干细胞的成血管成骨能力研究(中央高校基本科研业务费-学科交叉项目)
5. 3D微结构打印掺锂β-TCP复合microRNA-21转染骨髓间充质干细胞治疗股骨头坏死的实验研究(国家自然科学基金-面上项目81572145,57万)
6. miR-210修饰的BMMSCs来源外泌体复合可注射水凝胶激活PI3K/Akt通路治疗激素性股骨头坏死(国家自然科学基金-面上项目81772355,55万)
1. Pei J, Fan LH(*), Nan K, Li J, Shi Z, Dang X, Wang K. Excessive Activation of TLR4/NF-κB Interactively Suppresses the Canonical Wnt/β-catenin Pathway and Induces SANFH in SD Rats.Sci Rep. 2017 Sep 20;7(1):11928.
2. Pei JP, Fan LH(*), Nan K1, Li J, Dang XQ, Wang KZ. HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury.J Neuroinflammation. 2017 May 3;14(1):97.
3. Li, Jia,Ge, Zhaogang,Fan, Lihong,Wang, Kunzheng,Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.,BMC Musculoskelet Disord,2017.2.2,18(1):58~58
4. Zefeng Yu,Lihong Fan(*),Jia Li,Zhaogang Ge,Xiaoqian Dang,Kunzheng Wang(*),Lithiumprevents rat steroid-related osteonecrosis of the femoral head by β-catenin activation,Endocrine,2016.5.01,52(2):380~390
5. Fan L, Zhang C, Yu Z, Shi Z, Dang X, Wang K. Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and osteogenesis in rabbit femoral head osteonecrosis. Bone. 2015 Dec;81:544-53.
6. Yu Z, Fan L, Li J, Ge Z, Dang X, Wang K. Lithium chloride attenuates the abnormal osteogenic/adipogenic differentiation of bone marrow-derived mesenchymal stem cells obtained from rats with steroid-related osteonecrosis by activating the β-catenin pathway.Int J Mol Med. 2015 Nov;36(5):1264-72.
7. Zhang C, Ma J, Fan L, Zou Y, Dang X, Wang K, Song J. Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating. Tissue Cell. 2015 Jun;47(3):291-300.
8. Liu R, Li Y, Fan L, Mu M, Wang K, Song W. Depression and anxiety before and after limb length discrepancy correction in patients with unilateral developmental dysplasia of the hip. J Psychosom Res. 2015 Dec;79(6):574-9.
9. Fan L, Li J, Yu Z, Dang X, Wang K. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Prevents Steroid-Associated Osteonecrosis of the Femoral Head in Rabbits by Promoting Angiogenesis and Inhibiting Apoptosis. PLoS One. 2014 Sep 22;9(9):e107774.
10. Fan L, Yu Z, Li J, Dang X, Wang K. Immunoregulation Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Xenogeneic Acellular Nerve Grafts Transplant.Cell Mol Neurobiol. 2014 Jun 17.
11. Fan L, Li J, Yu Z, Dang X, Wang K. The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration.Biomed Res Int. 2014;2014:239356.
12. Fan L, Yu Z, Li J, Dang X, Wang K. Schwann-like cells seeded in acellular nerve grafts improve nerve regeneration. BMC Musculoskelet Disord. 2014 May 21;15:165.
13. You W, Fan L, Duan D, Tian L, Dang X, Wang C, Wang K. Foxc2 over-expression in bone marrow mesenchymal stem cells stimulates osteogenic differentiation and inhibits adipogenic differentiation.Mol Cell Biochem. 2014 Jan;386(1-2):125-34.
14. Feng M, Zhang R, Gong F, Yang P, Fan L, Ni J, Bi W, Zhang Y, Wang C, Wang K. Protective effects of necrostatin-1 on glucocorticoid-induced osteoporosis in rats. J Steroid Biochem Mol Biol. 2014 Sep 9;144PB:455-462.
15. Tian L, Wen Q, Dang X, You W, Fan L, Wang K. Immune response associated with Toll-like receptor 4 signaling pathway leads to steroid-induced femoral head osteonecrosis.BMC Musculoskelet Disord. 2014 Jan 15;15(1):18.
16. You W, Gao H, Fan L, Duan D, Wang C, Wang K. Foxc2 regulates osteogenesis and angiogenesis of bone marrow mesenchymal stem cells.BMC Musculoskelet Disord. 2013 Jul 2;14:199.
17. Fan L, Dang X, Wang K. Comparison between bipolar hemiarthroplasty and total hip arthroplasty for unstable intertrochanteric fractures in elderly osteoporotic patients.PLoS One. 2012;7(6):e39531.
18. Fan L, Dang X, Shi Z, Zhang C, Wang K. Hydroxysafflor yellow A protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation.Cell Mol Neurobiol. 2011 Nov;31(8):1187-94.
19. Fan L, Wang K, Shi Z, Die J, Wang C, Dang X. Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.J Vasc Surg. 2011 Jul;54(1):192-200.
20. Liu C, Shi Z, Fan L, Zhang C, Wang K, Wang B. Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury.Brain Res. 2011 Feb 16;1374:100-9.
21. Die J, Wang K, Fan L, Jiang Y, Shi Z. Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions.Brain Res. 2010 Jul 30;1346:251-61.
22. Fan LH, Wang KZ, Cheng B, Wang CS, Dang XQ. Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.BMC Neurosci. 2006 Jun 14;7:48.
23. 樊立宏 王坤正 党晓谦 王春生. 金属对金属全髋关节表面置换术早中期临床报告 《中国骨与关节外科》
24. 樊立宏 刘瑞宇 时志斌党晓谦 王坤正 刘颖 刘原. 基于临床路径的PBL教学法在骨科研究生临床带教中的应用. 《中国医学教育技术》
25. 樊立宏 王坤正 党晓谦 王春生 时志斌 张晨. 大粗隆延长截骨结合记忆合金内固定在股骨柄翻修术中的应用. 《中华关节外科杂志(电子版)》
26. 葛兆刚 樊立宏 刘琪 时志斌 党晓谦 王坤正. 髌骨周围去神经化对保留髌骨的全膝关节置换术后影响的meta分析.《中国医师杂志》
27. 时志斌 强辉 樊立宏 王坤正 党晓谦. 重组人骨形态发生蛋白7基因腺相关病毒载体的构建及其体外生物学活性.《西安交通大学学报(医学版)》
28. 郑世成 高宗强 樊立宏 时志斌 王坤正 陈君长 王小燕. 损伤控制骨科理论指导一体化救治模式在骨科严重多发伤中的应用.
29. 田雷 周东生 孙水 张晨 樊立宏 王坤正. Toll样受体4信号通路过度激活在大鼠激素性股骨头坏死中的作用.
30. 党晓谦 王坤正 王春生 柏传毅 时志斌 王伟 杨佩 樊立宏. 吻合血管腓骨移植结合交叉穿针外固定治疗中青年陈旧性股骨颈骨折 《中华显微外科杂志》
31. 倪建龙 王坤正 党晓谦 时志斌 樊立宏 杨佩. 全髋关节置换术治疗髋臼骨折后创伤性关节炎的疗效观察.《中华关节外科杂志(电子版)》
32. 张晨 王坤正 党晓谦 王春生 杨佩 樊立宏. hVEGF165及hBMP-7共表达重组腺相关病毒载体对兔激素性股骨头坏死的修复作用研究. 《中华关节外科杂志(电子版)》
授权国家发明专利:
1. 双层仿生颈椎间盘假体及其制造方法 [发明专利] CN200510041794.7
2. 一种复合种子细胞的组织工程神经的制备方法 [发明专利] CN201310364793.0